Tag: M.W=150-200

Liu, Xuan-Yu published the artcileIron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds, HPLC of Formula: 401-55-8, the publication is Organic Letters (2019), 21(15), 5873-5878, database is CAplus and MEDLINE.

An efficient, economical, and practical Reformatskii reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and com. iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lu, Dengfu published the artcileCu-Catalyzed C_(sp3)-N Coupling and Alkene Carboamination Enabled by Ligand-Promoted Selective Hydrazine Transfer to Alkyl Radicals, Recommanded Product: Ethylbromofluoroacetate, the publication is ACS Catalysis (2022), 12(6), 3269-3278, database is CAplus.

In this work, di-tert-Bu hydrazodiformate was found to be a unique effective amination reagent in Cu-catalyzed C(sp³)-N bond formation reactions that involve alkyl radical intermediates. This method was applicable to both electron-deficient and electron-rich radicals, and were able to achieve the direct C-N coupling of activated bromides, as well as the carboamination of general alkenes based on this chem. Mechanistic studies suggested that the hydrazodiformate forms a reducing dinuclear complex with Cu and the ligand which, upon 1e-oxidation, turns into an open-shell species with the major spin d. on N atoms. With the assistance of a ligand, this species can selectively deliver the hydrazine moiety onto an alkyl radical (prior to halide transfer), leading to the formation of a C(sp³)-N bond. The products obtained with this amination method could be easily deprotected to afford alkyl hydrazines and further derived to primary amines or N-heterocycles.

ACS Catalysis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kong, Qunshou published the artcileN-Arylimidazoliums as Highly Selective Biomimetic Antimicrobial Agents, HPLC of Formula: 111-83-1, the publication is Journal of Medicinal Chemistry (2022), 65(16), 11309-11321, database is CAplus and MEDLINE.

Antibiotic resistance has become one of the greatest health threats in the world. In this study, a charge-dispersed dimerization strategy is described for the antimicrobial peptide (AMP) mimics via a tunable cationic charge to improve the selectivity between prokaryotic microbes and eukaryotic cells. This strategy is demonstrated with a series of charge-dispersed AMP mimics based on N-arylimidazolium skeletons. These N-arylimidazolium AMP mimics show potent antibacterial activity against strains along with a low rate of drug resistance, good hemocompatibility, and low cytotoxicity. In addition to the elimination of planktonic bacteria, N-arylimidazolium AMP mimics can also inhibit biofilm formation and destroy the established biofilm. More importantly, methicillin-resistant Staphylococcus aureus (MRSA)-induced lung-infected mice can be effectively treated by the i.v. administration of N-arylimidazolium AMP mimic, which enable the design of N-arylimidazolium AMP mimics to offer an alternative avenue to eradicate drug-resistant bacterial infection.

Journal of Medicinal Chemistry published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, HPLC of Formula: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Rui published the artcileDesign, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment, Safety of 2-Bromoethyl Methyl Sulfone, the publication is European Journal of Medicinal Chemistry (2021), 113004, database is CAplus and MEDLINE.

In this study, a series of novel tetrahydroisoquinoline I [R¹ = CHO, CH₂CH₂SO₂Me, CH₂CO₂Me, etc.; configuration = S, Rac, R], II [R² = Bn, Et; R³ = CO₂Me, CHO, etc.; configuration = S, Rac] and III [R⁴ = Et, Me; R⁵ = 5-phenyl-1H-indolyl, 5-methoxy-1H-indolyl, etc.; configuration = S, Rac] were developed based on the crystal structure of PDE4D in complex with I [R¹ = CHO, configuration = S]. Anti-inflammatory effects of these compounds were evaluated and III [R⁴ = Me, R⁵ = 7-chloro-1H-indolyl, configuration = S] with high safety, permeability and selectivity, exhibited significant inhibitory potency against the enzymic activity of PDE4D and the TNF-α release from the LPS-stimulated RAW 264.7 and hPBMCs. Moreover, an in-vivo study demonstrated that a topical administration of III [R⁴ = Me, R⁵ = 7-chloro-1H-indolyl, configuration = S] achieved more significant efficacy than calcipotriol to improve the features of psoriasis-like skin inflammation. Overall, this study provided a basis for further development of tetrahydroisoquinoline-based PDE4 inhibitors against psoriasis.

European Journal of Medicinal Chemistry published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C8H16N2O, Safety of 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Renyong published the artcileImproved synthetic method of captopril, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Shenyang Yaoke Daxue Xuebao (1997), 14(4), 262-264, database is CAplus.

An improved synthetic method for captopril using methacrylic acid as the starting material was described. Treatment of methacrylic acid with hydrogen bromide gave 3-bromo-2-methylpropanoic acid which underwent chlorination with thionyl chloride, condensation with L-proline gave N-(R,S-3-bromo-2-methylpropanoyl)-L-prolin (I). I was resolved into optically pure stereo-isomer, which was treated with sodium trithiocarbonate to give captopril.

Shenyang Yaoke Daxue Xuebao published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lv, You published the artcileSynthesis, crystal structure and fungicidal activity of 3-chloro-4-(3,4-dichloroisothiazol-5-yl)-5-hydroxy-7-methyl-2H-chromen-2-ones, SDS of cas: 401-55-8, the publication is Chinese Journal of Structural Chemistry (2021), 40(8), 1068-1074, database is CAplus.

3-Chloro-4-(3,4-dichloroisothiazol-5-yl)-5-hydroxy-7-methyl-2H-chromen-2-ones I [R = H, Me, Et, F, Cl] coumarin derivatives, were synthesized by β-ketoester formation and cyclization. Target compound I [R = Cl] was crystallized from methanol for structural identification as monoclinic crystal system, space group C2/c with a = 16.2700(6), b = 7.1801(5), c = 23.4861(10) Å, V = 2742.6(2) Å3, Z = 8, Dc = 1.756 g/cm3, F(000) = 1456 and μ = 0.827 mm-1. 8308 Reflections were collected (6.01≤2θ≤50.05°), of which 2428 were unique (Rint = 0.0432) and used in all calculations The final R = 0.0408 (I > 2σ(I)) and wR = 0.1056 (reflections). In-vitro bioassay indicated that compounds I [R = F, Cl] possessed good activity against Botrytis cinerea, Physalospora piricola, Rhizoctonia solani, and Sclerotinia sclerotiorum with lower EC₅₀ values falling between 0.50 and 4.85μg/mL than that of pos. control osthole with its EC₅₀ values between 7.38 and 74.59μg/mL. In-vivo screening showed that I [R = Cl] exhibited 98% and 95% efficacy against Pseudoperonospora cubensis (Berk. & Curt.) Rostov. at 100 and 50μg/mL, resp. These studies observed that the combination of bioactive substructures of isothiazole with coumarin were an effective way to novel fungicide development.

Chinese Journal of Structural Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lv, You published the artcileDesign, synthesis and fungicidal activity of 3,4-dichloroisothiazolocoumarin-containing strobilurins, SDS of cas: 401-55-8, the publication is Molecular Diversity (2022), 26(2), 951-961, database is CAplus and MEDLINE.

Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins I (R¹ = H, F, Cl, Me, Et; R² = H, 6-Me, 8-Me, 8-Cl), II were rationally designed and synthesized. Preliminary bioassay showed that compounds I (R¹ = H, R² = 8-Cl (III); R¹ = Cl, R² = 6-Me; R¹ = Me, R² = 6-Me) exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50μg/mL, compound III exhibited good activity against S. sclerotiorum with median effective concentration (EC₅₀) of 4.08μ/mL, while the pos. control coumoxystrobin showed EC₅₀ of 1.00μg/mL. In addition, compound I (R¹ = H, R² = 6-Me) showed better fungicidal activity with a lower EC₅₀ value of 7.65μg/mL against Botrytis cinerea than that of pos. control trifloxystrobin with its EC₅₀ value of 21.96μg/mL. In this study, it was indicated that 3,4-dichloroisothiazolocoumarin-containing strobilurins I, II were promising fungicide lead deserved for further study.

Molecular Diversity published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Armstrong, Megan K. published the artcileDifferential Dihydrofunctionalization of Terminal Alkynes: Synthesis of Benzylic Alkyl Boronates through Reductive Three-Component Coupling, Formula: C7H11Br, the publication is Journal of the American Chemical Society (2019), 141(15), 6173-6179, database is CAplus and MEDLINE.

The differential dihydrofunctionalization of terminal alkynes is accomplished through the reductive three-component coupling of terminal alkynes, aryl halides, and pinacolborane. The transformation results in hydrofunctionalization of both π-bonds of an alkyne in a single reaction promoted by cooperative action of a Cu/Pd catalyst system. The differential dihydrofunctionalization reaction has excellent substrate scope and can be accomplished in the presence of esters, nitriles, alkyl halides, epoxides, acetals, alkenes, aryl halides, and silyl ethers. Mechanistic experiments indicate that the reaction proceeds through Cu-catalyzed hydroboration followed by a 2nd hydrocupration. The resulting heterobimetallic complex is the key intermediate that participates in the subsequent Pd-catalyzed cross-coupling, which furnishes benzylic alkyl boronate products.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Formula: C7H11Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Jicheng published the artcilePhotoredox-Catalyzed Cross-Coupling of Enamides for the Assembly of β-Difluoroimine Synthons, Category: bromides-buliding-blocks, the publication is Organic Letters (2017), 19(20), 5653-5656, database is CAplus and MEDLINE.

A photoredox-catalyzed formal C_sp3-C_sp3 cross-coupling reaction of enamides with bromodifluoro compounds is established. The resulting gem-difluoromethylenated γ-imines indicated high stability, excellent E/Z control, and broad functional group tolerance. These synthetic intermediates can efficiently transfer to difluoromethylenated γ-amino acids or δ-amino alcs. Mechanistic anal. indicates that a radical/SET mechanism proceeding via a difluoroalkyl radical may be involved in the catalytic cycle.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C6H8O3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhong, Mingmin published the artcileSynthesis of CoNi-layered double hydroxide on graphene oxide as adsorbent and construction of detection method for taste and odor compounds in smelling water, Safety of 1-Bromooctane, the publication is Journal of Hazardous Materials (2022), 128227, database is CAplus and MEDLINE.

Taste and odor (T&O) compounds are important water pollutant, some of which are toxic. The relevant studies are all expand upon the well-known T&O compounds but for the unknown odors in smelling water. In this work, a method combining purge and trap with gas chromatograph-mass spectrometer (PT-GC/MS) and disperse solid-phase extraction with gas chromatograph (GC) was first proposed to detect T&O compounds in unknown odorous water accurately. Firstly, PT-GC/MS was used for a qual. test on unknown odors in smelling water and determine the analytes. The hollow CoNi-layered double hydroxide (LDH) on graphene oxide (GO) was then used as a composite adsorbent to pretreat the water, in which the GO provided large sp. surface, and the LDH worked as a confinement cavity to enhance capture and retention capacity for volatile organic compounds (VOCs). According to the properties of T&O compounds determined by PT-GC/MS in water, a corresponding GC method was established for accurately quant. anal. In this paper, five T&O compounds were detected simultaneously, including di-Me sulfide, meistylene, N, N-dimethylbenzylamine, 2, 4-dimethylbenzaldehyde and 2, 4-di-tert-butylphenol. Extraction parameters were optimized, including ratio of desorption solvent, amount of adsorbent, pH value, etc. Under the optimal conditions, the detection limits for anal. were 1.14 μg/L to 3.07 mg/L. The satisfactory recoveries were 94-98%. Furthermore, two optimal determination outcomes of odor waters from different places support the practicability of the method, which is expected to be widely used in the detection of unknown odors in smelling water.

Journal of Hazardous Materials published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C18H28N2O7, Safety of 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary