Tag: M.W=150-200

Nam, Doo H. published the artcileAn improved synthesis of captopril, Safety of 3-Bromo-2-methylpropanoic acid, the publication is Journal of Pharmaceutical Sciences (1984), 73(12), 1843-4, database is CAplus and MEDLINE.

An improved synthesis of captopril using methacrylic acid as the starting material is described. Treatment of methacrylic acid with a hydrogen halide gave the 3-halogneo-2-methylpropanoic acids, which were treated with SOCl₂ to yield the corresponding 3-halogeno-2-methylpropanoyl chlorides. Treatment of the chlorides with L-proline yielded the N-(R,S-3-halogeno-2-methylpropanoyl)-L-prolines (I, R = Br, Cl) (II) which were separated into optically pure R– and S-diastereoisomers using dicyclohexylamine. Treatment of (R)-II with methanolic NH₄SH gave captopril (I, R = SH).

Journal of Pharmaceutical Sciences published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Safety of 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wojcieszak, Marta published the artcileSurface activity and phytotoxicity of morpholinium herbicidal ionic liquids, HPLC of Formula: 111-83-1, the publication is Journal of Molecular Liquids (2022), 119750, database is CAplus.

The use of efficient synthesis methods to obtain novel herbicidal ionic liquids (HILs) with biol. activity is extremely important because it can eliminate certain neg. environmental impacts. The authors of this work succeeded in the experiment, which resulted in the synthesis of 18 novel ionic liquids with high yields. Furthermore, a number of physicochem. and biol. properties have been investigated, including surface activity, thermal anal., and phytotoxicity. In addition, it was proven that morpholinium ionic liquids with phenoxyacid anions were more effective against cress than HILs previously studied in the literature. To the best of our knowledge, this is the first report of surface-active ionic liquids with herbicidal anions where leaf surfaces were used for anal. An important aspect of this work was to compare the wettability of the surfaces of wheat leaves and weeds. Moreover, it was shown that using paraffin as a reference surface was not sufficient to describe the wetting properties of HILs. The research reported here proved that morpholinium ionic liquids were effective in wetting weed surfaces while they do not adversely affect wheat leaf surfaces. Our results could be significant for meeting the environmental challenges and agricultural demands of the future.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C9H10ClN5, HPLC of Formula: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chen, Bo published the artcileManganese(III)-Promoted Double Carbonylation of Anilines Toward α-Ketoamides Synthesis, Recommanded Product: 1-Bromooctane, the publication is Advanced Synthesis & Catalysis (2022), 364(3), 487-492, database is CAplus.

Employing anilines as nucleophiles in double carbonylation is a longstanding challenge. In this communication, a Mn(III)-promoted double carbonylation of alkylborates or Hantzsch esters with anilines toward the synthesis of α-ketoamides has been developed. By using easily available potassium alkyltrifluoroborates or Hantzsch esters as the starting material, and cheap and non-toxic Mn(OAc)₃ · 2H₂O as the promotor, a broad range of alkyl α-ketoamide derivatives were synthesized in moderate to good yields with excellent selectivity.

Advanced Synthesis & Catalysis published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Malysheva, S. F. published the artcileChemoselective Synthesis of Alkylphosphinic Acids from Red Phosphorus and Alkyl Bromides in the System KOH/H₂O/Toluene/Micellar Catalyst, Computed Properties of 111-83-1, the publication is Russian Journal of Organic Chemistry (2022), 58(2), 192-199, database is CAplus.

Alkylphosphinic acids, including long-chain ones, were synthesized in up to 76% yields from red P and n-AlkBr (Alk = C₄-C₁₄) under micellar catalysis conditions. The reaction proceeds efficiently and chemoselectively upon heating (85-90°, 6 h) in a KOH/H₂O/toluene/cetyltrimethylammonium bromide system.

Russian Journal of Organic Chemistry published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Computed Properties of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yin, Hongfei published the artcilePalladium Catalyzed Carbonylative Coupling of Alkyl Boron Reagents with Bromodifluoroacetamides, HPLC of Formula: 401-55-8, the publication is ACS Catalysis (2018), 8(5), 3853-3858, database is CAplus.

A catalytic protocol for the preparation of α,α-difluoro-β-alkyl-β-ketoamides is developed employing a Pd-mediated carbonylative Suzuki coupling between alkylboron reagents and bromodifluoroacetamides with COgen as the CO source. The reaction reveals good functional group tolerance providing a broad selection of α,α-difluoro-β-alkyl-β-ketoamides in moderate to good yields, which represent useful precursors for further synthetic manipulation. Finally, the methodol. is amenable to ¹³C-isotope labeling at the ketone carbon applying ¹³C-COgen.

ACS Catalysis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C16H14O6, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lorion, Melanie M. published the artcileCobalt-Catalyzed α-Arylation of Substituted α-Bromo α-Fluoro β-Lactams with Diaryl Zinc Reagents: Generalization to Functionalized Bromo Derivatives, Recommanded Product: Ethylbromofluoroacetate, the publication is Chemistry – A European Journal (2020), 26(58), 13163-13169, database is CAplus and MEDLINE.

A cobalt-catalyzed cross-coupling of α-bromo α-fluoro β-lactams with diarylzinc or diallylzinc reagents is herein disclosed. The protocol proved to be general, chemoselective and operationally simple allowing the C4 functionalization of β-lactams. The substrate scope was expanded to α-bromo lactams and amides, α-bromo lactones and esters as well as N- and O-containing heterocycles.

Chemistry – A European Journal published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Huihui published the artcileRadical-Mediated Distal Ipso-Migration of O/S-Containing Heteroaryls and DFT Studies for Migratory Aptitude, Category: bromides-buliding-blocks, the publication is Organic Letters (2020), 22(15), 5947-5952, database is CAplus and MEDLINE.

Herein we describe an efficient distal ipso-migration of O- and S-containing heteroaryls and the radical heteroarylation of unactivated alkenes. The migration is triggered by various fluoroalkyl radicals, leading to valuable multifunctionalized ketones. The comparisons of migratory aptitude for O-/S-containing heteroaryls are comprehensively investigated. The origin of the chemoselective migration could be partially attributed to the discrepancy in the energy level of the LUMO of each heteroaryl group.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C10H16Br3N, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Arlow, Sophie I. published the artcileSynthesis, Characterization, and Reactivity of Palladium Fluoroenolate Complexes, Recommanded Product: Ethylbromofluoroacetate, the publication is Journal of the American Chemical Society (2017), 139(45), 16088-16091, database is CAplus and MEDLINE.

Cross-coupling reactions of aryl groups with α-fluoro carbonyl compounds catalyzed by Pd complexes are reported, but Pd fluoroenolate intermediates relevant to such reactions were not isolated or even detected previously. The authors report the synthesis, structural characterization, and reactivity of C-bound arylpalladium fluoroenolate complexes ligated by monophosphines and bisphosphines. DPPF-ligated arylpalladium fluoroenolate complexes (DPPF = 1,1-bis(diphenylphosphino)ferrocene) derived from a monofluoroester, a difluoroester, difluoroamides, and difluoroacetonitrile underwent reductive elimination in high yields. Reductive elimination was faster from complexes containing less electron-withdrawing fluoroenolate groups and longer Pd-C(enolate) bonds than from complexes containing more electron-withdrawing fluoroenolate groups and shorter Pd-C(enolate) bonds. The rates of reductive elimination from these C-bound fluoroenolate complexes were significantly faster than those of the analogous trifluoromethyl complexes.

Journal of the American Chemical Society published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Levitre, Guillaume published the artcileSynthesis of α-Fluorinated Areneacetates through Photoredox/Copper Dual Catalysis, Application In Synthesis of 401-55-8, the publication is Organic Letters (2022), 24(17), 3194-3198, database is CAplus and MEDLINE.

A metallaphotoredox method for the preparation of α-fluorinated areneacetates R-R¹ [R = 4-MeC₆H₄, 3-FC₆H₄, 4-BrC₆H₄, etc.; R¹ = CFC(O)OEt, CF₂C(O)OEt, CF₂P(O)OEt₂] based on the synergistic combination of Ir/Cu dual catalysis from boronic acids was reported. The mild conditions allowed broad functional group tolerance, including substrates containing aldehydes, free phenols and N-Boc-protected amines. Mechanistic investigations support a process proceeding via photoredox/copper dual catalysis.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application In Synthesis of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Magagnano, G. published the artcilePhotocatalytic ATRA reaction promoted by iodo-Bodipy and sodium ascorbate, Recommanded Product: Ethylbromofluoroacetate, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(10), 1591-1594, database is CAplus and MEDLINE.

Using ascorbate as a sacrificial reductant, iodo-Bodipy dye 1b is able to promote the ATRA reaction between bromoderivatives and alkenes. This finding expands the possibility of using Bodipy dyes to promote photocatalytic reactions in efficient ways.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary