Tag: M.W=150-200

Rosso, Cristian published the artcileUnveiling the Synthetic Potential of Substituted Phenols as Fully Recyclable Organophotoredox Catalysts for the Iodosulfonylation of Olefins, Computed Properties of 111-83-1, the publication is ACS Catalysis (2022), 12(8), 4290-4295, database is CAplus.

An efficient photocatalytic procedure for the direct iodosulfonylation of terminal olefins RCHCH₂ (R = Bu, cyclohexylmethyl, 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl, etc.) with α-iodo phenylsulfones R¹S(O)₂CH(R²)I (R¹ = Me, Ph, cyclohexyl, naphthalene-1-yl, etc.; R² = H, Me) was described. Specifically, the process uses the simple, robust, and fully recyclable phenol derivative I as the precatalytic system and occurs with visible-light irradiation (450 nm). Mechanistic investigations proved the key role of the in situ generated photocatalyst, namely phenolate anion, which has shown high catalytic activity and considerable stability toward the operating conditions. Importantly, this photocatalytic transformation provides a wide variety of densely functionalized alkyl iodides RCH(I)CH₂CH(R²)S(O)₂R¹ (23 examples, up to 95% yield). Finally, the synthetic potential of this photochem. transformation was demonstrated by scaling up the process under microfluidic conditions (up to 0.67 mmol h^-1) while accessing a series of relevant product manipulations.

ACS Catalysis published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Computed Properties of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lemouzy, Sebastien published the artcileUnderstanding the Reshaping of Fluorinated Polyester Vitrimers by Kinetic and DFT Studies of the Transesterification Reaction, Application In Synthesis of 401-55-8, the publication is Chemistry – A European Journal, database is CAplus and MEDLINE.

Vitrimers are a third class of polymers gathering the mech. properties and solvent resistance of 3D thermosets and the reprocessability of thermoplastics. This unique behavior is due to the triggering of certain covalent exchange reactions that allow the network to rearrange upon application of a stimulus. The constitutive feature of vitrimers is the adoption of a glass-like viscosity during the rearrangement of the network, often due to an associative mechanism for the exchange reaction. Transesterification networks are one of the most studied type of vitrimers that usually require the incorporation of a catalyst, implying the associated drawbacks. Following up on a recent report on catalyst-free transesterification vitrimers in which the ester functions are particularly reactive thanks to the presence of fluorine atoms in α- or β-position, parallel DFT calculations and an exptl. kinetic study on model mols. are presented in order to quant. assess the effect of neighboring fluorinated groups on the transesterification reaction rate.

Chemistry – A European Journal published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application In Synthesis of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sarkar, Bhaswati published the artcileInsights into the Formations of Host-Guest Complexes Based on the Benzimidazolium Based Ionic Liquids-β-Cyclodextrin Systems, Recommanded Product: 1-Bromooctane, the publication is ACS Physical Chemistry Au (2022), 2(1), 3-15, database is CAplus.

Inclusion complexation is one of the best strategies for developing a controlled release of a toxic drug without unexpected side effects from the very beginning of the administration to the target site. In this study, three benzimidazolium based ionic liquids (ILs) having bromide anion and cation bearing long alkyl chains, hexyl- ([C₆CFBim]Br), octyl- ([C₈CFBim]Br), and decyl- ([C₁₀CFBim]Br) were designed and synthesized as antibacterial drugs. Inclusion complexes (ICs) of studied ILs have been prepared by the combination of β-cyclodextrin (β-CD), considering these conjugations should enhance the benignity of ILs and make them potential candidates for the controlled drug release. Characterizations and structural anal. of studied ICs have been performed by ¹H NMR, 2D-ROESY NMR, FT-IR, HRMS, TGA, DSC, surface tension, ionic conductivity, dynamic light scattering (DLS), and isothermal titration calorimetry (ITC). Further, the morphol. of the ICs has been analyzed by SEM and TEM. Furthermore, neat ILs and ICs have been treated against Escherichia coli and Bacillus subtilis to investigate their antibacterial activity, which confirms the prevention of bacterium growth and the shrinkage of the bacterial cell wall. The findings of this work provide the proof of concept that studied benzimidazolium based ILs-β-CD host-guest complexes should act as a potential candidate in controlled drug delivery and other biomedical applications.

ACS Physical Chemistry Au published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Biro, Robert published the artcilePolymeric ionic liquid absorbents for n-butanol recovery from aqueous solution, Category: bromides-buliding-blocks, the publication is AIChE Journal (2022), 68(8), e17676, database is CAplus.

A wide-ranging study of imidazolium-based polymeric ionic liquids (PILs) as absorbents in two-phase partitioning bioreactor applications is presented, with a particular focus on the removal of n-butanol from dilute aqueous solutions The study begins with a description of the synthesis and phase transition temperatures of poly(1-vinyl-3-alkylimidazolium) bromides bearing alkyl groups of different lengths, architecture, and composition, as well as analogs bearing various inorganic and carboxylate anions. Knowledge of polymer structure is used to generate insight into the solute affinity of each PIL, as quantified by the measurements of n-butanol partition coefficient (PC_BuOH) and n-butanol/water selectivity (α_b/w). These equilibrium experiments are extended to create a complete P[(VC_12-linIm)(Br)]/n-BuOH/water ternary phase diagram that is used to propose a streamlined n-butanol recovery process.

AIChE Journal published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

de Paula, Fernando H. M. published the artcileAlkyl glyceryl ethers as water-based lubricant additives in mixtures with xanthan gum, Recommanded Product: 1-Bromooctane, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2022), 127881, database is CAplus.

Water-based lubricants are greener and more environmentally friendly than comparable oil-based lubricants. However, water-based lubricants typically have a poorer performance and, thus, need to be formulated with various additives. Here, alkyl glyceryl ethers, a class of nonionic surfactants, were investigated as lubricant additives. To this purpose, aqueous solutions of newly synthesized ethers (with different alkyl chain lengths, C8, C10, C12, and C14) were formulated with xanthan gum. The lubrication performance of these formulations was then tested exptl. Clearly, alkyl glyceryl ethers showed a significantly improved performance (higher friction reduction) with increasing the alkyl chain length. However, the ethers had to be formulated with xanthan gum, with which they formed a complex, which promoted ether dispersion and probably adsorption on the metal surface in the aqueous phase, thereby drastically reducing friction. Thus, the alkyl glyceryl ethers synthesized in this work are attractive green and highly efficient lubricant additives, which can improve the sustainability of industrial lubrication processes.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liautard, Virginie published the artcileIn situ generation of radical initiators using amine-borane complexes for carbohalogenation of alkenes, Computed Properties of 401-55-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(13), 2124-2127, database is CAplus and MEDLINE.

Atom transfer radical addition of alkyl halides to alkenes was developed using a low amount of a stable initiator, amine borane complexes. Thanks to a slow hydroboration step, the overall carbohalogenation process led to good isolated yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Computed Properties of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Durand-Reville, Thomas F. published the artcileDiscovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases, Formula: C4H6BrFO2, the publication is Journal of Medicinal Chemistry (2020), 63(21), 12511-12525, database is CAplus and MEDLINE.

Multidrug resistant Gram-neg. bacterial infections are an increasing public health threat due to rapidly rising resistance toward β-lactam antibiotics. The hydrolytic enzymes called β-lactamases are responsible for a large proportion of the resistance phenotype. β-Lactamase inhibitors (BLIs) can be administered in combination with β-lactam antibiotics to negate the action of the β-lactamases, thereby restoring activity of the β-lactam. Newly developed BLIs offer some advantage over older BLIs in terms of enzymic spectrum but are limited to the i.v. route of administration. Reported here is a novel, orally bioavailable diazabicyclooctane (DBO) β-lactamase inhibitor. This new DBO, ETX1317(I), contains an endocyclic carbon-carbon double bond and a fluoroacetate activating group and exhibits broad spectrum activity against class A, C, and D serine β-lactamases. The ester prodrug of ETX1317, ETX0282(II), is orally bioavailable and, in combination with cefpodoxime proxetil, is currently in development as an oral therapy for multidrug resistant and carbapenem-resistant Enterobacterales infections.

Journal of Medicinal Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Formula: C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ghirardello, Mattia published the artcileSynthesis of Chiral Ionic Liquids from Natural Monosaccharides, Safety of 1-Bromooctane, the publication is European Journal of Organic Chemistry (2022), 2022(21), e202200100, database is CAplus.

Three series of new ionic liquids (ILs), namely imidazolium-, pyrazolium-, and bis-benzimidazolium-containing ILs, were prepared from low-cost, unprotected carbohydrates. Information on anion-cation interactions and solvation shell were obtained via diffusion NMR and heteronuclear Overhauser correlation maps (HOESY), resp.

European Journal of Organic Chemistry published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Safety of 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ding, Yahui published the artcileIdentification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells, Name: 7-Bromohept-1-yne, the publication is Journal of Hematology & Oncology (2021), 14(1), 19, database is CAplus and MEDLINE.

TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of action for overcoming current challenges in TNBC treatment. Different inhibitors were used to study the cell death manner of DMOCPTL. RNA silencing was used to evaluate the functions of GPX4 in ferroptosis and apoptosis of TNBC cells and functions of EGR1 in apoptosis. Immunohistochem. assay of tissue microarray were used for investigating correlation of GPX4 and EGR1 with TNBC. Computer-aided docking and small mol. probe were used for study the binding of DMOCPTL with GPX4. DMOCPTL, a derivative of natural product parthenolide, exhibited about 15-fold improvement comparing to that of the parent compound PTL for TNBC cells. The cell death manner assay showed that the anti-TNBC effect of DMOCPTL mainly by inducing ferroptosis and apoptosis through ubiquitination of GPX4. The probe of DMOCPTL assay indicated that DMOCPTL induced GPX4 ubiquitination by directly binding to GPX4 protein. To the best of our knowledge, this is the first report of inducing ferroptosis through ubiquitination of GPX4. Moreover, the mechanism of GPX4 regulation of apoptosis is still obscure. Here, we firstly reveal that GPX4 regulated mitochondria-mediated apoptosis through regulation of EGR1 in TNBC cells. Compound 13, the prodrug of DMOCPTL, effectively inhibited the growth of breast tumor and prolonged the lifespan of mice in vivo, and no obvious toxicity was observed These findings firstly revealed novel manner to induce ferroptosis through ubiquitination of GPX4 and provided mechanism for GPX4 inducing mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Moreover, compound 13 deserves further studies as a lead compound with novel mode of action for ultimate discovery of effective anti-TNBC drug.

Journal of Hematology & Oncology published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Name: 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Marks, Adam published the artcileSynthetic Nuances to Maximize n-Type Organic Electrochemical Transistor and Thermoelectric Performance in Fused Lactam Polymers, SDS of cas: 111-83-1, the publication is Journal of the American Chemical Society (2022), 144(10), 4642-4656, database is CAplus and MEDLINE.

A series of fully fused n-type mixed conduction lactam polymers p(g₇NC_nN), systematically increasing the alkyl side chain content, are synthesized via an inexpensive, nontoxic, precious-metal-free aldol polycondensation. Employing these polymers as channel materials in organic electrochem. transistors (OECTs) affords state-of-the-art n-type performance with p(g₇NC₁₀N) recording an OECT electron mobility of 1.20 x 10^-2 cm² V^-1 s^-1 and a μC* figure of merit of 1.83 F cm^-1 V^-1 s^-1. In parallel to high OECT performance, upon solution doping with (4-(1,3-dimethyl-2,3-dihydro-1H-benzoimidazol-2-yl)phenyl)dimethylamine (N-DMBI), the highest thermoelec. performance is observed for p(g₇NC₄N), with a maximum elec. conductivity of 7.67 S cm^-1 and a power factor of 10.4 μW m^-1 K^-2. These results are among the highest reported for n-type polymers. Importantly, while this series of fused polylactam organic mixed ionic-electronic conductors (OMIECs) highlights that synthetic mol. design strategies to bolster OECT performance can be translated to also achieve high organic thermoelec. (OTE) performance, a nuanced synthetic approach must be used to optimize performance. Herein, we outline the performance metrics and provide new insights into the mol. design guidelines for the next generation of high-performance n-type materials for mixed conduction applications, presenting for the first time the results of a single polymer series within both OECT and OTE applications.

Journal of the American Chemical Society published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, SDS of cas: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary