Tag: M.W=150-200

Khotavivattana, Tanatorn published the artcileSynthesis and Reactivity of ¹⁸F-Labeled α,α-Difluoro-α-(aryloxy)acetic Acids, Safety of Ethylbromofluoroacetate, the publication is Organic Letters (2017), 19(3), 568-571, database is CAplus and MEDLINE.

The authors describe the ¹⁸F-labeling of α,α-difluoro-α-(aryloxy)acetic acid derivatives and demonstrate that these building blocks are amenable to post-¹⁸F-fluorination functionalization. Protodecarboxylation offers a new entry to ¹⁸F-difluoromethoxyarenes, and the value of this approach is further demonstrated with coupling processes leading to representative ¹⁸F-labeled TRPV1 inhibitors and TRPV1 antagonists.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Safety of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Pommainville, Alice published the artcileThe Synthetic Potential of Thiophenium Ylide Cycloadducts, Application In Synthesis of 111-83-1, the publication is Angewandte Chemie, International Edition (2022), 61(32), e202205963, database is CAplus and MEDLINE.

Intramol. (3+2) cycloaddition reaction between alkynyl sulfides (neutral TAC) and alkynes to provided key thiophenium ylide intermediates was first reported. These reactive species provided access to highly substituted fused thiophenes following predictable chem. sequences. Structural features on the obtained thiophenes were highly configurable by judicious choice of both alkynyl sulfide substitution and reaction conditions.

Angewandte Chemie, International Edition published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Application In Synthesis of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Shan published the artcileThe effective separation of yttrium and other heavy rare earth elements with salicylic acid derivatives, Formula: C8H17Br, the publication is Minerals Engineering (2022), 107396, database is CAplus.

In order to develop stable and efficient extractant to meet the needs of ion adsorbed rare earth ores for Y separation, two novel salicylic acid derivatives, i.e., o-octyloxybenzoic acid (OOBA) and o-ethylhexyloxybenzoic acid (EHOBA), are synthesized. OOBA is an oily liquid with single component at room temperature, which is suitable for solvent extraction and has the consistent properties. The extraction behavior of Y by OOBA is resembled to light rare earth elements (LREEs) than heavy rare earth elements (HREEs). Thus, OOBA has better selectivities for Y and other HREEs than common carboxylic acids, such as NA and sec-octyl phenoxyacetic acid (CA-12). By FT-IR and slope anal., it can be inferred that the extraction mechanism of OOBA is cation exchange, and the extracted complex can be expressed as REL₃. The effects of pH value, saponification degree, loading concentration, RE concentration and OOBA concentration on the extraction and separation of HREEs by OOBA are also discussed. OOBA has been provided with low stripping acid concentration, good cycle stability and less loss in the extraction process. The concentration of OOBA in the raffinate is only about 28 ppm. Finally, a process for separating Y from the industrial Y-enriched HREEs feed liquid is developed. Through the simulated fractional extraction including 9-stage extraction and 6-stage scrubbing, Y product with the purity of 99.4% and the yield of 96.4% is obtained.

Minerals Engineering published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H8O3, Formula: C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chatalova-Sazepin, Claire published the artcileXenon Difluoride Mediated Fluorodecarboxylations for the Syntheses of Di- and Trifluoromethoxyarenes, Safety of Ethylbromofluoroacetate, the publication is Organic Letters (2016), 18(18), 4570-4573, database is CAplus and MEDLINE.

XeF₂ is demonstrated to be a more proficient fluorine-transfer reagent than either NFSI or Selectfluor in fluorodecarboxylations of both mono- and difluoroaryloxy acetic acid derivatives This method efficiently converts a wide range of neutral and electron-poor substrates to afford the desired di- and trifluoromethyl aryl ethers in good to excellent yields. The purifications are facile, and the reaction times are less than 5 min, which makes these fluorodecarboxylations promising for future PET-imaging applications.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Safety of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Paliwal, Khushboo S. published the artcileIonic Liquid Functionalized Chitosan Catalyst with Optimized Hydrophilic/Hydrophobic Structural Balance for Efficient CO₂ Fixation, Quality Control of 111-83-1, the publication is Asian Journal of Organic Chemistry (2022), 11(6), e202200121, database is CAplus.

In this work a series of chitosan-based catalysts with ranging hydrophobic/hydrophilic balance are successfully prepared by varying the ionic liquid and hydrocarbon chain length attached to chitosan. The chitosan modified with eight carbon units displayed efficient catalytic activity for the conversion of a wide range of epoxides to their corresponding cyclic carbonates under 1 atm pressure of carbon dioxide without cocatalyst and solvent. The optimized catalyst was able to convert even diepoxides and sterically bulky epoxides like t-Bu glycidyl ether to their corresponding cyclic carbonates. This study provides an insight into catalyst designing based on possible mol. interaction between reactants and active sites of the catalyst.

Asian Journal of Organic Chemistry published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Quality Control of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nikiforov, Petar O. published the artcileFragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays, Name: (2-Bromoethyl)cyclopentane, the publication is ACS Chemical Biology (2017), 12(5), 1390-1396, database is CAplus and MEDLINE.

Small-mol. inhibitors of the mycobacterial transcriptional repressor EthR have previously been shown to act as boosters of the second-line antituberculosis drug ethionamide. Fragment-based drug discovery approaches have been used in the past to make highly potent EthR inhibitors with ethionamide boosting activity both in vitro and ex vivo. Herein, we report the development of fragment-sized EthR ligands with nanomolar min. effective concentration values for boosting the ethionamide activity in Mycobacterium tuberculosis whole-cell assays.

ACS Chemical Biology published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Name: (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ardon-Munoz, Luis G. published the artcileOxidative Cyclization of 4-(2-Mercaptophenyl)-Substituted 4H-1,2,4-Triazolium Species to Tricyclic Benzothiazolium Salts, Application In Synthesis of 111-83-1, the publication is European Journal of Organic Chemistry (2022), 2022(20), e202200121, database is CAplus.

Herein authors report a generally applicable method for the preparation of N-substituted benzo[4,5]thiazolo[2,3-c][1,2,4]triazol-1-ium salts from air stable precursors. This transformation features selective deprotection of a para-methoxybenzyl protected thiol followed by C-H functionalization of the linked 1,2,4-triazolium salts under oxidative conditions. Using this procedure, authors synthesized a variety of tricyclic thiazolium salts which contain both electron-withdrawing and electron-donating aromatic substituents as well as aliphatic substituents. Authors approach also tolerates many functional groups including alkynes, alcs., diols, amides, and polyethers.

European Journal of Organic Chemistry published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Application In Synthesis of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Antoniak, Damian published the artcileAlkylation of Nitropyridines via Vicarious Nucleophilic Substitution, SDS of cas: 111-83-1, the publication is Organic Letters (2022), 24(2), 516-519, database is CAplus and MEDLINE.

Electrophilic nitropyridines reacted with sulfonyl-stabilized carbanions gave alkylated nitropyridins I [R = H, Me, n-octyl, etc.; R¹ = Me, Et, n-octyl, etc.; R² = H, OMe, SPh, etc.] products of C-H alkylation via vicarious nucleophilic substitution was reported. The process consisted of formation of the Meisenheimer-type adduct, followed by base-induced β-elimination of the sulfinic acid (e.g., PhSO₂H).

Organic Letters published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, SDS of cas: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Recsei, Carl published the artcileSynthesis of bis(aryloxy)fluoromethanes using a heterodihalocarbene strategy, Computed Properties of 401-55-8, the publication is Beilstein Journal of Organic Chemistry (2021), 813-818, database is CAplus and MEDLINE.

A simple and new procedure was developed for the construction of a bis(aryloxy)fluoromethane moiety I and ROCH(F)OR [R = 4-O₂NC₆H₄, 2,5-di-ClC₆H₄], for which no existing method was available.

Beilstein Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Computed Properties of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Heuser, Stefan published the artcileSynthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators, HPLC of Formula: 18928-94-4, the publication is Tetrahedron Letters (2006), 47(16), 2675-2678, database is CAplus.

A synthetic route towards cyclopropylic compounds, which act as glucokinase activators is described herein. The present synthesis gives easy and rapid access to a wide variety of either sulfones or sulfonamides starting from readily available late-stage intermediates.

Tetrahedron Letters published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, HPLC of Formula: 18928-94-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary