M.W=150-200 Archives - Page 29 of 156 - Bromides-buliding-blocks

Yohe, G. R.’s team published research in Journal of the American Chemical Society in 50 | CAS: 18928-94-4

Journal of the American Chemical Society published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C13H10N2S, SDS of cas: 18928-94-4.

Yohe, G. R. published the artcileCyclopentylalkylacetic acids and ω-cyclopentylethylalkylacetic acids and their bactericidal action towards B. leprae, SDS of cas: 18928-94-4, the publication is Journal of the American Chemical Society (1928), 1503-8, database is CAplus.

cf. preceding abstract Cyclopentylethanol, b₂₄ 96.5-7°, n_D²⁰ 1.4577, d₄²⁰ 0.9180; bromide, b₁₉ 75-7°, 1.4863, 1.2860. Cyclopentylbutanol, b₂ 88-92°, 1.4613, 0.9033 (70-5% yield); bromide, b₁₇ 110-1°, 1.4820, 1.1872 (60-5% yield); cyanide, b₁₇ 124-6.5°, 1.4542, 0.8887 (80-5% yield); hydrolysis with NaOH in 60% EtOH gives 80-5% of δ-cyclopentylpentanoic acid, b₂ 124-8°, 1.4594, 0.9752. Di-Et δ-cyclopentylbutylmalonate, b_2.2 154-60°, 1.4493, 0.9934 (40% yield); the acid, m. 121-4° (85% yield); heating the acid 2 hrs. at 160-80° gives 75% of ε-cyclopentylhexanoic acid, b_1.8 133-5°, m. 33-3.5°, n_D³⁵ 1.4549, d₄³⁵ 0.9518. The following di-Et cyclopentylalkylmalonates were prepared where R in the formula C₅H₉C(CO₂Et)₂R is: C₇H₁₅, b₁ 143-6°, n_D²⁰ 1.4548, d₄²⁰ 0.9749; C₈H₁₇, b₁ 160-5°, 1.4553, 0.9659; C₉H₁₉, b_0.6 152-5°, 1.4567, 0.9817; C₁₀H₂₁, b₁ 169-71°, 1.4571, 0.9560; C₁₁H₂₃, b₁ 186-9°, 1.4580, 0.9522. Di-Et β-cyclopentylethylalkylmalonates, C₅H₉(CH₂)₂C(CO₂Et)₂R: R is H, b₂ 125°, 1.4478, 1.0082; Et, b_1.9 126-9°, 1.4511, 0.9924; Pr, b_1.7 134-5°, 1.4510, 0.9873; Bu, b_1.8 136-40°, 1.4523, 0.9783; Am, b_1.1 148-50°, 1.4526, 0.9688; C₆H₁₃, 157-62°, 1.4531, 0.9624; C₇H₁₅, b₂ 172-4°, 1.4541, 0.9563; C₈H₁₇, b_1.2 182-4°, 1.4548, 0.9524. β-Cyclopentylethylalkylmalonic acids, C₅H₉(CH₂)₂C(CO₂H)₂R: R is H, m. 126.5°, Et, m. 141-3°; Pr, m. 137-8°; Bu, m. 139-40.5°; Am, m. 124-7°; C₆H₁₃, m. 129.5-30°. β-Cyclopentylalkylacetic acids, C₅H₉CH(CO₂H)R: R is C₇H₁₅, b_1.4 155-60°, 1.4594, 0.9312; C₈H₁₇, b₂ 166-9°, 1.4609, 0.9279; C₉H₁₉, b_1.4 177-8.5°, m. 37-7.5°; C₁₀H₂₁, b_1.7 189-90°, m. 34.5-6°; C₁₁H₂₃, b_1.3 193-7°, m. 43.5-5.5°. β-Cyclopentylethylalkylacetic acids, C₅H₉(CH₂)₂CH(CO₂H)R: R is H, b_2.4 115-8°, 1.4575, 0.9849; Et, b_1.3 122-4.5°, 1.4590, 0.9602; Pr, b_1.9 130-2°, 1.4595, 0.9533; Bu, b₁ 136-7°, 1.4608, 0.9435; Am, b_1.9 150-4°, 1.4610, 0.9360; C₆H₁₃, b_1.9, 157-61°, 1.4616, 0.9303; C₇H₁₅, b₂ 167-9°, 1.4621, 0.9252; C₈H₁₇, b_1.5 173-6°, 1.4629, 0.9210. Undecyl bromide, b₁₈ 134-7°, 1.4571, 1.052l. Di-Et cyclopentylmalonate, b₂ 115-7°, 1.4440, 1.0325. The greatest bactericidal action is found in the acids containing 16-18 C atoms; the β-cyclopentylethylalkylacetic acids are slightly more effective than the isomeric cyclopentylalkylacetic acids; a similar slight difference could be detected in the cyclohexyl series. Cyclopentylnonylacetic acid and cyclopentylethylheptylacetic acid, isomeric with dihydrohydnocarpic acid, are far more bactericidal than the latter compound There is no significant difference in bactericidal effect between the cyclohexyl and cyclopentyl compounds of equal mol. weight or of equal length side chain, though the figures appear to favor the cyclohexyl compounds The bactericidal action is not affected markedly by the presence of the double bond.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Fengqian’s team published research in Angewandte Chemie, International Edition in 61 | CAS: 111-83-1

Angewandte Chemie, International Edition published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C13H10F2, Related Products of bromides-buliding-blocks.

Zhao, Fengqian published the artcileCopper-Catalyzed Substrate-Controlled Carbonylative Synthesis of α-Keto Amides and Amides from Alkyl Halides, Related Products of bromides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202200062, database is CAplus and MEDLINE.

Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. A novel copper-catalyzed highly selective double carbonylation of alkyl bromides was developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double- and mono-carbonylation can be achieved controllably under different conditions.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Caputo, Paolino’s team published research in International Journal of Adhesion and Adhesives in 118 | CAS: 111-83-1

International Journal of Adhesion and Adhesives published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Quality Control of 111-83-1.

Caputo, Paolino published the artcilePolyalkylated gallic esters and acids, high performant warm mix asphalt and adhesion promoters for bitumen, Quality Control of 111-83-1, the publication is International Journal of Adhesion and Adhesives (2022), 103228, database is CAplus.

The main use of bitumen is the construction of road pavements due to its role as binder in asphalt concrete. For this specific scope, it is important for bitumen to have low viscosity so that the working temperature is the lowest possible. This would allow it to be easily processed while reducing the toxic fumes emanated during coating. Furthermore, the final product must be resistant to aging phenomenon and harsh weather conditions while also having a good affinity with the stones underneath in order to avoid its peeling off the road with time. To achieve all these stipulated objectives, the addition of chem. additives to asphalt concrete is being studied. In the present study, bitumen has been modified by incorporating (1% weight/weight) alkylated gallic esters and acids of alkyl chains of different length (8, 14 and 18 carbon atoms) in low amounts with the aim of improving the rheol. properties of bitumen as well as increasing the interaction forces between bitumen and stone aggregates usually employed as underneath layer for road pavement. For this purpose, gallic ester/acid additives were tested as rheol. modifiers, adhesion activators and Warm Mix Asphalt (WMA) agents through Differential Scanning Calorimetry, Thermogravimetric measurements, Dynamic Shear Rheol. and Boiling tests. The results show that alkylated gallic acids are bad WMA candidates increasing the viscosity of bitumen while corresponding gallic Me esters are excellent for WMA showing that the shorter the chain, the better the performance. Thus, C8 alkylated Me gallate decreases the overall viscosity of bitumen of about 70 Pa s at 70°C, which is nearly 4 times better than what commonly employed com. waxes provide. Furthermore, gallic ester and acid derivatives are excellent adhesion activators showing increased efficiency as the alkyl chain length increases reaching a 95% coverage on Trentino porphyry stones obtained from the boiling test carried out on the C18 alkylated Me gallate sample.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Palmer, Wylie S.’s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 16523-02-7

Bioorganic & Medicinal Chemistry Letters published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, SDS of cas: 16523-02-7.

Palmer, Wylie S. published the artcileDevelopment of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead, SDS of cas: 16523-02-7, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(5), 1486-1492, database is CAplus and MEDLINE.

A series of amino-pyrimidines was developed based upon an initial kinase cross-screening hit from a CDK2 program. Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole hit to a potent and selective JNK inhibitor, compound 24f (JNK1 and 2 IC₅₀ = 16 and 66 nM, resp.), with bioavailability in rats and suitable for further in vivo pharmacol. evaluation.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Singh, I. D.’s team published research in Acta Ciencia Indica, Physics in 1980 | CAS: 452-63-1

Acta Ciencia Indica, Physics published new progress about IR spectra. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Synthetic Route of 452-63-1.

Singh, I. D. published the artcileInfrared studies of 3-fluoro-6-bromotoluene and 4-fluoro-3-bromotoluene, Synthetic Route of 452-63-1, the main research area is IR bromofluorotoluene; toluene bromo fluoro IR.

The IR absorption spectra of 3-fluoro-6-bromotoluene and 4-fluoro-3-bromotoluene in the form of thin films were investigated in the frequency range 200-4000 cm-1. Modes of vibrations were assigned to different observed vibrational frequencies in each case. Me group vibrations are discussed.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Jingtao’s team published research in Materials Science & Engineering, A: Structural Materials: Properties, Microstructure and Processing in 1996-10-15 | CAS: 452-63-1

Materials Science & Engineering, A: Structural Materials: Properties, Microstructure and Processing published new progress about Annealing. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Product Details of C7H6BrF.

Wang, Jingtao published the artcileEnhanced grain growth in an Al-Mg alloy with ultrafine grain size, Product Details of C7H6BrF, the main research area is aluminum magnesium alloy annealing grain growth.

A submicrometer-grained (SMG) microstructure, with an average grain size of ∼0.2 μm, was introduced into an Al-3% Mg solid solution alloy by equal-enhanced angular pressing. The SMG structure was heterogeneous with regions of equiaxed elongated grains and with grain boundaries in a non-equilibrium configuration. Samples were annealed for various times at a temperature of 473 K and then examined using transmission electron microscopy. The results show that the grain boundaries evolve with time into an equilibrium condition and some limited grain occurs primarily in the grains where recovery has taken place. The results establish that the SMG structure is reasonably stable in the Al-3% Mg alloy at a temperature of 473 K.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bugday, Nesrin’s team published research in Molecular Catalysis in 2022-09-30 | CAS: 452-63-1

Molecular Catalysis published new progress about Arylation. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Quality Control of 452-63-1.

Bugday, Nesrin published the artcilePd-NHC complex catalyzed C-H bond activation reactions of caffeine and 2-isobutylthiazole, Quality Control of 452-63-1, the main research area is palladium NHC imidazolidinylidene benzimidazole caffeine complex preparation arylation catalyst; CH activation benzimidazole purine thiazole arylation palladium catalyst.

A series of new Pd-NHC complexes [(SI-Ar)PdCl2(1-BuBIm)] (4a-c, SI-Ar = 1,3-diaryl-2-imidazolidinylidene, Ar = 2,6-Me2C6H3, 2,4,6-Me3C6H2, 2,6-iPr2C6H3; 1-BuBIm = 1-butyl-5,6-dimethylbenzimidazole-κN3), [(SI-Xyl)PdCl2(Caf)] (5a, Caf = caffeine-κN7), [(SI-Mes)PdCl2(2-HOCHMeBIm)] (5b) were synthesized, characterized, and utilized as catalysts on 8-(hetero)arylation of xanthines and C-5 (hetero)arylation of 2-isobutylthiazole. All the synthesized derivatives were characterized by NMR, Q-TOF-LC/MS, FTIR, and X-ray anal. In addition, DFT calculations and computational NBO studies for Pd-NHC complexes were examined, and HOMO and LUMO energy levels and electron d. of each Pd-NHC complex were defined. Complexes 4a-c and 5a-b showed good catalytic activity in C-H bond activation reactions. DFT studies have also been conducted to examine the reaction mechanism following the CMD pathway. Complex 5a was chosen as a representative catalyst for the reaction of unsubstituted Ph with caffeine and 2-isobutylthiazole. Although the ΔE values of the complexes are so close, slight difference in the catalytic activity were observed for 4a-c and 5a-b. Since this low ΔE value facilitates the oxidative addition reaction of (hetero)aryl bromides, thanks to this catalytic system, new 8-(hetero)aryl xanthines and 5-(hetero)aryl thiazole derivatives could be synthesized with high yields and low catalyst loading.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ahemed, Jakeer’s team published research in Journal of Photochemistry and Photobiology, A: Chemistry in 2021-10-01 | CAS: 452-63-1

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Band gap. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, COA of Formula: C7H6BrF.

Ahemed, Jakeer published the artcileSynthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light, COA of Formula: C7H6BrF, the main research area is zinc methyl arene ODP industrial wastewater photooxidation photodecomposition.

Synthesis of new Schiff′s base Zn-complexes for photo-oxidation of Me arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of Me arenes which are converted into its resp. aldehydes with moderate yields under visible light irradiation The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the Me groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of Me arenes is reported under visible-light-driven conditions.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baumgarth, Manfred’s team published research in European Journal of Organic Chemistry in 2000-06-30 | CAS: 452-63-1

European Journal of Organic Chemistry published new progress about eniporide preparation. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Computed Properties of 452-63-1.

Baumgarth, Manfred published the artcileA concise and efficient synthesis of [2-methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoyl]guanidinium methanesulfonate (eniporide), Computed Properties of 452-63-1, the main research area is eniporide preparation.

A new synthesis of the benzoylguanidine-type Na+/H+ antiporter inhibitor eniporide is described. Starting from 2-bromo-5-fluorotoluene, aromatic substituents were introduced by methanesulfonylation, Pd-catalyzed carboxylation with CO, and halogen-pyrrole exchange. Guanidine acylation was performed using Mukaiyama’s procedure.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xiang, Feifei’s team published research in Nature Chemistry in 2022-08-31 | CAS: 452-63-1

Nature Chemistry published new progress about Adsorption. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene.

Xiang, Feifei published the artcilePlanar π-extended cycloparaphenylenes featuring an all-armchair edge topology, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene, the main research area is armchair edge topol planar cycloparaphenylene.

The [n]cycloparaphenylenes ([n]CPPs)-npara-linked phenylenes that form a closed-loop-have attracted substantial attention due to their unique cyclic structure and highly effective para-conjugation leading to a myriad of fascinating electronic and optoelectronic properties. However, their strained topol. prevents the π-extension of CPPs to convert them either into armchair nanobelts or planarized CPP macrocycles. Here we successfully tackle this long-standing challenge and present the bottom-up synthesis and characterization of atomically precise in-plane π-extended [12]CPP on Au(111) by low-temperature scanning probe microscopy and spectroscopy combined with d. functional theory. The planar π-extended CPP is a nanographene with an all-armchair edge topol. The exclusive para-conjugation at the periphery yields delocalized electronic states and the planarization maximizes the overlap of p orbitals, which both reduce the bandgap compared to conventional CPPs. Calculations predict ring currents and global aromaticity in the doubly charged system. The intriguing planar ring topol. and unique electronic properties make planar π-extended CPPs promising quantum materials. [graphic not available: see fulltext]

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary