Tag: M.W=150-200

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Computed Properties of 4897-84-1

Zhang, Panpan;Wang, Ze;Mou, Chenye;Zou, Jiamei;Xie, Yanfei;Liu, Zhiwen;Benjamin Naman, C.;Mao, Yuechun;Wei, Jiaxin;Huang, Xinghan;Dong, Jiahui;Yang, Mengxiang;Wang, Ning;Jin, Haixiao;Liu, Fufeng;Lin, Dongdong;Liu, Hao;Zhou, Fei;He, Shan;Zhang, Bin;Cui, Wei research published 《 Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer′s disease》, the research content is summarized as follows. Alzheimer′s disease (AD) is a prevalent neurodegenerative disorder that has multiple causes. Therefore, multiple-target-directed ligands (MTDLs), which act on multiple targets, have been developed as a novel strategy for AD therapy. In this study, novel drug candidates were designed and synthesized by the covalent linkings of tacrine, a previously used anti-AD acetylcholinesterase (AChE) inhibitor, and dipicolylamine, an β-amyloid (Aβ) aggregation inhibitor. Most tacrine-dipicolylamine dimers potently inhibited AChE and Aβ1-42 aggregation in vitro, and 13a exhibited nanomolar level inhibition. Mol. docking anal. suggested that 13a could interact with the catalytic active sites and the peripheral anion site of AChE, and bind to Aβ1-42 pentamers. Moreover, 13a effectively attenuated Aβ1-42 oligomers-induced cognitive dysfunction in mice by activating the cAMP-response element binding protein/brain-derived neurotrophic factor signaling pathway, decreasing tau phosphorylation, preventing synaptic toxicity, and inhibiting neuroinflammation. The safety profile of 13a in mice was demonstrated by acute toxicity experiments All these results suggested that novel tacrine-dipicolylamine dimers, especially 13a, have multi-target neuroprotective and cognitive-enhancing potentials, and therefore might be developed as MTDLs to combat AD.

Computed Properties of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C4H7BrO2.

Zhang, Xiaheng;Smith, Russell T.;Le, Chip;McCarver, Stefan J.;Shireman, Brock T.;Carruthers, Nicholas I.;MacMillan, David W. C. research published 《 Copper-mediated synthesis of drug-like bicyclopentanes》, the research content is summarized as follows. Multicomponent reactions are relied on in both academic and industrial synthetic organic chem. owing to their step- and atom-economy advantages over traditional synthetic sequences¹. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular 1,3-disubstituted BCP moieties have become widely adopted in medicinal chem. as para-Ph ring replacements². These structures are often generated from [1.1.1]propellane via opening of the internal C-C bond through the addition of either radicals or metal-based nucleophiles^3-13. The resulting propellane-addition adducts are then transformed to the requisite polysubstituted BCP compounds via a range of synthetic sequences that traditionally involve multiple chem. steps. Although this approach was effective so far, a multicomponent reaction that enables single-step access to complex and diverse polysubstituted drug-like BCP products would be more time efficient compared to current stepwise approaches. Here the authors report a one-step three-component radical coupling of [1.1.1]propellane to afford diverse functionalized bicyclopentanes using various radical precursors and heteroatom nucleophiles via a metallaphotoredox catalysis protocol. This copper-mediated reaction operates on short timescales (five minutes to one hour) across multiple (more than ten) nucleophile classes and can accommodate a diverse array of radical precursors, including those that generate alkyl, α-acyl, trifluoromethyl and sulfonyl radicals. This method was used to rapidly prepare BCP analogs of known pharmaceuticals, one of which is substantially more metabolically stable than its com. progenitor.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Application of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C6H7BrN2.

Zhang, Xiao;Li, Jiao-Yang;Zhang, Kai;Ding, Lei;Wang, Chuan-Kui;Fung, Man-Keung;Fan, Jian research published 《 Highly efficient thermally activated delayed fluorescence emitters with suppressed energy loss and a fast reverse intersystem crossing process》, the research content is summarized as follows. Thermally activated delayed fluorescence (TADF) emitters with low non-radiative decay and a fast reverse intersystem crossing (RISC) process are highly desirable for achieving efficient organic light-emitting diodes (OLEDs). This work revealed the excited-state structural relaxation induced emission behavior of the frequently used donor unit, spiro[acridine-9,9′-fluorene] (spAc). This structural change at the excited state from bent conformation to planar conformation was suppressed greatly by doping the emitter in a solid matrix, thus avoiding the non-radiative energy loss and enhancing the utilization of excitons. Furthermore, the spAc-based emitters achieved small ΔE(¹CT-³CT) and ΔE(³LE-³CT) with the aid of the robust configuration design, thus promoting a fast RISC process up to 1.69 x 10⁶ s^-1. As a result, these TADFs demonstrated excellent photoluminescence quantum yields (PLQYs) in the range of 91.0-98.2%. OLEDs based on BPCN-spAc showed a state-of-the-art efficiency with an external quantum efficiency (EQE) of nearly 30% and power efficiency (PE) over 80 lm W^-1 at 592 nm. This study deepened the understanding of the luminescent behavior of robust TADF emitters in solution and in the solid state, which could provide helpful guidance for the design of efficient TADF materials.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Product Details of C6H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Electric Literature of 4897-84-1

Zhang, Xinyu;Sivaguru, Paramasivam;Zanoni, Giuseppe;Han, Xinyue;Tong, Minghui;Bi, Xihe research published 《 Catalytic Asymmetric C(sp³)-H Carbene Insertion Approach to Access Enantioenriched 3-Fluoroalkyl 2,3-Dihydrobenzofurans》, the research content is summarized as follows. A rhodium-catalyzed enantioselective intramol. carbene insertion into ether α-C(sp³)-H bonds under mild conditions using the operationally safe and easily decomposable fluoroalkyl N-triftosylhydrazones 2-OCH₂R-4-R¹-5-R¹C₆H₂C(=NNHTfs)CF₂R³ [R = cyclopropyl, CN, 4-fluorophenyl, etc.; R¹ = H, OMe; R² = H, Me, Br, NO₂, etc.; R³ = F, CF₃, COOEt] as the carbene source was reported. This method enables the efficient synthesis of a range of previously inaccessible chiral fluoroalkyl 2,3-dihydrobenzofuran derivatives I in good to high yield with excellent diastereoselectivity and high enantioselectivity. The usefulness of this transformation is exemplified in the straightforward synthesis of several CF₃-analogs of natural products and bioactive mols. DFT calculations provide insights into the underlying stepwise pathway and the origin of enantioselectivity.

Electric Literature of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Product Details of C5H9BrO2

Zhang, Xu;Fang, Wan-Yin;Lekkala, Ravindar;Tang, Wenjian;Qin, Hua-Li research published 《 An Easy, General and Practical Method for the Construction of Alkyl Sulfonyl Fluorides》, the research content is summarized as follows. A visible light-induced reductive addition of 1°, 2° and 3° alkyl iodides to ethenesulfonyl fluoride, employing Hantzsch ester as a hydrogen source at room temperature was developed for the synthesis of alkyl sulfonyl fluorides RCH₂CH₂SO₂F [R = cyclohexyl, Bn, 1-adamantyl, etc.]. This method featured a wide substrate scope and great functional group compatibility, providing facile and robust process to alkyl sulfonyl fluorides including enzyme inhibitors, natural products and drugs derivatives in up to 99% yield. Further derivatization of resultant aliphatic sulfonyl fluorides was also achieved through sulfur fluoride exchange (SuFEx) reactions to deliver sulfonates and sulfonamides as privileged motifs for medicinal chem.

Product Details of C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C5H9BrO2.

Zhang, Xuan;He, Yonghan;Zhang, Peiyi;Budamagunta, Vivekananda;Lv, Dongwen;Thummuri, Dinesh;Yang, Yang;Pei, Jing;Yuan, Yaxia;Zhou, Daohong;Zheng, Guangrong research published 《 Discovery of IAP-recruiting BCL-X_L PROTACs as potent degraders across multiple cancer cell lines》, the research content is summarized as follows. Targeting BCL-X_L via PROTACs is a promising strategy in reducing BCL-X_L inhibition associated platelet toxicity. Recently, we reported potent BCL-X_L PROTAC degraders that recruit VHL or CRBN E3 ligase. However, low protein expression or mutation of the responsible E3 ligase has been known to result in decreased protein degradation efficiency of the corresponding PROTACs. To overcome these mechanisms of resistance, PROTACs based on recruiting alternative E3 ligases could be generated. Thus, we designed and synthesized a series of PROTACs that recruit IAP E3 ligases for BCL-X_L degradation Among those PROTACs, compound 8a(I) efficiently degrades BCL-X_L in malignant T-cell lymphoma cell line MyLa 1929 while CRBN-based PROTACs that have high potency in other cancer cell lines show compromised potency, likely due to the low CRBN expression. Moreover, compared with the parent compound ABT-263, PROTAC 8a shows comparable cell killing effects in MyLa 1929 cells whereas the on-target platelet toxicity is significantly reduced. Our findings expand the anti-tumor spectra of BCL-X_L degraders and further highlight the importance of selecting suitable E3 members to achieve effective cellular activity.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 629-04-9.

Zhan, Yi-Zhou;Xiao, Nan;Shu, Wei research published 《 Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group》, the research content is summarized as follows. The nickel-catalyzed intermol. cross-dialkylation of alkynes devoid of directing or activating groups afforded multiple aliphatic substituted alkenes in a syn-selective fashion at room temp was reported. The combination of two-electron oxidative cyclometallation and single-electron cross-electrophile coupling of nickel enabled the syn-cross-dialkylation of alkynes at room temperature This reductive protocol enabled the sequential installation of two different alkyl substituents onto alkynes in a regio- and stereo-selective manner, circumvented the tedious preformation of sensitive organometallic reagents. The synthetic utility of this protocol was demonstrated by efficient synthesis of multi-substituted unfunctionalized alkenes and diverse transformations of the product.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Quality Control of 629-04-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. HPLC of Formula: 5445-17-0.

Zhang, Cheng;Bates, Morgan W.;Geng, Zhishuai;Levi, Adam E.;Vigil, Daniel;Barbon, Stephanie M.;Loman, Tessa;Delaney, Kris T.;Fredrickson, Glenn H.;Bates, Christopher M.;Whittaker, Andrew K.;Hawker, Craig J. research published 《 Rapid Generation of Block Copolymer Libraries Using Automated Chromatographic Separation》, the research content is summarized as follows. A versatile and scalable strategy is reported for the rapid generation of block copolymer libraries spanning a wide range of compositions starting from a single parent copolymer. This strategy employs automated and operationally simple chromatog. separation that is demonstrated to be applicable to a variety of block copolymer chemistries on multigram scales with excellent mass recovery. The corresponding phase diagrams exhibit increased compositional resolution compared to those traditionally constructed via multiple, individual block copolymer syntheses. Increased uniformity and lower dispersity of the chromatog. libraries lead to differences in the location of order-order transitions and observable morphologies, highlighting the influence of dispersity on the self-assembly of block copolymers. Significantly, this separation technique greatly simplifies the exploration of block copolymer phase space across a range of compositions, monomer pairs, and mol. weights (up to 50000 amu), producing materials with increased control and homogeneity when compared to conventional strategies.

HPLC of Formula: 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 4897-84-1.

Zhang, Hualin;Xie, Ruliang;AI-furas, Hawaa;Li, Yupeng;Wu, Qingxia;Li, Jian;Xu, Fang;Xu, Tianfeng research published 《 Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation》, the research content is summarized as follows. The tertiary epidermal growth factor receptor (EGFR) C797S mutation predominates in the acquired mutational resistance in cancer patients to third-generation EGFR inhibitors. Small-mol. inhibitors targeting the EGFR C797S mutation have been developed with good efficiency. However, these compounds may still induce new EGFR mutations to evade the inhibition pathway. One EGFR protein degrader based on an allosteric inhibitor has shown some benefits of degrading the EGFR L858R/T790M/C797S triple mutant. However, the degrader of the other important triple EGFR mutation Del19/T790M/C797S has not been reported. Here we present the design and synthesis of a series of EGFR proteolysis-targeting chimeras (PROTACs) that can rapidly and potently induce EGFR degradation in Ba/F3 cells expressing the EGFR^{Del19/T790M/C797S} mutant. One representative compound 6h time- and dose-dependently induced EGFR degradation with a DC₅₀ of 8 nM. It also showed good antiproliferation activity (IC₅₀ = 0.02μM) against Ba/F3-EGFR^{Del19/T790M/C797S} cells. 6h may serve as a lead compound to develop therapeutic agents for the treatment of resistant non-small cell lung cancer patients with EGFR C797S mutants.

Synthetic Route of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of 4224-70-8.

Zhang, Jian-Xin;Shu, Wei research published 《 Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides》, the research content is summarized as follows. Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R¹CH₂CHR²CH₂C(O)NHAr [R¹ = cyanomethyl, H₂CCO₂Et, (2-oxotetrahydrofuran-3-yl); R² = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC₆H₄, 3-MeOC₆H₄, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp³-Csp³ bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance.

Quality Control of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary