Tag: M.W=150-200

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organic compounds having carbon bonded to bromine are called organic bromides. Synthetic Route of 1575-37-7.

Yang, Chun;Song, Lili;Miao, Zhong;Jiang, Lingyun;Li, Ting;Zhi, Xiaoyan;Hao, Xiaojuan;Cao, Hui research published 《 Discovery of novel obovatol-based phenazine analogs as potential antifungal agents: synthesis and biological evaluation in vitro》, the research content is summarized as follows. To explore candidate fungicides from plant secondary metabolites, 16 novel obovatol-type phenazine derivatives were semi-synthesized from obovatol isolated from the leaves of Magnolia obovata Thunb. The antifungal activity of synthesized compounds was investigated in vitro against four phytopathogenic fungi using the spore germination method. The bioassay results showed that eight derivatives exhibited better antifungal activity against Fusarium solani than two pos. controls, especially compounds 3-allyl-1-(4-allylphenoxy)-7,8-difluorophenazine (IC₅₀ = 64.61μg mL-1) and 3-allyl-1-(4-allylphenoxy)-8-chlorophenazine (IC₅₀ = 79.97μg mL-1) showed pronounced inhibition of spore germination activity against F. solani. They could be used as lead compounds for further structural optimization. Addnl., the preliminary structure-activity relationships (SARs) illustrated that the introduction of a benzene ring monosubstituted with electron-withdrawing groups into the obovatol scaffold could lead to potentially antifungal compounds

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Synthetic Route of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Reference of 1575-37-7.

Yang, Gao-feng;Li, Guang-xun;Huang, Jin;Fu, Ding-qiang;Nie, Xiao-kang;Cui, Xin;Zhao, Jin-zhong;Tang, Zhuo research published 《 Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine》, the research content is summarized as follows. The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chem. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with sym. and unsym. o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1).

Reference of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Product Details of C6H7BrN2.

Yang, Guang;Wang, Shoucai;Nie, Hongsheng;Xiong, Zhicheng;Li, Xuan;Ji, Fanghua;Jiang, Guangbin research published 《 An efficient transition metal-free difunctionalization of alkenes in water for the green preparation of sulfone compounds》, the research content is summarized as follows. A direct difunctionalization method of alkenes with quinoxalin-2(1H)-ones and sodium sulfonates toward sulfone derivatives I [R¹ = Et, prop-2-ynyl, (CH₂)₃HCCH₂, p-tolylmethyl, (4-tert-butylphenyl)methyl; R² = Ph, 2-ClC₆H₄, Bn, etc.; R³ = H, 6-F, 6-Br, 6,7-di-Me, 6,7-di-Cl; R⁴ = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; R⁵ = H; R²R⁵ = (CH₂)₃] had been developed under environmentally friendly conditions. This strategy represented an efficient and practical difunctionalization of olefins using water/aqueous media as a sustainable solvent. In addition, this transition metal-free reaction was high yield, and operationally simple, and in particular, proceeds under mild conditions to afford desired sulfones with high functional group compatibility.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Product Details of C6H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Product Details of C6H7BrN2.

Yang, Guang;Xiong, Zhicheng;Nie, Hongsheng;He, Meiqin;Feng, Qiong;Li, Xuan;Huang, Huabin;Wang, Shoucai;Ji, Fanghua;Jiang, Guangbin research published 《 Copper-Catalyzed Divergent C-H Functionalization Reaction of Quinoxalin-2(1H)-ones and Alkynes Controlled by N1-Substituents for the Synthesis of (Z)-Enaminones and Furo[2,3-b]quinoxalines》, the research content is summarized as follows. With control by N1-substituents, switchable divergent C-H functionalization reaction of quinoxalin-2(1H)-ones was achieved for the synthesis of (Z)-enaminones I (R¹ = Et, H₂C:CHCH₂, cyclopropylmethyl, 4-O₂NC₆H₄CH₂, etc.; R² = H, 7-MeO, 6,7-Cl₂, etc.; R³ = cyclopropyl, Ph, 2-BrC₆H₄, 2-thienyl, etc.) and furo[2,3-b]quinoxalines II (R⁴ = H, 6-F₃C, 6-F, 8-Me, 6,7-Me₂, etc.; R⁵ = Ph, 3-BrC₆H₄, 4-EtOC₆H₄, etc.) using the combination of copper catalyst and oxidant. This new protocol features mild reaction conditions, readily available materials and broad substrate scope. Gram-scale and mechanistic studies were also investigated. Furthermore, some of the products exhibited excellent antitumor activity against A549, HepG-2, MCF-7 and Hela cells, which were tested by MTT assay.

Product Details of C6H7BrN2, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 4-Bromobenzene-1,2-diamine.

Yang, Hao-Yu;Zhang, Heng-yuan;Zhang, Ming;Fan, Xiao-chun;Lin, Hui;Tao, Si-Lu;Zheng, Cai-Jun;Zhang, Xiao-Hong research published 《 Multiplying the efficiency of red thermally activated delayed fluorescence emitter by introducing intramolecular hydrogen bond》, the research content is summarized as follows. As one of the three primary colors, red organic light-emitting diodes (OLEDs) are indispensable in practical applications. However, red emitters are generally subject to severe non-radiative exciton loss due to their narrow energy gap. In this work, three new thermally activated delayed fluorescence (TADF) emitters were developed, namely 4-(acenaphtho[1,2-b]quinoxalin-9-yl)-N,N-diphenylaniline (TPA-AP), 4-(acenaphtho[1,2-b]pyrido[2,3-e]pyrazin-10-yl)-N,N-diphenylaniline (TPA-APy), and 4-(acenaphtho[1,2-b]pyrazino[2,3-e]pyrazin-9-yl)-N,N-diphenylaniline (TPA-APm), employing a series of finely modified acenaphtho[1,2-b]quinoxaline (AP) derivatives as acceptor units. Among three TADF emitters, an intramol. hydrogen bond is formed between the donor (D) and acceptor (A) units in TPA-APm. Consequently, the overlap of the frontier Mol. orbitald (FMOs) of TPA-APm can increase appropriately, and the fluorescence radiative rate (k_F) of TPA-APm is nearly twofold than that of TPA-AP and TPA-APy. Furthermore, the non-radiative decay rate (k_nr) of TPA-APm is less than that of TPA-AP and TPA-APy by an order of magnitude, which is attributed to the improved mol. rigidity caused by intramol. hydrogen bond. As a result, TPA-APm-based OLEDs achieved a multiplied external quantum efficiency (EQE) of 21.1% with the electroluminescence peak at 590 nm, comparing to only 7.0% and 11.5% for the TPA-AP-based and TPA-APy-based devices, resp. These results demonstrate appropriate intramol. hydrogen bond can suppress the influence of non-radiative decay by simultaneously enhancing mol. rigidity and facilitating the fluorescence process, and have great potential in the design of efficient red TADF emitters.

Recommanded Product: 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: 4-Bromo-N-methylaniline.

Yang, Jinfei;Wu, Xiaolong;Yang, Banghua;Liu, Yirong;Cheng, Rui;Gong, Zijun;Sun, Fei research published 《 Mn(II)-Catalysed ortho-alkenylation of aromatic amines and its application in reproductive diseases》, the research content is summarized as follows. A Mn(II)-catalyzed ortho-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl2 was critical for the ortho-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds 3m on 8 wk-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 wk-old adult male rats with azoospermia with 1 mg kg-13m after two weeks, while treatment with 10 mg kg-13m led to obvious sperm production Notably, if we increase the dose to 100 mg kg-1, there will be a lot of sperm production in the epididymis and testes after two weeks of treatment. The results of this study will be of great significance in research on drugs for treating azoospermia and oligospermia diseases.

Recommanded Product: 4-Bromo-N-methylaniline, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Name: 1-Bromoheptane.

Yang, Liu-qing;Yu, Shao-peng;Yang, Yan-tao;Zhao, Yi-shuang;Wang, Fei-yun;Chen, Yao;Li, Qing-hua;Tian, Ping;Zhu, Yu-ying;Zhang, Jian-ge;Lin, Guo-qiang research published 《 Muscone derivative ZM-32 inhibits breast tumor angiogenesis by suppressing HuR-mediated VEGF and MMP9 expression》, the research content is summarized as follows. Inhibition of tumor angiogenesis is a highly effective strategy for cancer treatment. Human antigen R (HuR), an RNA-binding protein, is overexpressed in many cancers and regulates the mRNAs of multiple angiogenic factors by binding to the adenylate-uridylate-rich element in their 3&′ untranslated region. HuR protein has been demonstrated to be an important regulatory factor in macrophage-mediated angiogenesis, a process in which macrophages are critical for tumor progression. Muscone is a synthetic equivalent of musk, and recent studies have shown that it has a regulatory effect on angiogenesis. In this study, we synthesized five series of muscone derivatives and discovered that compound ZM-32 was effective in preventing HuR RRM1/2-Vegf-a mRNA complex formation. ZM-32 bound to HuR RRM1/2 protein with a KD value of 521.7 nmol/L. Furthermore, ZM-32 inhibited endothelial cell proliferation, migration, and tubule formation, and suppressed the VEGF/VEGFR2/ERK1/2 signaling axis mediated by macrophages in vitro. We also demonstrated that ZM-32 effectively prevented the proliferation and migration of breast cancer cells and inhibited the growth and angiogenesis of MDA-MB-231 xenograft tumors without any obvious toxicity in vivo. Mechanistically, exposure to ZM-32 influenced the mRNA stability of Vegf-a and Mmp9 in a HuR-dependent manner in both macrophages and MDA-MB-231 cells. Thus, in this study we identified a new muscone derivative, ZM-32, with anti-angiogenesis effects mediated via targeting HuR in breast cancer, that may become a potentially valuable lead compound for anti-cancer angiogenesis.

Name: 1-Bromoheptane, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Name: 6-Bromohexanoic acid.

Yang, Mao-Xia;Luo, Yang;Zhang, Wei;Lin, Wen-hao;He, Jiao;Shan, Pei-hui;Tao, Zhu;Xiao, Xin research published 《 Cucurbit[10]uril-mediated Supramolecular Assembly for Optically Tunable Dimers and Near White-light Emissive Materials》, the research content is summarized as follows. Cucurbit[10]uril (Q[10]), the cucurbit[n]uril with a large cavity, exhibits several new features in the development of the host-guest complex. Based on Q[10] and π-conjugated mol., oligo(p-phenylenevinylene) derivative (OPVCOOH), the host-guest complexes with 3 different interaction ratios of 1:2, 2:2, and 3:2 assemblies (Q[10]:guest) were fabricated. Depending on the host/guest ratio, the emission color of these complexes ranged from blue to yellow-green. The extra Fe²⁺ coordinated with a bare carboxyl group of the Q[10]-OPVCOOH (3:2) assembly, obstructing its rotaxane structure and forming Q[10]-OPVCOOH-Fe²⁺ assembly, which may be used as a coating for near-white LED bulbs.

Name: 6-Bromohexanoic acid, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Xu, Yuankang;Yang, Lei;Wang, Hanyu;Zhang, Yanxia;Yang, Xiaofeng;Pei, Meishan;Zhang, Guangyou research published 《 A new “off-on-off” sensor for sequential detection of Al³⁺ and Cu²⁺ with excellent sensitivity and selectivity based on different sensing mechanisms》, the research content is summarized as follows. A new simple Schiff base, (E)-N-(2-hydroxybenzylidene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), was designed and synthesized based on salicylaldehyde and imidazo[2, 1-b]thiazole. X could be used as a sensor to identify Al³⁺ through a significant fluorescence enhancement because of CHEF and inhibition of PET process and then to detect Cu²⁺ through a highly efficient quenching behavior due to the paramagnetic quenching. The sensor showed a high selectivity for Al³⁺ and Cu²⁺ in methanol solution at pH = 5 and was not disturbed by other competing metal ions. Furthermore, based on the equation 3σ/slope, the detection limits of sensor for Al³⁺ and Cu²⁺ were calculated to be 3.1 x 10^-10 M and 9.8 x 10^-11 M, resp. Addnl., the association constants of X[Al³⁺] and X[Cu²⁺] were also determined to be 2.3 x 10⁴ M^-1 and 6.1 x 10⁴ M^-1 on basis of Benesi-Hildebrand equation. In addition, the titration experiment of fluorescence and mass spectrometry showed that sensor was combined with Al³⁺ or Cu²⁺ both in 1:1 ratio. Moreover, the optimized structure and energy calculations of X, X[Al³⁺] and X[Cu²⁺] were obtained by Gaussian software based on the basis set of B3LYP/6-31 G(d) and B3LYP/LANL2DZ. And, the sensor successfully detected Al³⁺ and Cu²⁺ in the real water sample with a satisfactory recovery (91.4 % – 107.1 %) and RSD values (0.66 % – 1.91 %).

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Recommanded Product: Ethyl 3-bromo-2-oxopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, Application of C4H7BrO2

Xuan, Jun;Haelsig, Karl T.;Sheremet, Michael;Machicao, Paulo A.;Maimone, Thomas J. research published 《 Evolution of a Synthetic Strategy for Complex Polypyrrole Alkaloids: Total Syntheses of Curvulamine and Curindolizine》, the research content is summarized as follows. Structurally unprecedented antibacterial alkaloids containing multiple electron-rich pyrrole units have recently been isolated from Curvularia sp. and Bipolaris maydis fungi. This article documents the evolution of a synthetic program aimed at accessing the flagship metabolites curvulamine and curindolizine, which are presumably a dimer and trimer of a C₁₀N biosynthetic building block, resp. Starting with curvulamine, we detail several strategies to merge two simple, bioinspired fragments, which while ultimately unsuccessful, led us toward a pyrroloazepinone building block-based strategy and an improved synthesis of this 10π-aromatic heterocycle. A two-step annulation process was then designed to forge a conserved tetracyclic bis-pyrrole architecture and advanced into a variety of late-stage intermediates; unfortunately, however, a failed decarboxylation thwarted the total synthesis of curvulamine. By tailoring our annulation precursors, success was ultimately found through the use of a cyanohydrin nucleophile which enabled a 10-step total synthesis of curvulamine I. Attempts were then made to realize a biomimetic coupling of curvulamine with an addnl. C₁₀N fragment to arrive at curindolizine, the most complex family member. Although unproductive, we developed a 14-step total synthesis of this alkaloid, II, through an abiotic coupling approach. Throughout this work, effort was made to harness and exploit the innate reactivity of the pyrrole nucleus, an objective which has uncovered many interesting findings in the chem. of this reactive heterocycle.

Application of C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary