Tag: M.W=150-200

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Application In Synthesis of 70-23-5

Rani, Chekuri Sharmila;Reddy, Alugubelli Gopi;Susithra, E.;Mak, Kit-Kay;Pichika, Mallikarjuna Rao;Reddymasu, Sreenivasulu;Rao, Mandava Venkata Basaveswara research published 《 Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines》, the research content is summarized as follows. Abstract: A novel series of amide functionalized imidazo[1,2-a]pyridine (14a-14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14 showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC₅₀ values of 0.021 ± 0.0012μM, 0.95 ± 0.039μM, 0.091 ± 0.0053μM, and 0.24 ± 0.032μM, resp.

Application In Synthesis of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 4897-84-1.

Raubo, Piotr;Carbajo, Rodrigo J.;McCoull, William;Raubo, Joanna;Thomas, Morgan research published 《 Diversity-orientated synthesis of macrocyclic heterocycles using a double S_NAr approach》, the research content is summarized as follows. An efficient macrocyclization approach based on the double aromatic nucleophilic substitution (SNACK) was developed. This methodol. allows a facile incorporation of heterocyclic motifs into macrocyclic rings and rapid synthesis of a significant number of structurally diverse macrocycles e.g., I. SNACK macrocyclization enables preparation of stable diastereoisomers of conformationally restricted macrocycles (atropisomers) e.g., II and e.g., III. Practical application of SNACK macrocyclization in a drug discovery project was exemplified by the identification of high affinity macrocyclic binders of B-cell lymphoma 6 (BCL6).

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Synthetic Route of 4897-84-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Related Products of 6911-87-1.

Ray, Ritwika;Hartwig, John F. research published 《 Oxalohydrazide Ligands for Copper-Catalyzed C-O Coupling Reactions with High Turnover Numbers》, the research content is summarized as follows. Here, we report a class of ligands based on oxalohydrazide cores and N-amino pyrrole and N-amino indole units that generates long-lived copper catalysts for couplings that form the C-O bonds in biaryl ethers. These Cu-catalyzed coupling of phenols with aryl bromides occurred with turnovers up to 8000, a value which is nearly two orders of magnitude higher than those of prior couplings to form biaryl ethers and nearly an order of magnitude higher than those of any prior copper-catalyzed coupling of aryl bromides and chlorides. This ligand also led to copper systems that catalyze the coupling of aryl chlorides with phenols and the coupling of aryl bromides and iodides with primary benzylic and aliphatic alcs. A wide variety of functional groups including nitriles, halides, ethers, ketones, amines, esters, amides, vinylarenes, alcs. and boronic acid esters were tolerated, and reactions occurred with aryl bromides in pharmaceutically related structures.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Related Products of 6911-87-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Safety of Ethyl 3-bromo-2-oxopropanoate

Reddy, Ramesh B.;M, Vijay;Krishnan, Mena Asha;Chelvam, Venkatesh research published 《 Synthesis of tubuvaline (Tuv) fragment of tubulysin via diastereoselective dihydroxylation of homoallylamine》, the research content is summarized as follows. Tubulysins are natural anticancer mols. that directly bind and inhibit tubulin polymerization in actively dividing cells leading to apoptosis and cell death. Structurally, tubulysins are linear tetrapeptides, constituted by a natural amino acid (Ile) and three non-canonical amino acids (Mep, Tuv, and Tup). Herein, we report a convenient strategy for the practical synthesis of tubuvaline fragment of tubulysin natural products. In this approach, we describe the regioselective ring opening of a chiral aziridine with vinyl Grignard reagent to obtain (R)-tert-butyl(2-methylhex-5-en-3-yl)(tosyl)carbamate which was further subjected to Sharpless asym. dihydroxylation with AD-mix-β resulting in the formation of (2 R,4R)-4-((tert-butoxycarbonyl)amino)-2-(methoxymethoxy)-5-methylhexanoic acid that was finally transformed to tubuvaline by heterocyclization.

Safety of Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 6911-87-1, formula is C7H8BrN, The most pervasive is the naturally produced bromomethane. Application In Synthesis of 6911-87-1

Ren, Jiangmeng;Cao, Fu-Rong;Sun, Xue-Qin;Xu, Xuan;Liu, Gui-Xia;Zeng, Bu-Bing research published 《 Studies towards DIAD promoted N-demethylation of N,N-dimethylanilines》, the research content is summarized as follows. The demethylation of N,N-dimethylanilines promoted by diisopropyl azodicarboxylate (DIAD) to provide N-methylanilines was achieved in this paper. This protocol featured with mild reaction condition, simple operation and moderate to good yield. The intermediates were isolated and identified by means of spectroscopy methods. The reaction mechanism was investigated exptl. and further verified by theor. calculations This method could be applied to the study of the metabolites of medicines containing N,N-dimethylaniline fragments.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Application In Synthesis of 6911-87-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Computed Properties of 5445-17-0.

Ren, Qiang;Deng, Liming;Zhou, Zongtao;Wang, Xuekun;Hu, Lijun;Xie, Rongrong;Li, Zheng research published 《 Design, synthesis, and biological evaluation of novel dual PPARα/δ agonists for the treatment of T2DM》, the research content is summarized as follows. Dual PPARα/δ agonists have been considered as potential therapeutics for the treatment of type 2 diabetes mellitus. After comprehensive structure-activity relationship study based on GFT505, a novel dual PPARα/δ agonist compound 6 was identified with highly activities on PPARα/δ and higher selectivity against PPARγ than that of GFT505. The modeling study revealed that compound 6 binds well to the binding pockets of PPARα and PPARδ, which formed multiple hydrogen bonds with key residues related to the activation of PPARα and PPARδ. Moreover, oral glucose tolerance test exhibited that compound 6 exerts dose-dependent anti-diabetic effects in ob/ob mice and reveals similar potency to that of GFT505, the most advanced candidate in this field. These findings suggested that compound 6 is a promising candidate for further researches, and the extended chem. space might help us to explore better PPARα/δ agonist.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Computed Properties of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline, Computed Properties of 6911-87-1

Ren, Shuang;Xu, Guiming;Guo, Yongjia;Liu, Qiang;Guo, Cancheng research published 《 Iron porphyrin-catalyzed N-trifluoroethylation of anilines with 2,2,2-trifluoroethylamine hydrochloride in aqueous solution》, the research content is summarized as follows. Preparation of trifluoroethylated amines ArN(R)CH₂CF₃ [Ar = Ph, 3-MeC₆H₄, 4-MeOC₆H₄, etc.; R = H, Me] via iron porphyrin-catalyzed N-trifluoroethylation of anilines was developed with 2,2,2-trifluoroethylamine hydrochloride as the fluorine source. This one-pot N-H insertion reaction was conducted via cascade diazotization/N-trifluoroethylation reactions. The developed transformation can afford a wide range of N-trifluoroethylated anilines in good yields using readily available primary amines and secondary anilines as starting materials.

Computed Properties of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 629-04-9.

Qi, Liangliang;Pang, Xiaobo;Yin, Kai;Pan, Qiu-Quan;Wei, Xiao-Xue;Shu, Xing-Zhong research published 《 Mn-mediated reductive C(sp³)-Si coupling of activated secondary alkyl bromides with chlorosilanes》, the research content is summarized as follows. Reductive coupling of activated secondary alkyl halides FG-CHXR¹ (FG = phosphinyl, sulfonyl; R¹ = Me, Et, PhCH₂CH₂, C₆H₁₃) with chlorosilane ClSiMe₂(CH:CH₂) mediated by manganese metal afforded secondary alkylsilanes FG-CH(R¹)SiMe₂(CH:CH₂) with high yields. The construction of secondary alkylsilanes is a challenging subject in the synthetic community. The cross-coupling provides a practical solution to address this problem, but it typically relies on organometallic species. Herein, we report an Mn-mediated reductive C(sp³)-Si coupling to synthesize these compounds from alkyl and silyl electrophiles. This approach avoids the requirement for activation of Si-Cl by transition metals and thus allows for the coupling of various common chlorosilanes. The reaction proceeds under mild conditions and shows good functional group compatibility. The method offers access to α-silylated organophosphorus and sulfones with a scope that is complementary to those obtained from the established methods.

Application In Synthesis of 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Category: bromides-buliding-blocks.

Qin, Hengfei;Li, Yan;Dong, Ruoyu;Yuan, Jiafeng;Zhou, Yue;Hu, Yaxin;Jia, Hailang;Bai, Jirong;Gong, Jie;Jiang, Jinlong;Zhou, Quanfa research published 《 An Efficient Catalyst Derived from Carboxylated Lignin-Anchored Iron Nanoparticle Compounds for Carbon Monoxide Hydrogenation Application》, the research content is summarized as follows. Catalytic activity and target product selectivity are strongly correlated to the size, crystallog. phase, and morphol. of nanoparticles. In this study, waste lignin from paper pulp industry is employed as the carbon source, which is modified with carboxyl groups at the mol. level to facilitate anchoring of metals, and a new type of carbon-based catalyst was obtained after carbonization. As a result, the size of the metal particles is effectively controlled by the chelation between -COO^– and Fe³⁺. Furthermore, Fe/CM-CL with a particle size of 1.5-2.5 nm shows excellent catalytic performance, the conversion of carbon monoxide reaches 82.3%, and the selectivity of methane reaches 73.2%.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, Application In Synthesis of 5445-17-0

Qin, Xing;Wu, Chu;Niu, Dechao;Qin, Limei;Wang, Xia;Wang, Qigang;Li, Yongsheng research published 《 Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy》, the research content is summarized as follows. Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H₂O₂) production and catalase for H₂O₂ degradation, which serves as an intracellular H₂O₂ regulator to degrade toxic peroxides to water. Inspired by this biochem. pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and catalase (CAT) into Fe₃O₄ nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated as FIGs-LC). Based on the O2 redistribution and H₂O₂ activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical (·OH) and singlet oxygen (¹O₂) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H₂O₂ and further cascade decomposing H₂O₂ into O₂. The regulation reactions of FIGs-LC significantly elevate the intracellular ROS level and cause fatal damage to cancer cells inducing the effective inhibition of tumor growth. Such enzyme complex loaded hybrid nanogel present potential for biomedical ROS regulation, especially for the tumors with different redox state, size, and s.c. depth.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Application In Synthesis of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary