Tag: M.W=150-200

Qu, Yi published the artcileVisible-Light-Mediated [2+2+1] Carbocyclization Reactions of 1,7-Enynes with Bromofluoroacetate to Form Fused Monofluorinated Cyclopenta[c]quinolin-4-ones, HPLC of Formula: 401-55-8, the publication is Journal of Organic Chemistry (2020), 85(8), 5379-5389, database is CAplus and MEDLINE.

Herein, we describe a new protocol for photoinduced radical [2+2+1] carbocyclization reactions of 1,7-enynes with bromofluoroacetate. These reactions, which proceed via a cascade involving fluoroalkylation, 6-exo-dig and 5-endo-trig cyclizations, H-transfer step, and oxidative dehydrogenation, provide an efficient and general route to a variety of fused monofluorinated cyclopenta[c]quinolin-4-one derivatives

Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Xu, Zhuo-Wei published the artcileAn efficient method for the N-formylation of amines under catalyst- and additive-free conditions, Category: bromides-buliding-blocks, the publication is Tetrahedron Letters (2019), 60(18), 1254-1258, database is CAplus.

A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives A mechanism that involves difluorocarbene is proposed for this reaction.

Tetrahedron Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C6H13I, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Deng, Qinfei published the artcilePhotoredox-catalyzed cascade addition/cyclization of N-propargyl aromatic amines: access to 3-difluoroacetylated or 3-fluoroacetylated quinolines, HPLC of Formula: 401-55-8, the publication is Organic Chemistry Frontiers (2018), 5(1), 19-23, database is CAplus.

The 3-difluoroacetylated quinolines I [R = C₆H₅, 4-CH₃CH₂CO(O)C₆H₄, 9H-fluoren-2-yl, thiophen-2-yl, etc.; R¹ = H, 6-F, 7-CH₃, 6-OCF₃, etc.; X = 2-CF₂C(O)OCH₂CH₃] and 3-fluoroacetylated quinolines I [X = 2-CHFC(O)OCH₂CH₃] were synthesized via a visible-light-induced cascade addition/cyclization of N-propargyl aromatic amines R²C₆H₄NHCH₂CCR (R² = H, 3-Me, 4-Cl, etc.) with Et bromodifluoroacetate or Et bromofluoroacetate catalyzed by fac-Ir(ppy)₃ under mild conditions. For the substrates bearing various substituents on the aniline ring and benzene ring, the reaction proceeded smoothly to give the corresponding difluoroacetylated I [X = 2-CF₂C(O)OCH₂CH₃] or fluoroacetylated quinolines I [X = 2-CHFC(O)OCH₂CH₃] in moderate to high yields.

Organic Chemistry Frontiers published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tang, Wei-Ke published the artcileIrradiation-Induced Cobaloxime-Catalyzed C-H Monofluoroalkylation of Styrenes at Room Temperature, Formula: C4H6BrFO2, the publication is Organic Letters (2019), 21(1), 196-200, database is CAplus and MEDLINE.

A cobaloxime-catalyzed photochem. synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C10H17N3O2, Formula: C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tsuji, Hayato published the artcileIndium-catalyzed cycloisomerization of ψ-Alkynyl-β-keto esters into six- to fifteen-membered rings, Application In Synthesis of 81216-14-0, the publication is Angewandte Chemie, International Edition (2007), 46(42), 8060-8062, database is CAplus and MEDLINE.

Many different sizes of rings are made available via heating of ψ-alkynyl-β-keto esters in the presence of In(NTf₂)₃ (Tf = trifluoromethanesulfonyl). The products, produces six- to fifteen-membered ring compounds are produced in good yields. The reaction features low catalyst loading and moderately dilute conditions, and the formation of medium-sized rings is sometimes faster than that for the corresponding six-membered rings. Cycloisomerization of 3-oxo-16-heptadecynoic acid Me ester gave 2-methyl-15-oxo-1-cyclopentadecene-1-carboxylic acid Me ester. Reduction of the latter gave 2-methyl-15-oxo-1-cyclopentadecanecarboxylic acid Me ester. Decarboxylation of this intermediate gave (±)-muscone (i.e., 3-methylcyclopentadecanone).

Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C18H10F3NO3S2, Application In Synthesis of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

An, Xiang published the artcileUniversal 4-qualifiable fluorene-based building blocks for potential optoelectronic applications, Synthetic Route of 111-83-1, the publication is Chinese Chemical Letters (2022), 33(12), 5137-5141, database is CAplus.

Herein, a universal 4-qualifiable fluorene-based building block I, which is a fundamental mol. segment to functionalize and obtain novel conjugated materials, was demonstrated. Compared to the traditional modification at 9-site, addnl. 4-position functionalization provided an exciting blueprint to not only tune electronic structure and excited state via p-n mol. design engineering and space charge-transfer strategy, but also allow for optimizing intermol. arrangement and obtaining solution-processing ability. The introduction of the 4-site substituent in fluorene based semiconductors may endow materials with unique properties. Finally, two stable deep-blue light-emitting conjugated polymers, PODOPF and PODOF, by utilizing the 4-substituent fluorene based building block were successfully prepared It is believable that the performance, stability and processibility of reported outstanding fluorene-based conjugated mols. can be further optimized based on this universal building block.

Chinese Chemical Letters published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Synthetic Route of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Jin, Weiwei published the artcileVisible-light induced three-component alkynyl-difluoroalkylation of unactivated alkenes, Application In Synthesis of 401-55-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(57), 7924-7927, database is CAplus and MEDLINE.

A visible-light induced three-component reaction of difluoroalkyl halides, unactivated alkenes, and alkynyl sulfones is described, providing a direct and general approach to the construction of synthetically valuable β-difluoroalkylated alkynes under room temperature conditions. This represents the first intermol. alkynyl-difluoroalkylation of unactivated alkenes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application In Synthesis of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Han, Shuaijun published the artcileCopper-catalyzed remote C-H monofluoromethylation of 8-aminoquinolines with dimethyl phosphonate as reductant, Related Products of bromides-buliding-blocks, the publication is Tetrahedron Letters (2019), 60(40), 151077, database is CAplus.

A simple and efficient copper-catalyzed monofluoromethylation of 8-aminoquinolines with 2-bromo-2-fluoroacetate was described with HPO(OMe)₂ (di-Me phosphonate) as reductant. The reaction tolerated a variety of quinoline amides and monofluoroalkyl bromides. Significant advantages of this protocol include synthetic convenience and high reaction efficiency.

Tetrahedron Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tang, Nana published the artcilePractical, metal-free remote heteroarylation of amides via unactivated C(sp³)-H bond functionalization, Application of (2-Bromoethyl)cyclopentane, the publication is Chemical Science (2019), 10(28), 6915-6919, database is CAplus and MEDLINE.

A new, efficient, site-selective heteroarylation of amides via C(sp³)-H bond functionalization. Amidyl radicals were directly generated from the amide N-H bonds under mild conditions, which triggered the subsequent 1,5-HAT process. A wide scope of aliphatic amides including carboxamides, sulfonamides and phosphoramides were readily modified at remote C(sp³)-H bonds by installing diverse heteroaryl groups. Borne out of pragmatic consideration, this protocol was used for the late-stage functionalization of amides.

Chemical Science published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C3H9ClOS, Application of (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Shuo published the artcileRegioselective Vinylation of Remote Unactivated C(sp³)-H Bonds: Access to Complex Fluoroalkylated Alkenes, Product Details of C4H6BrFO2, the publication is Angewandte Chemie, International Edition (2019), 58(5), 1499-1503, database is CAplus and MEDLINE.

Regioselective incorporation of a particular functional group into aliphatic sites by direct activation of unreactive C-H bonds is of great synthetic value. Despite advances in radical-mediated functionalization of C(sp³)-H bonds by a hydrogen-atom transfer process, the site-selective vinylation of remote C(sp³)-H bonds still remains underexplored. Reported herein is a new protocol for the regioselective vinylation of unactivated C(sp³)-H bonds. The remote C(sp³)-H activation is promoted by a C-centered radical instead of the commonly used N and O radicals. The reaction possesses high product diversity and synthetic efficiency, furnishing a plethora of synthetically valuable E alkenes bearing tri-/di-/mono-fluoromethyl and perfluoroalkyl groups.

Angewandte Chemie, International Edition published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C8H16O2, Product Details of C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary