Tag: M.W=150-200

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Application of C7H15Br.

Nakum, Kiran J.;Katariya, Kanu D.;Gupta, Vivek K.;Jadeja, Rajendrasinh N. research published 《 Synthesis, characterization, crystal structure and mesomorphic behavior of thiophene based homologous series》, the research content is summarized as follows. Through condensation of 4-n-alkoxybenzaldehydes with (E)-1-(4-aminophenyl)-3-(thiophen-2-yl)prop-2-en-1-one, new homologous series of rod shaped calamite liquid crystals that merge Schiff base, chalcone and thiophene units I (R = Et, n-Bu, n-heptyl, etc.) have been prepared All synthesized compounds were characterized by FT-IR, ¹H-NMR and ¹³C-NMR spectroscopy. The liquid crystalline properties of the synthesized compounds were investigated using a polarizing optical microscope (POM) and differential scanning calorimetry (DSC). The results indicate that n-heptyloxy to n-tetradecyloxy derivatives exhibited monotropic nematic phase while the remaining derivatives of homologous series are non mesomorphic. The n-ethoxy derivative I (R = Et) crystallizes under monoclinic, space group P21/c with unit cell dimension a = 19.343(4) Å , b = 5.8353(9) Å , c = 16.574(4) Å , β = 98.78(2) °, V = 1848.8(7) Å 3. The dihedral angle between two Ph rings of imine linkage in compound I (R = Et) is 51.64 (2)°.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Application of C7H15Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 629-04-9.

Nayak, Rashmi Ashwathama;Veerabhadraswamy, Bhyranalyar Nagarajappa;Shankar Rao, Doddamane S.;Sudhakar, Achalkumar Ammathnadu;Yelamaggad, Channabasaveshwar V. research published 《 Room-Temperature, Deep-Red/NIR-Emissive, C₃-Symmetric (n,π-conjugated) Columnar Liquid Crystals: C_3h-Tris(keto-hydrazone)s》, the research content is summarized as follows. The first examples of deep-red/near-IR (NIR) photoluminescent, (n,π-conjugated) discotics, namely, C_3h-tris(keto-hydrazone)s, which are the tautomers of tris(azo-enol)s, have been synthesized via a facile one-step triple azo-coupling and characterized. The n,π-resonance-assisted intramol. H-bonding, rendering planarity and shape persistence to the central core, facilitates their self-assembly into either a hexagonal columnar (Col_h) phase (p6mm lattice) or a columnar rectangular (Col_r) phase (p2mm lattice), over an extended thermal range including room temperature, fluorescing in the deep-red/NIR-I region. The low band gap with deep-red/NIR emission makes them ideal candidates for NIR-organic light-emitting diodes (OLEDs) and bioimaging.

Electric Literature of 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Safety of 6-Bromohexanoic acid

Nayak, Rashmi Ashwathama;Bhat, Sachin A.;Rao, D. S. Shankar;Yelamaggad, C. V. research published 《 Wide thermal range, exclusive occurrence of technically significant chiral nematic phase: synthesis and mesomorphism of cholesterol-based non-symmetric dimers》, the research content is summarized as follows. Fifteen new non-sym. chiral dimers belonging to three different series have been synthesized and evaluated for their mesomorphic properties. They were formed by interlinking cholesterol with salicylaldimine (SAN) cores (with reverse imine groups) via an ω-oxyalkanoyloxy spacer. Within a series, the length of the terminal n-alkoxy tails had been varied for a fixed even-parity spacer. Three even-parity spacers such as 4-oxybutanoyloxy, 6-oxyhexanoyloxy and 8-oxyoctanoyloxy have been used to join two cores, whereas the terminal tails such as n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy chains have been attached to the SAN core. Microscopic and calorimetric exptl. results show that all the dimers behave identically exhibiting the chiral nematic (N*) phase solely, which was authenticated by powder X-ray diffraction studies carried out on some selected samples. In the vast majority of the cases,the phase was thermodynamically stable, and while cooling, it exists over a wide thermal range covering room temperature(RT)due to supercooling. Finding was notable given the fact that the N* phase possesses technol. significant optical properties. At RT, the N* phase displayed one of the iridescent colors characteristically caused by interference and diffraction of the reflected and scattered light. A comparative study reveals that the lengths of both the terminal chain and central spacer influence the clearing temperature of the dimers, and also the temperature range of the N* phase. The selective reflection measurements revealed that the pitch of the N* phase was either temperature sensitive or temperature insensitive. Temperature-dependent CD (CD) spectra were recorded for the planar texture of the N* phase formed by a dimer, as a representative case. The presence of an intense neg. CD band suggests the left-handed screw sense of the N* phase helix.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Safety of 6-Bromohexanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 1575-37-7.

Nayek, Nayana;Karmakar, Pintu;Mandal, Mullicka;Karmakar, Indrajit;Brahmachari, Goutam research published 《 Photochemical and electrochemical regioselective cross-dehydrogenative C(sp²)-H sulfenylation and selenylation of substituted benzo[a]phenazin-5-ols》, the research content is summarized as follows. A dual synthetic strategy based on visible-light (white LEDs/direct sunlight) irradiation and electrosynthesis has been explored for the regioselective cross-dehydrogenative C(sp²)-H sulfenylation and selenylation of substituted benzo[a]phenazin-5-ols in an oxygen atm. under mild reaction conditions. The photochem. process does not require any external photoredox catalysts. Photocatalytic application of in situ generated deprotonated species of benzo[a]phenazin-5-ol mols. has also been accomplished. This is the first report on the synthesis of functionalized phenazine derivatives

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Quality Control of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Electric Literature of 4224-70-8

Ndima, Lubabalo;Hosten, Eric C.;Betz, Richard research published 《 The crystal structure of 6-bromohexanoic acid, C6H11BrO2》, the research content is summarized as follows. C6H11BrO2, monoclinic, P21/n (number 14), a = 10.6730(14) Å, b = 5.2781(6) Å, c = 14.7781(18) Å, β = 109.610(4)°, V = 784.21(17) Å3, Z = 4, Rgt(F) = 0.0225, wRref(F2) = 0.0564, T = 200(2) K.

Electric Literature of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Name: 6-Bromohexanoic acid

Nie, Fang-Yuan;Cai, Yi-Ping;Song, Qin-Hua research published 《 Visible Light-Driven Decarboxylative Alkylation of Aldehydes via Electron Donor-Acceptor Complexes of Active Esters》, the research content is summarized as follows. In this paper, authors have developed photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes. The photochem. reactions are initiated via photoinduced single electron transfer from triethylamine to N-hydroxyphthalimide esters in electron donor-acceptor complexes. This photochem. method can achieve to translate 15 pyridinaldehydes and 11 2-quinolinaldehydes to the corresponding ketones. Furthermore, this strategy can also achieve two other transformations, disulfanes to aryl sulfides and a styrene sulfone to the alkyl-substituted alkene.

Name: 6-Bromohexanoic acid, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Computed Properties of 1575-37-7.

Nie, Shenyou;Zhao, Jidong;Wu, Xiaowei;Yao, Yuan;Wu, Fangrui;Lin, Yi-Lun;Li, Xin;Kneubehl, Alexander R.;Vogt, Megan B.;Rico-Hesse, Rebecca;Song, Yongcheng research published 《 Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease》, the research content is summarized as follows. Zika virus belongs to the Flavivirus family of RNA viruses, which include other important human pathogens such as dengue and West Nile virus. There are no approved antiviral drugs for these viruses. The highly conserved NS2B-NS3 protease of Flavivirus is essential for the replication of these viruses and it is therefore a drug target. Compound screen followed by medicinal chem. optimization yielded a novel series of 2,6-disubstituted indole compounds that are potent inhibitors of Zika virus protease (ZVpro) with IC50 values as low as 320 nM. The structure-activity relationships of these and related compounds are discussed. Enzyme kinetics studies show the inhibitor 66 most likely exhibited a non-competitive mode of inhibition. In addition, this series of ZVpro inhibitors also inhibit the NS2B-NS3 protease of dengue and West Nile virus with reduced potencies. The most potent compounds 66 and 67 strongly inhibited Zika virus replication in cells with EC68 values of 1-3 μM. These compounds are novel pharmacol. leads for further drug development targeting Zika virus.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Computed Properties of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of C7H8BrN.

Nie, Xiao-Di;Han, Xiao-Li;Sun, Jian-Ting;Si, Chang-Mei;Wei, Bang-Guo;Lin, Guo-Qiang research published 《 Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines》, the research content is summarized as follows. The first Ni(OTf)₂-catalyzed hydroamination of ynamides e.g., N-benzyl-4-methyl-N-(2-phenylethynyl)benzene-1-sulfonamide was developed by reacting with secondary amines e.g., N-methylaniline. This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds e.g., I were prepared in moderate to excellent yields with high regioselectivities.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Product Details of C7H8BrN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Product Details of C5H9BrO2.

Mkhonazi, Blessing D.;Shandu, Malibongwe;Tshinavhe, Ronewa;Simelane, Sandile B.;Moshapo, Paseka T. research published 《 Solvent-free iron(III) chloride-catalyzed direct amidation of esters》, the research content is summarized as follows. The synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters was reported. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Product Details of C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. COA of Formula: C5H7BrO3.

Moghaddas, Seyyed Ali;Hossaini, Zinatossadat;Zareyee, Daryoush research published 《 Green synthesis and investigation of antioxidant ability new pyrazines containing pyrrolo[2,1-a]isoquinolines derivatives》, the research content is summarized as follows. In this study, a new, easy and high yield procedure was investigated for the generation of pyrazine containing pyrrolo[2,1-a]isoquinoline derivatives I [R¹ = CO₂Et, 4-MeC₆H₄, 4-BrC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄ R² = H, CO₂Me, CO₂Et; R³ = Me, Et; X = H, Me, OMe; X¹ = H, Me; X² = NH, O] II [R¹ = CO₂Et, 4-MeOC₆H₄; R² = CO₂Me; R³ = Me; X¹ = H; X² = NH, O] using multicomponent reaction of phthalaldehyde or its derivatives, primary amines, α-haloalketones, electron deficient acetylenic compounds, ammonium acetate and KF/Clinoptilolite nanoparticles (KF/CP NPs) as catalyst in water at room temperature Also, in this work, antioxidant ability was studied for a number of prepared compounds [R¹ = CO₂Et, 4-MeC₆H₄, 4-BrC₆H₄; R² = H, CO₂Me; R³ = Me; X = H, Me; X¹ = H, Me; X² = NH, O] employing the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and evaluating results with synthetic antioxidants (TBHQ and BHT). Comfortable, simple, fast and fresh procedure was the advantages of this study.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary