Tag: M.W=150-200

Organic compounds having carbon bonded to bromine are called organic bromides. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. HPLC of Formula: 1575-37-7.

Mahadik, Suraj S.;Garud, Dinesh R.;Pinjari, Rahul V.;Kamble, Rajesh M. research published 《 Synthesis, optical, electrochemical and theoretical studies of 2,3-Di(pyridin-2-yl)quinoxaline amine derivatives as blue-orange emitters for organic electronics》, the research content is summarized as follows. We herein report the design and synthesis of six new donor-acceptor (D-A) type, bipolar compounds containing 2,3-di(pyridin-2-yl)quinoxaline as an acceptor and diaryl/heterocyclic amine donors prepared by palladium catalyzed Buchwald-Hartwig coupling reaction. The synthesized compounds have been characterized by different spectroscopic techniques, electrochem. anal. and thermal method. Further, the structure of compound 4 shown as I was confirmed by single crystal X-ray anal. The characteristic absorption (λ_max) with ICT feature and emission maxima (λ_emm) in various solvents of 2-7 are found in the range of 389-440 nm and 460-555 nm, resp., with stoke’s shift within 3664-6945 cm^-1. The pos. solvatochromism due to solvent polarity observed in dyes confirmed by the Mc-Rae and Weller’s plots. The dyes 2-7 show cyan blue to orange emission (λ_emm = 493-581 nm) in solid film. The cyclic voltammetry (CV) was used to analyze the HOMO and LUMO energy levels of the mols. and further it was correlated by d. functional theory (DFT) calculations The excellent thermal stability and opto-electronic properties warrants the application of these dyes in opto-electronic devices.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., HPLC of Formula: 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C6H11BrO2.

Majoinen, Johanna;Bouilhac, Cecile;Rannou, Patrice;Borsali, Redouane research published 《 Unidirectional Perpendicularly Aligned Lamella-Structured Oligosaccharide (A) ABA Triblock Elastomer (B) Thin Films Utilizing Triazolium⁺/TFSI^– Ionic Nanochannels》, the research content is summarized as follows. We designed and synthesized high χ-low N maltoheptaose-(triazolium⁺/N(SO₂CF₃)₂^–)-polyisoprene-(triazolium⁺/N(SO₂CF₃)₂^–)-maltoheptaose ABA triblock elastomers featuring triazolium⁺/N(SO₂CF₃)₂^– (TFSI^–) counteranion ionic interfaces separating their constituting polymeric sub-blocks. Spin-coated and solvent vapor annealed (SVA) MH_1.2k-(T⁺/TFSI^–)-PI_4.3k-(T⁺/TFSI^–)-MH_1.2k thin films demonstrate interface-induced charge cohesion through ca. 1 nm “thick” ionic nanochannels which facilitate the self-assembly of a perpendicularly aligned lamellar structure. Atomic force microscopy (AFM) and (grazing-incidence) small-angle X-ray scattering ((GI)SAXS) characterizations of MH_1.2k-(T⁺/TFSI^–)-PI_4.3k-(T⁺/TFSI^–)-MH_1.2k and pristine triBCP analogous thin films revealed sub-10 nm block copolymer (BCP) self-assembly and unidirectionally aligned nanostructures developing over several μm² areas. Solvated TFSI^– counterions enhance the oligosaccharide sub-block packing during SVA. The overall BCP phase behavior was mapped through (GI)SAXS characterizations comparing di vs. triblock polymeric architectures, middle PI sub-block with two different mol. masses, and TFSI^– or I^– counteranion effects. This work highlights the benefits of inducing single-point electrostatic interactions within chem. structures of block copolymers to master the long-range self-assembly of prescribed morphologies.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Application of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: 4-Bromobenzene-1,2-diamine.

Malasala, Satyaveni;Ahmad, Naiyaz Md;Akunuri, Ravikumar;Shukla, Manjulika;Kaul, Grace;Dasgupta, Arunava;Madhavi, Y. V.;Chopra, Sidharth;Nanduri, Srinivas research published 《 Synthesis and evaluation of new quinazoline-benzimidazole hybrids as potent anti-microbial agents against multidrug resistant Staphylococcus aureus and Mycobacterium tuberculosis》, the research content is summarized as follows. In the current study, fifteen new Quinazoline-benzimidazole hybrids I (R = H, 4-nitro, 4-chloro, 4-fluoro, 4-bromo; R¹ = Ph, 3,4-dimethoxyphenyl, 4-chlorophenyl), II (R² = trifluoromethyl, 4-bromo-2-florophenyl, 8-chloroquinolin-3-yl, naphthalen-2-yl) and III were designed, synthesized, and evaluated for their antimicrobial activity against S. aureus ATCC 29213 and M. tuberculosis H37Rv. These studies led to the identification of nine compounds potent antibacterial agents I (R = 4-nitro, R¹ = Ph; R = 4-chloro, R¹ = Ph; R = H, R¹ = Ph; R = 4-fluoro, R¹ = Ph; R = 4-nitro, R¹ = 3,4-dimethoxyphenyl; R = 4-chloro, R¹ = 3,4-dimethoxyphenyl; R = H, R¹ = 4-chlorophenyl; R = 4-fluoro, R¹ = 4-chlorophenyl) and II (R² = 8-chloroquinolin-3-yl) with MICs in the range of 4-64μg/mL. Further, these selected compounds were found to possess potent antibacterial potential against a panel of drug-resistant clin. isolates which include methicillin and vancomycin-resistant S. aureus. The selected compounds were found to be less toxic to Vero cells (CC₅₀ = 40-≥200μg/mL) and demonstrated a favorable selectivity index. Based on the encouraging results obtained these new benzimidazol-2-yl quinazoline derivatives I have emerged as promising antimicrobial agents for the treatment of MDR- S. aureus and Mycobacterial infections.

Name: 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane, Product Details of C7H15Br

Malysheva, S. F.;Kuimov, V. A.;Belogorlova, N. A.;Khrapova, K. O.;Apartsin, K. A.;Gusarova, N. K. research published 《 Chemoselective Synthesis of Alkylphosphinic Acids from Red Phosphorus and Alkyl Bromides in the System KOH/H₂O/Toluene/Micellar Catalyst》, the research content is summarized as follows. Alkylphosphinic acids, including long-chain ones, were synthesized in up to 76% yields from red P and n-AlkBr (Alk = C₄-C₁₄) under micellar catalysis conditions. The reaction proceeds efficiently and chemoselectively upon heating (85-90°, 6 h) in a KOH/H₂O/toluene/cetyltrimethylammonium bromide system.

Product Details of C7H15Br, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Formula: C5H9BrO2

Man, Yan;Ren, Junan;Li, Bingru;Jin, Xinxin;Pan, Ligang research published 《 A simple, highly sensitive colorimetric immunosensor for the detection of alternariol monomethyl ether in fruit by non-aggregated gold nanoparticles》, the research content is summarized as follows. Alternariol monomethyl ether (AME) is one of the major Alternaria mycotoxins present in a wide range of fruits, vegetables, grains, and their products, and possesses the properties of mutagenicity and carcinogenicity. In this study, a simple, rapid, and highly sensitive colorimetric immunosensor based on magnetic nanoparticles (MNPs) was firstly developed for the detection of AME in fruit by nonaggregated gold nanoparticles (GNPs). AME-BSA-Fe₃O₄ MNP conjugates and free AME mols. in samples competitively bind with monoclonal antibody (mAb)-GNP conjugates. After magnetic separation, the UV absorbance of the nonaggregated GNP supernatant was measured directly. The absorption intensity was proportional to the concentration of AME in the sample. Carboxyl-group-modified AME, AME-bovine serum albumin (BSA) conjugates, anti-AME mAbs, AME-BSA-Fe₃O₄ MNP conjugates, and mAb-GNP conjugates were prepared and characterized. The effect of GNP sizes (16, 24, and 40 nm) on the colorimetric determination of AME was studied. Under optimized conditions, the limit of detection and the linear range for AME were 0.16 ng/mL and 0.08-0.48 ng/mL, resp. Moreover, the colorimetric immunosensor developed has lower cross-reactivity with AME analogs. The recoveries of spiked fruits ranged from 80.6% to 90.7%. The colorimetric immunosensor developed provides a promising method for simple, rapid, highly sensitive, and highly specific detection of other mycotoxins in the field of food safety. [Figure not available: see fulltext.].

Formula: C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Synthetic Route of 629-04-9.

Manivannan, Ramalingam;Ryu, Jiwon;Son, Young-A. research published 《 DPP based dual-sensing probe for the multi-color detection of toxic Co²⁺/Sn²⁺ and CN^– ions in water: An electronic eye development》, the research content is summarized as follows. A dual-sensing mechanism probe for the multi-color detection of toxic Co²⁺/Sn²⁺ and CN^– ions in water based on a diketopyrrolopyrrole (DPP) moiety was designed and successfully synthesized. Colorimetric and fluorimetric methods were used to confirm the sensing performance of the probe. Different colors were achieved for the detecting ions Co²⁺, Sn²⁺, and CN^–. pink for Co²⁺, red for Sn²⁺, and colorless for CN^–, denoting high selectivity in the developed probe. A dual-sensing mechanism confirmed for the metal ion the sensing is via complexation resulting in color (different) change through metal to ligand charge-transfer transition (MLCT), and for anion (cyanide), it is through addition reaction with a disconnection in intramol. charge-transfer transition (ICT). Pre-added selected ions to the different water samples effectively detect different colors. We developed an electronic eye (RGB-Arduino device) for the detection of toxic ions effectively.

Synthetic Route of 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 6911-87-1.

Manssen, Manfred;Deng, Danfeng;Zheng, Cameron H. M.;DiPucchio, Rebecca C.;Chen, Dafa;Schafer, Laurel L. research published 《 Ureate Titanium Catalysts for Hydroaminoalkylation: Using Ligand Design to Increase Reactivity and Utility》, the research content is summarized as follows. Herein, an earth-abundant and cost-efficient titanium catalyst generated in situ using com. available Ti(NMe₂)₄ and a simple to synthesize urea proligand was described. This system demonstrated high TOFs for hydroaminoalkylation with unactivated substrates and features easy to use com. available titanium amido precursors. Addnl., a high catalytic activity, scope of reactivity, and regioselectivity were all demonstrated in the transformation of unactivated terminal olefins with various alkyl and aryl secondary amines. Finally, syntheses of useful amine-containing monomers suitable for the generation of amine-containing materials, as well as amine-containing building blocks for medicinal chem., were disclosed. These preparative methods avoid the necessity of glovebox techniques and were modified to be useful to all synthetic chemists.

SDS of cas: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C4H7BrO2.

Mao, Jiayi;Niu, Dechao;Huang, Gaoxu;Jin, Xiaopan;Wei, Chi;Cai, Jia;Li, Yongsheng;Shi, Jianlin research published 《 A Ni/Ni₂P heterostructure in modified porous carbon separator for boosting polysulfide catalytic conversion》, the research content is summarized as follows. The intrinsic sluggish conversion kinetics and severe shuttle effect in lithium-sulfur (Li-S) batteries are responsible for their poor reversible capacity and cycling longevity, which have greatly hindered their practical applications. To address these drawbacks, herein, we design and construct a heterostructured Ni/Ni₂P embedded in a mesoporous carbon nanosphere composite (Ni/Ni₂P-MCN) for boosting polysulfide catalytic conversion in Li-S batteries. The Ni/Ni₂P-MCN-modified separator could not only prevent the shuttle effect significantly through abundant chem. adsorptive sites, but also demonstrate superior catalytic reactivities for the conversion of polysulfides. More importantly, the conductive carbon matrix with an exposed mesoporous structure can serve as an effective phys. barrier to accommodate deposited insoluble Li₂S. Consequently, the cells with the Ni/Ni₂P-MCN-modified separator exhibit greatly boosted rate capability (431 mA h g^-1 at 5 C) and cycling stability (a capacity decay of 0.031% per cycle after 1500 cycles). Even at an enhanced sulfur loading of 4.2 mg cm^-2, a stable and superior areal capacity (about 3.5 mA h cm^-2) has been demonstrated. We envision that the unique Ni/Ni₂P heterostructure in the porous carbon matrix could offer great potential for high-performance and sustained energy storage devices.

Product Details of C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 6911-87-1.

Lu, Chunlei;Qiu, Zetian;Xuan, Maojie;Huang, Yan;Lou, Yongjia;Zhu, Yiling;Shen, Hao;Lin, Bo-Lin research published 《 Direct N-Alkylation/Fluoroalkylation of Amines Using Carboxylic Acids via Transition-Metal-Free Catalysis》, the research content is summarized as follows. A scalable protocol of direct N-mono/di-alkyl/fluoroalkylation of primary/secondary amines was constructed with various carboxylic acids as coupling agents under the catalysis of a simple air-tolerant inorganic salt, K₃PO₄. Advantageous features include 100 examples, 10 drugs and drug-like amines, fluorinated complex tertiary amines, gram-scale synthesis and isotope-labeling amine, thus demonstrating the potential applicability in industry of this methodol. The involvement of relatively less reactive silicon-hydride compared with the traditional reactive metal-hydride or boron-hydride species required to reduce the amide intermediates presumably contributes to the remarkable functional group compatibility.

Quality Control of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Application In Synthesis of 4897-84-1

Lu, Dehua;Qu, Lailiang;Wang, Cheng;Luo, Heng;Li, Shang;Yin, Fucheng;Liu, Xingchen;Chen, Xinye;Luo, Zhongwen;Cui, Ningjie;Peng, Wan;Ji, Limei;Kong, Lingyi;Wang, Xiaobing research published 《 Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy》, the research content is summarized as follows. Overexpression of histone deacetylases (HDACs) are observed in different types of cancers, but histone deacetylase inhibitors (HDACIs) have not shown significant efficacy as monotherapy against solid tumors. Recently, studies demonstrated that it is promising to combine HDACIs with DNA damage agents to improve DNA damage level to gain better effect on treating solid tumor. Harmine has been demonstrated to cause DNA damage by intercalating DNA. Therefore, we designed a series of harmine-based inhibitors targeting HDAC and DNA with multi-target strategy, the most potential compound 27 could bind to DNA and cause DNA damage. Furthermore 27 caused cells apoptosis through p53 signaling pathway, and exhibited significant anti-proliferation effects against HCT-116 cells (IC50 = 1.41 μM). As a DNA damage agent, 27 displayed low toxicity in normal cells. Compound 27 was demonstrated as a dual inhibitor targeting HDAC (HDAC1 IC50 = 0.022 μM and HDAC6 IC50 = 0.45 μM) and DNA, and had the potential in the treatment of solid tumor.

Application In Synthesis of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary