Tag: M.W=150-200

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Name: 4-Bromobenzene-1,2-diamine.

Laurin, Corentine M. C.;Bluck, Joseph P.;Chan, Anthony K. N.;Keller, Michelle;Boczek, Andrew;Scorah, Amy R.;See, K. F. Larissa;Jennings, Laura E.;Hewings, David S.;Woodhouse, Fern;Reynolds, Jessica K.;Schiedel, Matthias;Humphreys, Philip G.;Biggin, Philip C.;Conway, Stuart J. research published 《 Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi》, the research content is summarized as follows. The Trypanosoma cruzi (T. cruzi) parasite is the cause of Chagas disease, a neglected disease endemic in South America. The life cycle of the T. cruzi parasite is complex and includes transitions between distinct life stages. This change in phenotype (without a change in genotype) could be controlled by epigenetic regulation, and might involve the bromodomain-containing factors 1-5 (TcBDF1-5). However, little is known about the function of the TcBDF1-5. Here we describe a fragment-based approach to identify ligands for T. cruzi bromodomain-containing factor 3 (TcBDF3). We expressed a soluble construct of TcBDF3 in E. coli, and used this to develop a range of biophys. assays for this protein. Fragment screening identified 12 compounds that bind to the TcBDF3 bromodomain. On the basis of this screen, we developed functional ligands containing a fluorescence or ¹⁹F reporter group, and a photo-crosslinking probe for TcBDF3. These tool compounds will be invaluable in future studies on the function of TcBDF3 and will provide insight into the biol. of T. cruzi.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Name: 4-Bromobenzene-1,2-diamine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, SDS of cas: 4897-84-1

Lawer, Aggie;Rossi-Ashton, James A.;Stephens, Thomas C.;Challis, Bradley J.;Epton, Ryan G.;Lynam, Jason M.;Unsworth, William P. research published 《 Internal Nucleophilic Catalyst Mediated Cyclisation/Ring Expansion Cascades for the Synthesis of Medium-Sized Lactones and Lactams》, the research content is summarized as follows. A strategy for the synthesis of medium-sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the need for the high-dilution conditions usually associated with medium-ring cyclisation protocols, as the reactions operate exclusively via kinetically favorable “normal”-sized cyclic transition states. This same feature also enables biaryl-containing medium-sized rings to be prepared with complete atroposelectivity by point-to-axial chirality transfer.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., SDS of cas: 4897-84-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Quality Control of 70-23-5

Kordmahalleh, Mohaddeseh Yahyanezhad;Moradi, Ali Varasteh;Hossaini, Zinatossadat;Golsefidi, Maziar Ahmadi research published 《 Synthesis and evaluation of antioxidant and antimicrobial activity of new spiropyrrolopyrrolizine compounds: Using Fe₃O₄/TiO₂/Multiwall carbon nanotubes (MWCNTs) magnetic nanocomposites》, the research content is summarized as follows. The Fe₃O₄/TiO₂/multiwall carbon nanotubes (MWCNTs) magnetic nanocomposites was synthesized using water extract of Spinacia oleracea leaves, and the high performance of synthesized catalyst was confirmed by employing of it in the multicomponent reaction of reaction of isatoic anhydride, tert-butylisocyanide, diamines, or hydroxyamines, electron-deficient acetylenic ester, α-haloketones and Et₃N in water at ambient temperature for the production of new spiropyrrolopyrrolizine compounds in high yields. This catalyst could be used several times in these reactions and have main role in the yield of product. The synthesized compounds have NH and OH group in their structure and for this reason have good antioxidant activity. Also, employing Gram-pos. and Gram-neg. bacteria in the disk diffusion procedure confirmed the some spiropyrrolopyrrolizine derivatives antimicrobial effect. The results showed that synthesized compounds prevented the bacterial growth. This used procedure for preparation of spiropyrrolopyrrolizine derivatives have some advantages such as low reaction time, product with high yields and simple separation of catalyst and products.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Quality Control of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Related Products of 1575-37-7

Kozlova, Arina;Thabault, Leopold;Dauguet, Nicolas;Deskeuvre, Marine;Stroobant, Vincent;Pilotte, Luc;Liberelle, Maxime;Van den Eynde, Benoit;Frederick, Raphael research published 《 Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase》, the research content is summarized as follows. Selenium is an underexplored element that can be used for bioisosteric replacement of lower mol. weight chalcogens such as oxygen and sulfur. More studies regarding the impact of selenium substitution in different chem. scaffolds are needed to fully grasp this element′s potential. Herein, we decided to evaluate the impact of selenium incorporation in a series of tryptophan 2,3-dioxygenase (TDO2) inhibitors, a target of interest in cancer immunotherapy. First, we synthesized the different chalcogen isosteres through Suzuki-Miyaura type coupling. Next, we evaluated the isosteres′ affinity and selectivity for TDO2, as well as their lipophilicity, microsomal stability and cellular toxicity on TDO2-expressing cell lines. Overall, chalcogen isosteric replacements did not disturb the on-target activity but allowed for a modulation of the compounds′ lipophilicity, toxicity and stability profiles. The present work contributes to our understanding of oxygen/sulfur/selenium isostery towards increasing structural options in medicinal chem. for the development of novel and distinctive drug candidates.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Related Products of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 1575-37-7.

Kozlova, Arina;Thabault, Leopold;Liberelle, Maxime;Klaessens, Simon;Prevost, Julien R. C.;Mathieu, Caroline;Pilotte, Luc;Stroobant, Vincent;Van den Eynde, Benoit;Frederick, Raphael research published 《 Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase》, the research content is summarized as follows. Tryptophan 2,3-dioxygenase (TDO2) is a heme-containing enzyme constitutively expressed at high concentrations in the liver and responsible for L-tryptophan (L-Trp) homeostasis. Expression of TDO2 in cancer cells results in the inhibition of immune-mediated tumor rejection due to an enhancement of L-Trp catabolism via the kynurenine pathway. In the study herein, we disclose a new 6-(1H-indol-3-yl)-benzotriazole scaffold of TDO2 inhibitors developed through rational design, starting from existing inhibitors. Rigidification of the initial scaffold led to the synthesis of stable compounds displaying a nanomolar cellular potency and a better understanding of the structural modulations that can be accommodated inside the active site of hTDO2.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Application In Synthesis of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 4-Bromo-N-methylaniline.

Kuanr, Nirmalendu;Gilmour, Damon J.;Gildenast, Hans;Perry, Mitchell R.;Schafer, Laurel L. research published 《 Amine-Containing Monomers for Ring-Opening Metathesis Polymerization: Understanding Chelate Effects in Aryl- and Alkylamine-Functionalized Polyolefins》, the research content is summarized as follows. Ring-opening metathesis polymerization (ROMP) of two different types of amine-functionalized monomers, aminonorbornenes (ANs) and aminocyclooctenes (ACs), has been studied using [(H2IMes)(PCy3)(Cl)2Ru = CHPh] Grubbs second generation catalyst, G2, and [(H2IMes)(pyr)2(Cl)2Ru = CHPh] Grubbs third generation catalyst, G3. Despite the known detrimental effects of unprotected amine functionalities on Ru-based ROMP catalysts, amino polyolefins can be readily prepared using G2 and G3. The influence of the amine substituent of the monomer on the polymerization process, as probed by monitoring reaction kinetics, confirmed that the basicity/nucleophilicity of the amine group has a detrimental influence on the ROMP process. Reaction kinetics of homopolymerization of both these classes of monomers revealed faster polymerization of ACs than the more strained AN counterpart, which was attributed to the favored chelated catalyst resting states in the case of ANs. Hammett studies show increased polymerization rates in the presence of electron-withdrawing aryl amine-containing monomers. These observed kinetic effects were used to benefit copolymerization of AN and AC monomers to access a gradient polymer with different reactivity profiles than their homopolymerization trends. Polyolefins with unprotected secondary alkyl amines could be synthesized by leveraging the unfavorable chelate formation in the case of AC monomers. The strategic selection of cyclic alkene and relative positioning of amine substitution allows for the diverse incorporation of secondary amines into polymers by ROMP.

Name: 4-Bromo-N-methylaniline, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Product Details of C4H7BrO2.

Kucwaj-Brysz, Katarzyna;Ali, Wesam;Kurczab, Rafal;Sudol-Talaj, Sylwia;Wilczynska-Zawal, Natalia;Jastrzebska-Wiesek, Magdalena;Satala, Grzegorz;Mordyl, Barbara;Zeslawska, Ewa;Agnieszka-Olejarz-Maciej;Czarnota, Kinga;Latacz, Gniewomir;Partyka, Anna;Wesolowska, Anna;Nitek, Wojciech;Handzlik, Jadwiga research published 《 An exit beyond the pharmacophore model for 5-HT₆R agents – a new strategy to gain dual 5-HT₆/5-HT_2A action for triazine derivatives with procognitive potential》, the research content is summarized as follows. Herein, the first highly potent 5-HT₆/5-HT_2A receptor (5-HT₆/5-HT_2AR) dual antagonists in a group of 1,3,5-triazine compounds have been discovered as a result of an exit beyond the hydrophobic feature of the pharmacophore model for 5-HT₆R antagonists. Design and synthesis of the series I (X = O, S; R¹ = 4-PhOC₆H₄, 4-PhC₆H₄, 2-naphthyl, 1-naphthyl; R² = H, Me, Et, n-Bu, R³ = H; R² = R³ = Me) of ether and thioether derivatives of 1,3,5-triazines with the double-ring aromatic region have been performed. The new compounds I were examined within the comprehensive pharmacol. screening, including: radioligand binding assays, functional and ADMET studies in vitro as well as behavioral tests in rats. Crystallog. aspects and computer-aided structure-activity relationship were analyzed as well. This comprehensive approach led to selection of the compound I [X = S; R¹ = 2-naphthyl; R² = R³ = Me; (II)] with the most significant dual 5-HT₆/5-HT_2AR antagonistic action (5-HT₆R K_i = 11 nM, 5-HT_2AR K_i = 39 nM). Moreover, the compound II has satisfactory ADMETox properties in vitro, i.e.: the high permeability through biol. membranes, high metabolic stability, neither mutagenic nor hepatotoxic effects and moderate ability to inhibit CYP3A4. Above all, the compound II showed ability to reverse the pharmacol.-induced (MK-801) memory impairment at low doses (1-3 mg/kg) in Novel Object Recognition (NOR) test in rats. These results indicate a promising potency of dual 5-HT₆/5-HT_2AR antagonism in the search for novel strategy to fight Alzheimer’s disease, which remains an unmet clin. need.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Product Details of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of 629-04-9.

Kuimov, Vladimir A.;Malysheva, Svetlana F.;Belogorlova, Natalia A.;Albanov, Alexander I.;Gusarova, Nina K.;Trofimov, Boris A. research published 《 Synthesis of Long-Chain n-Alkylphosphonic Acids by Phosphonylation of Alkyl Bromides with Red Phosphorus and Superbase under Micellar/Phase Transfer Catalysis》, the research content is summarized as follows. Long-chain n-Alkylphosphonic acids, AlkP(O)(OH)₂, are synthesized in up to 91% yield (mostly 40-60%) by straightforward phosphonylation of alkyl bromides (AlkBr, Alk=C₄-C₁₈) with red phosphorus (P_n) in the multiphase KOH/H₂O/toluene system in the presence of 2-10 mol % of cetyltrimethylammonium bromide (CTAB), acting as a micellar/phase transfer catalyst and as a generator/transporter of superbasic hydroxide anions, the intermediate potassium phosphinates being in situ oxidized/neutralized by nitric acid. The key steps of the phosphonylation mechanism are the P-P bond cleavage of P_n polymeric mols. by superbasic ^–OH anions, dissolved in the CTAB micelles, and phase transfer of polyphosphide anions to the organic phase and their alkylation with AlkBr.

Quality Control of 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: 1-Bromoheptane.

Khairul, Wan M.;Rahamathullah, Rafizah;Joni, Janice Roria;Isa, M. I. N. research published 《 Density functional theory (DFT) calculations, synthesis and electronic properties of alkoxylated-chalcone additive in enhancing the performance of CMC-based solid biopolymer electrolyte》, the research content is summarized as follows. Alkoxylated-chalcone having push-pull system has been integrated as additive in solid biopolymer electrolyte (SBE) based on CM-cellulose (CMC) doped with ammonium chloride (NH₄Cl). The structural, optical and thermal stability of the additive were characterized via FT-IR spectroscopy, UV-Vis, 1D NMR and TGA prior film casting as SBE. The optical band gaps (E^opt_g) of alkoxylated-chalcone additive exhibited low range, 3.14 eV which are comparable to that corresponding simulated findings, whereas they lie within the range of organic semiconductor materials. Frontier MOs (FMO) anal., chem. reactivity and mol. electrostatic potential (MEP) revealed that the oxygen on alkoxy chain and -NO₂ substituent tuning the energy level of HOMO and LUMO. The investigation of their potential as additive in SBE system has been accomplished by incorporating CMC-NH₄Cl electrolyte using solution-casting method. A various weight ratio (0-8%) of additive was tested and doped with CMC-NH₄Cl as new SBE. The highest ionic conductivity achieved was 2.3 x 10^-2 Scm^-1 at ambient temperature (303K) for the system containing 8 weight% of chalcone-based additive. The findings imply that the designated chalcone-based moiety has a potential to be employed as additive materials towards the performance enhancement for electrochem. the interests.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Recommanded Product: 1-Bromoheptane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Reference of 4224-70-8.

Kim, Won Young;Won, Miae;Koo, Seyoung;Zhang, Xingcai;Kim, Jong Seung research published 《 Mitochondrial H₂S_n-mediated anti-inflammatory theranostics》, the research content is summarized as follows. The insistent demand for space-controllable delivery, which reduces the side effects of non-steroidal anti-inflammatory drugs (NSAIDs), has led to the development of a new theranostics-based approach for anti-inflammatory therapy. The current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the infammatory site biomarker, hydrogen polysulfde (H₂S_n). Here, we report a novel theranostic agent 1 (TA1), consisting of three parts: H₂S_n-mediated triggering part, a two-photon fuorophore bearing mitochondria targeting unit (Rhodol-TPP), and anti-infammatory COX inhibitor (indomethacin). In vitro experiments showed that TA1 selectively reacts with H₂S_n to concomitantly release both Rhodol-TPP and indomethacin. Confocal-microscopy imaging of infammation-induced live cells suggested that TA1 is localized in the mitochondria where the H₂S_n is overexpressed. The TA1 reacted with H₂S_n in the endogenous and exogenous H₂S_n environments and in lipopolysaccharide treated infammatory cells. Moreover, TA1 suppressed COX-2 level in the infammatory-induced cells and prostaglandin E2 (PGE2) level in blood serum from infammation-induced mouse models. In vivo experiments with infammation-induced mouse models suggested that TA1 exhibits infammation-site-elective drug release followed by signifcant therapeutic efects, showing its function as a theranostic agent, capable of both anti-infammatory therapy and precise diagnosis. Theranostic behavior of TA1 is highly applicable in vivo model therapeutics for the infammatory disease.

Reference of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary