Haroon, Muhammad team published research in RSC Advances in 2021 | 70-23-5

Application In Synthesis of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 70-23-5.

Haroon, Muhammad;de Barros Dias, Mabilly Cox Holanda;Santos, Aline Caroline da Silva;Pereira, Valeria Rego Alves;Barros Freitas, Luiz Alberto;Balbinot, Rodolfo Bento;Kaplum, Vanessa;Nakamura, Celso Vataru;Alves, Luiz Carlos;Brayner, Fabio Andre;Leite, Ana Cristina Lima;Akhtar, Tashfeen research published ã€?The design, synthesis, and in vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivativesã€? the research content is summarized as follows. Given this, novel 1,3-thiazoles I (Ar = Ph, 3-chlorophenyl, furan-2-yl, etc.; R = H, Me) and 4-thiazolidinones II (R1 = (phenylmethylidene)aminyl, [(4-hydroxy-3-methoxyphenyl)methylidene]aminyl, 1,2,3,4-tetrahydronaphthalen-1-iminyl, etc.; R2 = Me, Et) using bioisosteric and esterification strategies to develop improved and safer drug candidates were synthesized. Then, in vitro assays were performed, against Leishmania infantum and Leishmania amazonensis promastigotes, Trypanosoma cruzi trypomastigotes and amastigotes, for selected compounds I and II to determine IC50 and SI, with cytotoxicity on LLC-MK2 cell lines. Overall, 1,3-thiazoles I exhibited better trypanocidal activity than 4-thiazolidinones II. The compound I[Ar = 2-bromophenyl, R = H] (III), an ortho-bromobenzylidene-substituted 1,3-thiazole (IC50 = 0.83μM), is the most potent of them all. In addition, compounds I and II had negligible cytotoxicity in mammalian cells (CC50 values > 50μM). Also noteworthy is the examination of the cell death mechanism of T. cruzi, which showed that compound III induced necrosis and apoptosis in the parasite. SEM anal. demonstrated that the treatment of Trypanosoma cruzi trypomastigote cells with the compound III at different IC50 concentrations promoted alterations in the shape, flagella and body surface, inducing parasite death. Together, the data revealed a novel series of 1,3-thiazole structure-based compounds I with promising activity against Trypanosoma cruzi and Leishmania spp., broadening ways for scaffold optimization.

Application In Synthesis of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hassan, Ahmed H. E. team published research in Bioorganic & Medicinal Chemistry in 2018 | 4897-84-1

Application In Synthesis of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 4897-84-1.

Hassan, Ahmed H. E.;Cho, Min Chang;Kim, Hye In;Yang, Ji Seul;Park, Kyung Tae;Hwang, Ji Young;Jang, Choon-Gon;Park, Ki Duk;Lee, Yong Sup research published �Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CB2R affinity� the research content is summarized as follows. CRA13; a peripheral dual CB1R/CB2R agonist with clin. proven analgesic properties, infiltrates into CNS producing adverse effects due to central CB1R agonism. Such adverse effects might be circumvented by less lipophilic compounds with attenuated CB1R affinity. Metabolism produces less lipophilic metabolites that might be active metabolites. Some CRA13 oxidative metabolites and their analogs were synthesized as less lipophilic CRA13 analogs. Probing their CB1R and CB2R activity revealed the alc. metabolite I as a more potent and more effective CB2R ligand with attenuated CB1R affinity relative to CRA13. Also, the alc. analog II and Me ester III possessed enhanced CB2R affinity and reduced CB1R affinity. The CB2R binding affinity of alc. analog II was similar to CRA13 while that of Me ester III was more potent. In silico study provided insights into the possible mol. interactions that might explain the difference in the elicited biol. activity of these compounds

Application In Synthesis of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gu, Ruirui team published research in Journal of the American Chemical Society in 2021 | 4224-70-8

Related Products of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Organic compounds having carbon bonded to bromine are called organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Related Products of 4224-70-8.

Gu, Ruirui;Lehn, Jean-Marie research published �Constitutional Dynamic Selection at Low Reynolds Number in a Triple Dynamic System: Covalent Dynamic Adaptation Driven by Double Supramolecular Self-Assembly� the research content is summarized as follows. A triple dynamic complex system has been designed, implementing a dynamic covalent process coupled to two supramol. self-assembly steps. To this end, two dynamic covalent libraries (DCLs), DCL-1 and DCL-2, have been established on the basis of dynamic covalent C=C/C=N organo-metathesis between two Knoevenagel derivatives and two imines. Each DCL contains a barbituric acid-based Knoevenagel constituent that may undergo a sequential double self-organization process involving first the formation of hydrogen-bonded hexameric supramol. macrocycles that subsequently undergo stacking to generate a supramol. polymer SP yielding a viscous gel state. Both DCLs display selective self-organization-driven amplification of the constituent that leads to the SP. Dissociation of the SP on heating causes reversible randomization of the constituent distributions of the DCLs as a function of temperature Furthermore, diverse distribution patterns of DCL-2 were induced by modulation of temperature and solvent composition The present dynamic systems display remarkable self-organization-driven constitutional adaptation and tunable composition by coupling between dynamic covalent component selection and two-stage supramol. organization. In more general terms, they reveal dynamic adaptation by component selection in low Reynolds number conditions of living systems where frictional effects dominate inertial behavior.

Related Products of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guan, Yu-Qing team published research in iScience in 2021 | 5445-17-0

SDS of cas: 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 5445-17-0.

Guan, Yu-Qing;Min, Xiang-Ting;He, Gu-Cheng;Ji, Ding-Wei;Guo, Shi-Yu;Hu, Yan-Cheng;Chen, Qing-An research published ã€?The serendipitous effect of KF in Ritter reaction: Photo-induced amino-alkylation of alkenesã€? the research content is summarized as follows. The Ritter reaction has been recognized as an elegant strategy to construct the C-N bond. Its key feature is forming the carbocation for nucleophilic attack by nitriles. Herein, authors report a complementary visible-light-induced three-component Ritter reaction of alkenes, nitriles, and α-bromo nitriles/esters, thereby providing mild and rapid access to various γ-amino nitriles/acids. Mechanistic studies indicated that traceless fluoride relay, transforming KF into imidoyl fluoride intermediate, is critical for the efficient reaction switch from atom transfer radical addition (ATRA) to the Ritter reaction. This approach to amino-alkylation of alkenes is chemoselective and operationally simple.

SDS of cas: 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gulvi, Nitin R. team published research in Computational & Theoretical Chemistry in 2022 | 5445-17-0

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Name: Methyl 2-bromopropanoate

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5445-17-0, formula is C4H7BrO2, The most pervasive is the naturally produced bromomethane. Name: Methyl 2-bromopropanoate

Gulvi, Nitin R.;Maliekal, Parimal J.;Thorat, Ramchandra;Badani, Purav M. research published �Effect of functional group on dissociation kinetics of ester and acid derivative of bromopropane� the research content is summarized as follows. Hitherto, it has been considered that mols. with same functional groups are expected to possess similar properties. In present study, we have demonstrated theor. the crucial role of substituent decides the fate of a chem. reaction. Decomposition of un-substituted ester/acid derivative of propane results in generation of ketene, while the pyrolysis of Br substituted ester and acid derivate of propane generates unsaturated ester and aldehyde resp. The byproduct generated in the latter case was HBr. The mechanism underlying the formation of byproduct was distinct in case of ester and acid. Thermal decomposition of 2-bromopropionate resulted in formation of mol. HBr with unsaturated ester, via a 4-centered mechanism. However, due to the presence of acidic proton in 2-bromopropanoic acid, this elimination channel gets generated by a 5-centered mechanism with addnl. dissociation products of aldehyde and carbon monoxide. Work done in the present paper is supplemented via energy estimations and kinetic anal.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Name: Methyl 2-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gunter, Kevin team published research in ACS Applied Polymer Materials in 2020 | 5445-17-0

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Reference of 5445-17-0

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, Reference of 5445-17-0

Gunter, Kevin;Sorci, Mirco;Belfort, Georges research published ã€?A Simplified Predictive Tool for Design and Analysis of SET-LRP Reactions with Mechanistic Insightã€? the research content is summarized as follows. Single-electron transfer (SET)-living radical polymerization (LRP) is a robust, fast, “green,” grafting method, similar but different from atom transfer radical polymerization, that operates at ambient temperature in the presence of oxygen and is industrially attractive. Solving a simplified reaction model with only five rather than 12 reactions in solution, for describing the SET-LRP scheme and verifying it with exptl. data, we provide (i) a useful tool to predict conversion given initial conditions and rate constants, and (ii) key mechanistic insights with a parametric sensitivity anal., illustrating the effects of initial conditions, kinetic rate constants, temperature, and copper particle size. Findings include: (i) Increasing the formation rate of radicals (i.e., kact) exhibited a maximum in monomer conversion. (ii) The optimal ratio of initial conditions was found to be [MA]0/[PnX]0/[CuIIX2/L]0 = 222/1/1.5, where [MA]0 = 7.4 M. (iii) Increasing the temperature strongly improved monomer conversion with an inflection point. (iv) Using an order-of-magnitude and Damköhler number anal., we provide a rationale for selecting small diameter particles and specify how they are likely to perform with SET-LRP reactions. Assumptions of the model include: Solid copper concentration was an infinite source of dissolved CuI and CuII and was available instantaneously (with Damkohler number â‰?1, for reaction rather than diffusion limitation). Also, the reverse reaction of the disproportionation of CuI was negligible, polymer chain length did not affect reaction kinetics, and all intermediate reactions were neglected.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Reference of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Jingwen team published research in European Journal of Organic Chemistry in 2021 | 1575-37-7

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Recommanded Product: 4-Bromobenzene-1,2-diamine

Guo, Jingwen;Zhang, Lina;Du, Xinyue;Zhang, Liting;Cai, Yuepiao;Xia, Qinqin research published �Metal-Free Direct Oxidative C-N Bond Coupling of Quinoxalin-2(1H)-ones with Azoles under Mild Conditions� the research content is summarized as follows. Direct C3-H amination of quinoxalin-2(1H)-ones with azoles under mild conditions promoted by PIFA has been achieved in good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds through a radical process. In addition, this method could be applied to gram-scale reaction.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Luxia team published research in Advanced Synthesis & Catalysis in 2021 | 6911-87-1

SDS of cas: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organic compounds having carbon bonded to bromine are called organic bromides. SDS of cas: 6911-87-1.

Guo, Luxia;Ye, Meng;Vaccaro, Luigi;Li, Minghao;Gu, Yanlong research published ã€?Two-Step Access to β-Substituted o-Hydroxyphenyl Ethyl Ketones from 4-Chromanone and its Application in Preparation of a Silica-Supported Cobalt(II) Salen Complexã€? the research content is summarized as follows. A base-mediated ring opening of 4-chromanone was used to introduce the β-ethoxyl o-hydroxyphenyl Et ketone intermediary, followed by nucleophile substitution under BF3·Et2O assisted conditions to give the desired β-carbon, nitrogen, or thiol substituted o-hydroxyphenyl Et ketones I [R = p-tolyl-thiol, 1H-indol-3-yl, 2,4,5-(OMe)3C6H2, etc.; R1 = H, 5-Me, 4-OMe, etc.]. With the aid of this protocol, a silica-supported cobalt(II) salen complex was successfully prepared and its structure was confirmed by FTIR, 13C MAS NMR, UV-Vis absorption and XPS spectra. The immobilized cobalt(II) salen catalyst displayed comparable catalytic activity in the synthesis of several heterocycles including 1,3-oxazolidines II [R2 = H, F; R3 = H, Me, Cl, etc.], benzimidazole and benzoxazole as compared with their homogeneous counterparts and also could be recycled for several times without obvious loss of its catalytic activity.

SDS of cas: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Menglu team published research in ACS Medicinal Chemistry Letters in 2022 | 4897-84-1

Application of C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application of C5H9BrO2.

Guo, Menglu;He, Shipeng;Cheng, Junfei;Li, Yu;Dong, Guoqiang;Sheng, Chunquan research published ã€?Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cellsã€? the research content is summarized as follows. The development of KRAS-PDEδ protein-protein interaction (PPI) inhibitors is generally hampered by limited antitumor activity. Herein, the first hydrophobic tagging (HyT)-based PDEδ degraders were designed. Compound 17c (I) efficiently bound to PDEδ and induced degradation of PDEδ in SW480 colon cancer cells. As compared with PDEδ inhibitor deltazinone, HyT-based degrader 17c exhibited improved antitumor activity toward KRAS mutant cancer cells. This study highlighted the potential of HyT as a valuable chem. tool for tumorigenic PDEδ knockdown, which could be developed into a promising strategy for antitumor drug discovery.

Application of C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Peng team published research in Organic Letters in 2022 | 4224-70-8

Category: bromides-buliding-blocks, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Organic compounds having carbon bonded to bromine are called organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Category: bromides-buliding-blocks.

Guo, Peng;Pang, Xiaobo;Wang, Ke;Su, Pei-Feng;Pan, Qiu-Quan;Han, Guan-Yu;Shen, Qian;Zhao, Zhen-Zhen;Zhang, Wenhua;Shu, Xing-Zhong research published �Nickel-Catalyzed Reductive Csp3-Ge Coupling of Alkyl Bromides with Chlorogermanes� the research content is summarized as follows. Reductive cross-coupling provides facile access to organogermanes, but it remains largely unexplored. Herein the authors report a Ni-catalyzed reductive Csp3-Ge coupling of alkyl bromides with chlorogermanes. This work established a new method for producing alkylgermanes. The reaction proceeds under very mild conditions and tolerates various functionalities including ether, alc., alkene, nitrile, amine, ester, phosphonates, amides, ketone, and aldehyde. The application of this method to the modification of bioactive mols. is demonstrated.

Category: bromides-buliding-blocks, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary