Tag: M.W=150-200

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Category: bromides-buliding-blocks

Guo, Tao;Liu, Tianwei;He, Jianghua;Zhang, Yuetao research published ã€?One-Pot Transformation of Lignin and Lignin Model Compounds into Benzimidazolesã€? the research content is summarized as follows. It is a challenging task to simultaneously achieve selective depolymerization and valorization of lignin due to their complex structure and relatively stable bonds. We herein report an efficient depolymerization strategy that employs 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as oxidant/catalyst to selectively convert different oxidized lignin models to a wide variety of 2-phenylbenzimidazole-based compounds in up to 94% yields, by reacting with o-phenylenediamines with varied substituents. This method could take full advantage of both C_β and/or C_γ atom in lignin structure to furnish the desirable products instead of forming byproducts, thus exhibiting high atom economy. Furthermore, this strategy can effectively transform both the oxidized hardwood (birch) and softwood (pine) lignin into the corresponding degradation products in up to 45 wt% and 30 wt%, resp. Through a “one-pot” process, we have successfully realized the oxidation/depolymerization/valorization of natural birch lignin at the same time and produced the benzimidazole derivatives in up to 67 wt% total yields.

Category: bromides-buliding-blocks, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 6911-87-1, formula is C7H8BrN, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 6911-87-1

Guo, Wei;Cai, Liuhuan;Xie, Zhen;Mei, Weijie;Liu, Gongping;Deng, Ling;Zhuo, Xiaoya;Zhong, Yumei;Zou, Xiaoying;Zheng, Lvyin;Fan, Xiaolin research published ã€?Photocatalyzed intermolecular amination for the synthesis of hydrazonamidesã€? the research content is summarized as follows. A sequential multi-component reaction of β-ketonitriles with N,N-disubstituted hydrazines is designed and developed through a photocatalyzed intermol. amination process to afford hydrazonamides I [R = Et, Ph, 2-furyl, etc.; R¹ = Me, Et, n-Pr, etc.; R² = Ph, 3-MeC₆H₄, 4-ClC₆H₄, etc.]. This work reported the first example of the use of N,N-disubstituted hydrazines as two different “amine” sources, characterized by isotope labeling experiments The C-CN/N-N bonds were cleaved and new C-N/C=N bonds were constructed in a one-pot reaction. This protocol could be carried out without the addition of any external metals, ligands, bases, oxidants and reductants, and possessed the advantages of operational simplicity, mild reaction conditions, and good functional group tolerance. Furthermore, this approach enabled late-stage modifications of structurally complex bioactive mols., natural products and drugs, thus showing potential applications in the field of organo-pharmaceutical chem.

HPLC of Formula: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, COA of Formula: C4H7BrO2

Guo, Wengang;Luo, Yuzheng;Sung, Herman H.-Y.;Williams, Ian D.;Li, Pingfan;Sun, Jianwei research published ã€?Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of α-Tertiary Amino Ketones from Sulfonium Ylidesã€? the research content is summarized as follows. Herein we disclose a new catalytic asym. approach for the synthesis of chiral α-amino ketones, which is particularly useful for the less accessible acyclic α-tertiary cases. By a protonation-amination sequence, our approach represents a rare asym. H-heteroatom bond insertion by α-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermol. C-N bond formation was catalyzed by chiral phosphoric acids with excellent efficiency and enantioselectivity. The products are precursors to other important chiral amine derivatives, including drug mols. and chiral ligands. The enantioselectivity was controlled by dynamic kinetic resolution in the amination step, rather than the initial protonation. This process opens up a new platform for the development of other related insertion reactions.

COA of Formula: C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: 4-Bromobenzene-1,2-diamine.

Gillespie, James E.;Morrill, Charlotte;Phipps, Robert J. research published �Regioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines� the research content is summarized as follows. The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the arene ortho position. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly to ortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsym., selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuable ortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Recommanded Product: 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline, Safety of 4-Bromo-N-methylaniline

Gockel, Samuel N.;Lee, SangHyun;Gay, Brittany L.;Hull, Kami L. research published �Oxidative Three-Component Carboamination of Vinylarenes with Alkylboronic Acids� the research content is summarized as follows. The three-component carboamination of alkenes is of significant interest due to the ease by which functionalized amines can be produced from readily available chem. building blocks. Previously, a variety of carbon-centered radical precursors have been studied as the carbon components for this reaction; however, the use of general alkyl sources has remained as an unsolved challenge. Herein we present our efforts to develop an oxidative carboamination protocol that utilizes alkylboronic acids as carbon-centered radical precursors. The presented work demonstrates 34 examples, ranging from 17 to 88% yields, with a broad scope in vinylarenes, amines, and alkylboronic acids. Preliminary mechanistic studies suggest that a single-electron oxidation of the alkylboronic acid generates a carbon-centered radical intermediate that adds across the olefin followed by C-N bond formation via Cu-mediated inner-sphere or carbocation-mediated pathways.

Safety of 4-Bromo-N-methylaniline, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Related Products of 1575-37-7.

Gong, Kai;Li, Cunhao;Zhang, Daquan;Lu, Huilin;Wang, Yunyun;Li, Haoran;Zhang, Huimin research published ã€?Sulfonic acid functionalized covalent organic frameworks as efficient catalyst for the one-pot tandem reactionsã€? the research content is summarized as follows. A covalent organic framework containing hydroxyl groups (HO-COF) has been predesigned and synthesized by the cyclotrimerization reaction of acetyls, which was used as a pre-established network to introduce Pr sulfonic acid through post-synthetic modification strategy, for the fabrication of SO₃H-COF with graphene-like multilayer structure. SO₃H-COF was employed as an effective heterogeneous catalyst for the synthesis of benzimidazoles, the synthesis of benzodiazepines and one-pot reductive amination of carbonyl compounds The results indicated that the developed protocol has several advantages, such as high activity, broad substrate scope, short reaction time and excellent yields. The distinctive structures of SO₃H-COF endowed the fantastic catalytic properties, good stability and circulation performance.

Related Products of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Category: bromides-buliding-blocks.

Gong, Yuxin;Su, Lei;Zhu, Zhaodong;Ye, Yang;Gong, Hegui research published ã€?Nickel-Catalyzed Thermal Redox Functionalization of C(sp³)-H Bonds with Carbon Electrophilesã€? the research content is summarized as follows. A Ni-catalyzed arylation and alkylation of C(sp₃)-H bonds with organohalides to forge C(sp₃)-C bonds by merging economical Zn and tBuOOtBu (DTBP) as the external reductant and oxidant was reported. The mild and easy-to-operate protocol enabled facile carbofunctionalization of N-/O-α- and cyclohexane C-H bonds, and preparation of a few intermediates of bioactive compounds and drug derivatives Preliminary mechanistic studies implied addition of an alkyl radical to a NiII salt.

Category: bromides-buliding-blocks, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 629-04-9, formula is C7H15Br, The most pervasive is the naturally produced bromomethane. COA of Formula: C7H15Br

Gong, Yuxin;Su, Lei;Zhu, Zhaodong;Ye, Yang;Gong, Hegui research published ã€?Nickel-Catalyzed Thermal Redox Functionalization of C(sp³)-H Bonds with Carbon Electrophilesã€? the research content is summarized as follows. A Ni-catalyzed arylation and alkylation of C(sp₃)-H bonds with organohalides to forge C(sp₃)-C bonds by merging economical Zn and tBuOOtBu (DTBP) as the external reductant and oxidant was reported. The mild and easy-to-operate protocol enabled facile carbofunctionalization of N-/O-α- and cyclohexane C-H bonds, and preparation of a few intermediates of bioactive compounds and drug derivatives Preliminary mechanistic studies implied addition of an alkyl radical to a NiII salt.

COA of Formula: C7H15Br, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of C7H8BrN.

Gonzalez-Lainez, Miguel;Jimenez, M. Victoria;Azpiroz, Ramon;Passarelli, Vincenzo;Modrego, F. Javier;Perez-Torrente, Jesus J. research published ã€?N-Methylation of Amines with Methanol Catalyzed by Iridium(I) Complexes Bearing an N,O-Functionalized NHC Ligandã€? the research content is summarized as follows. A set of neutral [IrBr(L₂)(κC-^tBuImCH₂PyCH₂OMe)] and cationic [Ir(L₂)(κ²C,N-^tBuImCH₂PyCH₂OMe)]PF₆ (L₂ = cod, (CO)₂) Ir(I) compounds featuring a flexible lutidine-derived polydentate ligand having NHC and -OMe as donor functions were evaluated as catalyst precursors for the N-methylation of aniline using MeOH both as a reducing agent and a C1 source. The carbonyl complexes are somewhat more active than the related diene compounds with the neutral compound [IrBr(CO)₂(κC-^tBuImCH₂PyCH₂OMe)] being the more active. A range of aromatic primary amines, including heterocyclic amines, were selectively transformed into the corresponding N-methylamino derivatives using this catalyst at a low catalyst loading (0.1 mol %) and substoichiometric amounts of Cs₂CO₃ (half equiv) as a base, in MeOH at 423 K. For aliphatic primary amines, selective N,N-dimethylation was achieved under the same catalytic conditions. The unselective deprotonation of the methylene linkers in [IrBr(CO)₂(κC-^tBuImCH₂PyCH₂OMe)] affords two isomeric neutral complexes featuring a coordinated dearomatized pyridine core, which were converted into [Ir(OMe)(CO)₂(κC-^tBuImCH₂PyCH₂OMe)] upon addition of MeOH. This compound undergoes thermal activation of a C-H bond of the tert-Bu group to give the cyclometalated Ir(I) complex [Ir(CO)₂{κ²C,C-(-CH₂Me₂C-ImCH₂PyCH₂OMe)}] featuring a bidentate C,C-coordinated NHC ligand. Mechanistic studies support a borrowing H mechanism proceeding through Ir(I) intermediates with the methoxo complex as the catalytic active species and the cyclometalated complex as the catalyst resting state. D labeling experiments demonstrated that both species are in equilibrium under catalytic conditions, which is consistent with the exhibited catalytic activity of the cyclometalated complex.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Product Details of C7H8BrN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Application of C6H7BrN2.

Gotzmann, Carla;Blacque, Olivier;Fox, Thomas;Alberto, Roger research published ã€?[Re(η⁶-C₆H₅-benzimidazole)₂]⁺ and Derivatives as Dye Mimics; Synthesis, UV Absorption Studies and DFT Calculationsã€? the research content is summarized as follows. Functionalizations of highly oxidation and hydrolysis stable mono-cationic rhenium bis-arene complexes [Re(η⁶-C₆H₆)₂]⁺ are of great interest. We directly built up structural features of the well-known Hoechst Dye on the coordinated arenes as a model for prospective DNA minor groove binding studies. Extensions of the aromatic bis-arene unit with functionalized and derivatized benzimidazole moieties resulted in a deep orange color of the complexes, showing UV/Vis absorption spectra with multiple transition maxima. These have been assigned with support of DFT calculations to gain information about their charge transfer natures. The different transitions of the complexes, which are either intra-ligand, ligand-to-ligand or metal-to-ligand charge transitions, were addnl. compared and discussed with the spectra of the corresponding free ligands.

Application of C6H7BrN2, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary