Fan, Xu team published research in Tetrahedron in 2022 | 6911-87-1

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Computed Properties of 6911-87-1

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Computed Properties of 6911-87-1.

Fan, Xu;Liu, Hui;Ma, Shidi;Wang, Feng;Yang, Jinhui;Li, Dianjun research published �Visible light-induced PPh2Cy/CsI-promoted cascade radical decarboxylative/cyclization of redox-active esters with acrylamides� the research content is summarized as follows. A visible-light-induced PPh2Cy/CsI-promoted tandem radical decarboxylative/alkylarylation of alkyl substituted redox-active esters I (R = t-Bu, cyclohexyl, cyclopentyl, etc.) and N-acrylamides 2-R5-3-R4-4-R2-5-R3C6HN(R1)C(O)C(=CH2)CH3 (R1 = H, Me, Ph, etc.; R2 = H, Cl, Br, Me; R3 = H, Me; R4 = H, Me; R5 = H, Cl, Me, F; R4R5 = -CH=CH-CH=CH-) or N-methyl-N-(2-methylprop-2-enoyl)benzamides 2-R9-3-R8-4-R7-5-R6C6HC(O)N(Me)C(O)C(=CH2)Me (R6 = H, Me; R7 = H, Cl, F, MeO; R8 = H, Me; R9 = H; R8R9 = -CH=CH-CH=CH-) to generate 3,3-dialkyl substituted oxindoles II and isoquinoline-1,3-diones derivatives III was developed under metal-free conditions. This transformation provides an alternative and mild method for the synthesis of highly functionalized five- 3,3-dialkyl substituted oxindoles and isoquinoline-1,3-diones derivatives

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Computed Properties of 6911-87-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fang, Lincheng team published research in Bioorganic & Medicinal Chemistry in 2021 | 70-23-5

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Fang, Lincheng;Hu, Zhaoxue;Yang, Yifei;Chen, Pan;Zhou, Jinpei;Zhang, Huibin research published ã€?Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) familyã€? the research content is summarized as follows. Bromodomain and extra-terminal (BET) is a promising therapeutic target for various hematol. cancers. We used the BRD4 inhibitor compound 13 (I) as a lead compound to develop a variety of compounds, and we introduced diverse groups into the position of the compound 13 orienting toward the ZA channel. A series of compounds bearing triazolopyridazine motif exhibited remarkable BRD4 protein inhibitory activities. Among them, compound 39 (II) inhibited BRD4(BD1) protein with an IC50 of 0.003μM which was superior to lead compound 13. Meanwhile, compound 39 possess activity, IC50 = 2.1μM, in antiproliferation activity against U266 cancer cells. On the other hand, compound 39 could arrest tumor cells into the G0/G1 phase and induce apoptosis, which was consistent with its results in inhibiting cell proliferation. Biol. and biochem. data suggest that BRD4 protein might be a therapeutic target and that compound 39 is an excellent lead compound for further development.

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fang, Xiong team published research in European Journal of Medicinal Chemistry in 2022 | 4224-70-8

Electric Literature of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 4224-70-8.

Fang, Xiong;Meng, Qian;Zhang, Huijun;Fang, Xiao;Huang, Lina S.;Zhang, Xingquan;Schooley, Robert T.;Ciechanover, Aaron;An, Jing;Xu, Yan;Huang, Ziwei research published ã€?A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonistã€? the research content is summarized as follows. Here, employed a fragment integrational approached, designed and synthesized a new and potent small mol. CXCR4 antagonist (named as HF51116 I), as well as a fluorescent (FITC)-labeled HF51116 I (FITC-HF51116 I). I exhibited very high CXCR4 binding affinity with IC50 of 12 nM in competitive binding with a CXCR4 specific antibody 12G5, which was comparable to the wild type chemokines or synthetic peptides of much larger mol. sizes. Direct binding measurement using FITC-HF51116 I further revealed the compound’s high CXCR4 affinity. HF51116 I strongly antagonized SDF-1α-induced cell migration, calcium mobilization, and CXCR4 internalization. Furthermore, HF51116 I inhibited HIV-1 infection via CXCR4, demonstrating its antiviral therapeutic potential. The mechanism of HF51116 I-CXCR4 interaction was analyzed by site-directed mutagenesis and mol. modeling which suggested that the compound recognized the minor and major subpockets of CXCR4. Its binding to CXCR4 was found to block G protein-dependent downstream signal pathways as detected by luciferase reporter assays. With its potent bioactivities and asym. structure amenable to chem. diversification, HF51116 I may serve as a prototype for developing a new class of CXCR4-targeted therapeutics and proof of the concept of similar strategies for studying other GPCRs.

Electric Literature of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fasiuddin, G. S. team published research in Journal of Molecular Structure in 2022 | 1575-37-7

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Quality Control of 1575-37-7

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine, Quality Control of 1575-37-7

Fasiuddin, G. S.;Liakath Ali Khan, F.;Sakthivel, S.;Muthu, S.;Irfan, Ahmad research published ã€?Synthesis, Spectroscopic, Molecular Docking and inhibitory activity of 6-Bromo-2-(4-chlorophenyl)-1H-benzimidazole- a DFT approachã€? the research content is summarized as follows. A novel compound 6-bromo-2-(4-chlorophenyl)-1H-benzimidazole was synthesized to treat antimicrobial infections and characterized by FT-IR, FT-Raman, 1H-NMR, UV-Vis. The stable conformer and structural optimization were carried out using the DFT-B3LYP (6-311 ++ G (d, p)) method in Gaussian 16 W. FT-IR and FT-Raman exptl. and theor. wavenumbers with the complete vibrational assignment were reported. NMR of 1H -13C and UV-Vis is calculated at different solvents using the IEF-PCM method. The conductivity, reactivity and stability of the title compound are determined by HOMO-LUMO values. The antibacterial activity was tested against S. aureus and A. niger to indicate a significant zone of inhibition than the reference drug ciprofloxacin at the concentration of 25μg/mL, and protein and ligand interaction site in docking was determined by MEP. Finally, the mol. docking between the title and the reference compound ligand with the A. niger / 3EQA was studied and compared the binding energy of the compound at the active sites.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Quality Control of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fayed, Eman a. team published research in Journal of Molecular Structure in 2021 | 1575-37-7

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 4-Bromobenzene-1,2-diamine.

Fayed, Eman a.;Ammar, Yousry a.;Saleh, Marwa a.;Bayoumi, Ashraf h.;Belal, Amany;Mehany, Ahmed b. m.;Ragab, Ahmed research published ã€?Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitorsã€? the research content is summarized as follows. A new series of quinoxaline derivatives I (R = 6-Br, 6-Cl, 7-PhCO; X = MeO, H2NNH) and II [R = H, 6-Br-6-Cl-7-PhCO; X = HO, MeO, EtO, H2NNH, PhC(O)NHNH, 4-MeC6H4CH:NNH, etc.] were synthesized and pharmacol. evaluated against HepG-2, HCT-116, and MCF-7 cell lines. Seven compounds I (R = 6-Cl, 6-Br; X = H2NNH), II (R = 6-Cl, 6-Br, 7-PhCO, X = MeO; R = 6-Cl, X = EtO) and 3,4-dihydro-2H-pyrano[2,3-b]quinoxalin-2-one were found to possess the highest activities against the examined cell lines with IC50 values ranging from (7.57 to 28.44μM). These compounds were further selected to analyze their apoptotic potential in MCF-7 cells. Interestingly, it was found that the Bcl-2 level decreased by 1.95-3.99 times and the BAX level increased by 7.2-10.6 times relative to the control. These compounds also increased the active Caspase-3 level by 5.77-10.69 folds compared to untreated cells. WI-38 cells were treated with these compounds to estimate the cytotoxicity level of in non-tumorigenic cells, and these compounds displayed higher IC50 values (142.21-335.03μM). Further studies on the mechanism of the most promising compounds I (R = 6-Br; X = H2NNH), II (R = 6-Cl, 6-Br; X = MeO) and 3,4-dihydro-2H-pyrano[2,3-b]quinoxalin-2-one, revealed that they increase apoptotic cells and induce cell cycle arrest at pre-G1 and G2/M phases. Besides, evaluation of both wild EGFRWT and mutant EGFRL858R-TK inhibitory activity for these derivatives showed IC50 values ranging from 0.075-1.547μM vs. wild EGFRWT and 63.70-87.34 nM vs. the mutant type. Erlotinib was used as a standard reference with IC50 values of 0.0656μM and 59.56 nM vs. both types. Finally, the mol. docking study of most potent quinoxaline derivatives exhibited a good binding inside the active site of EGFR (1M17), with binding energy ranged between (-15.86 to -16.97) compared to Erlotinib (-17.84) kcal/mol. Also, by applying Lipinski’s parameters, it was found that these derivatives showed no violations and indicated possibility to formulate orally.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Feng, Xinshu team published research in Polyhedron in 2021 | 6911-87-1

HPLC of Formula: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organic compounds having carbon bonded to bromine are called organic bromides. HPLC of Formula: 6911-87-1.

Feng, Xinshu;Huang, Ming research published �Effect of the ancillary ligand in N-heterocyclic carbene iridium(III) catalyzed N-alkylation of amines with alcohols� the research content is summarized as follows. A series of air-stable N-heterocyclic carbene (NHC) Ir(III) complexes (Ir1-Ir6), bearing various combinations of chlorine, pyridine and NHC ligands, were assayed for the N-alkylation of amines with alcs. It was found that Ir3, with two monodentate 1,3-bis-methyl-imidazolylidene (IMe) ligands, emerged as the most active complex. A large variety of amines and primary alcs. were efficiently converted into mono-N-alkylated amines in 53-96% yields. As a special highlight, for the challenging MeOH, selective N-monomethylation could be achieved using KOH as a base under an air atm. Moreover, this catalytic system was successfully applied to the gram-scale synthesis of some valuable compounds

HPLC of Formula: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Du, Hongtao team published research in Bioorganic & Medicinal Chemistry Letters in 2020 | 4224-70-8

Electric Literature of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Electric Literature of 4224-70-8.

Du, Hongtao;Jiang, Xinyu;Ma, Meng;Xu, Huili;Liu, Shuang;Ma, Fang research published ã€?Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregationã€? the research content is summarized as follows. A novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (AChE) and β-amyloid peptide (Aβ) aggregation inhibitors for the treatment of Alzheimer’s disease. The derivatives had multifunctional profiles, including AChE inhibition, Aβ1-42 aggregation inhibition, and neuroprotective properties. Inspiringly, hybrids (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 3-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)propanoate and (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 5-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)pentanoate displayed excellent inhibitory activities against hAChE (IC50 = 0.93 and 1.08 nM, resp.) and Aβ1-42 self-aggregation (IC50 = 19.71 and 2.05μM, resp.). In addition, (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 3-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)propanoate and (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 5-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)pentanoate showed low cytotoxicity and good neuroprotective activity against Aβ1-42-induced damage in SH-SY5Y cells.

Electric Literature of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Du, Rongrong team published research in Angewandte Chemie, International Edition in 2021 | 629-04-9

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Electric Literature of 629-04-9

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 629-04-9.

Du, Rongrong;Liu, Luhua;Xu, Senmiao research published ã€?Iridium-catalyzed regio- and enantioselective borylation of unbiased methylene C(sp3)-H bonds at the position β to a nitrogen centerã€? the research content is summarized as follows. Reported herein is the pyrazole-directed iridium-catalyzed enantioselective borylation of unbiased methylene C-H bonds at the position β to a nitrogen center. The combination of a chiral bidentate boryl ligand, iridium precursor, and pyrazole directing group was responsible for the high regio- and enantioselectivity observed The method tolerated a vast array of functional groups to afford the corresponding C(sp3)-H functionalization products with good to excellent enantioselectivity.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Electric Literature of 629-04-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Du, Zaizhi team published research in Pharmaceuticals in 2022 | 4224-70-8

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Product Details of C6H11BrO2

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C6H11BrO2.

Du, Zaizhi;Liu, Han;Huang, Xie;Li, Yang;Wang, Liting;Liu, Jing;Long, Shuang;Li, Rong;Xiang, Qiang;Luo, Shenglin research published �Design and Synthesis of a Mitochondria-Targeting Radioprotectant for Promoting Skin Wound Healing Combined with Ionizing Radiation Injury� the research content is summarized as follows. Wound healing is seriously retarded when combined with ionizing radiation injury, because radiation-induced excessive reactive oxygen species (ROS) profoundly affect cell growth and wound healing. Mitochondria play vital roles not only as cellular energy factories but also as the main source of endogenous ROS, and in this work a mitochondria-targeting radioprotectant (CY-TMP1) is reported for radiation injury-combined wound repair. It was designed, synthesized and screened out from different conjugates between mitochondria-targeting heptamethine cyanine dyes and a peroxidation inhibitor 2,2,6,6-tetramethylpiperidinyloxy (TEMPO). CY-TMP1 specifically accumulated in mitochondria, efficiently mitigated mitochondrial ROS and total intracellular ROS induced by 6 Gy of X-ray ionizing irradiation, thereby exhibiting a notable radioprotective effect. The mechanism study further demonstrated that CY-TMP1 protected mitochondria from radiation-induced injury, including maintaining mitochondrial membrane potential (MMP) and ATP generation, thereby reducing the ratio of cell apoptotic death. Particularly, an in vivo experiment showed that CY-TMP1 could effectively accelerate wound closure of mice after 6 Gy of whole-body ionizing radiation. Immunohistochem. staining further indicated that CY-TMP1 may improve wound repair through angiogenesis and re-epithelialization. Therefore, mitochondria-targeting ROS scavengers may present a feasible strategy to conquer refractory wound combined with radiation injury.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Product Details of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Duan, Jicheng team published research in Organic Letters in 2021 | 4224-70-8

Formula: C6H11BrO2, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Formula: C6H11BrO2

Duan, Jicheng;Wang, Yuquan;Qi, Liangliang;Guo, Peng;Pang, Xiaobo;Shu, Xing-Zhong research published �Nickel-Catalyzed Cross-Electrophile C(sp3)-Si Coupling of Unactivated Alkyl Bromides with Vinyl Chlorosilanes� the research content is summarized as follows. Cross-electrophile C-Si coupling has emerged as a promising tool for the construction of organosilanes, but the potential of this method remains largely unexplored. Herein, we report a C(sp3)-Si coupling of unactivated alkyl bromides with vinyl chlorosilanes. The reaction proceeds under mild conditions, and it offers a new approach to alkylsilanes. Functionalities such as Grignard-sensitive groups (e.g., acid, amide, alc., ketone, and ester), acid-sensitive groups (e.g., ketal and THP protection), alkyl fluoride and chloride, aryl bromide, alkyl tosylate and mesylate, silyl ether, and amine were tolerated. Incorporation of the -Si(vinyl)R2 moiety into complex mols. and the immobilization of a glass surface by formed organosilanes were demonstrated.

Formula: C6H11BrO2, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary