Tag: M.W=150-200

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline, Computed Properties of 6911-87-1

Duan, Peng;Zhao, He;Yang, Jian;Cao, Liang;Jiang, Huanfeng;Zhang, Min research published ã€?Construction of Fluorinated Amino Acid Derivatives via Cobalt-Catalyzed Oxidative Difunctionalization of Cyclic Ethersã€? the research content is summarized as follows. A new synthetic method for the efficient construction of novel fluorinated γ-amino acid esters I (n = 1, 2; R = H, Me; R¹ = methyl(phenyl)aminyl, 1,2,3,4-tetrahydroquinolin-1-yl, 1H,2H,3H-pyrrolo[2,3-b]pyridin-1-yl, etc.) via difunctionalization of the α- and β-sites of cyclic ethers such as THF, tetrahydropyran, 2-methyloxolane and 2,3-dihydrofuran, by employing a CoBr₂/m-CPBA catalyst system was demonstrated. Several cyclic ethers were transformed in combination with a vast range of amines such as 4-methylaniline, thiomorpholine, tetrahydroquinoline, etc. and Et trifluoropyruvate into the desired products I under mild conditions, making this method a practical platform to enrich the library of fluorinated amino acid derivatives from cost-effective and readily available feedstocks.

Computed Properties of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H8BrN.

Duarte de Almeida, Leandro;Bourriquen, Florian;Junge, Kathrin;Beller, Matthias research published ã€?Catalytic Formal Hydroamination of Allylic Alcohols Using Manganese PNP-Pincer Complexesã€? the research content is summarized as follows. Several manganese-PNP pincer catalysts for the formal hydroamination of allylic alcs. were presented. The resulting γ-amino alcs. were selectively obtained in high yields applying compound I in a tandem process under mild conditions.

Application of C7H8BrN, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: Methyl 4-bromobutanoate.

Elhaj, Elrasheed;Wang, Huajun;Gu, Yanlong research published ã€?Functionalized quaternary ammonium salt ionic liquids (FQAILs) as an economic and efficient catalyst for synthesis of glycerol carbonate from glycerol and dimethyl carbonateã€? the research content is summarized as follows. A series of functionalized quaternary ammonium salt ionic liquids (FQAILs) with different functional groups, such as hydroxyl, carboxyl, ether group, and amino, were prepared and used as a catalyst for the synthesis of glycerol carbonate from transesterification of glycerol and di-Me carbonate without any addnl. organic solvent and co-catalyst. The effects of functional groups, anions (Cl^–, Br^–, I^–, OH^–), and reaction parameters were investigated in detail. It is found that both the cation and anion of FQAILs display an important effect on its catalytic activity. Among these FQAILs, hydroxyl functionalized ionic liquid, [HPTPA]OH possesses the highest activity because there are the strong interactions between hydroxyl and di-Me carbonate mol. and between anion OH- and glycerol mol., which were shown by FTIR spectra. The glycerol conversion of 96.2% and glycerol carbonate yield of 87.6% can be obtained over [HPTPA]OH under moderate conditions of reaction temperature of 80 °C, reaction time of 90 min, di-Me carbonate/glycerol molar ratio of 3, and catalyst amount of 0.9 mol% based on glycerol amount The [HPTPA]OH catalyst can be reused at least three cycles without significant reduction in its catalytic activity. Finally, a possible reaction mechanism for the synthesis of glycerol carbonate is also proposed.

Recommanded Product: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Electric Literature of 1575-37-7

Elumalai, Vijayaragavan;Hansen, Joern H. research published �A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines� the research content is summarized as follows. A highly efficient and catalyst-free protocol was reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds Remarkably simple and green reaction conditions employed methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature The conditions allow at least 10 g scale synthesis of quinoxalines and preferred starting point for optimization and method of choice for applications in the synthetic community.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Electric Literature of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Synthetic Route of 4897-84-1

Diaz-Peralta, Lucero;Razo-Hernandez, Rodrigo Said;Pastor, Nina;Santiago, Angel;Guevara-Salazar, Juan Alberto;Fernandez-Zertuche, Mario research published ã€?1,4-Disubstituted-1,2,3-triazole GABA Analogues: Synthesis, In-Vitro Evaluation, Quantum QSAR and Molecular Docking against Pseudomonas fluorescens GABA-ATã€? the research content is summarized as follows. The synthesis of a new series of γ-aminobutyric acid (GABA) analogs was reported where the nitrogen at the γ-position contained in a 1,4-disubstituted-1,2,3-triazole ring system. The triazole ring system was assembled by the Cu(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuACC) protocol. Two compounds were identified two active compounds with 43 and 59% inhibition resp. A descriptive quantum QSAR study was carried out to correlate this activity with the structural changes in the GABA scaffold. The inhibitory activity of the compounds was related to the electronic properties of the triazole ring and substituents. The interaction with P. fluorescens GABA-aminotransferase (GABA-AT) was evaluated by mol. docking, using a homol. model of the biol. target. One compound showed the best interaction energy, the thiophene- substituted triazole, with a value that correlates well with the exptl. inhibition results. The triazole ring is determinant for a proper orientation for interaction with the GABA-AT enzyme. In addition, the mol. docking revealed the importance of a hydrophobic pocket near the PLP prosthetic group and how this pocket can be used to improve the inhibitory activity of GABA analogs. Human GABA-AT mol. docking studies of these analogs showed their great potential as competitive inhibitors of this enzyme.

Synthetic Route of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Dietrich, Justin D.;Longenecker, Kenton L.;Wilson, Noel S.;Goess, Christian;Panchal, Sanjay C.;Swann, Steven L.;Petros, Andrew M.;Hobson, Adrian D.;Ihle, David;Song, Danying;Richardson, Paul;Comess, Kenneth M.;Cox, Philip B.;Dombrowski, Amanda;Sarris, Kathy;Donnelly-Roberts, Diana L.;Duignan, David B.;Gomtsyan, Arthur;Jung, Paul;Krueger, A. Chris;Mathieu, Suzanne;McClure, Andrea;Stoll, Vincent S.;Wetter, Jill;Mankovich, John A.;Hajduk, Philip J.;Vasudevan, Anil;Stoffel, Robert H.;Sun, Chaohong research published ã€?Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Designã€? the research content is summarized as follows. Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biol. drugs that inhibit TNFα has led to improved clin. outcomes for patients with rheumatoid arthritis and other chronic autoimmune diseases; however, TNFα has proven to be difficult to drug with small mols. Herein, we present a two-phase, fragment-based drug discovery (FBDD) effort in which we first identified isoquinoline fragments that disrupt TNFα ligand-receptor binding through an allosteric desymmetrization mechanism as observed in high-resolution crystal structures. The second phase of discovery focused on the de novo design and optimization of fragments with improved binding efficiency and drug-like properties. The 3-indolinone-based lead compound 12 (I) presented here displays oral, in vivo efficacy in a mouse glucose-6-phosphate isomerase (GPI)-induced paw swelling model comparable to that seen with a TNFα antibody.

Category: bromides-buliding-blocks, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Reference of 1575-37-7.

Ding, Ling;Niu, Kaikai;Liu, Yuxiu;Wang, Qingmin research published �Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones� the research content is summarized as follows. Herein, authors report a practical electro-reductive protocol for the direct C-H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Reference of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of 4897-84-1.

Ding, Xiong;Wang, Pengfei research published �Using the 3-Diethylaminobenzyl Group as a Photocage in Aqueous Solution� the research content is summarized as follows. Authors have demonstrated that the 3-diethylaminobenzyl (DEABn) photolabile protecting group (PPG) is an effective and structurally simple PPG for releasing mols. in aqueous environment. In general, the photoreaction is clean, and the released substrate and the PPG product, i.e., 3-diethylaminobenzyl alc., are obtained in high yield. The clean photoreaction can also be achieved under mild ambient conditions with sunlight, while the reactant is stable under indoor lighting. Release of two substrates from one PPG chromophore in aqueous solution has been demonstrated to be feasible. Authors have also compared the uncaging properties of the DEABn and the widely used o-nitrobenzyl (o-NB) group, given their comparable structural simplicity. With its clean and efficient photochem. reaction, DEABn should find wide applications, including in the basic and applied research areas where o-NB and its various derivatives are widely used.

Synthetic Route of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. COA of Formula: C7H8BrN.

Ding, Yuxin;Kuang, Jinqiang;Xiao, Xuqiong;Wang, Lei;Ma, Yongmin research published ã€?Environmentally Benign Synthesis of Quinoline-Spiroquinazolinones by Iron-Catalyzed Dehydrogenative [4 + 2] Cycloaddition of Secondary/Tertiary Anilines and 4-Methylene-quinazolinonesã€? the research content is summarized as follows. An efficient iron-catalyzed cross-dehydrogenative coupling [4 + 2] annulation of secondary/tertiary anilines with quinazolinones to generate quinoline-spiroquinzolinones I [R¹ = H, 7-Me; R² = n-Pr, 3-ClC₆H₄, Bn, etc.; R³ = H, 6-Br, 7-Me, etc.; X = O, S] was reported. The reaction proceeded smoothly with a relatively broad variety of functional groups, a cheap transition metal catalyst (FeCl₃), and environmentally friendly oxidant (H₂O₂/O₂) under mild reaction conditions. Creatively, N-methylanilines were employed for the first time for the cycloaddition as both Me and methylene sources attached to the N atom of tetrahydroquinolines.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., COA of Formula: C7H8BrN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane, Name: 1-Bromoheptane

Ding, Zhonghua;Chen, Hongjin;Han, Yiying;Liu, Jian research published ã€?Molecular engineering of π-extended viologens consisting of quinoxaline-based bridges for tunable electrochromic devicesã€? the research content is summarized as follows. In this work, four novel π-extended viologens have been developed by introducing quinoxaline-based units for electrochromism. The optical and electrochem. properties of these four π-extended viologens were investigated, which were dependent on the substituents on their π-conjugated bridges. All-in-one electrochromic devices were prepared by using each π-extended viologen as cathode material and ferrocene as anode material, resp. All these four devices exhibited efficient electrochromic performance involving high optical contrast over 80%, and short switching time around 1 s, as well as good coloration efficiency. Among them, device based on HBOV showed a high optical contrast of 82% at 582 nm with bleaching time and coloring time of 0.84 s and 0.68 s, resp., and a coloration efficiency of 334 cm²/C. Moreover, the color of these new type viologens in both bleaching and coloring states can be tuned by varying the substituents on quinoxaline units.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Name: 1-Bromoheptane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary