Tag: M.W=200-250

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 20469-65-2.

Djukanovic, Dimitrije;Heinz, Benjamin;Mandrelli, Francesca;Mostarda, Serena;Filipponi, Paolo;Martin, Benjamin;Knochel, Paul research published 《 Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene》, the research content is summarized as follows. The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25° within 40 s the corresponding aryllithiums which were acylated with various functionalized N,N-dimethylamides including easily enolizable amides at -20° within 27 s, producing highly functionalized ketones in 48-90% yield (36 examples). This method was well suited for the preparation of α-chiral ketones such as naproxen and ibuprofen derived ketones with 99% ee. A one-pot stepwise bis-addition of two different lithium organometallics to 1,1,3,3-tetramethylurea (TMU) provided unsym. ketones in 69-79% yield (9 examples).

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., Quality Control of 20469-65-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organic compounds having carbon bonded to bromine are called organic bromides. Synthetic Route of 20469-65-2.

Dogga, Bhushanarao;Kumar, C. S. Ananda;Joseph, Jayan T. research published 《 Palladium-catalyzed reductive carbonylation of (hetero)aryl halides and triflates using cobalt carbonyl as CO source》, the research content is summarized as follows. An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co₂(CO)₈ and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

Synthetic Route of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 585-76-2.

Dong, Chaomin;Wang, Xiao;Gong, Wenqi;Ma, Wenbo;Zhang, Meng;Li, Jingjie;Zhang, Yuan;Zhou, Zixing;Yang, Zhijian;Qu, Shuli;Wang, Qian;Zhao, Zhu;Yang, Guohui;Lv, Anqi;Ma, Huili;Chen, Qiushui;Shi, Huifang;Yang, Yang;An, Zhongfu research published 《 Influence of Isomerism on Radioluminescence of Purely Organic Phosphorescence Scintillators》, the research content is summarized as follows. There are few reports about purely organic phosphorescence scintillators, and the relation between mol. structures and radioluminescence in organic scintillators is still unclear. An isomerism strategy to study the effect of mol. structures on radioluminescence is presented. Bromobenzoic acid (BA) isomers can achieve phosphorescence efficiency of ≤22.8% by UV irradiation Under x-ray irradiation, both m-BA and p-BA show excellent radioluminescence, while o-BA has almost no radioluminescence. Through exptl. and theor. study, radioluminescence was not only affected by nonradiation in emissive process, but also highly depended on the material conductivity caused by the different mol. packing. This study allows clear understanding of the relation between the mol. structures and radioluminescence and provides a guidance to rationally design new organic scintillators.

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , SDS of cas: 585-76-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Guowei; Yang, Yaqing; Yang, Yanming; Song, Gao; Li, Shanshan; Zhang, Jiajun; Yang, Weimin; Wang, Liang-Liang; Weng, Zhiying; Zuo, Zhili published the artcile< The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation>, Safety of 4-Bromoisobenzofuran-1,3-dione, the main research area is adenylate cyclase agonist virtual screening cyclic adenosine monophosphate IL6; Adenylate cyclase; Agonist; Cyclic adenosine monophosphate; Interleukin-6; Virtual screening.

Adenylate cyclases (ACs), play a critical role in the conversion of ATP (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biol. assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chem. probe to study the physiol. function of AC2.

European Journal of Medicinal Chemistry published new progress about Drug screening (docking-based virtual screening). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Safety of 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Benzai, Amal; Shi, Xinzhe; Derridj, Fazia; Roisnel, Thierry; Doucet, Henri; Soule, Jean-Francois published the artcile< Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C-H Bond Arylations>, Category: bromides-buliding-blocks, the main research area is imidazole regioselective arylation aryl bromide palladium catalyst; Bifonazole regioselective arylation aryl bromide palladium catalyst; Climbazole regioselective arylation aryl bromide palladium catalyst; Ketoconazole regioselective arylation aryl bromide palladium catalyst.

Palladium-catalyzed C-H bond arylation of imidazoles has been applied to pharmaceuticals such as Bifonazole, Climbazole, and Ketoconazole. In the presence of phosphine-free Pd(OAc)2 catalyst, aryl bromides are efficiently coupled at the C5-position of the imidazole units, which are widely decorated. Under these conditions, only the C-H bond arylation reaction occurred without affecting the integrity of chem. structure of the imidazole-based pharmaceuticals. Moreover, with Bifonazole, Pd-catalyzed C-H bond diarylation at the C2- and C5-positions of imidazole unit has also been performed.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xiang; Huang, Wei; Liu, Yan-Qing; Kang, Jing-Wen; Xia, Dan; He, Gu; Peng, Cheng; Han, Bo published the artcile< Control of Activation Mode To Achieve Diastereodivergence in Asymmetric Syntheses of Chiral Spiropiperidinone Derivatives>, Category: bromides-buliding-blocks, the main research area is crystal mol structure furanyl tosyl azaspiro decanedione; azaspiro decanedione preparation; spiropiperidinone preparation stereoselective Michael hemiaminalization cascade aldehyde cyclic ketoamide; stereoselective Michael hemiaminalization cascade unsaturated aldehyde cyclic ketoamide; HOMO LUMO activation stereoselective Michael hemiaminalization cascade aldehyde ketoamide.

An efficient organocatalytic cascade reaction has been developed involving a Michael-hemiaminalization relay for the asym. synthesis of spiropiperidinone derivatives bearing adjacent quaternary and tertiary chiral centers via LUMO or HOMO activation. Importantly, this methodol. demonstrates that applying distinct activation modes to different substrates in the same reaction can diverge diastereoselectivity. To our knowledge, this is also one of the few published cases of primary amine catalytic [3+3] cycloaddition reactions involving α-branched β-ketoamides.

Journal of Organic Chemistry published new progress about Amides, oxo Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Borrajo-Calleja, Gustavo M.; Bizet, Vincent; Mazet, Clement published the artcile< Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans>, Application of C7H7BrO2, the main research area is tetrahydrofurobenzofuran preparation enantioselective intermol carboetherification palladium catalyst; carboetherification in situ generated chiral bisphosphine mono oxide ligand.

A novel enantioselective Pd-catalyzed intermol. carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.

Journal of the American Chemical Society published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation) (furobenzofurans). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Application of C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mousseau, James J.; Vallee, Frederic; Lorion, Melanie M.; Charette, Andre B. published the artcile< Umpolung Direct Arylation Reactions: Facile Process Requiring Only Catalytic Palladium and Substoichiometric Amount of Silver Salts>, Computed Properties of 6942-39-8, the main research area is palladium catalyzed umpolung direct arylation aryl halide arene; biaryl preparation umpolung direct arylation palladium catalyst; aryl iodide bromide arene reactant palladium catalyzed direct arylation.

An umpolung direct arylation process is described. The reaction requires only a catalytic amount of Pd(OAc)2 and a substoichiometric amount of silver salts, without any external base or ligand to proceed. The directed oxidative insertion of the transition metal followed by the coupling into the C-H bond of an unactivated arene has surprisingly not yet been reported, despite the clear advantages in the ease of starting material synthesis. The reaction is regioselective with regards to the arene partner, and the role of the acetate and carbonate groups has been elucidated. This methodol. adds to the very few examples of benzene coupling without the inclusion of electron-withdrawing groups to increase acidity.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Computed Properties of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zeng, Liang; Fu, Hua; Qiao, Renzhong; Jiang, Yuyang; Zhao, Yufen published the artcile< Efficient copper-catalyzed synthesis of N-(alkyl)anthranilic acids via an ortho-substituent effect of the carboxyl group of 2-halobenzoic acids at room temperature>, Related Products of 16426-64-5, the main research area is anthranilic acid alkyl preparation copper iodide BINOL; Ullmann reaction amine halobenzoic acid amination copper BINOL.

A method for the synthesis of the title compounds [i.e., 2-(aminoalkyl)benzoic acid derivatives, N-(alkyl)anthranilic acids] is reported here. The protocol uses inexpensive copper iodide/racemic 1,1′-binaphthyl-2,2′-diol (racemic-BINOL) as catalyst/ligand system, readily available 2-halobenzoic acids and aliphatic amines as starting materials. The coupling reactions were performed at room temperature, and various functionalities in the substrates were tolerated.

Advanced Synthesis & Catalysis published new progress about Alicyclic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Related Products of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yadav, Rahul; Darakshan; Bhaumick, Prabhas; Choudhury, Lokman H.; Parvin, Tasneem published the artcile< Synthesis of Pentacyclic Pyran Fused Pyrazolo Benzo[h]quinolines by Multicomponent Reaction and Their Photophysical Studies>, SDS of cas: 3893-18-3, the main research area is pentacyclic pyranpyrazolobenzoquinoline preparation photophys study; aldehyde hydroxy naphthoquinone aminopyrazole one pot three component reaction.

A one-pot method for the synthesis of pentacyclic pyran fused pyrazolo benzo[h]quinolines I (R1 = Ph, 4-chlorophenyl, anthracen-9-yl, etc.; R2 = Me, Ph, 4-methylphenyl, 4-chlorophenyl; R3 = Me, Ph, 4-methylphenyl) in acetic acid medium from the three-component reaction of 2-hydroxy-1,4-naphthoquinone, α, β-unsaturated aldehydes and 5-aminopyrazoles under the reflux conditions has been described. In this reaction, four new bonds (2 C-C, 1 C-N and 1 C-O) and two new rings (pyridine and pyran) were formed in one-pot. The novel products contain four bioactive moieties such as pyran, pyridine, pyrazole and α-naphthol. The salient features of this method are: one-pot process, short reaction time, easier purification, no need of column chromatog. and good yields of the products I. All the products I were characterized by IR, NMR and HRMS. Most of the synthesized compounds I were found highly fluorescent. Therefore, their photophys. properties were studied by UV-Visible and Fluorescence spectroscopy. Their quantum yields which were calculated and found in the range 0.243-0.424 in CHCl3 solution (c = 10-5 M) have been reported. Compound I (R1 = phenyl; R2 = phenyl; R3 = methyl) showed the highest quantum yield of 0.424.

ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary