Tag: M.W=200-250

Kanai, Yuki; Mueller-Borges, Dorian; Plenio, Herbert published the artcile< The Regioselective Arylation of 1,3-Benzodioxoles>, Application In Synthesis of 401-78-5, the main research area is aryl benzodioxole preparation regioselective; benzodioxole aryl bromide arylation palladium catalyst.

The direct arylation of 1,3-benzodioxole and 2,2-difluorobenzo[1,3]dioxole with different aryl bromides RBr (R = 4-methylphenyl, naphthalen-1-yl, 9,9-diethyl-9H-fluoren-2-yl, etc.) yields the resp. 4-substitued products I (R1 = H, F) in yields of >80% requiring between 0.05-1 mol% Na2PdCl4, 30 mol% pivalic acid, 1.3 equivalents K2CO3 and ca. 250 equivalents of diethylacetamide per Pd at T = 120°C. The nature of the amide and the concentration of the reactants are crucial for the optimization of the reaction conditions. The primary role of the acetamide is that of a ligand to Pd, it is not needed as a solvent.

Advanced Synthesis & Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application In Synthesis of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ban, Jaeyoung; Lim, Minkyung; Shabbir, Saira; Baek, Junghyun; Rhee, Hakjune published the artcile< Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination>, Synthetic Route of 51605-97-1, the main research area is carbazole preparation; aniline acetylation Ullmann homocoupling intramol amination.

Author synthesized various carbazoles I (R = H, 2,7-Me, 3,6-F, etc.) from anilines through a three-step process with good overall yields (up to 48%). This process comprises N-acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramol. amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

Synthesis published new progress about Acetylation. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Synthetic Route of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Jiabao; Zhao, Yizhuo; Wang, Peng; Song, Yang; Shao, Yifei; Zhu, Li; Yao, Xiaoquan published the artcile< Copper loaded nitrogen-rich mesoporous carbon nitride as a highly efficient photocatalyst for selective oxidative cleavage of C(sp3)-C(sp3) bonds at room temperature under visible light>, Electric Literature of 401-78-5, the main research area is amide preparation green chem; amine photocatalytic oxidative cleavage copper mesoporous carbon nitride nanocatalyst.

Herein, a novel copper loaded nitrogen-rich mesoporous carbon nitride material was designed and synthesized, and utilized as a highly efficient photocatalyst for the inert C-C bond cleavage of amines such as N-phenylmorpholine, 1,4-diphenylpiperazine, tributylamine, etc. under blue light irradiation With oxygen as a benign oxidant, good to excellent yields were achieved for various functionalized amines at room temperature, even including sluggish aliphatic amines. The method may provide a cost-effective and environmentally friendly alternative for the direct oxidative cleavage of amines.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Electric Literature of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Jia-Xiong; Xiao, Ya-Fang; Wang, Kai; Fan, Xiao-Chun; Cao, Chen; Chen, Wen-Cheng; Zhang, Xiang; Shi, Yi-Zhong; Yu, Jia; Geng, Feng-Xia; Zhang, Xiao-Hong; Lee, Chun-Sing published the artcile< Origin of thermally activated delayed fluorescence in a donor-acceptor type emitter with an optimized nearly planar geometry>, Recommanded Product: 2-Amino-4-bromobenzoic acid, the main research area is methyl phenoxazinyl pyrano pyridinone thermally activated delayed fluorescence.

Thermally activated delayed fluorescence (TADF) emitters generally require good separation of HOMO (HOMO)-LUMO (LUMO) overlaps to minimize the singlet-triplet energy offset. Observations of excellent TADF performance in several planar emitters with large HOMO-LUMO overlaps are counter-intuitive and not fully explained. To understand this, we prepared two isomeric TADF mols., 7-methyl-2-(10H-phenoxazin-10-yl)-5H-pyrano[4,3-b]pyridin-5-one (PXZ-PPO) and 2-methyl-7-(10H-phenoxazin-10-yl)-4H-benzo[d][1,3]oxazin-4-one (PXZ-BOO). PXZ-BOO has a stable highly-twisted configuration with a small HOMO-LUMO overlap leading to good TADF performance as expected. PXZ-PPO has a stable nearly-planar form and a large HOMO-LUMO overlap and is not expected to give TADF. While the solid crystal of PXZ-PPO only shows conventional fluorescence at 420 nm, its diluted solution is dominated by TADF at 610 nm. With a combined exptl. and theor. approach, PXZ-PPO is shown to have a stable nearly-planar form and a metastable highly-twisted form in the ground state. While the highly-twisted form only has a small population (<1%) in the ground state, its excited state has lower energy than the nearly-planar form. As a result, when the high population nearly-planar form is excited, its excited state energy can decay by transforming to the highly-twisted form which shows TADF characteristics. This work points out the importance of low population but energetically stable excited states and explains for the first time the origin of TADF in such nearly-planar emitters with large HOMO-LUMO overlaps. Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Density functional theory. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Recommanded Product: 2-Amino-4-bromobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sebastian-Perez, Victor; Garcia-Rubia, Alfonso; Seif el-Din, Sayed H.; Sabra, Abdel-Nasser A.; El-Lakkany, Naglaa M.; William, Samia; Blundell, Tom L.; Maes, Louis; Martinez, Ana; Campillo, Nuria E.; Botros, Sanaa S.; Gil, Carmen published the artcile< Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools>, Electric Literature of 20776-50-5, the main research area is quinazoline antischistosomal preparation target aldose reductase; Drug discovery; Schistosoma mansoni; quinazoline; target deconvolution.

A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in vivo studies in a S. mansoni mouse model show a significant reduction of total worms and a complete disappearance of immature eggs when administered concomitantly with praziquantel in comparison with the administration of praziquantel alone. This fact is of utmost importance because eggs are responsible for the pathol. and transmission of the disease. Subsequently, the chem. optimization of the structure in order to improve the metabolic stability of the parent compound was carried out leading to derivatives with improved drug-like properties. Addnl., the putative target of this new class of antischistosomal compounds was envisaged by using computational tools and the binding mode to the target enzyme, aldose reductase, was proposed.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Drug targets. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Electric Literature of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hayashi, Yujiro; Toyoshima, Maya; Gotoh, Hiroaki; Ishikawa, Hayato published the artcile< Diphenylprolinol Silyl Ether Catalysis in an Asymmetric Formal Carbo [3 + 3] Cycloaddition Reaction via a Domino Michael/Knoevenagel Condensation>, Application of C9H7BrO, the main research area is diphenylprolinol silyl ether catalyst unsaturated aldehyde oxopentanedioate stereoselective cycloaddition; Michael reaction Knoevenagel condensation diphenylprolinol silyl ether catalyst; cyclohexenone stereoselective preparation.

Diphenylprolinol silyl ether I (R1 = H, R2 = H, TMS, TBS; R1 = CF3, R2 = TMS) was found to catalyze the formal carbo [3 + 3] cycloaddition reaction through the domino reaction via the Michael reaction, followed by Knoevenagel condensation of the α,β-unsaturated aldehyde and di-Me 3-oxopentanedioate, affording substituted cyclohexenone derivatives, e.g. II, with excellent enantioselectivity.

Organic Letters published new progress about Cycloaddition reaction (asym. formal [3+3]). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peng, Fu; Zhao, Qian; Huang, Wei; Liu, Shuai-Jiang; Zhong, Ya-Jun; Mao, Qing; Zhang, Nan; He, Gu; Han, Bo published the artcile< Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process>, Application of C9H7BrO, the main research area is arylpropenal fluoroalkyl cyanobutenoate amine tandem Rauhut Currier reaction; fluoroalkyl biaryl ester preparation chemoselective regioselective green chem; trifluoromethyl oxopentenoate arylpropenal amine tandem Michael reaction; formyl trifluoromethyl terphenyl ester preparation regioselective chemoselective green chem; phenyl butenoate cinnamaldehyde amine chemoselective regioselective Rauhut Currier reaction; diphenyl ester preparation green chem.

A new strategy for the preparation of CF3-containing multi-substituted benzene compounds via an amine-catalyzed reaction under metal-free and air-tolerant conditions was developed. This green reaction provided a functional group-controlled synthetic strategy and the polysubstituted benzene derivatives were obtained in moderate to good yields. Using a tri-substituted alkene containing a cyano group as the starting material, CF3-functionalized benzene compounds with four adjacent substituents were formed via a Rauhut-Currier (RC) reaction-triggered [3 + 3] cascade. When the cyano group was replaced with a benzoyl group, Michael-initialized [4 + 2] aromatization occurred, producing the corresponding CF3-benzene with five contiguous substituent groups. The reaction also features numerous advantages, including excellent chemo- and regioselectivity, extensive substrate scope and environmentally friendly conditions. A simple conversion of an aldehyde into a terminal alkyne was also achieved and the utility of this environmentally compatible method and the one-pot reaction was demonstrated by synthesizing a CF3-functionalized benzene-zidovudine hybrid.

Green Chemistry published new progress about [3+3] Cycloaddition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Suresh, Pavithira; Thamotharan, Subbiah; Ganesan, Subramaniapillai Selva published the artcile< Driving NHC organocatalysis on water through hydrophobic hydration for the synthesis of diverse heterocycles and carbocycles>, HPLC of Formula: 3893-18-3, the main research area is heterocycle spirocyclic preparation heterocyclic carbene catalyst water solvent; carbocycle preparation heterocyclic carbene catalyst water solvent.

Unprecedented acceleration in the rate of the N-heterocyclic carbene (NHC) organocatalysis was observed while performing the reaction in water medium with NaCl as an additive during the synthesis of diverse spirooxindole-γ-butyrolactone derivatives, e.g., I. The seminal role of the hydrophobic hydration effect for the acceleration of the reaction was further proven by performing the reaction with antihydrophobic additive LiClO4 and using denser D2O solvent.

Catalysis Communications published new progress about Cycloalkenes Role: SPN (Synthetic Preparation), PREP (Preparation) (cyclopentenes). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, HPLC of Formula: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thomas, A. W. published the artcile< Product subclass 1: diaryl ethers>, Electric Literature of 135999-16-5, the main research area is review diaryl ether preparation organic synthesis.

A review of methods to prepare diaryl ethers.

Science of Synthesis published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Electric Literature of 135999-16-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Cong; Zhu, Yuhang; Jin, Shuqi; Xu, Kejie; Luo, Shuxin; Xu, Lixia; Zhong, Guofu; Zhong, Liangjun; Zhang, Jian published the artcile< Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol>, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate, the main research area is aryl alkene palladium catalyst regioselective diastereoselective alkenylation; preparation aryl alkadiene; phenyl alkatriene preparation.

N,N-bidentate-chelation-assisted α- and β-olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction

Organic Chemistry Frontiers published new progress about Alkadienes Role: SPN (Synthetic Preparation), PREP (Preparation). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary