Tag: M.W=200-250

Lutter, Ferdinand H.; Grokenberger, Lucie; Hofmayer, Maximilian S.; Knochel, Paul published the artcile< Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives>, Category: bromides-buliding-blocks, the main research area is thiopyridyl ester hetero arylzinc pivalate acylation catalyst; aryl ketone preparation.

A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S-pyridyl thioesters with (hetero)arylzinc pivalates was reported. The thioesters were prepared directly from the corresponding carboxylic acids under mild conditions, thus tolerating sensitive functional groups. Acylations of α-chiral S-pyridyl esters proceeded with very high stereoretention leaded to optically enriched α-chiral ketones.

Chemical Science published new progress about Acylation. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Chengbin; Li, He; Li, Chunzhi; Ren, Xiaomin; Yang, Qihua published the artcile< One-pot synthesis of mesosilica/nano covalent organic polymer composites and their synergistic effect in photocatalysis>, Synthetic Route of 20099-90-5, the main research area is mesosilica organic polymer composite photocatalysis synergistic effect.

Organic-inorganic hybrid materials provide a desirable platform for the development of novel functional materials. Here, we report the one-pot synthesis of mesoporous hybrid nanospheres by the in-situ sol-gel condensation of tetraethoxysilane around surfactant micelle-confined nano covalent organic polymer (nanoCOP) colloids. The hybrid nanospheres containing nanoCOPs uniformly distributed in the mesosilica network, inherited the visible light responsive properties of the nanoCOPs. The turnover frequency of the hybrid nanospheres is almost 12 times that of its corresponding bulk COP counterpart for the photocatalytic reductive dehalogenation of α-bromoacetophenone, which is attributed to activation of the Hantzsch ester reductant by the hydroxyl group. The existence of a volcano relationship between the activity and nanoCOP/mesosilica ratio confirmed the synergistic effect between nanoCOP and mesosilica. Our preliminary results suggest that hybridization of semiconductors and reactant-activating materials is an efficient strategy for enhancing the activity of a catalyst for photocatalysis.

Chinese Journal of Catalysis published new progress about Colloids. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Synthetic Route of 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Gui-Ling; Ullah, Farman; Deiana, Luca; Lin, Shuangzheng; Zhang, Qiong; Sun, Junliang; Ibrahem, Ismail; Dziedzic, Pawel; Cordova, Armando published the artcile< Dynamic kinetic asymmetric transformation (DYKAT) by combined amine- and transition-metal-catalyzed enantioselective cycloisomerization>, Electric Literature of 3893-18-3, the main research area is cyclopentene derivative asym synthesis; unsaturated aldehyde propargylated acid dynamic kinetic asym transformation cycloisomerization.

The first examples of one-pot highly chemo- and enantioselective dynamic kinetic asym. transformations (DYKATs) involving α,β-unsaturated aldehydes and propargylated carbon acids are presented. These DYKATs, which proceed by a combination of catalytic iminium activation, enamine activation, and Pd0-catalyzed enyne cycloisomerization, give access to functionalized cyclopentenes e. g., I with up to 99 % ee and can be used for the generation of all-carbon quaternary stereocenters.

Chemistry – A European Journal published new progress about Amines, chiral Role: CAT (Catalyst Use), USES (Uses). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tan, Mei-Ling; Tong, Shuo; Hou, Sheng-Kai; You, Jingsong; Wang, Mei-Xiang published the artcile< Copper-Catalyzed N,N-Diarylation of Amides for the Construction of 9,10-Dihydroacridine Structure and Applications in the Synthesis of Diverse Nitrogen-Embedded Polyacenes>, Synthetic Route of 89003-95-2, the main research area is amide haloarylmethane diarylation copper; acyldihydroacridine preparation deacylation oxidative aromatization; tetracene pentacene preparation; polyacene preparation; copper arylation catalyst.

A CuI/DMEDA catalyzed N,N-diarylation reaction of amides with various di(o-bromoaryl)methanes to produce diverse 9,10-dihydroacridine derivatives, is reported. The resulting 9,10-dihydroacridine derivatives were oxidized selectively under mild conditions to afford acridine, acridinone, and acridinium derivatives The copper-catalyzed N,N-diarylation reaction coupled with oxidative aromatization reaction enabled the facile construction of nitrogen atom-embedded tetracenes and pentacenes of different ortho-fused patterns. The luminescence properties, especially the effect of fusion pattern on fluorescence emission of acquired N-polyacenes, were also demonstrated.

Organic Letters published new progress about Absorption. 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Synthetic Route of 89003-95-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mo, Cheng; Zhang, Zhang; Li, Yupeng; Huang, Minhao; Zou, Jian; Luo, Jinfeng; Tu, Zheng-Chao; Xu, Yong; Ren, Xiaomei; Ding, Ke; Lu, Xiaoyun published the artcile< Design and Optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors>, Application In Synthesis of 51605-97-1, the main research area is imidazo pyrazinyl carboxamide derivative preparation DDR1 inhibitor cancer.

DDR1 is considered as a promising target for cancer therapy, and selective inhibitors against DDR1 over other kinases may be considered as promising therapeutic agents. Herein, we have identified a series of 3′-(imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as novel selective DDR1 inhibitors. Among these, compound 8v potently inhibited DDR1 with an IC50 of 23.8 nM, while it showed less inhibitory activity against DDR2 (IC50 = 1740 nM) and negligible activities against Bcr-Abl (IC50 > 10μM) and c-Kit (IC50 > 10μM). 8v also exhibited excellent selectivity in a KINOMEscan screening platform with 468 kinases. This compound dose-dependently suppressed NSCLC cell tumorigenicity, migration, and invasion. Collectively, these studies support its potential application for treatment of NSCLC.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Application In Synthesis of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cardinal-David, Benoit; Raup, Dustin E. A.; Scheidt, Karl A. published the artcile< Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates>, SDS of cas: 3893-18-3, the main research area is enal chalcone heterocyclic carbene Lewis acid catalyst stereoselective cyclization; cis trisubstituted cyclopentene stereoselective preparation.

A new approach that takes advantage of N-heterocyclic carbene/Lewis acid cooperative catalysis provides access to cis-1,3,4-trisubstituted cyclopentenes, e.g. I, from enals and chalcone derivatives with high levels of diastereoselectivity and enantioselectivity. The presence of Ti(OiPr)4 as the Lewis acid allows for efficient substrate preorganization, which translates into high levels of diastereoselectivity. Addnl., we demonstrate the possibility of controlling the absolute stereochem. of NHC-catalyzed reactions by employing a catalytic amount of a chiral Lewis acid as the unique source of optically active promoter.

Journal of the American Chemical Society published new progress about Alkenals Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghochikyan, Tariel V.; Vardanyan, Arpine S.; Samvelyan, Melanya A.; Galstyan, Armen S.; Langer, Peter published the artcile< Synthesis of cinnamyl substituted dihydrofuranones by the Heck cross-coupling reaction>, Application of C7H4BrF3, the main research area is cinnamyl substituted dihydrofuranone preparation; allyldihydrofuranone aryl bromide Heck palladium catalyst.

The Heck cross-coupling of 3-allyldihydrofuran-2(3H)-ones with aryl bromides afforded the corresponding 3-cinnamyl derivatives I [R = H, Me; R1 = H, CO2Et; Ar = Ph, 4-CO2MeC6H4, 3-F3CC6H4, etc.]. The structure of the products was confirmed by NMR spectroscopy, mass spectrometry and X-ray diffraction.

Mendeleev Communications published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zeyuan; Dai, Zhen; Ma, Xinkun; Liu, Yihan; Ma, Xiaojun; Li, Wanli; Ma, Chen published the artcile< Cu-catalyzed one-pot synthesis of fused oxazepinone derivatives via sp2 C-H and O-H cross-dehydrogenative coupling>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is oxazepinone preparation; benzamide quinolinyl phenol halo cross dehydrogenative coupling copper catalyst.

An efficient Cu-catalyzed cascade reaction protocol was developed for the synthesis of fused oxazepinone derivatives I (R1 = H, 7-Cl, 8-Me, 9-CF3, etc.; R2 = H, 3-Br, 4-Cl, 3-MeO, etc.; Q = quinolin-8-yl, 5-methoxyquinolin-8-yl; A = N, C) via sp2 C-H and O-H cross-dehydrogenative coupling. A readily available catalyst, Cu2O, was used in this modular and convergent approach. An unusual Smiles rearrangement reaction was involved in this synthesis. Various reaction parameters were evaluated and optimized and the target compounds were obtained in good-to-excellent yields.

Organic Chemistry Frontiers published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Dong; Li, Shiqing; Wang, Jinhua; Gou, Tiantian; Zhang, Linfeng; Wang, Guixia; Kong, Xiangfei published the artcile< Visible-Light-Mediated Synthesis of Rutaecarpine Alkaloids through C-N Cross-Coupling Reaction>, Related Products of 20776-50-5, the main research area is aniline benzamide cross dehydrogenation coupling amination oxidation photocatalyst light; quinazolinone alkaloid preparation; rutaecarpine preparation.

A visible-light-initiated cross-dehydrogenative-coupling amination is described, featuring metal- and photocatalyst-free, at room temperature, and using air as an oxidant. The reaction provides a facile approach for the synthesis of rutaecarpine and its derivatives The substrates with electron-withdrawing groups give higher yields than those with electron-donating groups, but the substituent position has a negligible influence on the yield. Using binaphthyl-diyl hydrogen phosphate and dibenzyl phosphate as catalysts both deliver satisfying yields. This straightforward light-driven strategy might be applicable to the synthesis of quinazolinone derivatives

Synlett published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhu, Bin-Bin; Ye, Wen-Bo; He, Zhi-Tao; Zhang, Shu-Sheng; Feng, Chen-Guo; Lin, Guo-Qiang published the artcile< Regioselective Tandem C-H Alkylation/Coupling Reaction of ortho-Iodophenylethylenes via C,C-Pallada(II)cycles>, Quality Control of 89003-95-2, the main research area is styrene iodo regioselective diastereoselective alkylation nucleophilic substitution palladacycle pyridone.

Five-membered C,C-pallada(II)cycles are a unique class of diorganopalladium species with favorable stability and an electron-rich nature, leading to efficient sequential reactions with diverse electrophiles and nucleophiles. Specifically, the development of aryl-alkenyl-palladacycle-based transformations could provide an attractive approach with regio- and stereocontrol for the construction of multifunctionalized arylethylenes. However, currently, the C,C-pallada(II)cycle formation relies on a rigid skeleton or steric congestion in the backbone to promote cyclopalladation, and the formation of aryl-alkenyl-palladacycle without an α-substituent has not been achieved. Furthermore, reactions that could discriminate between the two sp2 carbon centers of such C(sp2),C(sp2)-palladacycle remain elusive. Herein, a regioselective three-component tandem alkylation/coupling reaction applicable for a variety of non-, α-, or β-substituted and α,β-disubstituted ortho-iodophenylethylenes is reported. Electron-rich 2-pyridone ligands are employed to enable the cyclopalladation process leading to aryl-alkenyl-palladacycle intermediates, of which the two C-Pd bonds are discriminated toward alkylation by their inherent steric and electronic differences. Good linear free-energy relationships between regio-/chemoselectivities and Hammett σ values are observed

ACS Catalysis published new progress about Alkylation catalysts, regioselective. 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Quality Control of 89003-95-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary