Tag: M.W=200-250

Ghorbani-Choghamarani, Arash; Taherinia, Zahra published the artcile< New revolution in biaryl synthesis: transition metal-free C-C bond formation promoted by the mixture of 2-mercaptoethanol/KOH/DMSO>, Computed Properties of 401-78-5, the main research area is biaryl preparation; phenylboronic acid aryl halide transition metal free Suzuki type.

Biaryls RR1 [R = C6H5; R1 = C6H5, 3-MeOC6H4, 4-O2NC6H4, etc.] were synthesized via transition metal-free C-C cross coupling reaction of aryl halides with phenylboronic acid that was believed to be a new revolution in Suzuki type reactions. Carbon-carbon bond formation could be promoted by a mixture of 2-mercaptoethanol/KOH/DMSO without the aid of any transition metals. It has been suggested that this reaction proceeded through radical species, hence the electron transfer route was suggested for operation during oxidation of 2-mercaptoethanol in DMSO.

ChemistrySelect published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mikhailov, I. E.; Vikrishchuk, N. I.; Popov, L. D.; Beldovskaya, A. D.; Dushenko, G. A.; Revinskii, Yu. V.; Kurbatov, S. V. published the artcile< 5-(2-Hydroxyphenyl)-1,2-dimethyl(1-methyl-2-vinylaryl)-1H-1,3,4-triazoles and their complexes with Zn(II)>, Related Products of 3893-18-3, the main research area is zinc substituted triazolylphenolate chelate preparation luminescence.

The interaction of 2,3-dimethyl-4-oxo-1,3-benzoxazinium and 2-[β-(4-bromophenylvinyl)]-3-methyl-4-oxo-1,3-benzoxazinium perchlorates with hydrazine hydrate has afforded the corresponding triazoles that were used as ligands for the synthesis of zinc complexes L2Zn. Luminescent properties of the prepared complexes were studied.

Russian Journal of General Chemistry published new progress about Photoluminescence. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

D′Addio, Adriano; Malincik, Juraj; Fuhr, Olaf; Fenske, Dieter; Haussinger, Daniel; Mayor, Marcel published the artcile< Gelander Molecules with Orthogonal Joints: Synthesis of Macrocyclic Dimers>, Quality Control of 82-73-5, the main research area is carbazole thiophene macrocycle preparation conformation helicity CD; Geländer molecules; atropisomer; helical chirality; heteroarenes; macrocyclization.

Orthogonal joints, understood as connections with an angle of 90°, were introduced in the design of the “”Gelander”” model compounds 1 and 2. The banister, consisting of a conjugated carbazole dimer linked by either 1,3-butadiyne (2) or a single thiophene (1), wraps around an axis composed of a phthalimide dimer due to the dimensional mismatch of both subunits, which are interconnected by phenylene rungs. The “”Gelander”” structure was assembled from a monomer comprising the 1,4-diaminobenzene rung with one amino substituent as part of a 4-bromo phthalimide subunit forming the orthogonal junction to the axis, and the other as part of a masked 2-ethynyl carbazole as orthogonal joint to the banister. The macrocycle was obtained by two sequential homocoupling steps. A first dimerization by a reductive homocoupling assembled the axis, while an oxidative acetylene coupling served as ring-closing reaction. The formed butadiyne was further derivatized to a thiophene, rendering all carbons of the model compound sp2 hybridized. Both helical structures were fully characterized and chirally resolved. Assignment of the enantiomers was achieved by simulation of chiroptical properties and enantiopure synthesis.

Chemistry – A European Journal published new progress about Chirality. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Quality Control of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cui, Haishuai; Zhong, Linhao; Lv, Yang; Hao, Fang; Liu, Pingle; Xiong, Wei; Xiong, Shaofeng; Liu, Huajie; Luo, He′an published the artcile< A facile synthesis of in-situ formed amorphous zirconia catalysts for efficient transfer hydrogenation of unsaturated aldehydes>, Computed Properties of 3893-18-3, the main research area is amorphous zirconia catalyst unsaturated aldehyde transfer hydrogenation.

Several metal salts were used for the cinnamaldehyde transfer hydrogenation, and it was found that heterogeneous reactions coexisted in this superficial homogeneous catalytic system. Among these metal salts, Zr(NO3)4·5H2O exhibits the best catalytic performance. Notably, the in-situ formed amorphous zirconia during the reaction is identified as the active site of Zr(NO3)4·5H2O. The in-situ formed zirconia in the presence of cinnamaldehyde (self-selective ZrO2) possesses smaller particle size, better dispersion and more surface hydroxyl groups, which exhibits remarkably enhanced catalytic performance in cinnamaldehyde transfer hydrogenation as compared to the com. nano-zirconia and laboratory-prepared zirconia. The characterization and theor. anal. reveal that the synergistic catalytic effect between zirconium active site and surface hydroxyl groups can effectively activate C=O bonds in cinnamaldehyde and reduce the activation energy barrier, thus significantly improving the transfer hydrogenation performance. Moreover, the self-selective ZrO2 exhibits excellent catalytic performance for a series of unsaturated aldehydes.

Fuel published new progress about Adsorption energy. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Computed Properties of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yanai, Hikaru; Egawa, Saki; Yamada, Kenta; Ono, Junpei; Aoki, Motohide; Matsumoto, Takashi; Taguchi, Takeo published the artcile< 1,1-Bis(triflyl)alkadienes: Easy-To-Handle Building Blocks for Strongly Acidic Carbon Acids>, Synthetic Route of 3893-18-3, the main research area is unsaturated aldehyde triflylmethane condensation; bistriflylalkadiene preparation Mukaiyama aldol; carbon acid preparation catalysis.

1,1-Bis(triflyl)alkadienes I (Ar = C6H5, 4-CH3C6H4, 4-CH3OC6H4, 3-EtOC6H4, 4-ClC6H4, 2-BrC6H4, etc.) were easily prepared by mixing bis(triflyl)methane and α,β-unsaturated aldehydes and then used as easy-to-handle building blocks for the preparation of strongly acidic carbon acids. The reaction of these alkadienes with either NaBH4 or organocerium reagents gave the desired carbon acids through a β-selective nucleophilic addition reaction. Similar reactions of a 1,1-bis(trifyl)alkadiene with sterically bulky iPrMgBr resulted in a δ-selective alkylation instead. The present β-alkylation is the realization of the synthesis of β-branched 1,1-bis(triflyl)alkanes with an acidic C-H moiety. Furthermore, when submitted to a Mukaiyama aldol reaction, β-branched carbon acids had a higher catalyst activity than that of the corresponding nonbranched carbon acids.

Asian Journal of Organic Chemistry published new progress about Acidity. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Synthetic Route of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Shengzheng; Chen, Shuqiang; Guo, Zhongjie; He, Shipeng; Zhang, Fan; Liu, Xueying; Chen, Weiping; Zhang, Shengyong; Sheng, Chunquan published the artcile< Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity>, Related Products of 3893-18-3, the main research area is spiro tetrahydrothiopyran oxindole diastereoselective preparation SAR antitumor; indolinone unsaturated aldehyde Michael aldol cascade proline catalyst.

Using proline as a catalyst, an organocatalytic Michael-aldol cascade reaction was developed for the synthesis of spiro-tetrahydrothiopyran oxindoles I [R1 = H, F, Me, Cl, Br; R2 = 2-furyl, Ph, 4-BrC6H4, etc.; R3 = Et, n-Pr, Ph, etc.] from indolinones and α,β-unsaturated aldehydes. The highly functionalized scaffold was assembled in moderate to good yields (51-78%) and excellent diastereoselectivities (>20 : 1 dr). Interestingly, the oxindoles I displayed moderate to good in vitro antitumor activities and were validated as p53-MDM2 inhibitors, which represented promising lead compounds for antitumor drug discovery.

Organic & Biomolecular Chemistry published new progress about Aldol condensation catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pump, Eva; Poater, Albert; Zirngast, Michaela; Torvisco, Ana; Fischer, Roland; Cavallo, Luigi; Slugovc, Christian published the artcile< Impact of Electronic Modification of the Chelating Benzylidene Ligand in cis-Dichloro-Configured Second-Generation Olefin Metathesis Catalysts on Their Activity>, SDS of cas: 16426-64-5, the main research area is benzylidene ruthenium imidazolidene carbene chelating complex preparation catalyst polymerization; impact electronic modification chelating benzylidene ruthenium dichloro metathesis catalyst; configured olefin metathesis catalyst benzylidene ruthenium imidazolidene carbene complex; cis trans isomerization benzylidene ruthenium imidazolidene carbene dichloro complex; crystal mol structure benzylidene ruthenium imidazolidene carbene chelating complex.

A series of electronically modified second-generation cis-dichloro ruthenium ester chelating benzylidene complexes was prepared, characterized, and benchmarked in a typical ring-opening metathesis polymerization (ROMP) experiment The electronic tuning of the parent chelating benzylidene ligand (2-Et ester benzylidene) was achieved by substitution at the 4- and 5-positions with electron-withdrawing nitro or electron-donating methoxy groups. The effect of the electronic tuning on the cis-trans isomerization process was studied exptl. and theor. D. functional theory calculations clearly revealed the influence of electronic modification on the relative stability between the cis and trans isomers, which is decisive for the activity of the studied compounds as initiators in ROMP.

Organometallics published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, SDS of cas: 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Yuanqin; Zhou, Yuqiao; Zhang, Yan; Deng, Pengchi; Zhao, Xiaohu; Jiang, Shichao; Du, Guangxi; Shen, Xin; Xie, Xinyu; Su, Zhishan; Yu, Zhipeng published the artcile< Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for ""Photo-Clicked"" Access to Carbamoyl Formazan Photoswitches In Situ>, Computed Properties of 401-78-5, the main research area is functionalized carbamoyl formazan photochem preparation DFT NBO; diarylsydnone phenyl triazolidine dione photoswitchable ring opening water promoted; Azo compounds; Diarylsydnones; Photo-ligation; Photoswitches; Umpolung.

A “”photo-click”” method that involved nitrile imine from diarylsydnone to capture diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD was described. DFT calculation revealed that H-bonding interactions between PTAD and water were vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit anal. (NBO). The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z <-> E photo-switchable linker on target mols., including peptide and drugs, with excellent anti-fatigue performance. This strategy was showcased to construct highly functionalized carbamoyl formazans such as I [R = H, 4-F, 4-Ph, etc.; R1 = 4-CF3, 3-CN, etc.; R2 = H, 4-F, 4-MeO, etc.] in situ for photo-pharmacol. and material studies, which also expanded chem. of PTAD in aqueous media.

Chemistry – An Asian Journal published new progress about Decarboxylation. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Jin; Fu, Ronghui; Jing, Linhai; Qin, Dabin; Huang, Kun; Wang, Wei published the artcile< A convenient access to 3-substituted benzofuran derivatives via palladium nanoparticles-catalyzed intramolecular Heck reaction>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is benzofuran palladium nanoparticle catalyst intramol Heck reaction.

A concise and efficiently route for the synthesis of 3-substituted benzofurans via the intramol. Heck reaction of bromoaryl 3-phenylallyl ethers has been developed. This simple and highly efficient palladium nanoparticles-catalyzed system showed good catalytic activity. The desired products were afforded in good to high yields (45%∼96%).

Youji Huaxue published new progress about Heck reaction. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Heinrich, Timo; Peterson, Carl; Schneider, Richard; Garg, Sakshi; Schwarz, Daniel; Gunera, Jakub; Seshire, Anita; Koetzner, Lisa; Schlesiger, Sarah; Musil, Djordje; Schilke, Heike; Doerfel, Benjamin; Diehl, Patrizia; Boepple, Pia; Lemos, Ana R.; Sousa, Pedro M. F.; Freire, Filipe; Bandeiras, Tiago M.; Carswell, Emma; Pearson, Nicholas; Sirohi, Sameer; Hooker, Mollie; Trivier, Elisabeth; Broome, Rebecca; Balsiger, Alexander; Crowden, Abigail; Dillon, Christian; Wienke, Dirk published the artcile< Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is pyrazoloindole carboxylic TEAD binding fragment hit lead.

The dysregulated Hippo pathway and, consequently, hyperactivity of the transcriptional YAP/TAZ-TEAD complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-TEAD triggered gene transcription is an attractive strategy for therapeutic intervention. The deeply buried and conserved lipidation pocket (P-site) of the TEAD transcription factors is druggable. The discovery and optimization of a P-site binding fragment are described. Utilizing structure-based design, enhancement in target potency was engineered into the hit, capitalizing on the established X-ray structure of TEAD1. The efforts culminated in the optimized in vivo tool MSC-4106 (I), which exhibited desirable potency, mouse pharmacokinetic properties, and in vivo efficacy. In close correlation to compound exposure, the time- and dose-dependent downregulation of a proximal biomarker could be shown.

Journal of Medicinal Chemistry published new progress about Fused heterocyclic compounds Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary