Tag: M.W=200-250

Jiang, Peng-Ying; Fan, Kai-Fang; Li, Shaoyu; Xiang, Shao-Hua; Tan, Bin published the artcile< Metal-free oxidative cross-coupling enabled practical synthesis of atropisomeric QUINOL and its derivatives>, Application In Synthesis of 3893-18-3, the main research area is atropisomeric QUINOL chemoselective preparation; isoquinoline naphthol oxidative cross coupling metal free; QUINOL oxide enantioselective preparation; racemic QUINOL oxide kinetic resolution NHC catalyst.

A direct oxidative cross-coupling reaction between isoquinolines and 2-naphthols, providing a straightforward and scalable route to acquire privileged QUINOL scaffolds I [R1 = H, 7-Me, 6-Ph, etc.; R2 = H, 3-Me, 5-Br, etc.] in a metal-free manner was reported. Moreover, a NHC-catalyzed kinetic resolution of QUINOL N-oxides with high selectivity factor was established to access two types of promising axially chiral Lewis base catalysts in optically pure forms. The utility of this methodol. was further illustrated by facile transformations of products into QUINAP, an iconic ligand in asym. catalysis.

Nature Communications published new progress about Atom economy. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yamamoto, Satoshi; Hashiguchi, Shohei; Miki, Shokyo; Igata, Yumiko; Watanabe, Toshifumi; Shiraishi, Mitsuru published the artcile< Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers>, Synthetic Route of 81107-97-3, the main research area is benzoxazine preparation potassium channel opener.

A new series of 1,3-benzoxazine derivatives with a 2-pyridine 1-oxide group at C-4, I (R1 = Cl, Br, CF3, NO2, CCH, etc.; R2 = H, Cl, F, Br, OEt, Me), was designed to explore novel K+ channel openers. Synthesis was carried out by using a palladium(0)-catalyzed carbon-carbon bond formation reaction of imino-triflates II with organozinc reagents and via a new one-pot 1,3-benzoxazine skeleton formation reaction of benzoylpyridines. The compounds were tested for vasorelaxant activity in tetraethylammonium, chloride (TEA) and BaCl2-induced and high KCl-induced contraction of rat aorta to identify potential K+ channel openers, and also for oral hypotensive effects in spontaneously hypertensive rats. An electron-withdrawing group with the proper shape at C6 and a Me or halo group at C7 of the 1,3-benzoxazine nucleus were required for the development of optimal vasorelaxant and hypotensive activity. In particular, 2-(6-bromo-7-chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide showed more potent vasorelaxant activity (EC50 = 0.14 μm) against TEA and BaCl2-induced contraction and longer hypotensive effects than cromakalim.

Chemical & Pharmaceutical Bulletin published new progress about Potassium channel openers. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Synthetic Route of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Chunlin; Wang, Xinchao; Yang, Lei; Fu, Lei; Li, Gang published the artcile< Visible-light-driven regioselective carbocarboxylation of 1,3-dienes with organic halides and CO2>, HPLC of Formula: 401-78-5, the main research area is diene halide carbon dioxide iridium catalyst regioselective carbocarboxylation; alkenyl carboxylate preparation.

An unprecedented visible-light-driven regioselective carbocarboxylation of 1,3-dienes with CO2 using aryl and alkyl halides under mild conditions with low-cost potassium formate (HCOOK) to produce carbon dioxide radical anions as the potent reducing agent for the challenging organic halide reduction was reported. Highly 3,4-regioselective carbocarboxylation was achieved with 1,1-diaryl-substituted 1,3-dienes, while major 1,4-carbocarboxylation products were obtained with less hindered mono-aryl substituted 1,3-dienes. This protocol rendered a rapid method for producing complex β,γ-unsaturated carboxylic acids from easily available 1,3-dienes and organic halides with CO2.

Green Chemistry published new progress about 1,3-Alkadienes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, HPLC of Formula: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Achard, Thierry; Belokon’, Yuri N.; Fuentes, Jose A.; North, Michael; Parsons, Teresa published the artcile< Influence of aromatic substituents on metal(II)salen catalyzed, asymmetric synthesis of α-methyl α-amino acids>, Electric Literature of 81107-97-3, the main research area is amino acid methyl asym synthesis; alanine derivative asym benzylation salen copper catalyst mol structure; transition metal Schiff base complex catalyst preparation mol structure.

The influence of substituents on both the aromatic rings of the catalyst, and the benzylidene unit of the substrate are investigated in the (salen)copper(II) catalyzed asym. benzylation of alanine derivatives Catalysts with electron-donating, and electron-withdrawing substituents of various sizes and at various locations on the aromatic rings of the salen ligand were prepared, but all exhibited inferior enantioselectivity to the parent (salen)copper(II) complex. In contrast, the introduction of halogenated substituents onto the aromatic ring of the N-benzylidene alanine Me ester substrate was found to enhance the enantioselectivity of the alkylation with a para-chloro substituent giving optimal results. A new procedure for the preparation of the catalysts which avoids the need for chromatog. on sephadex LH20 is reported, and the optimal catalyst obtained in this way was found to be a cobalt(salen) complex.

Tetrahedron published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Electric Literature of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bolchi, Cristiano; Pallavicini, Marco; Rusconi, Chiara; Diomede, Luisa; Ferri, Nicola; Corsini, Alberto; Fumagalli, Laura; Pedretti, Alessandro; Vistoli, Giulio; Valoti, Ermanno published the artcile< Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency>, Safety of 2-Bromo-4-nitrobenzoic acid, the main research area is peptidomimetic inhibitor farnesyltransferase antiproliferative aorta smooth muscle atherosclerosis.

2-O-Tolyl or 2-o-anisyl substituted 4-hydroxy- and 4-carboxybenzamides of methionine, etherified and amidified with 2-hydroxymethyl- and 2-aminomethylpyridodioxane, resp., are described as inhibitors of Ras protein farnesyltransferase (FTase). Of the sixteen compounds, resulting from the substitution pattern of benzamide and the configuration of the two stereocenters, seven inhibited FTase activity with potencies in the nanomolar range. They were all 2-oxymethylpyridodioxane ethers and, among them, the four o-tolyl substituted stereoisomers also showed micromolar antiproliferative effect on human aortic smooth muscle cells interfering with Ras farnesylation. The docking anal. enlightened significant differences in enzyme interaction between oxymethylpyridodioxane and aminomethylpyridodioxane derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about Antiatherosclerotics. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Safety of 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Ping; Zhang, Xueguo; Chen, Baohua published the artcile< Direct synthesis of 2,4,5-trisubstituted imidazoles and di/tri-substituted pyrimidines via cycloadditions of α,β-unsaturated ketones/aldehydes and N'-hydroxyl imidamides>, Application of C9H7BrO, the main research area is hydroxyamidine phenyl arylpropenone iron catalyst iodine promoter cycloaddition; aroyl phenylimidazole regioselective preparation green chem; unsaturated carbonyl compound hydroxyamidine iron catalyst cycloaddition green chem; diarylpyrimidine regioselective preparation.

An efficient route for the synthesis of 5-acetylimidazoles and di/trisubstituted pyrimidines via iron-catalyzed cross-dehydrogenative coupling (CDC), with excellent tolerance and yields was developed. α,β-Unsaturated aldehydes/ketones and N’-hydroxyl imidamides underwent [3+2] and [3+3] cycloadditions in two processes, involving iron-mediated Michael reaction, Robinson Annulation and 1,5-electrocyclization.

Tetrahedron Letters published new progress about [3+2] Cycloaddition reaction (regioselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schmidt, Michael A. published the artcile< Effect of Terminal Alkylation of Aryl and Heteroaryl Hydrazines in the Fischer Indole Synthesis>, Recommanded Product: Ethyl 5-bromothiophene-2-carboxylate, the main research area is Fischer indole synthesis; hydrazine ketone alkylation amidation cross coupling.

The effect of alkylation on the terminal position of aryl and heteroaryl hydrazines in the Fischer indole synthesis was examined Compared to their unalkylated counterparts, reactions using alkylated s provided indole products with higher yields and faster rates. The reactions can be conducted at lower temperatures and are compatible with acid-sensitive functionality. The terminally alkylated hydrazines were readily prepared by a new two-step sequence and held as stable hydrazinium salts. The mild formation of the salts along with the favorable Fischer indole reaction conditions highlights the potential of this approach in later-stage synthetic use.

Journal of Organic Chemistry published new progress about Alkylation. 5751-83-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2S, Recommanded Product: Ethyl 5-bromothiophene-2-carboxylate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ikeuchi, Yutaka; Taguchi, Takeo; Hanzawa, Yuji published the artcile< Zirconocene-Mediated and/or Catalyzed Unprecedented Coupling Reactions of Alkoxymethyl-Substituted Styrene Derivatives>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is alkoxymethylstyrene alkoxy cleavage regioselective stereoselective homodimerization heterodimerization; hydrochrysene stereoselective preparation; aryl hydronaphthalene stereoselective preparation; zirconocene mediated stereoselective cyclization dimerization coupling ortho alkoxymethyl styrene; dependence product zirconocene mediated reaction alkoxymethyl styrene.

2-(Alkoxymethyl)styrenes I (R = H, Me; R1 = H, F, MeO; R2 = Me, PhCH2) undergo a variety of reactions involving cleavage of the alkoxy group with zirconocene generated from zirconocene dichloride and either butyllithium or butylmagnesium chloride. I (R = H) react with stoichiometric amounts of zirconocene to give 4-substituted-2-methylstyrenes or 4-substituted-2-(deuteromethyl)styrenes, while with two equivalent of zirconocene, I (R = R1 = H; R2 = PhCH2) gives 3-ethyl-1-(2-methylphenyl)butane or a trideuterated derivative; in the presence of catalytic zirconocene and 3 equivalent of butylmagnesium chloride, I (R = H; R1 = H, F; R2 = PhCH2) give mainly hexahydrochrysenes II (R = H; R1 = H, F) in 52-57% yields. In the presence of either catalytic or stoichiometric amounts of zirconocene, I (R = Me; R1 = H, F, MeO; R2 = Me, PhCH2) give II (R = Me; R1 = H, F, MeO) in 29-89% yields; with I (R = Me; R1 = F; R2 = Me), the aryltetrahydronaphthalene III {R1 = F; R3 = 2-[(MeO)Me2C]C6H4} is obtained in the presence of stoichiometric zirconocene in 28-50% yields as a single stereoisomer. I (R = Me; R1 = H; R2 = Me) couples with excess amounts of arylethylenes R3CH:CH2 [R3 = Ph, 4-FC6H4, 3,5-(F3C)2C6H3, 4-MeOC6H4, 2-MeOC6H4] in the presence of stoichiometric zirconocene to yield aryldihydronaphthalenes III [R1 = H; R3 = Ph, 4-FC6H4, 3,5-(F3C)2C6H3, 4-MeOC6H4, 2-MeOC6H4] in 11-85% yields (as single stereoisomers) in addition to 5-60% yields of II (R = Me; R1 = H).

Journal of Organic Chemistry published new progress about Aryl alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thanikachalam, Venugopal; Jayabharathi, Jayaraman; Karunakaran, Uthirapathy; Anudeebhana, Jagathratchagan; Thilagavathy, Shanmugam; Sivaraj, Seker published the artcile< Angular shaped AIE generator based luminophores for mechanochromism: An explosive sensor>, Reference of 3893-18-3, the main research area is aggregation induced emission enhancement generator based luminophore mechanochromism.

We have synthesized (E)-N,N-diphenyl-4-(2-(2-(4′-(1,2,2-triphenylvinyl)-[1,1′-biphenyl]- 4-yl)vinyl)- 1H-phenanthro[9,10-d]imidazol-1-yl)aniline (TPE-DBPPI) and (E)- 2-(4′-(2-(1-(4-(diphenylamino)phenyl)- 1H-phenanthro[9,10-d]imidazol-2-yl)vinyl)-[1,1′-biphenyl]- 4-yl)- 3,3-diphenylacrylonitrile (TPA-PPICN) consist of triphenylamine (donor), phenanthroimidazole (acceptor) and tetraphenylethylene (AIE generator). The twisted TPE-DBPPI and TPA-PPICN depict aggregation induced emission enhancement (AIEE) and demonstrated mechanochromic (MC) behavior between blue and green emission. The restricted-intramol.-rotation (RIR) of aryl rings of TPE (TPE-DBPPI) and TPA (TPA-PPICN) in the aggregated phase reduced the non-radiative relaxation channel hence, increase of emission intensity with high photoluminescence quantum yield (PLQY) in film state was observed The PLQY of TPE-DBPPI / TPA-PPICN in various phases are of 58/76% (pristine), 62/83% (grinding) and 65/88% (annealing). The film optical studies and powder XRD (PXRD) analyses implies that the change of twisted crystalline phase of TPE-DBPPI and TPA-PPICN to planar amorphous state results in mechanochromism. Also, these materials detect picric acid in aqueous and film owing to the proton-binding ability of azomethine nitrogen of imidazole which was confirmed by both NMR and DFT studies. The high neg. ΔGet [- 3.01 eV (TPE-DBPPI) and – 3.06 eV (TPA-PPICN)] indicates the thermodn. feasibility of photo electron transfer (PET) process.

Materials Today Communications published new progress about Absorption. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Wangsheng; Zhu, Gongming; Hong, Liang; Wang, Rui published the artcile< The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine-Metal Cooperative Catalysis [Erratum to document cited in CA156:362840]>, Product Details of C9H7BrO, the main research area is erratum enantioselective aza Michael carbocyclization reaction unsaturated aldehyde tosylpropargylamine; organo metal cooperative catalyst enantioselective synthesis erratum; pyrrole aryl dihydro enantioselective synthesis erratum.

On page 13962, Reference 14 contained an incorrect CCDC number; the corrected number is given.

Chemistry – A European Journal published new progress about Amines, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary