Tag: M.W=200-250

Jana, Amit Kumar; Singh, Jyotsana; Ganesher, Asha; Kumar, Amit; Banerjee, Arpita; Kumar, Deepak; Verma, Sarvesh Kumar; Sharma, Ashok Kumar; Bhatta, Rabi Sankar; Konwar, Rituraj; Panda, Gautam published the artcile< Tyrosine-Derived Novel Benzoxazine Active in a Rat Syngenic Mammary Tumor Model of Breast Cancer>, Reference of 81107-97-3, the main research area is benzoxazine derivative anticancer breast cancer apoptosis.

In continuing efforts of improving benzoxazepine derivatives as an anti-breast cancer agent, a new chem. entity, benzoxazine, was designed from scaffold morphing. Structure-activity relationship studies revealed that H, -OMe, -CF3, and -F were well tolerated on R1 and R2 positions of ring A, and R2 as -CH2CH2N(CH2)4 (N-Et pyrrolidine) and -CH2CH2N(CH2)5 (N-Et piperidine) chains on ring D increased activities (Series B, Figure 3). 13d selected as a lead compound (IC50: 0.20 to 0.65 μM) induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells. Compound 13d was formulated into 13d-f using cyclodextrin to improve its solubility for a pharmacokinetic, in vivo efficacy study. Both 13d and 13d-f regressed tumor growth at concentrations of 5 and 20 mg/kg better than tamoxifen without any mortality in a rat syngenic mammary tumor model. Collectively, our data suggest that tyrosine-derived novel benzoxazine 13d could be a potential lead for the treatment of breast cancer and hence deserve further in-depth studies.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Reference of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Gui-Ling; Rios, Ramon; Vesely, Jan; Eriksson, Lars; Cordova, Armando published the artcile< Organocatalytic enantioselective aminosulfenylation of α,β-unsaturated aldehydes>, Formula: C9H7BrO, the main research area is unsaturated aldehyde alkylthio succinimide chiral organocatalyst aminosulfenylation; sucnimido mercaptoaldehyde stereoselective preparation.

A simple, highly enantioselective organocatalytic aminosulfenylation of α,β-unsaturated aldehydes affords orthogonally protected β-amino-α-mercaptoaldehydes in high yields and 93 to > 99% ee. Notably, the catalytic transformation shows that it is possible to efficiently employ all components of an electrophile, which includes a nucleofuge, in organocatalytic domino reactions of enals.

Angewandte Chemie, International Edition published new progress about Addition reaction (aminosulfenylation, stereoselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Yang; Zhang, Cheng; Li, Zhuang; Gu, Peiyang; Wang, Zilong; Li, Hua; Lu, Jianmei; Zhang, Qichun published the artcile< Controlled deposition of large-area and highly-ordered thin films: effect of dip-coating-induced morphological evolution on resistive memory performance>, Reference of 20776-50-5, the main research area is resistive memory device dip coating morphol.

Developing a simple, versatile and efficient technique that enables both large-scale production and nano-scale control is highly desirable but very challenging for achieving high-performance organic-based memory electronic devices. Herein, the authors employed a dip-coating method to fabricate reliable and cost-effective organic memory devices (OMDs). This technique enables one to deposit high-quality, homogeneous and large-area nanopatterns on the surfaces of thin films and realize uniform OMD performances with a record reproducibility up to 96%. To the best of their knowledge, this is the first report on dip-coated OMDs with the highest reproducibility observed to date, which demonstrates the promising versatility of the dip-coating technique to fabricate organic memory devices and its suitability to scale-up for high-throughput solution processing.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Dip coating process. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Reference of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moeckel, Robert; Babaoglu, Emre; Hilt, Gerhard published the artcile< Iodine(III)-Mediated Electrochemical Trifluoroethoxylactonisation: Rational Reaction Optimisation and Prediction of Mediator Activity>, COA of Formula: C8H6BrFO2, the main research area is iodine mediated electrochem trifluoroethoxylactonisation rational reaction optimization prediction mediator; electrochemistry; hypercoordinate iodine; iodine(III); iodoarenes; multivariate linear regression.

A new electrochem. I(III)-mediated cyclization reaction for the synthesis of 4-(2,2,2-trifluoroethoxy)isochroman-1-ones is presented. Based on this reaction design of experiments and multivariate linear regression anal. were used to demonstrate their 1st application in an electrochem. reaction. The broad applicability of these reaction conditions could be shown by a range of substrates and an extensive compatibility test.

Chemistry – A European Journal published new progress about Cyclic voltammetry. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, COA of Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rueping, Magnus; Sugiono, Erli; Merino, Estibaliz published the artcile< Asymmetric organocatalysis: an efficient enantioselective access to benzopyrans and chromenes>, COA of Formula: C9H7BrO, the main research area is unsaturated aldehyde cycloalkanedione chiral diaryl prolinol ether; asym addition heterocyclization hydroxychromenone stereoselective preparation reduction oxidation aromatization; lactone oxadecalinone benzopyran stereoselective preparation; addition heterocyclization asym catalyst chiral diaryl prolinol ether.

Valuable, biol. active chromenones such as those depicted were synthesized based on a diaryl prolinol ether catalyzed, enantioselective reaction of diketones with α,β-unsaturated aldehydes. In these efficient addition-acetalization cascade reactions, diverse aliphatic and aromatic α,β-unsaturated aldehydes, as well as various diketones, can be successfully applied and the 2-hydroxychromenones can be isolated in good yields and with excellent enantioselectivities.

Chemistry – A European Journal published new progress about Acetalization catalysts (stereoselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yanagi, Kouichi; Komatsu, Toru; Ogihara, Shusuke; Okabe, Takayoshi; Kojima, Hirotatsu; Nagano, Tetsuo; Ueno, Tasuku; Hanaoka, Kenjiro; Urano, Yasuteru published the artcile< Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells>, Synthetic Route of 16426-64-5, the main research area is fluorescence imaging metabolic activity tumor cell glycolysis; chemical biology; coupled assays; fluorescent probes; glucolysis; glutaminolysis; metabolism.

In this study, we present a live-cell-based fluorometric coupled assay system to identify the compounds that can regulate the targeted metabolic pathways in live cells. The assay is established through targeting specific metabolic pathways and using “” input “” and “”output “” metabolite pairs. The changes in the extracellular output that are generated and released into the extracellular media from the input are assessed as the activity of the pathway. The screening for the glycolytic pathway and amino acid metabolism reveals the activities of the present drugs, 6-BIO and regorafenib, that regulate the metabolic fate of tumor cells.

Cell Reports published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Synthetic Route of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baker, Stephen J.; Zhang, Yong-Kang; Akama, Tsutomu; Wheeler, Conrad; Plattner, Jacob J.; Rosser, Richard M.; Reid, Ronald P.; Nixon, Neil S. published the artcile< Synthesis of isotopically labelled (3-14C)- and (3,3-2H2)-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), a new antifungal agent for the potential treatment of onychomycosis>, HPLC of Formula: 6942-39-8, the main research area is fluoro dihydro hydroxy benzoxaborole AN2690 radiolabeled antifungal onychomycosis.

5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) is a new antifungal agent for the potential treatment of onychomycosis. During the preclin. development phase, it was necessary to synthesize the radioisotope [3-14C]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole and the deuterium isotope [3,3-2H2]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole for in vitro studies. We report the synthesis of these two isotopically labeled derivatives

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about Fungicides. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, HPLC of Formula: 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Yu-Jie; Ji, Yuanyuan; Qi, Liangliang; Wang, Guanjun; Hui, Xin-Ping published the artcile< Asymmetric Synthesis of Cyclopenta[3,4]pyrroloindolones via N-Heterocyclic Carbene-Catalyzed Michael/Aldol/Lactamization Cascade Reaction>, COA of Formula: C9H7BrO, the main research area is heterocyclic carbene catalyst asym Michael aldol lactamization cascade reaction; asym Michael aldol lactamization cascade reaction enal indole enone; functionalized cyclopentapyrroloindolone stereoselective preparation.

The N-heterocyclic carbene-catalyzed asym. Michael/aldol/lactamization cascade reaction of enals and indole-derived enones for the synthesis of functionalized cyclopenta[3,4]pyrroloindolones with four consecutive stereogenic centers, e.g. I, has been achieved. The products were obtained in good yield with high diastereoselectivity and excellent enantioselectivity.

Organic Letters published new progress about Aldol addition catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dvorakova, Marcela; Langhansova, Lenka; Temml, Veronika; Pavicic, Antonio; Vanek, Tomas; Landa, Premysl published the artcile< Synthesis, Inhibitory Activity and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core>, Application In Synthesis of 20776-50-5, the main research area is quinazoline preparation cyclooxygenase inhibitor docking.

Three series of quinazoline derivatives I [R1 = 4-H2NC6H4O, 4-MeOC6H4CH2NH, 4-MeC6H4NH, etc.; R2 = CH:CHPh, Et2N, morpholino, pyrrolidin-1-yl, piperazin-1-yl; R3 = H, 4-MeOC6H4, 4-FC6H4, 2-thienyl] were prepared and tested for their potential inhibitory activity toward COX-1 and COX-2. Of the prepared compounds, 11 exhibited interesting COX-1 selectivity, with 8 compounds being totally COX-1-selective. The IC50 value of the best quinazoline inhibitor was 64 nM. The structural features ensuring COX-1 selectivity were elucidated using in silico modeling.

ACS Medicinal Chemistry Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Application In Synthesis of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Poornima, B.; Venkanna, A.; Swetha, B.; Kamireddy, Karthik Reddy; Siva, Bandi; Phani Babu, V. S.; Ummanni, Ramesh; Babu, K. Suresh published the artcile< Total synthesis, biological evaluation of dendrodolides A-D and their analogues>, Quality Control of 16426-64-5, the main research area is dendrodolide synthesis anticancer.

A concise total synthesis of dendrodolides A-D has been accomplished in 10 steps from com. available (R)-propylene oxide and 3-buten-1-ol as starting materials. The key steps involved in the synthesis are Jacobsen hydrolytic kinetic resolution, epoxide ring opening with 2-allyl-1,3-dithiane, Yamaguchi esterification and ring-closing metathesis (RCM). In addition, a series of ester derivatives were prepared utilizing Yamaguchi esterification at the C-3 position of the dendrodolide core and screened for their efficacy against cancer cell lines.

Tetrahedron published new progress about Antitumor agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Quality Control of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary