Tag: M.W=200-250

Hazra, Gurupada; Mishra, Gitanjali; Dandela, Rambabu; Thirupathi, Barla published the artcile< A Method to Access Highly Functionalized Dibenzobicyclo[3.2.1]octadienones: Application to the Construction of the 6/6/5/6/6 Carbon Skeleton of Rubialatin A>, Recommanded Product: 2-Bromo-3-methoxyphenol, the main research area is keto indandione aryne insertion diastereoselective; dibenzobicyclo octadienone stereoselective preparation.

The dibenzobicyclo[3.2.1]octadienone scaffold, which has been found in naphthocyclinones, engelharquinones, rubialatin A, etc., has been synthesized under mild transition metal-free conditions by aryne insertion reaction with 2-keto-1,3-indandiones. The application of this methodol. has been demonstrated for the synthesis of the 6/6/5/6/6 scaffold of rubialatin A. 1H NMR exptl. studies confirm that the reaction proceeds through the formation of benzocyclobutane followed by a 7-member carbocycle ring.

Journal of Organic Chemistry published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Recommanded Product: 2-Bromo-3-methoxyphenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhan, Bei-Bei; Jia, Zhen-Sheng; Luo, Jun; Jin, Liang; Lin, Xu-Feng; Shi, Bing-Feng published the artcile< Palladium-Catalyzed Directed Atroposelective C-H Allylation via β-H Elimination: 1,1-Disubstituted Alkenes as Allyl Surrogates>, Recommanded Product: 2-Bromo-4-isopropylaniline, the main research area is unsaturated ester enantioselective synthesis allylation elimination alkene methacrylate; allylation palladium catalyst.

Transition-metal-catalyzed dehydrogenative C-H allylation with 1,1-disubstituted alkenes via β-H elimination remains challenging, because of the low reactivity and difficulty of controlling selectivity. Herein, the development of a Pd(II)-catalyzed directed atroposelective C-H allylation with methacrylates is described. Exclusive allylic selectivity was achieved. A vast array of axially chiral biaryl-2-amines are efficiently synthesized with excellent enantioselectivities (up to >99% enantiomeric excess).

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Recommanded Product: 2-Bromo-4-isopropylaniline.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Su, Shihu; Zhou, Xia; Zhou, Yan; Liao, Guoping; Shi, Li; Yang, Xia; Zhang, Xian; Jin, Linhong published the artcile< Synthesis and biological evaluation of novel sulfone derivatives containing 1,3,4-oxadiazole moiety>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is sulfonyl oxadiazole preparation fungicidal SAR antibacterial toxic regression.

Series of novel sulfone derivatives containing 1,3,4-oxadiazole moiety I [R1 = 4-F-2-Me, 2,5-Cl2, 2-Br-4-F, etc.; R2 = Me, Et, CH(CH3)2, n-propyl] and II [R2 = Me, Et, CH2Ph] were synthesized. All the target compounds were characterized by 1H and 13C NMR, IR spectroscopy and elemental anal. Their antifungal activities were tested in vitro with six important phytopathogenic fungi, namely, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Phytophthora infestans, Paralepetopsis sasakii and Sclerotinia sclerotiorum using the mycelium growth inhibition method. Their antibacterial activities were tested in vitro with two important phytopathogenic bacteria, namely, Xanthomonas oryzae and Ralstonia solanacearum from tobacco bacterial by the turbid meter test. Compounds I [R1 = 2-Cl-4-F, 4-CF3; R2 = Me] and II [R2 = Me, Et] exhibited the most potent inhibition against R. solanacearum and X. oryzae with 50% inhibition concentration (EC50) from 1.97 to 7.75 μg/mL and 0.45 to 0.52 μg/mL, resp. Their antifungal tests indicated that among target compounds exhibited good antifungal activities against six kinds of fungi, especially against S. sclerotiorum with EC50 from 3.71 to 17.44 μg/mL. In vivo antibacterial activities tests demonstrated that the controlling effect of compound II [R2 = Me] (81.9%) against rice bacterial leaf blight were better than that of bismerthiazol (50.8%) and thiodiazole-copper (44.7%). The results also demonstrated that compounds I [R1 = 2-Cl-4-F; R2 = Me] and II [R2 = Me, Et] had a better antifungal and antibacterial activity, with good characteristics of broad spectrum. The structure-activity relationships were also discussed.

World Journal of Organic Chemistry published new progress about Agrochemical antibacterial agents. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

He, Yuli; Borjesson, Marino; Song, Huayue; Xue, Yuhang; Zeng, Daning; Martin, Ruben; Zhu, Shaolin published the artcile< Nickel-Catalyzed Ipso/Ortho Difunctionalization of Aryl Bromides with Alkynes and Alkyl Bromides via a Vinyl-to-Aryl 1,4-Hydride Shift>, Name: 3-Bromobenzotrifluoride, the main research area is polysubstituted arene preparation; aryl alkyl bromide alkyne ipso ortho difunctionalization nickel catalyst.

Polysubstituted arenes are ubiquitous structures in a myriad of medicinal agents and complex mols. Herein, a new catalytic blueprint that merges the modularity of nickel catalysis for bond formation with the ability to enable a rather elusive 1,4-hydride shift at arene sp2 C-H sites, thus allowing access to ipso/ortho-difunctionalized arenes from readily available aryl halides under mild conditions and exquisite selectivity profile is reported.

Journal of the American Chemical Society published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Name: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Panigrahi, Adyasha; Whitaker, Daniel; Vitorica-Yrezabal, Inigo J.; Larrosa, Igor published the artcile< Ag/Pd Cocatalyzed Direct Arylation of Fluoroarene Derivatives with Aryl Bromides>, SDS of cas: 401-78-5, the main research area is biaryl preparation; fluoroarene chromium tricarbonyl complex bromoarene arylation silver palladium catalyst.

Diverse C-H functionalizations catalyzed by Pd employ Ag(I) salts added as halide abstractors or oxidants. Recent reports have shown that Ag can also perform the crucial C-H activation step in several of these functionalizations. However, all of these processes are limited by the wasteful requirement for (super)stoichiometric Ag(I) salts. Herein, we report the development of a Ag/Pd cocatalyzed direct arylation of (fluoroarene) chromium tricarbonyl complexes with bromoarenes. The small organic salt, NMe4OC(CF3)3, added as a halide abstractor, enables the use of a catalytic amount of Ag, reversing the rapid precipitation of AgBr. We have shown through H/D scrambling and kinetic studies that a (PR3)Ag-alkoxide is responsible for C-H activation, a departure from previous studies with Ag carboxylates. Furthermore, the construction of biaryls directly from the simple arene is achieved via a one-pot chromium tricarbonyl complexation/C-H arylation/decomplexation sequence using (pyrene)Cr(CO)3 as a Cr(CO)3 donor.

ACS Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, SDS of cas: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Choi, Bonnie; Capozzi, Brian; Ahn, Seokhoon; Turkiewicz, Ari; Lovat, Giacomo; Nuckolls, Colin; Steigerwald, Michael L.; Venkataraman, Latha; Roy, Xavier published the artcile< Solvent-dependent conductance decay constants in single cluster junctions>, Quality Control of 3893-18-3, the main research area is single cluster junction decay constant solvent.

Single-mol. conductance measurements have focused primarily on organic mol. systems. Here, we carry out scanning tunneling microscope-based break-junction measurements on a series of metal chalcogenide Co6Se8 clusters capped with conducting ligands of varying lengths. We compare these measurements with those of individual free ligands and find that the conductance of these clusters and the free ligands have different decay constants with increasing ligand length. We also show, through measurements in two different solvents, 1-bromonaphthalene and 1,2,4-trichlorobenzene, that the conductance decay of the clusters depends on the solvent environment. We discuss several mechanisms to explain our observations.

Chemical Science published new progress about 3893-18-3. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Quality Control of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jayabharathi, Jayaraman; Sivaraj, Sekar; Thanikachalam, Venugopal; Anudeebhana, Jagathratchagan published the artcile< Multifunctional pyridine styrylphenanthroimidazoles: electron transport materials for blue FOLEDs with low efficiency roll-off and hosts for PHOLEDs with low turn-on voltage>, Electric Literature of 3893-18-3, the main research area is electron transport material organic electroluminescent device.

We have reported pyridine styrylphenanthroimidazole derivatives, SPPI-C2Py, SPPI-N1Py and SPPI-C2N1Py, as efficient electron transport materials (ETMs) for blue fluorescent OLEDs (FOLEDs) and host materials for phosphorescent organic light emitting diodes (PHOLEDs). The optical and carrier transport abilities of pyridine styrylphenanthroimidazoles have been analyzed in terms of the linkage position as well as number of pyridine fragments. Devices with SPPI-C2Py, SPPI-N1Py and SPPI-C2N1Py as ETMs exhibit a maximum current efficiency (CE) of 14.28, 9.63 and 16.93 cd A-1, power efficiency (PE) of 9.32, 4.74 and 11.23 lm W-1 and external quantum efficiency (EQE) of 7.93, 5.50 and 8.68% relative to the widely used ETM BPhen (CE – 11.69 cd A-1; PE – 5.01 lm W-1; EQE – 5.89%). The blue PHOLEDs using SPPI-C2Py, SPPI-N1Py and SPPI-C2N1Py as hosts exhibit a CE of 34.32, 30.65 and 43.23 cd A-1, PE of 32.09, 28.32 and 40.54 lm W-1 and EQE of 18.56, 16.32 and 22.43%. The red PHOLEDs using SPPI-C2N1Py as a host exhibit a maximum CE of 25.78 cd A-1, PE of 22.68 lm W-1 and EQE of 18.56%. The yellow PHOLEDs using SPPI-C2N1Py as a host exhibit a maximum CE of 70.53 cd A-1, PE of 40.86 lm W-1 and EQE of 25.89%, resp. These findings demonstrated that the new born pyridine styrylphenanthroimidazoles can be employed as potential ETMs for blue FOLEDs and hosts for blue, red and yellow PHOLEDs.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Dipole moment. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zuo, Zhijun; Wang, Jing; Liu, Jingjing; Wang, Yaoyu; Luan, Xinjun published the artcile< Palladium-Catalyzed [2+2+1] Spiroannulation via Alkyne-Directed Remote C-H Arylation and Subsequent Arene Dearomatization>, Formula: C7H7BrO2, the main research area is alkynyl iodobenzene bromophenol palladium catalyst tandem regioselective spiroannulation; C−H activation; aryl halides; cross-coupling; dearomatization; palladacycles.

A highly chemoselective Pd0-catalyzed alkyne-directed cross-coupling of aryl iodides with bromophenols, which was subsequently followed by phenol dearomatization was reported to furnish a very attractive [2+2+1] spiroannulated products. Notably, possible homo-coupling of aryl iodides was not observed at all. Mechanistic studies indicated that a five-membered aryl/vinyl palladacycle most likely accounts for promoting the key step of biaryl cross-coupling.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liedholm, Brita published the artcile< Copper(I)-induced bromine-hydrogen exchange of 2,3-dibromoanilines>, Application In Synthesis of 19128-48-4, the main research area is copper reduction dibromoaniline; aniline dibromo debromination copper; debromination dibromoaniline copper ion.

The Cu(I)-induced Br/H exchange reaction of 2,3-dibromoaniline and 5-substituted 2,3-dibromoanilines in the 2-position has been kinetically studied in aqueous HOAc-HCl medium at 90°. The dehalogenation reaction is 2nd order, 1st in both substrate and Cu+, and may be interpreted as a reductive substitution, composed of two 1-electron steps. The 2,3-dibromophenol was only qual. examined but gave similar results.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about Debromination. 19128-48-4 belongs to class bromides-buliding-blocks, and the molecular formula is C6H3BrClNO2, Application In Synthesis of 19128-48-4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ding, Zichao; Ni, Tingjunhong; Xie, Fei; Hao, Yumeng; Yu, Shichong; Chai, Xiaoyun; Jin, Yongsheng; Wang, Ting; Jiang, Yuanying; Zhang, Dazhi published the artcile< Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus>, Electric Literature of 20776-50-5, the main research area is triazole preparation SAR antifungal agent Aspergillus; Antifungal; CYP51; Molecular docking; Synthesis; Triazole.

The incidence of invasive fungal infections has dramatically increased for several decades. In order to discover novel antifungal agents with broad spectrum and anti-Aspergillus efficacy, a series of novel triazole derivatives containing 1,2,3-benzotriazin-4-one was designed and synthesized. Most of the compounds exhibited stronger in vitro antifungal activities against tested fungi than fluconazole. Moreover, 7-chloro-3-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)benzo [d][1,2,3]triazin-4(3H)-one showed comparable antifungal activity against seven pathogenic strains as voriconazole and albaconazole, especially against Aspergillus fumigatus (MIC = 0.25μg/mL), and displayed moderate antifungal activity against fluconazole-resistant strains of Candida albicans. A clear SAR study indicated that compounds with groups at the 7-position resulted in novel antifungal triazoles with more effectiveness and a broader-spectrum.

Bioorganic & Medicinal Chemistry Letters published new progress about Aspergillus. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Electric Literature of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary