Tag: M.W=200-250

Smith, Alan; Tranter, E. Karen; Cain, Ronald B. published the artcile< Utilization of some halogenated aromatic acids by Norcardia. Effects on growth and enzyme induction>, Recommanded Product: 2-Bromo-4-nitrobenzoic acid, the main research area is ENZYME INDUCTION NOCARDIA; HALOGENS ARYL NOCARDIA; NOCARDIA ARYL HALOGENS.

Halogen analogs of benzoate and p-nitrobenzoate did not support growth of N. erythropolis. These analogs, when present together with the parent compounds, inhibited growth of the organism. The halogen analogs similarly inhibited oxidation of benzoate or p-nitrobenzoate by competent cells. Fluoroacetate and 2-fluoro-4-nitrobenzoate caused comparable inhibition of growth on p-nitrobenzoate and both led to some citrate accumulation. The induction of the p-nitrobenzoate-oxidation system was strongly inhibited by all the 2-halogeno-4-nitrobenzoates although the 2-fluoro and 2-chloro derivatives also acted as inducers. Halogen analogs of benzoate also induced the benzoate-oxidation system.

Biochemical Journal published new progress about Nocardia. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Recommanded Product: 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Parthan, Anju; Kruse, Morgan; Yurgin, Nicole; Huang, Joice; Viswanathan, Hema N; Taylor, Douglas published the artcile< Cost effectiveness of denosumab versus oral bisphosphonates for postmenopausal osteoporosis in the US.>, Synthetic Route of 82-73-5, the main research area is .

BACKGROUND: In the US, 26 % of women aged ≥65 years, and over 50 % of women aged ≥85 years are affected with postmenopausal osteoporosis (PMO). Each year, the total direct health care costs are estimated to be $US12-18 billion. OBJECTIVE: The cost effectiveness of denosumab versus oral bisphosphonates in postmenopausal osteoporotic women from a US third-party payer perspective was evaluated. METHODS: A lifetime cohort Markov model was developed with seven health states: ‘well’, hip fracture, vertebral fracture, ‘other’ osteoporotic fracture, post-hip fracture, post-vertebral fracture, and dead. During each cycle, patients could have a fracture, remain healthy, remain in a post-fracture state or die. Relative fracture risk reductions, background fracture risks, mortality rates, treatment-specific persistence rate, utilities, and medical and drug costs were derived using published sources. Expected costs and quality-adjusted life years (QALYs) were estimated for generic alendronate, denosumab, branded risedronate, and branded ibandronate in the overall PMO population and high-risk subgroups: (a) ≥2 of the following risks: >70 years of age, bone mineral density (BMD) T score less than or equal to -3.0, and prevalent vertebral fracture; and (b) ≥75 years of age. Costs and QALYs were discounted at 3 % annually, and all costs were inflated to 2012 US dollars. Sensitivity analyses were conducted by varying parameters e.g., efficacies of interventions, costs, utilities, and the medication persistence ratio. RESULTS: In the overall PMO population, total lifetime costs for alendronate, denosumab, risedronate, and ibandronate were $US64,400, $US67,400, $US67,600 and $US69,200, respectively. Total QALYs were 8.2804, 8.3155, 8.2735 and 8.2691, respectively. The incremental cost-effectiveness ratio (ICER) for denosumab versus generic alendronate was $US85,100/QALY. Risedronate and ibandronate were dominated by denosumab. In the high-risk subgroup (a), total costs for alendronate, denosumab, risedronate and ibandronate were $US70,400, $US70,800, $US74,000 and $US76,900, respectively. Total QALYs were 7.2006, 7.2497, 7.1969 and 7.1841, respectively. Denosumab had an ICER of $US7,900/QALY versus generic alendronate and dominated all other strategies. Denosumab dominated all strategies in women aged ≥75 years. Base-case results between denosumab and generic alendronate were most sensitive to the relative risk of hip fracture for both drugs and the cost of denosumab. CONCLUSION: In each PMO population examined, denosumab represented good value for money compared with branded bisphosphonates. Furthermore, denosumab was either cost effective or dominant compared with generic alendronate in the high-risk subgroups.

Applied health economics and health policy published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Synthetic Route of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tlahuext-Aca, Adrian; Lee, Sarah Yunmi; Sakamoto, Shu; Hartwig, John F. published the artcile< Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis>, Quality Control of 401-78-5, the main research area is arene aryl bromide synergistic palladium silver catalyst regioselective arylation; biaryl preparation; C–H activation; aryl bromides; direct arylation; palladium and silver catalysts; synergistic catalysis.

The direct, catalytic arylation of simple arenes in small excess with aryl bromides was disclosed. The developed method did not require the assistance of directing groups and relies on a synergistic catalytic cycle in which phosphine-ligated silver complexes cleave the aryl C-H bond, while palladium catalysts enable the formation of the biaryl products. Mechanistic experiments, including kinetic isotope effects, competition experiments, and hydrogen-deuterium exchange, support a catalytic cycle in which cleavage of the C-H bond by silver is the rate-determining step.

ACS Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Quality Control of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Herrero, C. Alvarez published the artcile< Vitamin C. The effect of deproteinizing agents on its reductive power>, HPLC of Formula: 82-73-5, the main research area is .

Direct determinations of blood vitamin C by the method of Berend and Fischer (C.A. 31, 7970.8) are compared with determinations by the method of Farmer and Abt (C.A. 30, 8273.5) in which 5% HPO3, 10% Cl3CCO2H, or 15% sulfosalicylic acid were used for the precipitation of protein. The deproteinizing agents caused 25-40% loss of vitamin C, but HPO3 stabilized also the vitamin C which otherwise decompose quickly.

Medicina Colonial published new progress about Blood. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, HPLC of Formula: 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shimizu, Masaki; Mochida, Kenji; Katoh, Masaki; Hiyama, Tamejiro published the artcile< Synthesis and Photophysical Properties of 2-Donor-7-acceptor-9-silafluorenes: Remarkable Fluorescence Solvatochromism and Highly Efficient Fluorescence in Doped Polymer Films>, Reference of 81107-97-3, the main research area is photophys silafluorene derivative fluorescence solvatochromism.

The authors describe preparation, photophys. properties, and theor. calculations of 2-amino-7-acceptor-9-silafluorenes and show that these silafluorenes can potentially be used as novel chromophores for functional organic materials. The D-π-A type silafluorenes were prepared by Pd-catalyzed intramol. coupling of 2-(3-aminophenyldiisopropylsilyl)aryl triflates and the subsequent functional group conversion through reduction of the cyano group to a formyl and Knoevenagel condensation of the formyl group with malonitrile. The UV-visible absorption and fluorescence spectra of the D-π-A type silafluorenes exhibited a red-shift when the electron-withdrawing nature of the acceptor increased. The emission maxima of the fluorescence were highly dependent on the solvent. In the cases of formyl- and dicyanoethenyl-substituted silafluorenes, the emission colors ranged from blue to yellow for the formyl derivatives and from green to red for the dicyanoethenyl derivatives The noticeable fluorescence solvatochromism suggests the intramol. charge-transfer character of the excited states. The silafluorenes also exhibited fluorescence in the solid state (e.g., a neat thin film and a doped polymer film), and the emission color was dependent on the polarity of the polymer. In the solid state, the quantum yields of diphenylamino derivatives were generally higher than those of dimethylamino derivatives, presumably because the bulky diphenylamino group prevented chromophores from assembling close to each other. A comparison of the photophys. properties and theor. calculations of D-π-A type silafluorenes with those of the corresponding fluorenes revealed that the silicon bridge contributed to the extension of the effective conjugation length of the biphenyl moiety when the acceptor was either hydrogen, trifluoromethyl, or a cyano group, whereas there was no contribution of the silicon bridge to the π-extension in silafluorenes substituted by strong electron acceptors such as formyl and dicyanoethenyl groups. White photoluminescence was demonstrated with an excellent quantum yield of 0.81 in the solid state from the poly(Me methacrylate) film doped with Ph2N/CHO- and Ph2N/CH=(CN)2-substituted silafluorenes. This work reveals the potential of D-π-A type silafluorenes as versatile organic emitting materials.

Journal of Physical Chemistry C published new progress about Fluorescence. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Reference of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

China, Hideyasu; Kageyama, Nami; Yatabe, Hotaka; Takenaga, Naoko; Dohi, Toshifumi published the artcile< Practical synthesis of 2-iodosobenzoic acid (IBA) without contamination by hazardous 2-iodoxybenzoic acid (IBX) under mild conditions>, COA of Formula: C7H6BrNO2, the main research area is cyclic organoiodine compound iodosobenzoic acid preparation solvolytic functionalization; Oxone®; cyclic organoiodine(III) compounds; water, solvolytic functionalization, mild condition, metal-free, 2-iodosobenzoic acid.

A convenient and practical method for the preparation of nonexplosive cyclic hypervalent iodine(III) oxidants as efficient organocatalysts and reagents for various reactions using oxone in aqueous solution under mild conditions at room temperature is reported. The thus obtained 2-iodosobenzoic acids (IBAs) could be used as precursors of other cyclic organoiodine(III) derivatives by the solvolytic derivatization of the hydroxy group under mild conditions of 80° or lower temperature These sequential procedures are highly reliable to selectively afford cyclic hypervalent iodine compounds in excellent yields without contamination by hazardous pentavalent iodine(III) compound

Molecules published new progress about Acetylation. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, COA of Formula: C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Qiang; Sane, Neeraj; Klosowski, Daniel; Lee, Melissa; Rosenthal, Tay; Wang, Nick X.; Wiensch, Eric published the artcile< Mizoroki-Heck Cross-Coupling of Bromobenzenes with Styrenes: Another Example of Pd-Catalyzed Cross-Coupling with Potential Safety Hazards>, Product Details of C7H4BrF3, the main research area is bromobenzene styrene palladium catalyst diastereoselective Mizoroki Heck coupling safety; stilbene preparation.

The potential safety hazards associated with the Mizoroki-Heck cross-coupling of bromobenzenes with styrenes were evaluated. The heat output from the reaction in various solvents was comparable in a variety of solvents; however, the rate of reaction was significantly faster in the presence of water. Thermal stability evaluation of the postreaction mixtures in DMSO and 3:1 DMSO/water by differential scanning calorimetry indicated that the onset temperatures of thermal decomposition were significantly lower than that of neat DMSO. Evaluation of the substrate scope revealed that the substitution pattern on the bromobenzene did not affect the heat output. The reaction rate of electron-deficient bromobenzenes was slower than that of the electron-rich bromobenzenes. In general, substituted styrenes afforded similar magnitudes of exotherms; however, the reaction rate of bromobenzene with 2-methylstyrene was significantly slower than the other studied styrenes. The predicted heat of reaction using the d. functional theory method, B3LYP, was in good agreement with the exptl. data. Such excellent agreement suggests that this calculation method can be used as a preliminary tool to predict heat of reaction and avoid exothermic reaction conditions. In many of the studied cases, the maximum temperature of a synthesis reaction was considerably higher than the solvent b.p. and thermal decomposition onset temperatures when the reaction was performed in DMSO or 3:1 DMSO/water. It is crucial to understand the thermal stability of the reaction mixture to design the process accordingly and ensure the reaction temperature is maintained below the onset temperature of decomposition to avoid potential runaway reactions.

Organic Process Research & Development published new progress about Bromobenzenes Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Product Details of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Jingbo; Shi, Yabing; Chen, Shuting; Li, Fengyun; Wen, Wen; Wang, Yuanhong published the artcile< Discovery of evodiamine derivatives as potent insecticide candidates>, SDS of cas: 20776-50-5, the main research area is evodiamine derivative Mythimna Plutella Helicoverpa larvicide; Evodiamine; Insecticidal activity; Mode of action; Structure activity relationships.

In the search for novel more effective insecticides, natural products could be used as ideal template compounds due to their good environmental compatibility, various bioactivities, unique scaffolds and mode of action. We have found that natural product evodiamine, the main active component from the fruits of Evodia rutaecarpa (Juss.) Benth, displayed obvious insecticidal activities against lepidoptera pests. To continue our research, a series of evodiamine derivatives 3a-3aa were rationally designed and synthesized. The larvicidal activities results indicated that most of target compounds displayed better efficacy than evodiamine, matrine, and rotenone against Mythimna separata, Plutella xylostella and Helicoverpa armigera, among which 3z exhibited excellent larvicidal activities (65% at 2.5 mg/L against M. separata, 75% at 1.0 mg/L against P. xylostella, and 85% 10 mg/L against H. armigera, resp.), much better than evodiamine (0%), matrine (0%), and rotenone (0%). The preliminary structure activity relationships demonstrated that the fluorine atom at the E ring of evodiamine had a pos. influence on the larvicidal activity. The calcium imaging experiment studies indicated that 3z could act on the ryanodine receptor (RyR) of M. separata and was an effective calcium activator for RyR.

Bioorganic & Medicinal Chemistry published new progress about Endoplasmic reticulum. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, SDS of cas: 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Verma, Ram Subhawan; Khatana, Anil Kumar; Mishra, Monika; Kumar, Shailesh; Tiwari, Bhoopendra published the artcile< Access to enantioenriched 4-phosphorylated δ-lactones from β-phosphorylenones and enals via carbene organocatalysis>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is carbene catalyzed cycloaddition reaction phosphorylenone enal; enantioenriched phosphorylated gamma lactone preparation crystal structure reactivity; crystal structure enantioenriched phosphorylated gamma lactone; mol structure enantioenriched phosphorylated gamma lactone.

N-heterocyclic carbene (NHC) catalyzed direct access to enantioenriched 4-phosphorylated δ-lactones from β-phosphorylenones and enals was achieved. The sterically demanding β-phosphonate-substituted enones, having competing regiomeric reaction centers, have remained elusive so far in intermol. cycloaddition reactions under NHC catalysis. All the products were obtained in excellent yield and enantioselectivity. These phosphorylated δ-lactones could be transformed into challenging multi-functionalized chiral esters and amides loaded with a β-ketophosphonate functionality.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylidenes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhi-Yun; Cook, Silas P. published the artcile< Directed Ni-Catalyzed Reductive Arylation of Aliphatic C-H Bonds>, Quality Control of 401-78-5, the main research area is amidyl oxalate hydroxamic ester aryl halide reductive arylation nickel.

Herein, authors describe a nickel-catalyzed reductive arylation of remote C(sp3)-H bonds with aryl electrophiles. The reaction targets secondary and tertiary C(sp3)-H bonds to deliver all-carbon quaternary centers. The success of this method relies on a novel amidyl radical precursor that tolerates reducing conditions-O-oxalate hydroxamic acid esters.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Quality Control of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary