Tag: M.W=200-250

Nonami, Reina; Morimoto, Yusei; Kanemoto, Kazuya; Yamamoto, Yasunori; Shirai, Tomohiko published the artcile< Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes>, Product Details of C7H6BrNO2, the main research area is formylphenyl acetamide norbornene iridium catalyst enantioselective decarbonylation; norbornanyl phenyl acetamide preparation; C−H bond activation; asymmetric catalysis; cationic iridium; decarbonylation; decarbonylative arylation.

An unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asym. C-C bonds through the formation of an aryl-iridium intermediate. The decarbonylative aryl addition to bicyclic alkenes were fluidly performed without a stoichiometric aryl-metal reagent, such as aryl boronic acid, with a cationic iridium complex generated in-situ from Ir(cod)2(BArF4) and the sulfur-linked bis(phosphoramidite) ligand ((R,R)-S-Me-BIPAM). This reaction has broad functional group compatibility and no waste was generated, except carbon monoxide.

Chemistry – A European Journal published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Product Details of C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shah, Shalini; Goyal, Anju published the artcile< Synthesis and antimicrobial activity of some n'-(substituted benzylidene)-2-(7-bromo-phenylquinazolin-4-yloxy) acetohydrazide derivatives>, Related Products of 20776-50-5, the main research area is benzylidene bromophenylquinazolinyloxy acetohydrazide preparation antibacterial antifungal activity.

The title compounds were prepared by the reaction of bromoanthranilic acid with benzoyl chloride which gave 7-bromo-2-phenyl-4H-benzo(1,3)oxazin-4-one, further on reaction with formamide gave 7-bromo-2-phenylquinazolin-4(3H)-one. The esterification product of 7-bromo-2-phenylquinazolin-4(3H)-one reacted with hydrazine-hydrate gave (7-bromo-2-phenylquinazolin-4yloxy)acetohydrazide. The sub stituted benzaldehyde RCHO on reaction with (7-bromo-2-phenylquinazolin-4-yloxy)acetohydrazide yielded N’-(sub stituted benzylidene)-2-(7-bromo-2-phenylquinazolin-4-yloxy) acetohydrazide I (R = Cl, OH, NO2; R1 = MeO, NO2, Cl; R2 = Cl, MeO, F, OH, NO2; R3 = MeO). All synthesized derivative compounds I were evaluated for their in vitro antimicrobial activities using the disk diffusion technique. All the synthesized compounds exhibit antimicrobial activity and the compounds I (R = NO2; R1 = NO2; R2 = F, NO2) have a broad spectrum of activity at 50μg/mL.

International Journal of Pharmaceutical Sciences and Research published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kan, Jian; Huang, Shijun; Lin, Jin; Zhang, Min; Su, Weiping published the artcile< Silver-Catalyzed Arylation of (Hetero)arenes by Oxidative Decarboxylation of Aromatic Carboxylic Acids>, Synthetic Route of 16426-64-5, the main research area is carboxylic acid aromatic oxidative decarboxylative coupling Minisci arene heteroarene; biaryl preparation; CH activation; heterocycles; oxidation; radicals; silver.

The silver-catalyzed intermol. Minisci-type reaction of aromatic carboxylic acids was developed. With an inexpensive silver salt as a catalyst, this new reaction enabled a variety of aromatic carboxylic acids R1CO2H (R1 = 4-NCC6H4, 3-BrC6H4, 2-Cl-4-MeSO2C6H3, 2-chloro-3-pyridyl, etc.) to undergo decarboxylative coupling with electron-deficient arenes or heteroarenes R2H (R2 = Ph, 2,5-F2C6H3, pyridyl, etc.) regardless of the position of the substituents on the aromatic carboxylic acid, thus eliminating the need for ortho-substituted aromatic carboxylic acids, which were a limitation of previously reported methods.

Angewandte Chemie, International Edition published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Synthetic Route of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Hui; Li, Weishuang; Hu, Xu-Dong; Liu, Wen-Bo published the artcile< Enantioselective Synthesis of Fused Isocoumarins via Palladium-Catalyzed Annulation of Alkyne-Tethered Malononitriles>, Category: bromides-buliding-blocks, the main research area is isocoumarin preparation; phenylalkynyl malononitrile palladium catalyst enantioselective tandem oxypalladation intramol cycloaddition.

An enantioselective palladium-catalyzed annulation of alkyne-tethered malononitriles for the synthesis of 3,4-ring-fused isocoumarins were described. This cascade strategy involved oxypalladation of ortho-alkynylbenzoates and desymmetrizing addition onto one cyano group of the pendant malononitriles, which enabled the concurrent construction of two rings and an all-carbon quaternary stereocenter in a single operation.

Journal of Organic Chemistry published new progress about Aliphatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Orita, Ryoji; Franckevicius, Marius; Vysniauskas, Aurimas; Gulbinas, Vidmantas; Sugiyama, Haruki; Uekusa, Hidehiro; Kanosue, Kenta; Ishige, Ryohei; Ando, Shinji published the artcile< Enhanced fluorescence of phthalimide compounds induced by the incorporation of electron-donating alicyclic amino groups>, Category: bromides-buliding-blocks, the main research area is phthalimide derivative preparation crystal structure fluorescene property.

Due to their high thermal and environmental stability, polyimides (PIs) are one of the most attractive candidates for novel highly fluorescent polymers, though photophys. studies of PIs are challenging owing to their poor solubility in common solvents. To overcome these problems, we have synthesized and examined a series of low mol. weight model imide compounds: substituted N-cyclohexylphthalimides with alicyclic amino groups at the 3 or 4-positions of the benzene rings (x-NHPIs). Their photophys. properties were systematically investigated by steady-state UV/Visible absorption, fluorescence, and time-resolved fluorescence techniques. In solution, unsubstituted N-cyclohexylphthalimide (NHPI) showed almost no emission, while x-NHPIs exhibited enhanced fluorescence emission depending on the solvent polarity. Anal. of the solvatochromism of the x-NHPIs via Lippert-Mataga plots indicated the generation of large dipole moments in the excited singlet states originating from the intramol. charge-transfer (ICT) states. The significant difference in the fluorescence quantum yields (Φ) between the 3-substituted (3Pi and 3Pyr) and 4-substituted NHPIs (4Pi and 4Pyr) strongly suggests that the former form a twisted ICT (TICT) state, whereas the latter form a planar ICT (PICT) state when excited. 4-Substituted NHPIs also show high fluorescence yields in the crystalline state. A particularly large Φ value was obtained for the 4Pi crystal, which we explain by the large intermol. distances and the arrangement of mols. minimizing intermol. interactions as well as the small non-radiative deactivation rate. These facts clearly demonstrate that the introduction of an alicyclic amino group into NHPI at the 4-position enhances the fluorescence quantum yields significantly, which suggests a new pathway for the development of novel, highly fluorescent PIs.

Physical Chemistry Chemical Physics published new progress about Bond angle, dihedral. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Xiaoyun; Yang, Yuan; Liang, Yun published the artcile< Palladium-catalyzed double N-arylation to synthesize multisubstituted dibenzoazepine derivatives>, Application of C8H4BrNO, the main research area is double arylation primary amine bisbromophenylethene palladium catalyst; dibenzoazepine preparation.

Palladium-catalyzed double N-arylation of primary amines with (Z)-1,2-bis(2-bromophenyl)ethenes was investigated. E.g., in presence of Pd2(dba)3 and DPEphos, double N-arylation of 4-FC6H4NH2 with (Z)-1,2-bis(2-bromophenyl)ethene gave 81% dibenzoazepine derivative (I). A variety of dibenzoazepine derivatives were synthesized in good to excellent yields.

Tetrahedron Letters published new progress about Arylation. 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Application of C8H4BrNO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dietrich, Justin D.; Longenecker, Kenton L.; Wilson, Noel S.; Goess, Christian; Panchal, Sanjay C.; Swann, Steven L.; Petros, Andrew M.; Hobson, Adrian D.; Ihle, David; Song, Danying; Richardson, Paul; Comess, Kenneth M.; Cox, Philip B.; Dombrowski, Amanda; Sarris, Kathy; Donnelly-Roberts, Diana L.; Duignan, David B.; Gomtsyan, Arthur; Jung, Paul; Krueger, A. Chris; Mathieu, Suzanne; McClure, Andrea; Stoll, Vincent S.; Wetter, Jill; Mankovich, John A.; Hajduk, Philip J.; Vasudevan, Anil; Stoffel, Robert H.; Sun, Chaohong published the artcile< Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design>, Recommanded Product: 2-Amino-4-bromobenzoic acid, the main research area is antiinflammation TNF alpha FBDD allosteric desymmetrization drug like isoquinoline.

Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biol. drugs that inhibit TNFα has led to improved clin. outcomes for patients with rheumatoid arthritis and other chronic autoimmune diseases; however, TNFα has proven to be difficult to drug with small mols. Herein, we present a two-phase, fragment-based drug discovery (FBDD) effort in which we first identified isoquinoline fragments that disrupt TNFα ligand-receptor binding through an allosteric desymmetrization mechanism as observed in high-resolution crystal structures. The second phase of discovery focused on the de novo design and optimization of fragments with improved binding efficiency and drug-like properties. The 3-indolinone-based lead compound 12 (I) presented here displays oral, in vivo efficacy in a mouse glucose-6-phosphate isomerase (GPI)-induced paw swelling model comparable to that seen with a TNFα antibody.

Journal of Medicinal Chemistry published new progress about Allosteric modulators. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Recommanded Product: 2-Amino-4-bromobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gan, Zengyu; Huang, Jianping; Chen, Jinyin; Nisar, Muhammad Farrukh; Qi, Wenwen published the artcile< Synthesis and antifungal activities of cinnamaldehyde derivatives against Penicillium digitatum causing citrus green mold>, Application In Synthesis of 3893-18-3, the main research area is Cinnamaldehyde Penicillium antifungal activity citrus.

Penicillium digitatum (green mold) is pathogenic fungi and causes citrus fruit postharvest rotting that leads to huge economic losses across the world. The current study was aimed to develop a new derivative of cinnamaldehyde (4-methoxycinnamaldehyde) through the cross-hydroxyaldehyde condensation method with benzaldehyde substituted by a benzene ring under the catalysis of alk. reagent and, moreover, to test their antifungal potential against P. digitatum, the major citrus fruit rotting fungi. Multiple derivatives of cinnamaldehyde viz. 4-nitro CA, 4-chloro CA, 4-bromo CA, 4-Me CA, 4-methoxy CA, and 2,4-dimethoxy CA were synthesized in the current study whereas the 4-methoxy CA showed highest antifungal actions for citrus fruit postharvest rotting fungi P. digitatum. Moreover, 4-methoxy CA was found to reduce the spore germination and growth by damaging the fungal cell membrane, as well as declined the levels of reducing sugars.

Journal of Food Quality published new progress about Bases Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yan, Nicholas L.; Santos-Martins, Diogo; Nair, Reji; Chu, Alan; Wilson, Ian A.; Johnson, Kristen A.; Forli, Stefano; Morgan, Gareth J.; Petrassi, H. Michael; Kelly, Jeffery W. published the artcile< Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design>, Quality Control of 405931-46-6, the main research area is coumarin stabilizer amyloidogenic Ig light chain amyloidosis inhibitor.

In Ig light-chain (LC) amyloidosis, transient unfolding or unfolding and proteolysis enable aggregation of LC proteins, causing potentially fatal organ damage. A drug that kinetically stabilizes LCs could suppress aggregation; however, LC sequences are variable and have no natural ligands, hindering drug development efforts. We previously identified high-throughput screening hits that bind to a site at the interface between the two variable domains of the LC homodimer. We hypothesized that extending the stabilizers beyond this initially characterized binding site would improve affinity. Here, using protease sensitivity assays, we identified stabilizers that can be divided into four substructures. Some stabilizers exhibit nanomolar EC50 values, a 3000-fold enhancement over the screening hits. Crystal structures reveal a key π-π stacking interaction with a conserved tyrosine residue that was not utilized by the screening hits. These data provide a foundation for developing LC stabilizers with improved binding selectivity and enhanced physicochem. properties.

Journal of Medicinal Chemistry published new progress about Crystal structure. 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, Quality Control of 405931-46-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Wen-Xing; Chen, Si-Kai; Tian, Jin-Miao; Tu, Yong-Qiang; Wang, Shao-Hua; Zhang, Fu-Min published the artcile< A Triazole Organocatalyst with Spiropyrrolidine Framework and its Application to the Catalytic Asymmetric Addition of Nitromethane to α,β-Unsaturated Aldehydes>, COA of Formula: C9H7BrO, the main research area is triazole spiropyrrolidine organocatalyst preparation; stereoselective nitromethane Michael addition unsaturated aldehyde.

A series of new water-compatible “”spiropyrrolidine triazole”” catalysts was designed and synthesized. The asym. Michael addition of nitromethane and α,β-unsaturated aldehydes in an aqueous system was investigated to evaluate these new catalysts, and the resulting adducts were obtained with excellent enantioselectivity (up to 95.5% ee) and moderate to good yield (63-88%).

Advanced Synthesis & Catalysis published new progress about Enantioselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary