Tag: M.W=200-250

Buckle, Derek R.; Morgan, Neil J.; Ross, Janet W.; Smith, Harry; Spicer, Barbara A. published the artcile< Antiallergic activity of 2-nitroindan-1,3-diones>, Application In Synthesis of 82-73-5, the main research area is nitro indandione antiallergic.

Of 26 2-nitroindan-1,3-diones prepared, 2-nitroindan-1,3-dione (I) [3674-33-7] showed an activity close to that of disodium cromoglycate [15826-37-6] while 5,6-dimethyl-2-nitroindan-1,3-dione (II) [49561-92-4] and 2-nitrobenz[f]indan-1,3-dione (III) [49561-93-5] showed a marked increase in antiallergic activity as measured by the homocytotropic antibody-antigen induced passive cutaneous anaphylaxis reaction in the rat. The prepn of the 1,3-indandione nucleus was achieved by 3 routes, all procedures necessitating the appropriately substituted phthalate precursors which were obtained through a variety of synthetic methods.

Journal of Medicinal Chemistry published new progress about Antihistamines. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application In Synthesis of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fernandez, Ariadna; Diaz, Jose Luis; Garcia, Monica; Rodriguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Monica; Fernandez, Begona; Reinoso, Raquel F.; Vela, Jose Miguel; Almansa, Carmen published the artcile< Piperazinyl Bicyclic Derivatives as Selective Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels>, Application of C7H6BrNO2, the main research area is piperazinyl quinazolinone preparation calcium channel.

The synthesis and pharmacol. activities of a new series of piperazinyl quinazolin-4-(3H)-one derivatives I [R1 = H, 5-Br, 6-(4-pyridinyl), 8-Br, etc.; R2 = 2-methoxyethyl, benzyl, 2-furylmethyl, etc.; R3 = H, Me, Pr, n-Bu, etc.; R4 = piperazin-1-yl, (3R,5S)-3,5-dimethylpiperazin-1-yl, (S)-3-methylpiperazin-1-yl, etc.] acting toward the α2δ-1 subunit of voltage-gated calcium channels (Cavα2δ-1) were reported. Different positions of a micromolar HTS hit were explored, and best activities were obtained for compounds I containing a small alkyl group in position 3 of the quinazolin-4-(3H)-one scaffold and a 3-methyl-piperazin-1-yl- or 3,5-dimethyl-piperazin-1-yl-Bu group in position 2. The activity was shown to reside in the R enantiomer of the chain in position 2, and several eutomers reached single digit nanomolar affinities. Final modification of the central scaffold to reduce lipophilicity provided the pyrido[4,3-d]pyrimidin-4(3H)-one II, which showed high selectivity for Cavα2δ-1 vs. Cavα2δ-2, probably linked to its improved analgesic efficacy-safety ratio in mice over pregabalin.

ACS Medicinal Chemistry Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Application of C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tahir, Norini; Muniz-Miranda, Francesco; Everaert, Jonas; Tack, Pieter; Heugebaert, Thomas; Leus, Karen; Vincze, Laszlo; Stevens, Christian V.; Van Speybroeck, Veronique; Van Der Voort, Pascal published the artcile< Immobilization of Ir(I) complex on covalent triazine frameworks for C-H borylation reactions: A combined experimental and computational study>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is covalent triazine framework preparation carbon hydrogen borylation computational exptl.

Metal-modified covalent triazine frameworks (CTFs) have attracted considerable attention in heterogeneous catalysis due to their strong nitrogen-metal interactions exhibiting superior activity, stability and hence recyclability. Herein, authors report on a post-metalation of a bipyridine-based CTFs with an Ir(I) complex for C-H borylation of aromatic compounds Phys. characterization of the Ir(I)-based bipyCTF catalyst in combination with d. functional theory (DFT) calculations exhibit a high stabilization energy of the Ir-bipy moiety in the frameworks in the presence of B2Pin2. By using B2Pin2 as a boron source, Ir(I)@bipyCTF efficiently catalyzed the C-H borylation of various aromatic compounds with excellent activity and good recyclability. In addition, XAS anal. of the Ir(I)@bipyCTF gave clear evidence for the coordination environment of the Ir.

Journal of Catalysis published new progress about Borylation. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Cui; Huang, Kanglun; Wang, Bo; Xie, Longguang; Xu, Xiaohua published the artcile< Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: a general protocol for the construction of benzo[c]phenanthridine derivatives>, COA of Formula: C8H6BrFO2, the main research area is benzophenanthridine preparation palladium catalysis annulation methyl halobenzoate azabicyclic alkene.

The annulation reaction of Me o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodol. based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-sym. azabicyclic alkenes are achieved in high regioselectivity.

RSC Advances published new progress about Cyclization. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, COA of Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Kaiheng; Deiana, Luca; Grape, Erik Svensson; Inge, A. Ken; Cordova, Armando published the artcile< Catalytic Enantioselective Synthesis of Bicyclic Lactam N,S-Acetals in One Pot by Cascade Transformations>, SDS of cas: 3893-18-3, the main research area is bicyclic lactam acetal enantioselective preparation.

A versatile strategy for the enantioselective synthesis of bicyclic lactam N,S-acetals by one-pot cascade transformations is disclosed. The transformation of readily available substrates is promoted by chiral amines and creates bicyclic or tricyclic lactam N,S-acetals with high chemo- and stereoselectivity (up to > 99.5:0.5 dr and > 99 % ee) in one-pot operations.

European Journal of Organic Chemistry published new progress about Acetals, cyclic Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Pu Hua; Meng, Qing Qing; Zhou, Hu Chen published the artcile< Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride>, Recommanded Product: 2-Bromo-4-nitrobenzoic acid, the main research area is pyrrolobenzoxaborole preparation Friedel Crafts acylation acyl chloride stannic catalyst; acyl pyrrolobenzoxaborole preparation.

A novel pyrrolo-benzoxaborole, 6-(pyrrol-1-yl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, was synthesized with 27% overall yield over six steps from 2-bromo-1-methyl-4-nitrobenzene as starting material. Its derivation was achieved via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride with various acyl chlorides giving 3-acyl-1-phenylpyrroles as the main products.

Chinese Chemical Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Recommanded Product: 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dai, Xiao-Yang; Wu, Xiao-Yu; Fang, Hui-Hui; Nie, Lin-Lin; Chen, Jie; Deng, Hong-Mei; Cao, Wei-Guo; Zhao, Gang published the artcile< Enantioselective organocatalyzed cascade reactions to highly functionalized quinolizidines>, Formula: C9H7BrO, the main research area is enantioselective synthesis indoloquinolizidine benzoquinolizidine Michael addition Pictet Spengler; ketoamide unsaturated aldehyde enantioselective Michael addition Pictet Spengler organocalalyst.

An organocatalyzed one-pot Michael addition-Pictet-Spengler sequence of β-ketoamides and α,β-unsaturated aldehydes was developed, which provided access to highly substituted indolo[2,3-α]quinolizidines and benzo[α]quinolizidines in moderate to good yields and good to excellent enantioselectivity. For aromatic α,β-unsaturated aldehydes products containing a stable enol configuration, e.g. I were obtained.

Tetrahedron published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (β-ketoamides). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Elliott, Michael; Janes, Norman F.; Pearson, B. C. published the artcile< Pyrethrins and related compounds. IX. Alkenylbenzyl and benzylbenzyl chrysanthemates>, HPLC of Formula: 17100-65-1, the main research area is CHRYSANTHEMATES BENZYL; BENZYL CHRYSANTHEMATES; PYRETHRINS.

The syntheses of 4-allylbenzyl, 4-benzylbenzyl and other related benzyl chrysanthemates are described. The benzyl alcs. were made by reduction of benzoic esters if these were readily available; otherwise they were made either by Grignard reactions of appropriately substituted bromobenzenes with HCHO, or by reactions of alkenyl halides with Grignard derivatives of bromobenzyl alcs. in which the hydroxyl group was protected as its tetrahydropyranyl ether. 32 references.

Journal of the Science of Food and Agriculture published new progress about 17100-65-1. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, HPLC of Formula: 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gotoh, Hiroaki; Hayashi, Yujiro published the artcile< Diarylprolinol Silyl Ether as Catalyst of an exo-Selective, Enantioselective Diels-Alder Reaction>, COA of Formula: C9H7BrO, the main research area is aldehyde unsaturated enantioselective Diels Alder reaction catalytic; pyrrolidine siloxy fluoroacetic acid enantioselective Diels Alder catalyst aldehyde; bicycloheptaenecarboxaldehyde Diels Alder preparation; cyclohexenealdehyde Diels Alder preparation.

In combined use with CF3CO2H, 2-[bis(3,5-bis-trifluoromethylphenyl)triethylsiloxymethyl]pyrrolidine is an effective organocatalyst of an exo-selective, enantioselective Diels-Alder reaction of α,β-unsaturated aldehydes.

Organic Letters published new progress about Diels-Alder reaction catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thanikachalam, Venugopal; Jeeva, Palanivel; Jayabharathi, Jayaraman; Ramanathan, Periyasamy; Prabhakaran, Annadurai; Saroj Purani, Elayaperumal published the artcile< Nondoped Blue Organic Light Emitting Devices with Donor-π-Acceptor Derivatives as the Emissive Material>, Formula: C9H7BrO, the main research area is blue organic light emitting device MO photoluminescence solvent polarity.

Blue emitting devices based on donor-linker-acceptor geometry such as p-methoxynaphthylphenanthroimidazole-phenyl-phenylbenzenamine (TPA-MPI) and p-methoxynaphthylphenanthroimidazole-styryl-phenylbenzenamine (TPA-MPS) were synthesized and characterized. Due to the rigid mol. backbone composed of phenanthro[9,10-d]imidazole (acceptor), Ph (TPA-MPI) and styryl (TPA-MPS) spacers, and triphenylamine (donor), these compounds exhibit good thermal stability. The nondoped device based on TAP-MPS exhibits higher efficiencies, 1.73 cd A-1 (ηc), 1.46 lm W-1 (ηp), and 2.11% (ηex). The higher efficiency is attributed to the coemission from the intercrossed excited state of the emissive layer.

Industrial & Engineering Chemistry Research published new progress about Band gap. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary