Tag: M.W=200-250

Zhang, Baohua; Shi, Lanxiang published the artcile< Asymmetric Henry condensation catalyzed by ionic liquid-supported proline>, HPLC of Formula: 3893-18-3, the main research area is asym Henry condensation proline ionic liquid.

A functionalized ionic liquid-supported proline, 1-methyl-3-{2-[(2S)-pyrrolidine-2-carbonyloxy]-ethyl}-1H-imidazol-3-ium trifluoromethylcarbonate([Promim]CF3CO2), was used to catalyze the Henry condensation reaction of aldehydes with CH3CH2NO2 or CH3NO2. The desired products were obtained in 79%-95% yields, diastereomeric excess and enantiomeric excess was up to 3 : 1 and 85% under relatively mild conditions. [Promim] CF3CO2 could be efficiently recycled six times without the decrease of catalytic activity in the condensation reaction of 4-nitrobenzaldehyde and CH3CH2NO2. [Promim] CF3CO2 could be efficiently recycled six times without the decrease of catalytic activity in the condensation reaction of 4-nitrobenzaldehyde and CH3CH2NO2.

Yingyong Huaxue published new progress about Catalyst supports. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, HPLC of Formula: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cui, Chun-Xiao; Zhang, Jie; Qiu, Zaozao; Xie, Zuowei published the artcile< Palladium-catalyzed intramolecular dehydrogenative coupling of BH and OH: synthesis of carborane-fused benzoxaboroles>, Safety of 2-Bromo-3-methoxyphenol, the main research area is carborane fused benz.

Palladium acetate-catalyzed intramol. BH-OH coupling and cyclization of 2-hydroxyphenyl-substituted carboranes afforded carborane-fused benzoxaboroles I (2a-t; R1 = H, Me; R2 = H, halo, Me, OMe, Ph, tBu, benzo) and II (3a-p). A Pd-catalyzed intramol. dehydrogenative coupling of BH and OH for the construction of cage B-O bonds has been developed, leading to a new class of 1,3- and 1,4-o-carboranobenzoxaborole derivatives This represents a new route to C,B-carborane-fused heterocycles.

Dalton Transactions published new progress about Carboranes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Safety of 2-Bromo-3-methoxyphenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Galli, Marzia; Fletcher, Catherine J.; del Pozo, Marc; Goldup, Stephen M. published the artcile< Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins>, COA of Formula: C8H8BrF, the main research area is alkene hydrogen bromide regioselective hydrobromination; alkyl bromide preparation.

To improve access to a key synthetic intermediate a direct hydrobromination-Negishi route was targeted. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed Re-examination of early reports revealed that selective Markovnikov addition, often simply termed “”normal”” addition, was not always observed with HBr unless air was excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, COA of Formula: C8H8BrF.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Boelke, Andreas; Kuczmera, Thomas J.; Caspers, Lucien D.; Lork, Enno; Nachtsheim, Boris J. published the artcile< Iodolopyrazolium Salts: Synthesis, Derivatizations and Applications>, Computed Properties of 20776-50-5, the main research area is oxidative cyclization iodophenylpyrazole; iodolopyrazolium triflate preparation.

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodonium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.

Organic Letters published new progress about Oxidative cyclization. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Computed Properties of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mathew, Bini; Ruiz, Pedro; Dutta, Shilpa; Entrekin, Jordan T.; Zhang, Sixue; Patel, Kaval D.; Simmons, Micah S.; Augelli-Szafran, Corinne E.; Cowell, Rita M.; Suto, Mark J. published the artcile< Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-κB activators for the treatment of ALS>, SDS of cas: 20099-90-5, the main research area is amyotrophic lateral sclerosis superoxide dismutase NF kapaB ataluren hybrid; Amyotrophic lateral sclerosis; Ataluren; NF-ҡB; Superoxide dismutase.

ALS is a rare type of progressive neurol. disease with unknown etiol. It results in the gradual degeneration and death of motor neurons responsible for controlling the voluntary muscles. Identification of mutations in the superoxide dismutase (SOD) 1 gene has been the most significant finding in ALS research. SOD1 abnormalities have been associated with both familial as well as sporadic ALS cases. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through activation of NF-κBs. We previously reported that SRI-22819 increases NF-κB expression and activation in vitro, but it has poor ADME properties in general and has no oral bioavailability. Our initial studies were focused on direct modifications of SRI-22819. There were active compounds identified but no improvement in microsomal stability was observed In this context, we focused on making more significant structural changes in the core of the mol. Ataluren, an oxadiazole compound that promotes read-through and expression of dystrophin in patients with Duchenne muscular dystrophy, bears some structural similarity to SRI-22819. Thus, we synthesized a series of SRI-22819 and Ataluren (PTC124) hybrid compounds Several compounds from this series exhibited improved activity, microsomal stability and lower calculated polar surface area (PSA). This manuscript describes the synthesis and biol. evaluation of SRI-22819 analogs and its hybrid combination with Ataluren.

European Journal of Medicinal Chemistry published new progress about Amyotrophic lateral sclerosis. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, SDS of cas: 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fahandej-Sadi, Anis; Lundgren, Rylan J. published the artcile< Copper-Mediated Synthesis of Monofluoro Aryl Acetates via Decarboxylative Cross-Coupling>, Computed Properties of 14062-30-7, the main research area is fluoro oxopropanoic acid aryl boronate preparation copper decarboxylative arylation; aryl fluoroacetate preparation.

Cu-promoted oxidative cross-coupling of α-fluoromalonate half-esters and aryl boron reagents to deliver monofluoro α-aryl acetates under mild conditions (in air at room temperature) was reported. The reaction used a simple, readily available mono-fluorinated building block to generate arylated compounds with functional groups that were not easily tolerated by existing methods, such as aryl bromides, iodides, pyridines, and pyrimidines.

Synlett published new progress about Acetates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Computed Properties of 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Jianchun; Li, Renhe; Dong, Zhe; Liu, Peng; Dong, Guangbin published the artcile< Complementary site-selectivity in arene functionalization enabled by overcoming the ortho constraint in palladium/norbornene catalysis>, SDS of cas: 17100-65-1, the main research area is haloarene amine alkene palladium norbornene regioselective aromatic substitution catalyst; alkenyl amino arene preparation.

Achieving site-selectivity in arene functionalization that is complementary to the site-selectivity from electrophilic aromatic substitution reactions has been a long-standing quest in organic synthesis. Palladium/norbornene cooperative catalysis potentially offers a unique approach to this problem, but its use has been hampered by the ortho constraint, which is the requirement of an ortho substituent for mono ortho functionalization of haloarenes. Here, we show that such a challenge could be addressed using a new class of bridgehead-modified norbornenes, thereby enabling a broadly useful strategy for arene functionalization with complementary site-selectivity. A range of ortho-unsubstituted aryl iodides, previously problematic substrates, can now be employed to provide mono ortho-functionalized products effectively. This method is applicable for late-stage functionalization of complex bioactive mols. at positions that are difficult to reach by conventional approaches.

Nature Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, SDS of cas: 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moir, Michael; Lane, Samuel; Montgomery, Andrew P.; Hibbs, David; Connor, Mark; Kassiou, Michael published the artcile< The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist>, Related Products of 81107-97-3, the main research area is cannabinoid type 2 receptor structure activity relationship; CB(2)R selective; Cannabinoid; Docking; Pyrazolotriazine; Structure-activity relationship study; Synthesis.

The development of selective CB2 receptor agonists is a promising therapeutic approach for the treatment of inflammatory diseases, without CB1 receptor mediated psychoactive side effects. Preliminary structure-activity relationship studies on pyrazoylidene benzamide agonists revealed the -ylidene benzamide moiety was crucial for functional activity at the CB2 receptor. A small library of compounds with varying linkage moieties between the pyrazole and substituted Ph group has culminated in the discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine agonist 19 (CB2R EC50 = 19 nM, CB1R EC50 > 10μM). Docking studies have revealed key structural features of the linkage group that are important for potent functional activity.

European Journal of Medicinal Chemistry published new progress about Cannabinoid receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Venugopal, Thanikachalam; Palanivel, Jeeva; Jayaraman, Jayabharathi published the artcile< Nondoped blue fluorescent OLED based on cyanophenanthrimidazole-styryl-triphenylamine/carbazole materials>, SDS of cas: 3893-18-3, the main research area is cyano phenanthrimidazole styryl phenylamine carbazole fluorescent blue organic LED.

New 2-(4′-(9H-carbazole-9-yl)-styryl-1H-phenathro[9,10-d]imidazole-1-yl)benzonitrile (SPICN-Cz) and 4-(2-(4-(diphenylamino)phenyl-styryl)-1H-phenathro[9,10-d]imidazole-1-yl)benzonitrile (SPICN-TPA) were synthesized, and their photophys., electrochem., and electroluminescent properties were analyzed in comparison with their cyano-free parent compounds, SPI-Cz, and SPI-TPA. Solvatochromic effects show the transformation of an excited state character from locally excited (LE) state to charge transfer (CT) state. Using time-dependent d. functional theory calculation, the excited state properties of these donor-acceptor blue emissive materials were analyzed. Their excited state properties were tuned by replacing the strong donor triphenylamine to weak donor carbazole to achieve the combination of high photoluminance efficiency locally excited (LE) component and high exciton-using CT component in 1 excited state. Hybridization processes between LE and CT components of SPICN-Cz and SPICN-TPA in the emissive state were discussed. The nondoped organic light emitting diode device based on SPICN-Cz exhibit better electroluminescent performances than those of SPICN-TPA-based device: high external quantum efficiency of 2.58 %, current efficiency of 2.90 cd A-1, and power efficiency of 2.26 lm W-1 with Commission Internationale de l’Eclairage (CIE) coordinates of (0.15, 0.12). The excited state modulation and the composition of LE and CT states in the donor-acceptor system could be useful to design low-cost, high-efficiency fluorescent organic light emitting diode materials.

Journal of Physical Organic Chemistry published new progress about Blue-emitting electroluminescent devices. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pearce-Higgins, Robert; Hogenhout, Larissa N.; Docherty, Philip J.; Whalley, David M.; Chuentragool, Padon; Lee, Najung; Lam, Nelson Y. S.; McGuire, Thomas M.; Valette, Damien; Phipps, Robert J. published the artcile< An Enantioselective Suzuki-Miyaura Coupling To Form Axially Chiral Biphenols>, COA of Formula: C7H7BrO2, the main research area is arylbromide phenylboronate ester palladium sSPhos catalyst Suzuki Miyaura coupling; arylphenol enantioselective preparation.

The use of enantiopure, sulfonated SPhos (sSPhos), an existing ligand that has until now been used only in racemic form and that derived its chirality from an atropisomeric axis that was introduced through sulfonation. The attractive noncovalent interactions involving the ligand sulfonate group was responsible for the high levels of asym. induction that we obtain in the 2,2′-biphenol products of Suzuki-Miyaura coupling, and a highly practical resolution of sSPhos via diastereomeric salt recrystallization was developed.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, COA of Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary