Tag: M.W=200-250

Singh, Sudhir K.; Ruchelman, Alexander L.; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. published the artcile< Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity>, Application of C7H4BrNO4, the main research area is methylenedioxydibenzonaphthyridinone preparation topoisomerase inhibiting activity cytotoxicity; structure methylenedioxydibenzonaphthyridinone topoisomerase inhibiting activity cytotoxicity; nitro amino substitution methylenedioxydibenzonaphthyridinone topoisomerase targeting activity cytotoxicity.

Methylenedioxydibenzo[c,h][1,6]naphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et) are prepared as potential inhibitors of human topoisomerase I. Coupling of 2-bromobenzoic acids to amino(methylenedioxy)quinolines [prepared by displacement of 4-chloro-6,7-(methylenedioxy)quinoline] followed by palladium-catalyzed intramol. Heck arylation reactions and reduction of the pendant nitro groups (if present) yields methylenedioxydibenzonaphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et). I (R = H; R1 = H, O2N; R2 = O2N, H; R3 = Me2N) inhibit topoisomerase I-mediated DNA cleavage more effectively and are more cytotoxic than camptothecin; I have topoisomerase I inhibiting activities comparable to dimethoxydibenzonaphthyridinone I (R = H; R1 = R2 = MeO; R3 = Me2N).

Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Crosignani, Stefano; Pretre, Adeline; Jorand-Lebrun, Catherine; Fraboulet, Gaele; Seenisamy, Jeyaprakashnarayanan; Augustine, John Kallikat; Missotten, Marc; Humbert, Yves; Cleva, Christophe; Abla, Nada; Daff, Hamina; Schott, Olivier; Schneider, Manfred; Burgat-Charvillon, Fabienne; Rivron, Delphine; Hamernig, Ingrid; Arrighi, Jean-Francois; Gaudet, Marilene; Zimmerli, Simone C.; Juillard, Pierre; Johnson, Zoe published the artcile< Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases>, Product Details of C7H4BrF3O, the main research area is alkynylphenoxyacetic acid preparation CRTH2 receptor antagonist; DP2 receptor antagonist alkynylphenoxyacetic acid structure activity.

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound, I, by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with Ki < 10 nM) but also excellent potencies in a human whole blood assay (IC50 < 100 nM; PGD2-induced eosinophil shape change). Addnl. optimization of the pharmacokinetic characteristics led to the identification of several compounds suitable for in vivo testing. Of these, II (R1 = n-Pr, R2 = Me; R1 = n-Pr, R2 = F) were tested in two different pharmacol. models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg). Journal of Medicinal Chemistry published new progress about Allergic asthma. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Product Details of C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wei, Hao; Zhang, Yong Jian; Wang, Feijun; Zhang, Wanbin published the artcile< Novel atropisomeric bisphosphine ligands with a bridge across the 5,5'-position of the biphenyl for asymmetric catalysis>, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate, the main research area is biphenyl diphosphine atropisomeric preparation chiral ligand asym hydrogenation; cinnamic acid acetamido asym hydrogenation; phenylalanine substituted asym synthesis.

A new type of atropisomeric bisphosphine ligand I [X = (CH2)8, (CH2)10] with a bridge across the 5,5′-position of the biphenyl has been developed. The axial chirality of this type of ligands can be retained by macrocyclic ring strain produced from 5,5′-linkage of the biphenyl even without 6,6′-substituents on the biphenyls. Ligand (R)-I [X = (CH2)8] showed good catalytic activity and enantioselectivity for Rh(I)-catalyzed asym. hydrogenation of (Z)-α-acetamidocinnamic acids RCH:C(COOH)NHAc.

Tetrahedron: Asymmetry published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Feriancova, Lucia; Cigan, Marek; Gmucova, Katarina; Kozisek, Jozef; Nadazdy, Vojtech; Putala, Martin published the artcile< Effect of electron-withdrawing groups on molecular properties of naphthyl and anthryl bithiophenes as potential n-type semiconductors>, Safety of 5-Bromo-2,2′-bithiophene, the main research area is naphthylbithiophene anthrylbithiophene preparation semiconductor.

A series of ten 2-naphthyl and 2-anthrylbithiophene derivatives with electron acceptor groups were synthesized using the Negishi or Suzuki cross-coupling reaction as a key step. We present a comparison of theor. and exptl. values of the LUMO and gap energies of these derivatives and the effect of the various electron-withdrawing groups on their optical and electrochem. properties. DFT-calculated frontier orbital energy differences have shown a trend following the exptl. determined values. The participation of the electron-withdrawing group in π-conjugation decreases the LUMO level and narrows the energy gap in the order of perfluoroalkyl, acyl, perfluoroacyl, nitro ≈ dicyanovinyl in both series. TD-DFT calculations allowed better understanding of electronic transitions. X-ray structure anal. of naphthalene hexanoyl and perfluorooctanoyl derivatives revealed their herringbone or sandwich herringbone mol. packing, resp., having a planar naphthalene-bithiophene moiety with opposite (s-trans vs. s-cis) conformation of bithiophene.

New Journal of Chemistry published new progress about Absorption spectra. 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, Safety of 5-Bromo-2,2′-bithiophene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zhipeng; He, Zhiqin; Xie, Yuxing; He, Tiantong; Fu, Yaofeng; Yu, Yang; Huang, Fei published the artcile< Bronsted acid-catalyzed homogeneous O-H and S-H insertion reactions under metal- and ligand-free conditions>, Related Products of 81107-97-3, the main research area is alkoxy acetate preparation; alc diazo compound OH bond insertion Bronsted acid catalyzed; phenylethylidene amino oxy acetate preparation; oximes with diazo compound OH insertion Bronsted acid catalyzed; thio aryl acetate preparation; thiol diazo compound SH insertion Bronsted acid catalyzed.

Under metal- and ligand-free conditions, the economical and accessible CF3SO3H successfully catalyzed homogeneous O-H bond insertion reactions between hydroxyl compounds and diazo compounds to afford alkoxy acetates. Including phenols, alcs., water and oximes, these O-H bond insertion reactions were very general and functional-group tolerant. Here, the O-H bond insertion of oximes (ketoximes and aldoximes) to gave phenylethylidene(amino(oxy)acetates) was reported and their structures were characterized by X-ray crystallog. Moreover, a simple and effective method for S-H insertion reactions of thiols to gave thio(aryl)acetates was also developed, delivering the desired C-S bond products with good to excellent yields. It was worth noting that the efficacy of the developed methodol. could be further shown by the expeditious synthesis of the PPAR agonist MBX-102 acid.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gaisina, Irina N.; Lee, Sue H.; Kaidery, Navneet A.; Ben Aissa, Manel; Ahuja, Manuj; Smirnova, Natalya N.; Wakade, Sushama; Gaisin, Arsen; Bourassa, Megan W.; Ratan, Rajiv R.; Nikulin, Sergey V.; Poloznikov, Andrey A.; Thomas, Bobby; Thatcher, Gregory R. J.; Gazaryan, Irina G. published the artcile< Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors>, Formula: C9H8BrFO2, the main research area is phenylhydroxamic acid derivative preparation HDAC6 inhibitor neuroprotectant; HIF-1 activators; Nrf2 activators; Phenylhydroxamates; histone deacetylase inhibitors; neuroprotection; oxidative stress.

Activation of HIF-1α and Nrf2 is a primary component of cellular response to oxidative stress, and activation of HIF-1α and Nrf2 provides neuroprotection in models of neurodegenerative disorders, including ischemic stroke, Alzheimer’s and Parkinson’s diseases. Screening a library of CNS-targeted drugs using novel reporters for HIF-1α and Nrf2 elevation in neuronal cells revealed histone deacetylase (HDAC) inhibitors as potential activators of these pathways. We report the identification of phenylhydroxamates as single agents exhibiting tripartite inhibition of HDAC6, inhibition of HIF-1 prolyl hydroxylase (PHD), and activation of Nrf2. Two superior tripartite agents, ING-6 and ING-66, showed neuroprotection against various cellular insults, associated with stabilization of both Nrf2 and HIF-1, and expression of their resp. target genes in vitro and in vivo. Discovery of the innate ability of phenylhydroxamate HDAC inhibitors to activate Nrf2 and HIF provides a novel route to multifunctional neuroprotective agents and cautions against HDAC6 selective inhibitors as chem. probes of specific HDAC isoform function.

ACS Chemical Neuroscience published new progress about Histone deacetylase inhibitors. 85070-57-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Formula: C9H8BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chacon-Huete, Franklin; Covone, Jason; Zaroubi, Liana; Forgione, Pat published the artcile< Efficient Synthesis of Bis(5-arylfuran-2-yl)methane Scaffolds Utilizing Biomass-Derived Starting Materials>, SDS of cas: 401-78-5, the main research area is bisfuryl methane preparation green chem; aryl hydroxy methyl furan condensation; bromide aryl hydroxymethylfuroic acid decarboxylative cross coupling.

A new synthetic route utilizing biomass-derived furans like 5-hydroxymethylfuroic acid as a starting material for the production of bis(5-arylfuran-2-yl)methane scaffolds I (R = 4-F, 2-Me, 4-OMe, etc.) was developed. Decarboxylative cross-coupling of 5-hydroxymethylfuroic acid (HMFA) was studied in detail with overall good yields. Acid-catalyzed self-condensation was optimized to produce the target structures I in excellent yields. Overall, this report introduces a new expedient synthesis to obtain bis(furyl) methane scaffolds I that avoids the use of protecting groups and highlights the utilization of renewable carbon sources as starting materials.

European Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, SDS of cas: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Renzi, Polyssena; Azzi, Emanuele; Bessone, Enrico; Ghigo, Giovanni; Parisotto, Stefano; Pellegrino, Francesco; Deagostino, Annamaria published the artcile< Blue light enhanced Heck arylation at room temperature applied to allenes>, Product Details of C7H4BrF3, the main research area is tosyl alkdienylamine aryl bromide palladium catalyst Heck photochem arylation; arylvinyl tolylsulfonyl pyrrolidine preparation; aryl vinyl tolylsulfonyl piperidine preparation.

An unprecedented visible light enhanced room temperature Heck reaction between aryl halides and allenyl tosyl amines was here reported. A simple catalytic system (Pd(OAc)2/PPh3) was employed to afford arylated vinyl pyrrolidines and piperidines. A broad scope with high tolerance towards functional groups was observed Electronic effects play an important role in the efficiency of this process. Mechanistic studies, both exptl. and computational, indicated no evidence for a radical mechanism and a pivotal role of light in promoting the carbo-palladation step.

Organic Chemistry Frontiers published new progress about Allenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Product Details of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Liqun; Wang, Jingyang; Wang, Yue; Li, Xiaotong; Liu, Wei; Zhang, Zhaoguo; Xie, Xiaomin published the artcile< Stereoselective Synthesis of cis-2-Ene-1,4-diones via Aerobic Oxidation of Substituted Furans Catalyzed by ABNO/HNO3>, Application of C7H4BrF3, the main research area is furan ABNO nitric acid catalyst aerobic oxidation; alkenedione diastereoselective preparation.

A highly efficient and selective catalytic system, ABNO (9-azabicyclo-[3.3.1]nonane N-oxyl)/HNO3, for the aerobic oxidation of substituted furans to cis-2-ene-1,4-diones under mild reaction conditions using oxygen as the oxidant was reported. The catalyst system was amenable to various substituted (mono-, di-, and tri-) furans and tolerates diverse functional groups, including cyano, nitro, naphthyl, ketone, ester, heterocycle, and even formyl groups. Based on the control and 18O-labeling experiments, the possible mechanism of the oxidation was proposed.

Journal of Organic Chemistry published new progress about Diastereoselective synthesis. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bae, Eun Jung; Choi, Won Gun; Pagire, Haushabhau S.; Pagire, Suvarna H.; Parameswaran, Saravanan; Choi, Jun-Ho; Yoon, Jihyeon; Choi, Won-il; Lee, Ji Hun; Song, Jin Sook; Bae, Myung Ae; Kim, Mijin; Jeon, Jae-Han; Lee, In-Kyu; Kim, Hail; Ahn, Jin Hee published the artcile< Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease>, Quality Control of 17100-65-1, the main research area is oxadiazolylphenyl alanine derivative preparation TPH1 inhibitor obesity fatty liver.

Tryptophan hydroxylase 1 (TPH1) has been recently suggested as a promising therapeutic target for treating obesity and fatty liver disease. A new series of 1,2,4-oxadiazolylphenyl alanine derivatives were identified as TPH1 inhibitors. Among them, compound 23a was the most active in vitro, with an IC50 (half-maximal inhibitory concentration) value of 42 nM, showed good liver microsomal stability, and showed no significant inhibition of CYP and hERG. Compound 23a inhibited TPH1 in the peripheral tissue with limited BBB penetration. In high-fat diet-fed mice, 23a reduced body weight gain, body fat, and hepatic lipid accumulation. Also, 23a improved glucose intolerance and energy expenditure. Taken together, compound 23a shows promise as a therapeutic agent for the treatment of obesity and fatty liver diseases.

Journal of Medicinal Chemistry published new progress about Adipose tissue. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Quality Control of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary