Tag: M.W=200-250

Zhang, Xiang; Hou, Wenjuan; Zhang-Negrerie, Daisy; Zhao, Kang; Du, Yunfei published the artcile< Correction to ""Hypervalent Iodine-Mediated Intramolecular trans-Aminocarboxylation and Oxoaminocarboxylation of Alkynes: Divergent Cascade Annulations of Isocoumarins under Metal-Free Conditions"" [Erratum to document cited in CA163:585666]>, Related Products of 6942-39-8, the main research area is indoloisocoumarin spiroindolone preparation cyclization amino carboxy diarylalkyne hypervalent iodine; aminocarboxylation intramol heterocyclization aminoaryl carboxyaryl alkyne erratum; hypervalent iodine oxidation heterocyclization aminocarboxylation diarylalkyne preparation indoloisocoumarin spiroindolone; erratum.

In Scheme 4, the structure of Compound 2m was drawn incorrectly due to the position of Cl. Similarly, in the Supporting Information (Page S8), the structure of 2m was also wrong. The correct structural drawing is given.

Organic Letters published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Related Products of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Varga, Bence; Szemesi, Peter; Nagy, Petra; Herbay, Reka; Holczbauer, Tamas; Fogassy, Elemer; Keglevich, Gyorgy; Bagi, Peter published the artcile< Enantioseparation of P-Stereogenic Secondary Phosphine Oxides and Their Stereospecific Transformation to Various Tertiary Phosphine Oxides and a Thiophosphinate>, Computed Properties of 401-78-5, the main research area is phosphorus stereogenic secondary phosphine oxide preparation enantioseparation transformation; tertiary thiophosphinate phosphine oxide preparation; crystal mol phenylhydroxymethyl methylphenyl phosphine oxide TADDOL.

Secondary phosphine oxides incorporating various aryl and alkyl groups were synthesized in racemic form, and these products formed the library reported in this study. TADDOL derivatives were used to obtain the optical resolution of these P-stereogenic secondary phosphine oxides. The developed resolution method showed a good scope under the optimized reaction conditions, as 9 out of 14 derivatives could be prepared with an enantiomeric excess (ee) ≥ 79% and 5 of these derivatives were practically enantiopure >P(O)H compounds (ee ≥ 98%). The scalability of this resolution method was also demonstrated. Noncovalent interactions responsible for the formation of diastereomeric complexes were elucidated by single-crystal XRD measurements. (S)-(2-Methylphenyl)phenylphosphine oxide was transformed to a variety of P-stereogenic tertiary phosphine oxides and a thiophosphinate in stereospecific Michaelis-Becker, Hirao, or Pudovik reactions.

Journal of Organic Chemistry published new progress about Addition reaction (Pudovik). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meazza, Marta; Sitinova, Gabriela; Poderi, Cecilia; Mancinelli, Michele; Zhang, Kaiheng; Mazzanti, Andrea; Torres, Ramon Rios published the artcile< Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals>, Application In Synthesis of 3893-18-3, the main research area is synergistic catalysis enantioselective addition acetyl aza arene enal; Michael addition; acetyl aza-arenes; enals; secondary amine catalysis; synergistic catalysis.

A novel catalytic enantioselective methodol. based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal-Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations

Chemistry – A European Journal published new progress about Addition reaction, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cao, Yang; Aimaiti, Abudumijiti; Zhu, Zeyun; Zhou, Lu; Ye, Deyong published the artcile< Discovery of Novel 3-Hydroxyquinazoline-2,4(1H,3H)-Dione Derivatives: A Series of Metal Ion Chelators with Potent Anti-HCV Activities>, Application In Synthesis of 20776-50-5, the main research area is hydroxyquinazoline dione preparation mol docking anti HCV SAR; metal chelator; NS5B; anti-HCV; chelator; hydroxyquinazolinedione; synthesis.

Millions of people worldwide suffer from acute or chronic liver inflammation caused by the Hepatitis C virus (HCV). Some inhibitors with metal ion chelating structures have been proven to have good inhibitory activities on non-structural protein 5B (NS5B) polymerase. However, most of the reported metal ion chelators showed poor anti-HCV potency at the cellular level. Hence, authors designed and synthesized a series of 3-hydroxyquinazoline-2,4(1H,3H)-dione derivatives with novel metal ion chelating structures. Few compounds such as compound I, [R = 4-(trifluoromethyl)phenyl, 3-nitrophenyl, benzofuran-2-yl] showed better anti-HCV activities than ribavirin with EC50 values less than 10μM. Compound I [R = benzofuran-2-yl] is currently known as one of the metal ion chelators with the best anti-HCV potency (EC50 = 2.0μM) at the cellular level and has a better therapeutic index (TI > 25) as compared to ribavirin. In the thermal shift assay, the representative compounds 3-hydroxy-7-phenylquinazoline-2,4(1H,3H)-dione and 3-hydroxy-7-(3-nitrophenyl)quinazoline-2,4(1H,3H)-dione increased the melting temperature (Tm) of NS5B protein solution by 1.6°C and 2.1°C, resp., at the test concentration, indicating that these compounds may exert an anti-HCV effect by targeting NS5B. This speculation was also supported by mol. docking studies and UV-visible (UV-Vis) spectrophotometry assay, in which the possibility of binding of 3-hydroxyquinazoline-2,4(1H,3H)-diones with Mg2+ in the NS5B catalytic center was observed

International Journal of Molecular Sciences published new progress about Alkylation. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Application In Synthesis of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Sha; Zhang, Xiulan; Wei, Wei; Liu, Jingbo; Xiong, Lixia; Yang, Na; Li, Zhengming published the artcile< Design, synthesis and biological activities of novel trifluoromethylated phthalic acid diamides derivatives>, Reference of 82-73-5, the main research area is design synthesis trifluoromethyl phthalic acid diamide agrochem larvicides.

In order to find efficient, eco-friendly lead compounds, 10 novel phthalic acid diamide derivatives containing two trifluoromethylated aromatic amine moieties were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, HRMS and elemental anal. Their insecticidal activities against oriental armyworms and diamondback moths were also evaluated. The preliminary results of biol. evaluation showed that most compounds exhibited moderate to high larvicidal activity. These results provided further insights into the relationship between the structures and biol. activity.

Youji Huaxue published new progress about Agrochemicals. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Reference of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Zhaofeng; Zhao, Kun; Fu, Junkai; Zhang, Junlin; Yin, Weiyu; Tang, Yefeng published the artcile< Organocatalytic 1,4-conjugate addition of ascorbic acid to α,β-unsaturated aldehydes: bio-inspired total syntheses of leucodrin, leudrin and proposed structure of dilaspirolactone>, Quality Control of 3893-18-3, the main research area is crystal mol structure spirodilactone core ascorbylated natural product; leucodrin leudrin preparation ascorbylated natural product.

The organocatalytic additions of ascorbic acid to various α,β-unsaturated aldehydes via tandem 1,4-conjugate addition/hemiacetalization/hemiketalization were developed, which provided a rapid entry into the 5-5-5 spirodilactone cores of a family of ascorbylated natural products. Based on the described chem., total syntheses of leucodrin, leudrin and the proposed structure of dilaspirolactone were achieved.

Organic & Biomolecular Chemistry published new progress about Acetalization (hemi). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Quality Control of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rotbergs, J.; Oskaja, V. published the artcile< Condensation of 3-bromophthalic anhydride with β-dicarbonyl compounds>, Safety of 4-Bromoisobenzofuran-1,3-dione, the main research area is phthalic anhydride condensation; bromo indandionecarboxylic acid; dicarbonyl compound condensation.

3-Bromophthalic anhydride (I) condensed with AcCH2CO2Et in Ac2O-Et3N gave 85.9% II. Ir spectra of condensation products of I with AcCH2Ac, BzCH2Ac, BzCH2Bz, and CH2(CO2Et)2 were compared.

Uch. Zap. Latv. Univ. published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Safety of 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Hengchao; Chen, Hang; Zhou, Yang; Huang, Jin; Yi, Jundan; Zhao, Hongcai; Wang, Wei; Jing, Linhai published the artcile< Selective Synthesis of Z-Cinnamyl Ethers and Cinnamyl Alcohols through Visible Light-Promoted Photocatalytic E to Z Isomerization>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is cinnamyl ether alc diastereoselective photoisomerization iridium catalyst; allylic alcohols; cinnamyl ethers; iridium; isomerization; photocatalysis.

A photocatalytic E to Z isomerization of alkenes using an iridium photosensitizer under mild reaction conditions is disclosed. This method provides scalable and efficient access to Z-cinnamyl ethers and allylic alcs. in high yields with excellent stereoselectivity. Importantly, this method also provides a powerful strategy for the selective synthesis of Z-magnolol and honokiol derivatives possessing potential biol. activity.

Chemistry – An Asian Journal published new progress about Allyl ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yao; Liu, Yun-Qi; Hu, Le’an; Zhang, Xumu; Yin, Qin published the artcile< Asymmetric Reductive Amination/Ring-Closing Cascade: Direct Synthesis of Enantioenriched Biaryl-Bridged NH Lactams>, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate, the main research area is keto ester enantioselective ruthenium reductive amination ring closing cascade; chiral benzazepinone preparation.

We report here a Ru-catalyzed enantioselective synthesis of biaryl-bridged NH lactams through asym. reductive amination and a spontaneous ring-closing cascade from keto esters and NH4OAc with H2 as reductant. The reaction features broad substrate generality and high enantioselectivities (up to >99% ee). To showcase the practical utility, a highly enantioselective synthesis of 5-ethylindolobenzazepinone C, a promising antimitotic agent, has been rapidly completed. Furthermore, the amide group in the products enables versatile elaborations through directed C-H functionalization.

Organic Letters published new progress about Benzazepines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Fenghua; Chen, Cheng; Yang, Kailin; Xu, Yang; Liu, Xiaomei; Gao, Fan; Liu, He; Chen, Xia; Zhao, Qi; Liu, Xiang; Cai, Yan; Yang, Haitao published the artcile< Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus>, HPLC of Formula: 405931-46-6, the main research area is preparation Michael acceptor peptidomimetic porcine epidemic diarrhea virus protease.

Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role in viral replication. We solved the structure of PEDV Mpro complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing at. level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV Mpro. These compounds have potential as future therapeutics to combat PEDV infection.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, HPLC of Formula: 405931-46-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary