Tag: M.W=200-250

Wolff, Oliver; Waldvogel, Siegfried R. published the artcile< 3-substituted phthalic acid derivatives by Sonogashira coupling reaction>, Computed Properties of 82-73-5, the main research area is phthalic acid substituted preparation Sonogashira coupling reaction.

Phthalic acid derivatives with carbon substituents in position 3 are easily accessible by Sonogashira coupling reaction of the corresponding bromo derivative For reasonable conversions the phthaloyl moiety is masked as the N-phenylphthalimide, which can smoothly be converted into other phthalic acid derivatives For example, stirring 3-bromo-N-phenylphthalimide with oct-1-yne in DMF in the presence of Et3N, CuI, and bis(triphenylphosphine)palladium dichloride at 80° for 16 h gave 91% 3-(oct-1-ynyl)-N-phthalimide.

Synthesis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Wenyi; Shrestha, Mohini; Wang, Chenchen; Fang, Ke; Teng, Yaxin; Qu, Jingping; Chen, Yifeng published the artcile< Asymmetric synthesis of 3-benzyl and allyl isoindolinones by Pd-catalyzed dicarbofunctionalization of 1,1-disubstituted enamides>, Application of C7H4BrNO4, the main research area is disubstituted isoindolinone enantioselective preparation; boronic acid disubstituted enamide tandem Heck Suzuki palladium catalyst.

A palladium-catalyzed asym. synthesis of 3,3-disubstituted isoindolinones I [R = (E)-n-BuCH=CH, 3-thienyl, PMB, etc.; R1 = Bn, (CH2)2Ph, PMB; R2 = Me, iPr; R3 = H, 6-Cl, 5-NO2; etc.] via tandem Heck/Suzuki coupling of 1,1-disubstituted enamides with aryl/alkenyl boronic acids under mild reaction conditions was reported. This reaction exhibited both broad functional group tolerance and high enantioselectivity. The first dicarbo-functionalization of 1,1-disubstituted enamides to generate amide derivatives bearing quaternary stereocenters was reported. Finally, synthetic utility of this protocol was demonstrated by expedient synthesis of PI3K-delta inhibitor precursor.

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (enamides). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shintani, Ryo; Otomo, Haruka; Ota, Kensuke; Hayashi, Tamio published the artcile< Palladium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic Dibenzosiloles via Enantioselective C-H Bond Functionalization>, HPLC of Formula: 135999-16-5, the main research area is palladium catalyzed asym carbon hydrogen bond activation silylaryl triflate; dibenzosilole silicon stereogenic preparation; crystal structure dibenzosilole silicon stereogenic; mol structure dibenzosilole silicon stereogenic.

A Pd-catalyzed asym. synthesis of Si-stereogenic dibenzosiloles, e.g., 4-methoxy-5-tert-butyl-5-phenyl-5H-dibenzosilole, is developed through enantioselective C-H bond functionalization of prochiral 2-(arylsilyl)aryl triflates. High chemo- and enantioselectivities are achieved by employing a Josiphos-type ligand under mild conditions.

Journal of the American Chemical Society published new progress about Bidentate ligands Role: CAT (Catalyst Use), USES (Uses). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, HPLC of Formula: 135999-16-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Ming-Hui; Tu, Yong-Qiang; Tian, Jin-Miao; Zhang, Fu-Min; Wang, Shao-Hua; Zhang, Shi-Heng; Zhang, Xiao-Ming published the artcile< Asymmetric epoxidation of α,β-unsaturated aldehydes catalyzed by a spiro-pyrrolidine-derived organocatalyst>, COA of Formula: C9H7BrO, the main research area is epoxide preparation diastereoselective enantioselective; aldehyde unsaturated asym epoxidation spiro pyrrolidine organocatalyst.

The asym. epoxidation of α,β-unsaturated aldehydes R1R2C=CHCHO [R1 = CH3CH2, 4-ClC6H4, naphthalen-2-yl, etc.; R2 = H, CH3; R1R2 = -(CH2)4-], catalyzed by a spiro-pyrrolidine (SPD)-derived organocatalyst, has been accomplished with good diastereoselectivities (up to dr >20:1) and with high to excellent enantioselectivities (up to 99% ee).

Tetrahedron: Asymmetry published new progress about Alcohols, epoxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Boykin, David W.; Baumstark, Alfons L.; Kayser, Margaret M.; Soucy, Chantal M. published the artcile< Oxygen-17 nuclear magnetic resonance spectroscopic study of substituted phthalic anhydrides and phthalides>, Safety of 4-Bromoisobenzofuran-1,3-dione, the main research area is NMR oxygen phthalic anhydride phthalide.

17O chem. shift data (natural abundance) for 3-substituted phthalic anhydrides and 4- and 7-substituted phthalides in acetonitrile at 75° are reported. Steric interactions of substituents ortho to the carbonyl groups result in deshielding effects (9-22 ppm) relative to parent compounds regardless of the electronic character of the substituents. Factors contributing to the deshielding effects are discussed. The relationship between 17O chem. shifts and regiochem. of the phthalic anhydrides is discussed.

Canadian Journal of Chemistry published new progress about NMR (nuclear magnetic resonance). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Safety of 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tarnowicz, Stanislawa; Alsalahi, Waleed; Mieczynska, Ewa; Trzeciak, Anna M. published the artcile< Heck arylation of allyl alcohol catalyzed by Pd(0) nanoparticle>, Reference of 3893-18-3, the main research area is Heck arylation allyl alc palladium nanoparticle catalyzed; palladium nanoparticle preparation catalyst allyl alc Heck arylation.

Pd(0) nanoparticle ca. 2 nm in diameter were obtained by the reduction of PdCl2 and Pd(OAc)2 in water at 80° in the presence of a PVP-stabilizing polymer. Pd(0) NPs were successfully used in the Heck coupling of allyl alc. with iodo- and bromobenzenes. Iodobenzenes reacted under solventless conditions or in DMF solution producing 3-arylpropanals and 2-arylpropanals as the main products. The same products were obtained in the reaction of bromobenzene in TBAB as the reaction medium. The stability of Pd(0) NPs was evidenced in recycling experiments Similar Heck coupling results were also obtained with the palladium compounds PdCl2(cod) and Pd(OAc)2 under the same conditions.

Tetrahedron published new progress about Heck reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Darrah, Kristie; Wang, Ting; Cook, Ian; Cacace, Mary; Deiters, Alexander; Leyh, Thomas S. published the artcile< Allosteres to regulate neurotransmitter sulfonation>, Formula: C7H6BrNO, the main research area is SULT1A3 allosteric inhibitor catecholamine sulfonation; SULT1A3; allosteric regulation; allostery; catecholamine; dopamine; enzyme inhibitor; enzyme kinetics; enzyme mechanism; enzyme structure; epinephrine; inhibition; mechanism; neurotransmitter; norepinephrine; nuclear magnetic resonance (NMR); serotonin; spin label; sulfotransferase.

Catecholamine neurotransmitter levels in the synapses of the brain shape human disposition – cognitive flexibility, aggression, depression, and reward seeking – and manipulating these levels is a major objective of the pharmaceutical industry. Certain neurotransmitters are extensively sulfonated and inactivated by human sulfotransferase 1A3 (SULT1A3). To our knowledge, sulfonation as a therapeutic means of regulating transmitter activity has not been explored. Here, we describe the discovery of a SULT1A3 allosteric site that can be used to inhibit the enzyme. The structure of the new site is determined using spin-label-triangulation NMR. The site forms a cleft at the edge of a conserved ∼30-residue active-site cap that must open and close during the catalytic cycle. Allosteres anchor into the site via π-stacking interactions with two residues that sandwich the planar core of the allostere and inhibit the enzyme through cap-stabilizing interactions with substituents attached to the core. Changes in cap free energy were calculated ab initio as a function of core substituents and used to design and synthesize a series of inhibitors intended to progressively stabilize the cap and slow turnover. The inhibitors bound tightly (34 nm to 7.4μm) and exhibited progressive inhibition. The cap-stabilizing effects of the inhibitors were exptl. determined and agreed remarkably well with the theor. predictions. These studies establish a reliable heuristic for the design of SULT1A3 allosteric inhibitors and demonstrate that the free-energy changes of a small, dynamic loop that is critical for SULT substrate selection and turnover can be calculated accurately.

Journal of Biological Chemistry published new progress about Allosterism. 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Formula: C7H6BrNO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lux, Michaelyn C.; Boby, Melissa L.; Brooks, Joshua L.; Tan, Derek S. published the artcile< Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction>, Application In Synthesis of 81107-97-3, the main research area is diastereoselective synthesis bicyclic ether; palladium catalyzed oxidative cyclization cascade bicyclic ether synthesis.

Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates [e.g., I → II, (60% isolated) with complete cis-diastereoselectivity at ring junction and 4:1 dr (α/β) at vinyl side chain]. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Application In Synthesis of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Abt, Arthur F.; Hardy, J. Martin; Farmer, Chester J.; Maaske, Jessie D. published the artcile< Relation of vitamin C to scarlet fever, rheumatic infections and diphtheria in children>, HPLC of Formula: 82-73-5, the main research area is .

The ascorbic acid content of the blood plasma was significantly lowered in 76 patients with scarlet fever. Oral administration of ascorbic acid in large doses did not influence the course of the disease. The plasma ascorbic acid was not significantly altered in 17 patients with rheumatic fever, in 26 with acute rheumatic heart disease, in 2 with chorea or in 8 with acute pharyngeal diphtheria. High temperatures per se did not significantly lower the plasma ascorbic acid or increase its utilization in the body. Fever, accompanied by active infection, may cause an increased ascorbic acid utilization, which is reflected in a decrease in the plasma level and in urinary excretion.

American Journal of Diseases of Children published new progress about Blood plasma. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, HPLC of Formula: 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Yangyang; Chen, Chen; Li, Qiling; Liu, Yanbo; Wei, Ting; Liu, Youzhen; Zeng, Zebing; Bradshaw, Darren; Zhang, Bing; Huo, Jia published the artcile< Precise control of selective hydrogenation of α,β-unsaturated aldehydes in water mediated by ammonia borane>, Product Details of C9H7BrO, the main research area is unsaturated aldehyde selective hydrogenation ammonia borane catalyst.

Hydrogenation of unsaturated biomass in a control manner is highly desirable but challenging, especially under mild conditions. We here report selective hydrogenation of α,β-unsaturated aldehydes (UALs), featuring a precise control of all potential products by adjustment of the role of ammonia borane (AB) in transfer and/or catalytic hydrogenation. The hydrogenation can be readily operated in neat water without using any external H2-source, because AB as the H2-source is favorable in aqueous solution Impressively, unsaturated alcs. are prepared in 100% conversion by the room-temperature transfer hydrogenation of UALs with AB, while saturated aldehydes are obtained in 100% conversion and > 90% selectivity with high activity (i.e., turnover frequency = 0.98 s-1 for cinnamaldehyde), by the catalytic hydrogenation with H2 released from AB and Pd immobilized on two-dimensional metal organic layer. On the other hand, UALs can be completely converted into the saturated alcs. through a combination of transfer and catalytic hydrogenation in one pot. This strategy can be extended to more than 8 types of UALs, and provides a facile way to fine-control the selective hydrogenation of unsaturated compounds with competing bonds.

Applied Catalysis, B: Environmental published new progress about 3893-18-3. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary