Tag: M.W=200-250

Perez-Gomez, Marta; Herrera-Ramirez, Piedad; Bautista, Delia; Saura-Llamas, Isabel; Garcia-Lopez, Jose-Antonio published the artcile< Synthesis of Benzofused O- and N-Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C-C Cleavage of Cyclobutanols>, SDS of cas: 81107-97-3, the main research area is palladium catalyzed cascade carbopalladation alkylation alkyne cyclobutanol; benzofuranylvinyl palladium iodide complex preparation crystal structure; mol structure benzofuranylvinyl palladium iodide complex.

The authors report a Pd-catalyzed route to heterocycles bearing a tetrasubstituted alkene fragment. The authors’ approach merges the intramol. carbopalladation of tethered alkynes with an alkylation step produced by the C-C cleavage of cyclobutanol derivatives An alkenyl-Pd(II) intermediate was isolated and characterized by x-ray diffraction studies. The nature of the tethering alkynyl chain influences the E/Z stereochem. of the alkenyl fragment in the functionalized heterocycles.

Organometallics published new progress about Alkylation. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, SDS of cas: 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jin, Cong-Yang; Du, Ji-Yuan; Zeng, Chao; Zhao, Xian-He; Cao, Ye-Xing; Zhang, Xiang-Zhi; Lu, Xin-Yun; Fan, Chun-An published the artcile< Hypervalent iodine(III)-mediated oxidative dearomatizing cyclization of arylamines>, Application In Synthesis of 16426-64-5, the main research area is amido aryl amine iodane mediated oxidative dearomatizing spirocyclization; spiro lactam cyclohexadiene iminium preparation.

An oxidative dearomatizing cyclization of aryl amines promoted by iodobenzene bis(trifluoroacetate) [PhI(CF3CO2)2] was explored, leading to a novel synthetic approach to functionalized spirocyclic building blocks containing a structurally unique dieniminium moiety. This unprecedented methodol., featuring oxidative dearomatization and carbon-carbon bond-forming cyclization, to some extent, not only expands the synthetic potential of hypervalent iodine chem., but also enriches the oxidation chem. of arylamines.

Advanced Synthesis & Catalysis published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application In Synthesis of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ahmad, Maha; Gaumont, Annie-Claude; Durandetti, Muriel; Maddaluno, Jacques published the artcile< Direct Syn Addition of Two Silicon Atoms to a CC Triple Bond by Si-Si Bond Activation: Access to Reactive Disilylated Olefins>, Related Products of 81107-97-3, the main research area is syn addition silicon carbon triple bond activation disilylated olefin; stereoselective disilylated heterocycle preparation; crystal structure mol silylalkenyl silicon oxygen heterocycle preparation; cyclization; disilane; heterocycles; palladium; vinylsilane.

A catalytic intramol. silapalladation of alkynes affords, in good yields and stereoselectively, syn-disilylated heterocycles of different chem. structure and size. When applied to silylethers, this reaction leads to vinylic silanols that undergo a rhodium-catalyzed addition to activated olefins, providing the oxa-Heck or oxa-Michael products, depending on the reaction conditions.

Angewandte Chemie, International Edition published new progress about Addition reaction, stereoselective. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hynds, Hannah M.; Lemons, Holli E.; Willis, Jasmine D.; Bell, MarKayla J.; Bottcher, Sydney E.; Dye, Mei Lin N.; Echols, Emily T.; Garner, Edward L.; Hutchinson, Lauren E.; Phillips, Caleb M.; Stephens, Claudia P.; Gilbert, Thomas M.; Wilger, Dale J. published the artcile< Ni-Catalyzed Larock Indenone Annulation with Aliphatic- and Silyl-Substituted Alkynes Supported by Mechanistic Analysis>, Synthetic Route of 6942-39-8, the main research area is nickel catalyzed Larock annulation reaction ortho bromobenzoate alkyne; indenone derivative preparation.

A Ni-catalyzed annulation reaction to synthesize indenones is reported. The reaction provides high yields and regioselectivities when aliphatic- and silyl-substituted alkynes are employed. Both were challenging and underused substrate classes. Several mechanistic observations aided in the development of this reaction, including that β-hydride elimination is turnover-limiting for ortho-halogenated aldehyde substrates and that alkyne dissociation is rate-limiting for internal aliphatic alkynes. The authors anticipate that these methods will be rapidly adopted due to their synthetic ease and inherent versatility. The authors also anticipate that the mechanistic conclusions will inform further reaction development.

Organometallics published new progress about Alkynes Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Synthetic Route of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Dejiang; Tang, Ting; Zhang, Zhao; Le, Liyuan; Xu, Zhi; Lu, Hao; Tong, Zhou; Zeng, Dishu; Wong, Wai-Yeung; Yin, Shuang-Feng; Ghaderi, Arash; Kambe, Nobuaki; Qiu, Renhua published the artcile< Nickel- and Palladium-Catalyzed Cross-Coupling of Stibines with Organic Halides: Site-Selective Sequential Reactions with Polyhalogenated Arenes>, Application In Synthesis of 401-78-5, the main research area is chloro fluorophenyl tetrahydrodibenzoazastibocine preparation arylation aryl halide; crystal structure chloro fluorophenyl tetrahydrodibenzoazastibocine; mol structure chloro fluorophenyl tetrahydrodibenzoazastibocine; biphenyl preparation; arylstibine preparation coupling reaction aryl halide palladium nickel catalyst.

Herein, the authors disclose a general and efficient method for the synthesis of Sb-aryl and Sb-alkyl stibines by the Ni-catalyzed cross-coupling of halostibines with organic halides. The synthesized Sb-aryl stibines couple with aryl halides to give biaryls efficiently via Pd catalysis. Sequential reactions of stibines with polyhalogenated arenes bearing active C-I/C-Br sites and inactive C-Cl sites successfully proceeded, giving a variety of complex mols. with good site selectivity. Drugs such as diflunisal and fenbufen, as well as a fenofibrate derivative, were synthesized on gram scales in good yields, together with the high recovery of chlorostibine. Also, catalytic mechanisms are proposed based on the results of control experiments

ACS Catalysis published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application In Synthesis of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chidananda, N.; Poojary, Boja; Sumangala, V.; Kumari, N. Suchetha; Shetty, Prashanth; Arulmoli, T. published the artcile< Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles>, Category: bromides-buliding-blocks, the main research area is disubstituted triazolothiadiazole dihydrodisubstituted triazolothiadiazole synthesis antiinflammatory analgesic antioxidant antimicrobial; amino bromo methoxyphenyl dihydro triazolethione cyclocondensation carboxylic acid aldehyde; bromomethoxy benzoic acid cyclization hydrazone Mannich reaction condensation.

Two new series of compounds namely, 3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (I) (R1 = 4-methoxy Ph, 4-Me Ph, Ph, 3,5-dichlorophenyl, 4-aminophenyl, 3,5 -dimethyl Ph, 4-nitro Ph, 3,5 -dinitro Ph, 2-hydroxy-4-Me Ph, 2,4 -diiodo phenyl) and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (II) (R1 = 2-chloro Ph, Ph, 4-chloro Ph, 3-chlorophenyl, 2,4-dimethoxy Ph, 4-methoxy Ph, 2-methoxy Ph, 4-nitro Ph, biphenyl, 4-Me phenyl) were prepared In continuation of a previously reported study, the first series I were synthesized by the cyclocondensation of 4-amino-5-(2-bromo-5-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (III) with various substituted aromatic carboxylic acids in phosphorus oxychloride and the second series I by the reaction of III with various substituted aromatic aldehydes in the presence of p-Toluene sulfonic acid. Reaction of III with the aldehyde (IV) afforded the Schiff’s base (V) and not the cyclized product on treatment with p-Toluene sulfonic acid. Synthesized compounds were structurally confirmed by spectral anal. and studied for their anti-inflammatory, analgesic, anti-oxidant and antimicrobial activities. Some of the tested compounds showed significant pharmacol. activities.

European Journal of Medicinal Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moon, Patrick J.; Yin, Shengkang; Lundgren, Rylan J. published the artcile< Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis>, Related Products of 14062-30-7, the main research area is monoaryl acetate preparation; decarboxylative arylation coupling arylboron nucleophile malonic acid.

We report decarboxylative carbonyl α-arylation by coupling of arylboron nucleophiles with malonic acid derivatives This process is enabled by the merger of aerobic oxidative Cu catalysis with decarboxylative enolate interception reminiscent of malonyl-CoA reactivity in polyketide biosynthesis. This method enables the synthesis of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible with existing α-arylation reactivity paradigms. The utility of the reaction is demonstrated in drug intermediate synthesis and late-stage functionalization.

Journal of the American Chemical Society published new progress about Arylation. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Related Products of 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Albano, Gianluigi; Colli, Tony; Biver, Tarita; Aronica, Laura Antonella; Pucci, Andrea published the artcile< Photophysical properties of new p-phenylene- and benzodithiophene-based fluorophores for luminescent solar concentrators (LSCs)>, COA of Formula: C8H5BrS2, the main research area is photophys property phenylene benzodithiophene based fluorophore luminescent solar concentrator.

In this study, we report on the synthesis of new organic fluorophores containing either the p-phenylene or the benzodithiophene cyclic nucleus connected to thiophene units via triple bonds and carbonyl group, and on their application for the fabrication of luminescent solar concentrators (LSCs). Their optical properties were evaluated. Independent of the core, dyes containing the CO-thiophene residues seem to be the most promising for LSCs applications. In fact, carbonyl groups slightly enhance the quantum yield but significantly increase the red-shift of the emission so that the superimposition between the absorbance spectrum and the emission one is diminished. In the case of the benzodithiophene center, light emission in the yellow-red portion of the spectrum is achieved. The latter dye is then selected for tests in a poly(Me methacrylate) (PMMA) matrix. It showed good compatibility and homogenous distribution, no auto-absorption phenomena, and optical efficiencies of about 8% at 1 weight %, i.e. comparable with those PMMA/Lumogen Red films in the same range of concentration

Dyes and Pigments published new progress about Fluorescent substances. 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, COA of Formula: C8H5BrS2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Garcia-Rodriguez, Jose; Mendiratta, Saurabh; White, Michael A.; Xie, Xiao-Song; De Brabander, Jef K. published the artcile< Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs>, HPLC of Formula: 6942-39-8, the main research area is salicylihalamide synthesis anticancer antiviral structure activity relationship; VATPase inhibitor salicylihalamide analog preparation; Anticancer; Antiviral; Benzolactone; Salicylihalamide; V-ATPase.

An efficient total synthesis of the potent V-ATPase inhibitor saliphenylhalamide (SaliPhe), a synthetic variant of the natural product salicylihalamide A (SaliA), has been accomplished aimed at facilitating the development of SaliPhe as an anticancer and antiviral agent. This new approach enabled facile access to derivatives for structure-activity relationship studies, leading to simplified analogs that maintain SaliPhe’s biol. properties. These studies will provide a solid foundation for the continued evaluation of SaliPhe and analogs as potential anticancer and antiviral agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, HPLC of Formula: 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schmidt, Olivia P.; Blackmond, Donna G. published the artcile< Temperature-Scanning Reaction Protocol Offers Insights into Activation Parameters in the Buchwald-Hartwig Pd-Catalyzed Amination of Aryl Halides>, HPLC of Formula: 401-78-5, the main research area is temperature scanning reaction protocol Buchwald Hartwig amination activation parameter.

A temperature-scanning reaction (TSR) protocol allows deconvolution of the driving forces of concentration and temperature in a single experiment, demonstrated here for the Buchwald-Hartwig amination reaction using different amine substrates that exhibit different rate-determining steps. An Eyring anal. reveals that the observed reactivity differences between 1-hexylamine and benzophenone hydrazone are related primarily to the different contributions of activation entropy in the two cases. This TSR protocol combined with other in situ kinetic methodologies including reaction progress kinetic anal. and variable time normalization anal. provides a rapid and comprehensive mechanistic picture of complex multistep catalytic reactions.

ACS Catalysis published new progress about Activation enthalpy. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, HPLC of Formula: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary