Tag: M.W=200-250

Shen, Sida; Benoy, Veronick; Bergman, Joel A.; Kalin, Jay H.; Frojuello, Mariana; Vistoli, Giulio; Haeck, Wanda; Van Den Bosch, Ludo; Kozikowski, Alan P. published the artcile< Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease>, Product Details of C9H8BrFO2, the main research area is histone deacetylase inhibitor neuroprotectant; Charcot−Marie−Tooth disease; Selective histone deacetylase 6 inhibitor; hydroxamic acid; mitochondrial axonal transport; mutant HSPB1-expressing DRG neurons; tubulin acetylation.

Charcot-Marie-Tooth (CMT) disease is a disorder of the peripheral nervous system where progressive degeneration of motor and sensory nerves leads to motor problems and sensory loss and for which no pharmacol. treatment is available. Recently, it has been shown in a model for the axonal form of CMT that histone deacetylase 6 (HDAC6) can serve as a target for the development of a pharmacol. therapy. Therefore, the authors aimed at developing new selective and activity-specific HDAC6 inhibitors with improved biochem. properties. By utilizing a bicyclic cap as the structural scaffold from which to build upon, the authors developed several analogs that showed improved potency compared to tubastatin A while maintaining excellent selectivity compared to HDAC1. Further screening in N2a cells examining both the acetylation of α-tubulin and histones narrowed down the library of compounds to three potent and selective HDAC6 inhibitors. In mutant HSPB1-expressing DRG neurons, serving as an in vitro model for CMT2, these inhibitors were able to restore the mitochondrial axonal transport deficits. Combining structure-based development of HDAC6 inhibitors, screening in N2a cells and in a neuronal model for CMT2F, and preliminary ADMET and pharmacokinetic profiles, resulted in the selection of compound I that possesses improved biochem., functional, and druglike properties compared to tubastatin A.

ACS Chemical Neuroscience published new progress about Charcot-Marie-Tooth disease. 128577-47-9 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Product Details of C9H8BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mondragon, Alexander; Monsalvo, Ivan; Regla, Ignacio; Castillo, Ivan published the artcile< 2,4-Bis(fluorocarbon)-substituted phenols for high yield Newman-Kwart rearrangement reactions>, Synthetic Route of 81107-97-3, the main research area is thiocarbamate biphenyl trifluoromethyl preparation Newman Kwart thermal rearrangement hydrolysis; biphenylthiol trifluoromethyl preparation.

The Newman-Kwart thermal rearrangement of 2,4-disubstituted O-arylthiocarbamates I (R = Me, F3C, X = O, Z = S), prepared from the corresponding phenols, was reported. Clean conversion to the S-arylthiocarbamates I (R = Me, F3C, X = S, Z = O) in high yields was observed The rearrangement appears to be facilitated by the presence of electron-withdrawing substituents in the 2- and 4-positions of the aromatic ring.

Tetrahedron Letters published new progress about Carbamates Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (thio). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Synthetic Route of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ravindra, Barnala; Das, Braja Gopal; Ghorai, Prasanta published the artcile< Organocatalytic, Enantioselective, Intramolecular Oxa-Michael Reaction of Alkoxyboronate: A New Strategy for Enantioenriched 1-Substituted 1,3-Dihydroisobenzofurans>, Computed Properties of 89003-95-2, the main research area is chalcone formyl pinacolborane squaramide organocatalyst reduction intramol oxa Michael; dihydroisobenzofuran stereoselective preparation.

An unprecedented strategy for the synthesis of enantioenriched 1-substituted 1,3-dihydroisobenzofurans via an enantioselective oxa-Michael reaction of o-alkoxyboronate containing chalcone has been accomplished employing cinchona alkaloid based squaramide bifunctional organocatalyst in the presence of proton source. The corresponding alkoxyboronate intermediates have been readily prepared in situ from o-formyl chalcones using neutral borane as hydride source and a tertiary amine moiety which is a counterpart of the catalyst.

Organic Letters published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Computed Properties of 89003-95-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Belokon’, Yuri N.; Davies, R. Gareth; Fuentes, Jose A.; North, Michael; Parsons, Teresa published the artcile< The influence of imine structure, catalyst structure and reaction conditions on the enantioselectivity of the alkylation of alanine methyl ester imines catalyzed by Cu(ch-salen)>, Application In Synthesis of 81107-97-3, the main research area is alaninate imine preparation stereoselective alkylation copper salen catalyst.

Systematic variation of the substrate structure has shown that the most effective substrates for Cu(ch-salen)-catalyzed asym. enolate alkylation reactions carried out under phase-transfer conditions are the p-chlorophenyl imines of amino esters. The other reaction parameters (solvent and stirring speed) have also been optimized. The introduction of substituents onto the aryl rings of the salen ligand was found not to have a beneficial effect on the enantioselectivity of the reaction.

Tetrahedron Letters published new progress about Alkylation catalysts. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Application In Synthesis of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Namba, Tomoya; Hayashi, Yoshihiro; Kawauchi, Susumu; Shibata, Yu; Tanaka, Ken published the artcile< Rhodium-Catalyzed Cascade Synthesis of Benzofuranylmethylidene-Benzoxasiloles: Elucidating Reaction Mechanism and Efficient Solid-State Fluorescence>, Category: bromides-buliding-blocks, the main research area is rhodium catalysis cascade cycloisomerization bisethynylphenolsilane; benzofuranylmethylidenebenzoxasilole preparation mol modeling solid state fluorescence; fluorescence; isomerization; organosilicon compounds; rearrangement; rhodium; solid-state structures.

A new synthetic route to highly fluorescent benzofuranylmethylidenebenzoxasiloles through cationic rhodium(I)/binap complex-catalyzed cascade cycloisomerization of bis(2-ethynylphenol)silanes has been developed involving 1,2-silicon and 1,3-carbon (alkyne) migrations followed by oxycyclization. The present synthesis requires only three steps, starting from com. available dichlorodiisopropylsilane, which is markedly shorter than our previous synthesis (eight steps starting from com. available chlorodiisopropylsilane). Theor. calculations elucidated the mechanism of the above cascade cycloisomerization. This reaction is initiated by the formation of a rhodium vinylidene not through direct 1,2-silicon migration but rather through an unprecedented stepwise 1,5-silicon migration followed by C-Si bond-forming cyclization from a dearomatized allenylrhodium complex. Subsequent 1,3-carbon (alkyne) migration leading to a η3-allenyl/propargyl-rhodium complex followed by oxycyclization through π-bond (alkyne) activation with the cationic rhodium(I) complex affords the benzofuranylmethylidenebenzoxasilole product, e.g. I. The structure-fluorescence property relationships of the thus obtained benzofuranylmethylidenebenzoxasiloles were investigated, which revealed that good fluorescence quantum yields were generated in the solution state (φF=69-87 %) by introduction of electron-donating alkyl and Ph groups on two phenoxy groups. In the powder state, 4-methyl- and 4-methoxy-phenoxy derivatives exhibited efficient blue fluorescence (φF=52 % and 46 %, resp.). Especially, the 4-methylphenoxy derivative was thermally stable, and exhibited strong narrow-band fluorescence in the film state (blue, φF=95 %) and red shifted strong narrow-band fluorescence (green, φF=90 %) in the crystalline state as a result of the formation of an offset π-stacked dimer; the latter was confirmed by X-ray crystallog. anal. and by theor. calculations

Chemistry – A European Journal published new progress about Cycloisomerization. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Umekubo, Nariyoshi; Iwata, Ryohei; Hayashi, Yujiro published the artcile< One-pot Synthesis of Chiral cis-Hydrindanes via Diphenylprolinol Silyl Ether Mediated Domino Reaction and Aldol Condensation>, Category: bromides-buliding-blocks, the main research area is hydrindane preparation enantioselective; cyclopentanone enantioselective preparation aldol condensation acid catalyst; unsaturated aldehyde hexene dione domino Michael ether mediated.

Substituted chiral hydrindanes I [R = CO2Et, Ph, 2-BrC6H4, eyc.] were synthesized as single isomers in almost enantiopure forms through a one-pot process that proceeded via the diphenylprolinol silyl ether mediated-domino Michael/Michael reaction of α,β-unsaturated aldehydes and 3-hexene-2,5-dione, and a subsequent intramol. aldol condensation of the generated cyclopentanone intermediate.

Chemistry Letters published new progress about Aldol condensation catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alba, Andrea-Nekane; Companyo, Xavier; Moyano, Albert; Rios, Ramon published the artcile< Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β-Unsaturated Aldehydes>, Safety of 3-(4-Bromophenyl)acrylaldehyde, the main research area is unsaturated aldehyde fluorobisphenylsulfonyl methane chiral diphenylprolinol TMS ether; enantioselective nucleophilic addition fluorobisphenylsulfonylmethyl aldehyde stereoselective preparation reduction oxidation; reductive amination alc carboxylic acid amine stereoselective preparation; esterification reductive desulfonylation ester fluoroalc stereoselective preparation; oxidation fluoroaldehyde stereoselective preparation DEAD amination reduction aminoalc; nucleophilic addition enantioselective catalyst chiral diphenylprolinol TMS ether.

The first organocatalytic enantioselective fluoro(bisphenylsulfonyl)methylation od α,β-unsaturated aldehydes in high yields and enantioselectivities was described. The resulting compounds were converted into a wide range of derivatives to show the applicability of this new methodol. Moreover, valuable 4-fluoro-2-amino-1-alkanol that can be easily transformed to fluoroaminoacids or fluoroaminoalcs. by know procedures was synthesized.

Chemistry – A European Journal published new progress about Aldehydes, halo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Safety of 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Wei; Zeng, Qiang; Chen, Weiming published the artcile< Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329>, COA of Formula: C7H4BrF3O, the main research area is protein tyrosine phosphatase receptor allosteric inhibitor preparation antitumor activity.

NAZ2329 is the first cell-permeable small mol. allosteric inhibitor of protein tyrosine phosphatase receptor-type Z (PTPRZ), which was considered as a new potential mol. target for drug development in glioblastoma. A facile and high-efficient synthesis of NAZ2329 was developed by a straight-forward strategy starting from key ethoxy benzyl bromide intermediate obtained from com. available 4-(trifluoromethyl)phenol.

Russian Journal of General Chemistry published new progress about Antitumor agents. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, COA of Formula: C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hung, Vu Thai; Tran, Cong Chi; Yamamoto, Yuki; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya published the artcile< Clarification on the Reactivity of Diaryl Diselenides toward Hexacyclohexyldilead under Light>, HPLC of Formula: 401-78-5, the main research area is aryl cyclohexyl selenide preparation; diaryl diselenide hexacyclohexyldilead light irradation; diaryl dichalcogenides; hexacyclohexyldilead; homolytic substitution; photoirradiation.

In this study, the reactivity of organochalcogen compounds toward a representative alkyl-lead bond compound under light was investigated in detail. Under light irradiation, the Cy-Pb bond of Cy6Pb2 (Cy = cyclohexyl) undergoes homolytic cleavage to generate a cyclohexyl radical (Cy·). This radical can be successfully captured by di-Ph diselenide, which exhibits excellent carbon-radical-capturing ability. In the case of (PhS)2 and (PhTe)2, the yields of the corresponding cyclohexyl sulfides and tellurides were lower than that of (PhSe)2. This probably occurred due to the low carbon-radical-capturing ability of (PhS)2 and the high photosensitivity of the cyclohexyl-tellurium bond.

Molecules published new progress about Diselenides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, HPLC of Formula: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Davies, David L.; Singh, Kuldip; Tamosiunaite, Neringa published the artcile< Steric effects on acetate-assisted cyclometallation of meta-substituted N-phenyl and N-benzyl imidazolium salts at [MCl2Cp*]2 (M = Ir, Rh)>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is aryl benzyl meta substituted imidazolium cyclometalation preparation half sandwich; iridium rhodium half sandwich cyclometalated aryl benzyl imidazolylidene preparation; crystal mol structure iridium rhodium cyclometalated aryl benzyl imidazolylidene.

Meta-Substituted aryl and benzyl imidazolium salts [3-MeIm-1-(3-RC6H4)][OTf] (H2L-Ar) and [3-MeIm-1-(CH2-3-RC6H4)][OTf] (H2L-CH2Ar) undergo acetate-assisted cyclometalation to provide mixtures of ortho and para substituted cyclometalated complexes [(L-C2,C2′)ClMCp*] and [(L-C2,C6′)ClMCp*], resp. (L = LAr, L-CH2Ar). The effect of the substituents on the isomer ratios is discussed; steric effects are more important in the 6-membered rings derived from the N-benzyl imidazolium salts than 5-membered rings from the N-Ph salts. Comparisons are made to steric effects with some other common directing groups.

Dalton Transactions published new progress about Carbene complexes, N-heterocyclic, transition metal complexes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (cyclometalated). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary