Tag: M.W=200-250

Mao, Weizhong; Liu, Junhua; Yin, Bingqian; Miao, Shiwen; Li, Yafei; Kong, Deyu; Wang, Fang published the artcile< Co-Cr composite oxides efficiently catalyzed transfer hydrogenation of α, β-unsaturated aldehydes via N-doped carbon and interfacial electron migration>, Name: 3-(4-Bromophenyl)acrylaldehyde, the main research area is chromium copper oxide carbon catalyst cinnamaldehyde catalytic hydrogen transfer.

We present a simple catalyst preparation route, that is spinel-structured CoCrOx (1:2) loaded on N-doped carbon (CoCrOx (1:2)-CN). The as-synthesized CoCrOx (1:2)-CN catalyst promoted catalytic hydrogen transfer (CTH) of cinnamaldehyde (CMA), affording cinnamyl alc. (CMO) yield as high as 95.3% under mild reaction conditions. There are several reasons for the high yield of CMA: (a) Through interfacial electron migration and N-doped carbon, the acidity and basicity of mesoporous CoCrOx (1:2)-CN catalyst were enhanced, thereby achieving optimal acid-base synergy. (b) Kinetic studies indicated that spinel-structure and N-doped carbon could increase the reaction rate and achieve a low activation energy (69.2 kJ/mol). (c) DFT calculations revealed that both pyridyl-N and pyrrolyl-N doping lowered the energy barrier for adsorption and desorption of reactants resulting in improved catalytic activity. In addition, the CoCrOx (1:2)-CN catalyst showed good reusability.

Molecular Catalysis published new progress about Activation energy. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Name: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Singh, Avineesh; Patel, Vijay K.; Rajak, Harish published the artcile< Appraisal of pyrrole as connecting unit in hydroxamic acid based histone deacetylase inhibitors: Synthesis, anticancer evaluation and molecular docking studies>, Reference of 3893-18-3, the main research area is pyrrole hydroxamic acid preparation SAR antitumor mol docking human; histone deacetylase inhibitor.

SAHA and its synthetic analogs has demonstrated potent antitumor activity against numerous human cancer lines and different classes of HDACs. The objective of present studies was to incorporate pyrrole as connecting unit in hydroxamic acid based HDAC inhibitors for their anticancer evaluation and mol. docking studies. A series of novel 4-substituted Me 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)hexanoate I (R = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and 4-substituted 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)-N-hydroxyhexanamide II were synthesized and were evaluated for their anticancer activity using in-vitro method against leukemia (K-562), lung (A-549), breast (MCF-7), and cervical (HeLa) human cancer cell lines using Sulforhodamine B (SRB) assay method, HDAC1 and HDAC6 inhibitory assay and binding mode anal. using mol. docking studies. Interestingly, p-nitro-substituted mol. produced a most active derivative in the series. The in-vitro anticancer study of synthesized compounds indicated that the unsubstituted Ph derivative, II (R = Ph) have moderate antitumor activity against K-562 human leukemia cell line. Substitution at 4-Ph ring with weak and moderate electron withdrawing groups, such as fluoro, chloro, and bromo potentiated the cytotoxic activity. Compounds II were docked against different HDAC proteins to determine the exact binding mode and orientation. These studies can be further employed for the design and development of novel SAHA analogs with promising anticancer activity.

Journal of Molecular Structure published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carullo, Gabriele; Mazzotta, Sarah; Giordano, Francesca; Aiello, Francesca published the artcile< Green synthesis of new pyrrolo [1,2-a] quinoxalines as antiproliferative agents in GPER-expressing breast cancer cells>, Computed Properties of 51605-97-1, the main research area is pyrroloquinoxaline GPER breast cancer antiproliferative activity.

4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biol. properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER). In this work, the synthesis and preliminary antiproliferative activity of a small set of new 4,5-dihydropyrrolo[1,2-a]quinoxalines (18-20) and pyrrolo[1,2-a]quinoxalines (21, 22) has been reported, inspired by known antiproliferative agents (G-1, G-15, and G-36). The synthesis of the pyrroloquinoxalinic core was employed following the Pictet-Spengler reaction, using the surfactant p-dodecylbenzene sulfonic acid (p-DBSA), as catalyst. It demonstrated efficiency in the catalysis of the 4-phenylpyrrole [1,2-a] quinoxaline type compound formation in mild solvents such as water, ethanol, and hydroalcoholic solutions In addition, the reactions proceeded in a short time (between 15 and 120 min) at room temperature and with high yields. The in vitro MTT assays showed that the presence of iso-Pr groups furnished promising antiproliferative compounds Although, the acetyl group provided also antiproliferative effects, breaking down its responsibility in the GPER transactivation. Nevertheless, it is possible to conclude that the 4,5-dihydropyrrolo[1,2-a]quinoxalines remain a feasible scaffold to develop anticancer agents against GPER-expressing cells.

Journal of Chemistry published new progress about Antiproliferative agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Computed Properties of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jorgensen, P. Fischer published the artcile< A mathematical-statistical analysis of titration errors in the determination of ascorbic acid of serum by use of the 2,6-dichlorophenolindophenol method>, Computed Properties of 82-73-5, the main research area is .

373 determinations of ascorbic acid in serum were made, using a slight modification of the method of Farmer and Abt (cf. C.A. 30, 8273.5). The results are divided into 6 groups and the standard deviation determined for each group. The possible sources of error are investigated. Two types of errors can be distinguished: Group (a) comprises the exptl. errors. In this group the standard deviation is constant Group (b) is associated with the chemistry of the analytical method, and the standard deviation is found to be directly proportional to the ascorbic acid concentration The chem. significance of these errors is discussed.

Dansk Tidsskrift for Farmaci published new progress about Blood. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ibrahem, Ismail; Breistein, Palle; Cordova, Armando published the artcile< One-Pot Three-Component Catalytic Enantioselective Synthesis of Homoallylboronates>, Application of C9H7BrO, the main research area is copper catalyzed asym reaction diboron unsaturated aldehyde triphenylphosphoranylidene ester; enantioselective synthesis homo allyl boronate.

Authors have developed an efficient, novel one-pot three-component enantioselective reaction between a diboron reagent, α,β-unsaturated aldehydes, and 2-(triphenylphosphoranylidene)acetate esters. The asym. multicomponent reaction proceeds through a β-boration/Wittig sequence to give the corresponding homoallylboronates with high enantiomeric ratios using simple bench-stable chiral amines and copper catalysts. In addition, the study shows that it is possible to merge the catalytic cycles of transition-metal-catalyzed nucleophilic activation of diboron reagents with amine-catalyzed iminium activation of enals to achieve a highly 1,4- and enantioselective β boration of enals. The one-pot expansion of the cocatalytic three-component reaction to the asym. synthesis of homoallylic alcs. was also disclosed. Further development of this type of one-pot multicomponent cocatalytic asym. reaction and its application in total synthesis is ongoing in authors laboratories Thus, three-component trimethylsilyl substituted pyrrolidine amine/PPh3/Cu(OTf)2-catalyzed reaction of cinnamaldehyde with B2pin2 and Ph3P:CHCO2Et in MeOH/Et2O followed by treatment with 2-fluorobenzoic acid gave 65% (S,E)-Et 5-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pent-2-enolate stereoselectively.

Angewandte Chemie, International Edition published new progress about Amines, chiral Role: CAT (Catalyst Use), USES (Uses). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pave, Gregoire; Leger, Jean-Michel; Jarry, Christian; Viaud-Massuard, Marie-Claude; Guillaumet, Gerald published the artcile< Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy>, COA of Formula: C7H7BrO2, the main research area is asym synthesis spirocyclic aminochroman derivative cyano phenyl oxazolopiperidine substitution; crystal structure absolute configuration aminochroman derivative benzopyran piperidine.

Enantiomerically pure (3’R)- and (3’S)-3′,4′-dihydrospiro[piperidine-2,3′(2’H)-benzopyran]s I (R = H) and II (R = H) were successfully synthesized according to the CN(R,S) methodol. with the aim of serving as a pattern for the generation of related spirocyclic compounds Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine III. One of them was selected and used for the preparation of amines I (R = OMe) and II (R = OMe) starting from III and IV, resp. The enantiomeric purity of all final aminochroman derivatives was determined by capillary electrophoresis using β-cyclodextrin as the chiral selector.

Journal of Organic Chemistry published new progress about Absolute configuration. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, COA of Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ozols, J.; Vanags, G. published the artcile< Bromo-3-ethylidenephthalide and its transformations>, Reference of 82-73-5, the main research area is phthalides bromo; bromo phthalides; ketone aromatic.

A mixture of 7 g. 4-bromophthalic anhydride, 4.4 g. (EtCO)2O and 1.6 g. dry EtCO2Na was heated 3 hrs. at 170-80° and poured into 75 ml. H2O to yield 61% bromo-3-ethylidenephthalide (I), m. 115-16° (CCl4). With alkalis, I did not isomerize, but formed bromopropiophenone-o-carboxylic acid (II) which appeared in a tautomer form as 3-hydroxy-3-ethylbromophthalide (III). To 0.85 g. I in 20 ml. MeOH was added MeONa prepared from 0.08 g. Na and 2 ml. MeOH, and the mixture heated on a water bath 0.5 hr. and worked up to give 0.5 g. III m. 114-15° (EtOH). Similarly, III was obtained from I and 10% KOH. 10 references.

Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Reference of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moon, Patrick J.; Fahandej-Sadi, Anis; Qian, Wenyu; Lundgren, Rylan J. published the artcile< Decarboxylative Benzylation of Aryl and Alkenyl Boronic Esters>, Application of C10H11BrO2, the main research area is aryl boronic ester arylacetate potassium copper decarboxylative benzylation catalyst; alkenyl boronic ester arylacetate potassium copper decarboxylative benzylation catalyst; copper arylacetate aryl boronic ester potassium acetate decarboxylative benzylation; diarylmethane preparation; aerobic catalysis; boron; copper; cross-coupling; decarboxylation.

The copper-catalyzed decarboxylative benzylation of aryl and alkenyl boronic esters with electron-deficient aryl acetates is reported. The oxidative coupling proceeds under mild, aerobic conditions and tolerates a host of potentially reactive electrophilic functional groups that would be problematic with traditional benzylation methods (aryl iodides and bromides, protic heteroatoms, aldehydes, Michael acceptors). A reaction pathway in which a benzylic nucleophile is generated by aryl acetate decarboxylation and in turn is intercepted by the catalyst to form diarylmethane products is supported by mechanistic studies.

Angewandte Chemie, International Edition published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation) (diarylmethane). 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Application of C10H11BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Siddiqui, I. R.; Rahila; Rai, Pragati; Sagir, Hozeyfa; Waseem, Malik A. published the artcile< Molecular iodine catalysed domino cyclization in aqueous medium: a simple and efficient synthetic route to 1,4-dihydropyridazines>, Formula: C9H7BrO, the main research area is dihydropyridazine preparation green chem; benzylidene phenylhydrazine unsaturated aldehyde cyclization iodine catalyst.

A facile, efficient and environmentally friendly approach has been developed for the diverse synthesis of 1,4-dihydropyridazines I (R = Ph, 4-ClC6H4, 4-MeOC6H4, 1-naphthyl, 4-bromonaphthyl; R1 = Me, Ph, 4-NCC6H4, 3-O2NC6H4, etc.) from (E)-2-benzylidene-1-phenylhydrazines and α,β-unsaturated aldehydes under aqueous condition using mol. iodine as a green and recoverable catalyst. This procedure features low cost and easily available starting materials, an inexpensive and recoverable catalyst, short reaction time, reliable scalability, excellent yield and mild reaction conditions, as well as use of aqueous medium. The scope of this method was thoroughly explored under three different reaction conditions resulting in the generation of a library of title compounds In view of the various advantages of the present investigation, this methodol. gives a convenient and straightforward pathway to construct 1,4-dihydropyridazines in an eco-friendly fashion.

RSC Advances published new progress about Cyclization. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jensen, Kim L.; Poulsen, Pernille H.; Donslund, Bjarke S.; Morana, Fabio; Joergensen, Karl Anker published the artcile< Asymmetric Synthesis of γ-Nitroesters by an Organocatalytic One-Pot Strategy>, Reference of 3893-18-3, the main research area is unsaturated aldehyde nitroalkane diphenyltrimethylsilyloxymethylpyrrolidine enantioselective Michael addition oxidative esterification; gamma arylnitroester Baclofen piperidone stereoselective preparation; enantioselective Michael addition oxidative esterification catalyst diphenyl trimethylsilyloxymethyl pyrrolidine.

An enantioselective synthesis of γ-nitroesters by a one-pot asym. Michael addition/oxidative esterification of α,β-unsaturated aldehydes is presented. The procedure is based on merging the enantioselective organocatalytic nitroalkane addition with an N-bromosuccinimide-based oxidation The γ-nitroesters are obtained in good yields and enantioselectivities, and the method provides an attractive entry to optically active γ-aminoesters, 2-piperidones, and 2-pyrrolidones.

Organic Letters published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary