Tag: M.W=200-250

Vogt, David B.; Seath, Ciaran P.; Wang, Hengbin; Jui, Nathan T. published the artcile< Selective C-F Functionalization of Unactivated Trifluoromethylarenes>, Reference of 401-78-5, the main research area is difluoroalkylarene preparation; trifluoromethylarene alkene photocatalytic alkylation.

Fluorinated organic mols. are pervasive within the pharmaceutical and agrochem. industries due to the range of structural and physicochem. properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl-CF2 functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a general method for the synthesis of aryl-CF2R and aryl-CF2H compounds through activation of the corresponding trifluoromethyl arene precursors. This strategy is enabled by an endergonic electron transfer event that provides access to arene radical anions that lie outside of the catalyst reduction potential. Fragmentation of these reactive intermediates delivers difluorobenzylic radicals that can be intercepted by abundant alkene feedstocks or a hydrogen atom to provide a diverse array of difluoalkylaroms.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Reference of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hansa, Raj KC.; Khan, M. M. K.; Frangie, M. M.; Gilmore, D. F.; Shelton, R. S.; Savenka, A. V.; Basnakian, A. G.; Shuttleworth, S. L.; Smeltzer, M. S.; Alam, M. A. published the artcile< 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents>, Application of C6H4BrClFN, the main research area is anilinomethyl phenyl pyrazolyl benzoic acid preparation antibacterial cytotoxicity SAR; Antibiotics; Antimicrobial; Enterococcus; MRSA; Pyrazole; Staphylococcus aureus; Toxicity.

A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl Ph derived pyrazoles I [R = HO(O)C, F3C; R1 = Ph, 3-bromophenyl, 5-iodopyridin-2-yl, etc.] was synthesized and tested for antibacterial activity. The majority of trifluoromethyl Ph derivatives are highly potent growth inhibitors of Gram-pos. bacteria and showed low toxicity to human cultured cells. In particular, two compounds I [R = F3C; R1 = 3-fluoro-5-(trifluoromethyl)phenyl, 3,5-dichloro-4-fluorophenyl] were selected for addnl. studies. These compounds were highly effective against Staphylococcus aureus as shown by a low min. inhibitory concentration (MIC), a bactericidal effect in time-kill assays, moderate inhibition of biofilm formation as well as biofilm destruction and a bactericidal effect against stationary phase cells representing non-growing persister cells. Multistep resistance assays showed a very low tendency for S. aureus and Enterococcus faecalis to develop resistance through mutation. Addnl., in vivo mouse model studies showed no harmful effects at doses up to 50 mg/kg using 14 blood plasma organ toxicity markers or TUNEL assay in liver and kidney. Investigations into the mode of action by performing macromol. synthesis inhibition studies showed a broad range of inhibitory effects, suggesting targets that have a global effect on bacterial cell function.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, Application of C6H4BrClFN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Taherinia, Zahra published the artcile< (ZrO)2Fe2O5 as an efficient and recoverable nanocatalyst in C-C bond formation>, Computed Properties of 401-78-5, the main research area is zirconium ferrite recoverable nanocatalyst carbon bond formation.

In this paper, the synthesis and characterization of zirconium ferrite ((ZrO)2Fe2O5) magnetic nanoparticles (MNPs) and their application as a catalyst in C-C cross-coupling reaction will be described. The structure of the catalyst was studied by Fourier transform IR spectroscopy (FT-IR), SEM, energy dispersive spectrometry (EDS), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), vibrating sample magnetometer (VSM) and ICP-OES anal. The resulting zirconium ferrite [(ZrO)2Fe2O5] was efficient for C-C coupling reactions, affording the desired products in good to excellent yields. Moreover, the catalyst could be easily recovered by magnetic separation and recycled for four times without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cha, Mi Young; Lee, Kwang-Ok; Kim, Jong Woo; Lee, Chang Gon; Song, Ji Yeon; Kim, Young Hoon; Lee, Gwan Sun; Park, Seung Bum; Kim, Maeng Sup published the artcile< Discovery of A Novel Her-1/Her-2 Dual Tyrosine Kinase Inhibitor for the Treatment of Her-1 Selective Inhibitor-Resistant Non-Small Cell Lung Cancer>, SDS of cas: 115843-99-7, the main research area is tyrosine kinase inhibitor quinazolinyl pyrrolidine preparation SAR.

A novel series of (S)-1-acryloyl-N-[4-(arylamino)-7-(alkoxy)quinazolin-6-yl]pyrrolidine-2-carboxamides were synthesized and evaluated as Her-1/Her-2 dual inhibitors. In contrast to the Her-1 selective inhibitors, our novel compounds are irreversible inhibitors of Her-1 and Her-2 tyrosine kinases with the potential to overcome clin. relevant, mutation-induced drug resistance. The selected compounds, 19c and 19d (I), showed excellent EGFR inhibition activity even toward the T790M mutation of Her-1 tyrosine kinase with excellent selectivity. The excellent pharmacokinetic profiles of these compounds in rats and their robust in vivo efficacy in an A431 xenograft model clearly demonstrate that they merit further investigation as novel therapeutic agents for EGFR-targeting treatment of solid tumors, especially Her-1 selective inhibitor-resistant non-small cell lung cancer.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, SDS of cas: 115843-99-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Kai-Wei; Hsu, Wen-Li; Chen, Cheng-Ru; Tsai, Ming-Hsien; Yen, Chia-Jung; Tseng, Chih-Hua published the artcile< Discovery of triazolyl thalidomide derivatives as anti-fibrosis agents>, Name: 4-(2-Bromoacetyl)benzoic acid, the main research area is triazolyl thalidomide derivative preparation antifibrosis activity.

Fibrosis with excessive accumulation of extracellular matrix (ECM) often causes progressive organ dysfunction and results in many inflammatory and metabolic diseases, including systemic sclerosis, pulmonary fibrosis, advanced liver disease and advanced kidney disease. The store-operated calcium entry (SOCE) pathway and the related signaling pathway were both found to be the important routes for fibrogenesis. Our aim in this study was to discover novel compounds to inhibit fibrogenesis. A number of triazolyl thalidomide derivatives were synthesized and evaluated for their anti-fibrosis activities. Compounds inhibited intracellular Ca2+ activation and showed no cytotoxicity. Among them, 6-{4-[(3-(1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}hexanoic acid ( I ) with the most potent inhibitory effect was chosen for further examination The results revealed that compound I, a SOCE inhibitor, reversed the migratory ability of TGF-β1-induced myofibroblasts, dedifferentiated myofibroblasts to fibroblasts due to cytoskeleton remodeling, and restrained myofibroblast activation by targeting Orai1 and TGF-β1/SMAD2/3 signaling pathways. The in silico study indicated that compound I, with the appropriate lipophilic carbon chain and carboxylic acid, showed a good drug-likeness model score. Conclusively, the SOCE inhibitor, compound I, is used as a promising lead compound for the development of a new treatment for fibrosis.

New Journal of Chemistry published new progress about Antifibrotic agents. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Name: 4-(2-Bromoacetyl)benzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Xin; Ang, Esther Cai Xia; Yang, Ziqi; Kee, Choon Wee; Tan, Choon-Hong published the artcile< Synthesis of chiral sulfinate esters by asymmetric condensation>, Application of C7H7BrO2S, the main research area is alc sulfinate pentanidium catalyst enantioselective condensation; sulfinate ester preparation.

Here a straightforward access to enantioenriched sulfinate esters via asym. condensation of prochiral sulfinates and alcs. using pentanidium as an organocatalyst was reported. This study successfully coupled a wide range of sulfinates and bioactive alcs. stereoselectively. The initial sulfinates was prepared from existing sulfone and sulfonamide drugs and the resulting sulfinate esters were versatile for transformations to diverse chiral sulfur pharmacophores. Through late-stage diversification 11,12 of celecoxib and other drug derivatives, was demonstrate the viability of this unified approach towards sulfur stereogenic centers.

Nature (London, United Kingdom) published new progress about Condensation reaction catalysts (stereoselective). 5751-83-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2S, Application of C7H7BrO2S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zhao-Ming; Shuai, Bin; Ma, Cong; Fang, Ping; Mei, Tian-Sheng published the artcile< Nickel-Catalyzed Electroreductive Syntheses of Triphenylenes Using ortho-Dihalobenzene-Derived Benzynes>, Product Details of C7H7BrO2, the main research area is triphenylene preparation regioselective; bromobenzene electroreductive reaction nickel catalyst.

Electrochem. nickel-catalyzed syntheses of triphenylenes e.g., I, by a reductive trimerization of ortho-dibromobenzenes e.g.., 5,6-dibromoindane or ortho-bromoarylsulfurofluoridates e.g., 2-bromo-4-fluorophenyl sulfurofluoridate, or by reductive cross-coupling of ortho-dibromobenzenes to 2,2′-diiodobiphenyls, were described. The former provides a practical means for the construction of triphenylene derivatives e.g., ,I in up to 87% isolated yield at room temperature For 1,2-dihalo-3-methylbenzenes and related ortho-trisubstituted substrates, trimerizations proceed with high substrate-controlled regioselectivity for the non-C3h sym. triphenylene isomer.

Chinese Journal of Chemistry published new progress about Cross-coupling reaction. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Product Details of C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Armani, Elisabetta; Rizzi, Andrea; Capaldi, Carmelida; De Fanti, Renato; Delcanale, Maurizio; Villetti, Gino; Marchini, Gessica; Pisano, Anna Rita; Pitozzi, Vanessa; Pittelli, Maria Gloria; Trevisani, Marcello; Salvadori, Michela; Cenacchi, Valentina; Puccini, Paola; Amadei, Francesco; Pappani, Alice; Civelli, Maurizio; Patacchini, Riccardo; Baker-Glenn, Charles A. G.; Van de Poel, Herve; Blackaby, Wesley P.; Nash, Kevin; Amari, Gabriele published the artcile< Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease>, Quality Control of 85070-57-1, the main research area is M3 antagonist PDE4 inhibitor chronic obstructive pulmonary disease.

In this paper, we report the discovery of dual M3 antagonist-PDE4 inhibitor (MAPI) compounds for the inhaled treatment of pulmonary diseases. The identification of dual compounds was enabled by the intuition that the fusion of a PDE4 scaffold derived from our CHF-6001 series with a muscarinic scaffold through a common linking ring could generate compounds active vs. both the transmembrane M3 receptor and the intracellular PDE4 enzyme. Two chem. series characterized by two different muscarinic scaffolds were investigated. SAR optimization was aimed at obtaining M3 nanomolar affinity coupled with nanomolar PDE4 inhibition, which translated into anti-bronchospastic efficacy ex vivo (inhibition of rat trachea contraction) and into anti-inflammatory efficacy in vitro (inhibition of TNFα release). Among the best compounds, compound 92a achieved the goal of demonstrating in vivo efficacy and duration of action in both the bronchoconstriction and inflammation assays in rat after intratracheal administration.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 85070-57-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Quality Control of 85070-57-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Trauner, Florian; Reiners, Felix; Apaloo-Messan, Kodjo-Edmond; Nissl, Benedikt; Shahbaz, Muhammad; Jiang, Dongfang; Aicher, Julian; Didier, Dorian published the artcile< Strain-release arylations for the bis-functionalization of azetidines>, Quality Control of 401-78-5, the main research area is azetidine preparation; organometallic compound azabicyclobutane arylation nucleophilic substitution Buchwald Hartwig coupling.

The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N-arylation of resulting azetidines, employing either SNAr reactions or Buchwald-Hartwig couplings.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Quality Control of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Namm, Joshua D; Morris, Randal P; Speck, Fred L 3rd; Lindsey, Ronald W published the artcile< The Impact of Eccentric Diaphyseal Plate and Screw Placement on the Risk of Peri-Implant Fracture.>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is .

BACKGROUND: The objective of this study was to determine the impact of the type and orientation of peripheral screw placement in an eccentrically positioned locking plate on the structural integrity of the plate-diaphyseal bone interface. We hypothesized that central placement of the screw at the end of the plate in this setting is more important than screw type (locking versus nonlocking) to limiting the risk of subsequent fracture. METHODS: Twenty osteoporotic fourth-generation composite left humeri were divided into 4 groups and plated with stainless-steel 6-hole locking plates and 4.5-mm screws. Group 1 (control group) consisted of a centrally positioned plate with a centrally placed non-locking end screw at the sixth, most-proximal hole. Group 2 consisted of an eccentrically positioned plate with a non-locking proximal end screw placed through the center of the bone. Group 3 consisted of an eccentrically positioned plate with a locking proximal end screw placed perpendicular to the plate and eccentrically across the cortex. Group 4 consisted of an eccentrically positioned plate with a non-locking proximal end screw placed perpendicular to the plate and eccentrically across the cortex. Each group was tested with a single load to failure in torsion at a rate of 1°/second. RESULTS: The control group (Group 1) failed at significantly higher peak torque values (51.62 ± 7.35 Nm) than Group 2 (38.98 ± 6.78 Nm; p = 0.006), Group 3 (34.75 ± 1.81 Nm; p < 0.001), and Group 4 (31.55 ± 1.23 Nm; p < 0.001). Failure energy absorbed in Group 1 (2,591.49 ± 819.63 Nm/degree) was significantly higher than Group 3 (1,430.51 ± 449.99 Nm/degree; p = 0.04) and Group 4 (952.49 ± 123.52 Nm/degree; p = 0.004), but not significantly higher than Group 2 (1,847.73 ± 827.35 Nm/degree; p = 0.27). CONCLUSIONS: Eccentrically placed plating of humeral shaft fractures significantly increases the risk of peri-implant fracture compared with a centrally placed plate. Directing the proximal-end screw centrally in an eccentrically placed plate may help to mitigate this risk at the proximal end. CLINICAL RELEVANCE: When possible, care should be taken to place the plate centrally on the bone to avoid increased risk of peri-implant fracture at the proximal plate-bone interface. The Journal of bone and joint surgery. American volume published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary