Tag: M.W=200-250

Mochalov, S. S.; Fedotov, A. N.; Trofimova, E. V.; Gazzaeva, R. A.; Zefirov, N. S. published the artcile< Isomerization of 3-unsubstituted 4,5-dihydroisoxazoles over alumina. A new synthesis of β-hydroxy nitriles>, Application In Synthesis of 3893-18-3, the main research area is aryl hydroxypropane nitrile one pot synthesis; arylcyclopropane nitrosation dihydroisoxazole isomerization alumina catalyst chromatog.

3-Unsubstituted 4,5-dihydroisoxazoles obtained by nitrosation of arylcyclopropanes are capable of undergoing efficient isomerization into 3-aryl-3-hydroxypropanenitriles during chromatog. on alumina.

Russian Journal of Organic Chemistry published new progress about Hydroxynitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vogel, Wilfried; Heitz, Walter published the artcile< Liquid-crystalline poly(4-hydroxybenzoates) with phenethyl side chains>, Recommanded Product: 2-Bromo-4-nitrobenzoic acid, the main research area is polyhydroxybenzoate liquid crystal phenethyl substituent; statistical substituent polyester liquid crystal.

An important means to decrease the m.p. of liquid-crystalline polymers is the statistical arrangement of substituents along the chain. Thermotropic liquid-crystalline poly(4-hydroxybenzoates) bearing one phenethyl substituent in different positions of the monomer were synthesized via melt polycondensation. The relation between the arrangement of the substituent along the polymer backbone and the properties of the polyesters was investigated. The 2 polyesters with the substituent either in 2- or 3-position revealed highly crystalline and poorly soluble products. In contrast to this, the random copolyester is an amorphous and well-soluble polymer.

Makromolekulare Chemie published new progress about Crystallinity. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Recommanded Product: 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Haixia; Ding, Xinyu; Liu, Linyi; Mi, Qianglong; Zhao, Quanju; Shao, YuBao; Ren, Chaowei; Chen, Jinju; Kong, Ying; Qiu, Xing; Elvassore, Nicola; Yang, Xiaobao; Yin, Qianqian; Jiang, Biao published the artcile< Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is BCR ABL PROTAC cereblon E3 ligase drug design; BCR-ABL; CRBN; Degradation; Leukemia; PROTAC.

Protein degradation is a promising strategy for drug development. Proteolysis-targeting chimeras (PROTACs) hijacking the E3 ligase cereblon (CRBN) exhibit enormous potential and universal degradation performance due to the small mol. weight of CRBN ligands. In this study, the CRBN-recruiting PROTACs were explored on the degradation of oncogenic fusion protein BCR-ABL, which drives the pathogenesis of chronic myeloid leukemia (CML). A series of novel PROTACs were synthesized by conjugating BCR-ABL inhibitor dasatinib to the CRBN ligand including pomalidomide and lenalidomide, and the extensive structure-activity relationship (SAR) studies were performed focusing on optimization of linker parameters. Therein, we uncovered that pomalidomide-based degrader 17 (SIAIS056), possessing sulfur-substituted carbon chain linker, exhibits the most potent degradative activity in vitro and favorable pharmacokinetics in vivo. Besides, degrader 17 also degrades a variety of clin. relevant resistance-conferring mutations of BCR-ABL. Furthermore, degrader 17 induces significant tumor regression against K562 xenograft tumors. Our study indicates that 17 as an efficacious BCR-ABL degrader warrants intensive investigation for the future treatment of BCR-ABL+ leukemia.

European Journal of Medicinal Chemistry published new progress about Absorption. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Lei; Xu, Wen-Qiang; Liu, Tao; Wu, Yichen; Wang, Biqin; Wang, Peng published the artcile< Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands>, Category: bromides-buliding-blocks, the main research area is enantiopure spirobiphenoxasilin diol phosphonate preparation crystal mol structure; chiral ligand enantiopure spirobiphenoxasilin diol preparation catalyst asym reaction.

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asym. catalysis. Herein, authors report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chem. resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asym. reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asym. catalysis.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Companyo, Xavier; Alba, Andrea-Nekane; Cardenas, Francisco; Moyano, Albert; Rios, Ramon published the artcile< Asymmetric Organocatalytic Cyclopropanation - Highly Stereocontrolled Synthesis of Chiral Cyclopropanes with Quaternary Stereocenters>, SDS of cas: 3893-18-3, the main research area is unsaturated aldehyde bromo keto ester chiral silyloxymethylpyrrolidine asym cyclopropanation; cyclopropane carboxaldehyde derivative stereoselective preparation; chiral silyloxymethylpyrrolidine asym cyclopropanation organocatalyst.

A convenient and novel domino reaction for the synthesis of highly functionalized cyclopropanes is reported. The addition of 2-bromo keto esters to a variety of α,β-unsaturated aldehydes catalyzed by secondary amines leads to chiral cyclopropanes, e.g., I, with three stereogenic carbon atoms, including one quaternary stereocenter, in a highly stereocontrolled fashion.

European Journal of Organic Chemistry published new progress about Cycloalkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bhaumik, Asish; Eswaraiah, M. Chinna; Chakraborty, Raja published the artcile< Design and synthesis of some novel oxadiazole derivatives and evaluation of in vivo anti inflammatory activity followed by molecular docking against Cox-II enzyme>, Product Details of C7H4BrNO4, the main research area is oxadiazole mol docking anti inflammatory.

Oxadiazole is a versatile heterocyclic nucleus which attracted a wide attention of the medicinal chemists in search for new therapeutic mols. Out of its possible isomers 1, 3, 4-oxadiazole was widely exploited for various applications as medicinal agents. The literature survey revealed that 1, 3, 4-oxadiazoles were reported to possess a wide range of pharmacol. activities. The main aim and objective of the present research work was designed and synthesis of some novel 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives and evaluation of in vivo anti inflammatory activity followed by mol. docking against COX II enzyme. Based on this, a new series of compounds had been planned to synthesize by reacting paraacetamidophenol, ethylchloroacetate, hydrazine monohydrate and various aromatic acids. In continuation of these research work on 2, 5-disubstituted 1, 3, 4-oxadiazole and above observation promoted to synthesize the title compounds AB1-AB8 with their potent biol. activity. Mol. docking was performed to find out the binding affinity or mol. interaction energy (kcal/mol) of docked compounds Lowest (neg. value) energy of docked mol. indicated high binding affinity with the target protein. In silico mol. docking studies, the binding energies of the synthesized compounds were found to be AB1: -4.21; AB2: -5.21; AB3: -5.06; AB4: -3.96; AB5: -4.38; AB6: -3.45; AB7: -4.25; AB8: -3.83 (k.cal/mL); standard drug diclofenac sodium: -3.15 (k.cal/mL) which indicated that the compound had high binding affinity towards the target protein cyclooxygenase with PDB id 6COX (COX II). Anti inflammatory activity of each synthesized compound was evaluated by carrageenan induced paw edema method. The activity was studied at 100 mg/kg body weight and their responses were measured at 30, 60, 120 and 180 min. The in vivo exptl. data displayed that the compound AB2, AB3, AB5 and AB7 possessed very good anti inflammatory activity among the eight synthesized compounds and all the compounds exhibited highest activity at 120 min. The percent protection (%) of the synthesized compounds were found to be AB1: 19.63 ± 0.0294, AB2: 44.19 ± 0.031**, AB3: 42.73 ± 0.0351**, AB4: 19.04 ± 0.0828ns, AB5: 39.53 ± 0.0216*, AB6: 18.91 ± 0.0310, AB7: 35.43 ± 0.0623*, AB8: 18.84 ± 0.0935ns, standard drug diclofenac sodium (DFS): 49.67 ± 0.0095** etc.

International Journal of Pharmaceutical Sciences Review and Research published new progress about Anti-inflammatory agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Product Details of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luening, Ulrich; Fahrenkrug, Frank published the artcile< Synthesis of concave 1,10-phenanthrolines by a combination of Suzuki coupling, ring closing metathesis and hydrogenation>, Safety of 2-Bromo-3-methoxyphenol, the main research area is concave phenanthroline preparation Suzuki ring closing metathesis hydrogenation.

A wide variety of saturated and unsaturated concave 1,10-phenanthrolines have been synthesized in good yields starting from dichloro-1,10-phenanthroline. In the three step synthesis, Suzuki couplings of bis-ortho-substituted boronic acids were used to introduce two different or two identical aryl bridgeheads into the 2- and 9-positions of the 1,10-phenanthroline (yields ≥70%). The resulting diaryl-1,10-phenanthrolines, substituted with alkenyloxy groups of different lengths, underwent ring closing metathesis reactions giving (bi)macrocyclic 1,10-phenanthrolines in yields of 73-96%. The alkene chains of (bi)macrocyclic 1,10-phenanthrolines were saturated using hydrogen and Pd/C giving concave 1,10-phenanthrolines in yields of 75-99%. For example, the ring closing metathesis of a [bis(hexenyloxy)phenyl][(butenyloxy)(hexenyloxy)phenyl]phenanthroline derivative (I) gave an intermediate (II) which was hydrogenated to give a desired concave phenanthroline derivative

European Journal of Organic Chemistry published new progress about Hydrogenation. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Safety of 2-Bromo-3-methoxyphenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Messina, Cynthia; Douglas, Liam Z.; Liu, Jiang Tian; Forgione, Pat published the artcile< Successive Pd-Catalyzed Decarboxylative Cross-Couplings for the Modular Synthesis of Non-Symmetric Di-Aryl-Substituted Thiophenes>, COA of Formula: C7H7BrO2S, the main research area is thiophene ester heteroaromatic acid aryl bromide cross coupling palladium; non sym thiophene preparation.

Oligothiophenes are important organic mols. in a number of burgeoning industries as semi-conducting materials due to their extensive π-conjugation and charge transport properties. Typically, non-sym., di-aryl-substituted thiophenes are prepared by the successive formation of Grignards, organotin, and/or boronic acid intermediates that can be subsequently employed in cross-coupling reactions. While reliable, these approaches present synthetic difficulties due to the reactivity of organo-metallic/pseudo-metallic species, and produce considerable amounts of waste due to necessary pre-functionalization. We have developed a decarboxylative cross-coupling route as an effective strategy for the modular and less wasteful synthesis of a wide range of non-sym., di-arylthiophenes, e.g., I. This method uses a thiophene ester building block for successive decarboxylative palladium-catalyzed couplings that allows for the efficient synthesis and evaluation of the optoelectronic properties of a library of candidate semi-conductors with functional groups that could be challenging to access using previous routes.

European Journal of Organic Chemistry published new progress about Absorption spectra. 5751-83-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2S, COA of Formula: C7H7BrO2S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nalaoh, Phattananawee; Sungworawongpana, Nathas; Chasing, Pongsakorn; Waengdongbung, Wijitra; Funchien, Patteera; Kaiyasuan, Chokchai; Sudyoadsuk, Taweesak; Promarak, Vinich published the artcile< A Dimeric π-Stacking of Anthracene Inducing Efficiency Enhancement in Solid-State Fluorescence and Non-Doped Deep-Blue Triplet-Triplet Annihilation Organic Light-Emitting Diodes>, Application of C7H6BrNO2, the main research area is anthracene triplet annihilation fluorescence organic light emitting diode.

Triplet-triplet annihilation (TTA) mechanism utilizing the conversion of low triplet energy excitons to generate singlet excitons has been successfully employed in realizing highly efficient fluorescent organic light-emitting diodes (OLEDs). Herein, new anthracene-based TTA mols. (TPNACN and TPBACN) are developed as deep-blue emitters for high-efficiency non-doped TTA-OLEDs. Their structural, phys., and photophys. properties are exptl. and theor. investigated. These compounds in solid-state exhibit different photophys. properties due to a discrepancy in the mol. packing. Particularly, in the crystal of TPNACN, anthracene moieties are arranged with dimeric π-π stacking, and the material shows a strong excimer emission in the deep-blue region with ΦPL close to the ideal theor. value. The non-doped TTA-OLED based on TPNACN attains a high maximum external quantum efficiency of 7.89% (6.63 cd A-1) with a low turn-on voltage of 2.6 V, and displays deep-blue emission with CIE coordinates of (0.146, 0.101). These results prove that a separated dimeric π-stacked mol. alignment of anthracene enhances not only the fluorescence efficiency in the solid state but also the ratio of singlet exciton harvested by the TTA process in the device, bringing about excellent device electroluminescent properties. This can be a new tactic to designing new emissive materials for efficient OLED devices.

Advanced Optical Materials published new progress about Blue-emitting electroluminescent devices. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Application of C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jayabharathi, Jayaraman; Sarojpurani, Elayaperumal; Thanikachalam, Venugopal; Jeeva, Palanivel published the artcile< Far-Field Enhancement by Silver Nanoparticles in Organic Light Emitting Diodes Based on Donor-π-Acceptor Chromophore>, Computed Properties of 3893-18-3, the main research area is LED organic donor pi acceptor chromophore silver nanoparticle; diode light emitting organic donor acceptor chromophore silver nanoparticle; electroluminescent device organic donor pi acceptor chromophore silver nanoparticle.

Enhancement in brightness and luminous efficiency was harvested by the incorporation of Ag nanoparticles (Ag NPs) at ITO: 4,4′-bis[N-(1-naphthyl)-N-phenylamino]biphenyl (NPB) interface, using 4′-(1-(4-methoxyphenyl)-1H-phenanthro[9,10-d]imidazole-2-yl)styryl-N,N-diphenyl[1,1′-biphenyl]-4-amine (MPID-TPA) as emissive layer. The enhanced device performance was obtained with 35 nm distance between Ag NPs and emissive material (MPID-TPA). The Ag NPs deposited devices easily inject holes into NPB layer that results in stabilized vacuum level of anode and increase of the c.d. of OLEDs. The combined effect of far-field plasmonic coupling and hole injection ability of Ag NPs at ITO:HTL interface is the probable reason for the enhancement. A turn-off emission of MPID by Ag NPs and turn-on emission of MPID with the Ag NPs etched by H2O2 formed from the enzymic oxidation of glucose were analyzed.

Industrial & Engineering Chemistry Research published new progress about Chromophores. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Computed Properties of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary