Tag: M.W=200-250

Nikitine, Serge published the artcile< Anisotropic absorption of different radiations by some dyes>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is .

The photodichroism, after insolation in white light polarized rectilinearly, of several dyes (cyanine, pinacyanol, etc.) is measured as a function of λ.

Compt. rend. published new progress about Dichroism. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shrimp, Jonathan H.; Jing, Yihang; Gamage, Supuni Thalalla; Nelson, Kathryn M.; Han, Joseph; Bryson, Keri M.; Montgomery, David C.; Thomas, Justin M.; Nance, Kellie D.; Sharma, Sunny; Fox, Stephen D.; Andressen, Thorkell; Sinclair, Wilson R.; Wu, Hong; Allali-Hassani, Abdellah; Senisterra, Guillermo; Vedadi, Masoud; Lafontaine, Denis; Dahlin, Jayme L.; Marmorstein, Ronen; Walters, Michael A.; Meier, Jordan L. published the artcile< Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation>, Computed Properties of 20099-90-5, the main research area is remodelin cryptic assay interference chemotype NAT10 acetylase RNA acetylation.

Remodelin is a putative small mol. inhibitor of the RNA acetyltransferase NAT10 which has shown preclin. efficacy in models of the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS). Here we evaluate remodelin’s assay interference characteristics and effects on NAT10-catalyzed RNA cytidine acetylation. We find the remodelin chemotype constitutes a cryptic assay interference compound, which does not react with small mol. thiols but demonstrates protein reactivity in ALARM NMR and proteome-wide affinity profiling assays. Biophys. analyses find no direct evidence for interaction of remodelin with the NAT10 acetyltransferase active site. Cellular studies verify that N4-acetylcytidine (ac4C) is a nonredundant target of NAT10 activity in human cell lines and find that this RNA modification is not affected by remodelin treatment in several orthogonal assays. These studies display the potential for remodelin’s chemotype to interact with multiple protein targets in cells and indicate remodelin should not be applied as a specific chem. inhibitor of NAT10-catalyzed RNA acetylation.

ACS Medicinal Chemistry Letters published new progress about Homo sapiens. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Computed Properties of 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitsudo, Koichi; Kobashi, Yoshiaki; Nakata, Kaito; Kurimoto, Yuji; Sato, Eisuke; Mandai, Hiroki; Suga, Seiji published the artcile< Cu-Catalyzed Dehydrogenative C-O Cyclization for the Synthesis of Furan-Fused Thienoacenes>, HPLC of Formula: 81107-97-3, the main research area is thiophenyl phenol copper catalyst dehydrogenative cyclization coupling; furan fused thienoacene preparation.

The first Cu-catalyzed dehydrogenative C-O cyclization for the synthesis of furan-fused thienoacenes is described. A variety of heteroacenes including a thieno[3,2-b]furan or a thieno[2,3-b]furan skeleton were synthesized by intramol. C-H/O-H coupling. The use of a mixed solvent of N-methyl-2-pyrrolidone, ethylene glycol monomethyl ether, and toluene was essential for suppressing side reactions and efficiently promoting the reaction. Double C-O cyclization was also conducted to afford highly π-expanded furan-fused thienoacenes.

Organic Letters published new progress about Bond cleavage. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, HPLC of Formula: 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mal, Abhijit; Wani, Imtiyaz Ahmad; Goswami, Gaurav; Ghorai, Manas K. published the artcile< Synthesis of Nonracemic 1,4-Benzoxazines via Ring Opening/Cyclization of Activated Aziridines with 2-Halophenols: Formal Synthesis of Levofloxacin>, Formula: C7H4BrF3O, the main research area is benzoxazine preparation; aziridine halophenol ring opening cyclization.

Novel 3,4-dihydro-1,4-benzoxazine derivatives have been synthesized by an efficient and simple method in excellent enantio- and diastereospecificity (ee > 99%, de > 99%). The reaction proceeds via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with 2-halophenols followed by Cu(I)-catalyzed intramol. C-N cyclization in a stepwise fashion under one-pot conditions to furnish the 3,4-dihydro-1,4-benzoxazine derivatives in excellent yields (up to 95%). The strategy offers a short and efficient synthesis to (S)-3-methyl-1,4-benzoxazine (S)-3v, a late stage intermediate in the synthesis of levofloxacin.

Journal of Organic Chemistry published new progress about Aziridines Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Formula: C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Tian-Yuan; Xiao, Li-Jun; Zhou, Qi-Lin published the artcile< Nickel-Catalyzed Desymmetric Reductive Cyclization/Coupling of 1,6-Dienes: An Enantioselective Approach to Chiral Tertiary Alcohol>, Name: Methyl 2-bromo-4-methoxybenzoate, the main research area is chiral tertiary alc preparation enantioselective; diene desym reductive cyclization coupling nickel catalyst; 1,6-Dienes; Asymmetric Reductive Coupling; Desymmetric Catalysis; Nickel Catalysis; Tertiary Alcohols.

Authors have developed a nickel-catalyzed desym. reductive cyclization/coupling of 1,6-dienes. The reaction provides an efficient method for constructing a chiral tertiary alc. and a quaternary stereocenter by a single operation. The method has excellent diastereoselectivity and high enantioselectivity, a broad substrate scope, as well as good tolerance of functional groups. Preliminary mechanism studies show that alkyl nickel(I) species are involved in the reaction.

Angewandte Chemie, International Edition published new progress about Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Name: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Domaradzki, Maciej E.; Liu, Xiaochen; Ong, Jiye; Yu, Gyeongah; Zhang, Gan; Simantov, Ariel; Perl, Eliyahu; Chen, Yu published the artcile< Triflic acid mediated sequential cyclization of ortho-alkynylarylesters with ammonium acetate>, Quality Control of 17100-65-1, the main research area is isoquinolinone isochromenone preparation; alkynylarylester intramol cyclization triflic acid ammonium acetate.

A triflic acid (TfOH) mediated sequential cyclization of ortho-alkynylarylesters and ammonium acetate (NH4OAc) was reported. The reaction took place via a Bronsted acid-mediated intramol. cyclization of ortho-alkynylarylesters followed by an ammonium acetate participated substitution reaction, forming isoquinolin-1-ones as the major products. Different from most of the known synthetic methods of isoquinolin-1-ones, no metal catalyst was required in the reported reaction. The regioisomers – isoindolin-1-ones were obtained together with isoquinolin-1-ones in a few cases. The intermediate compounds – isochromen-1-ones and isobenzofuran-1-ones were also isolated. The interconversion experiments showed that the regioisomers formed during the Bronsted acid induced intramol. cyclization of ortho-alkynylarylesters. A natural product – ruprechstyril was prepared in a moderate yield employing the new method.

Tetrahedron published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation) (isochromenones). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Quality Control of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fouque, Amelie; Delalande, Olivier; Jean, Mickael; Castellano, Remy; Josselin, Emmanuelle; Malleter, Marine; Shoji, Kenji F.; Hung, Mac Dinh; Rampanarivo, Hariniaina; Collette, Yves; Weghe, Pierre van de; Legembre, Patrick published the artcile< A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells>, Electric Literature of 3893-18-3, the main research area is covalent mTOR inhibitor DHM25 antitumor breast cancer.

Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers. From a chromene backbone reported to inhibit class I PI3K catalytic subunits, several rounds of chem. syntheses led to the generation of a new collection of chromologues that showed enhanced ability to kill PI3K-addicted cancer cells and to inhibit Akt phosphorylation at serine 473, a hallmark of PI3K/mTOR activation. This initial screen uncovered a chromene designated DHM25 that exerted potent antitumor activity against breast tumor cell lines. Strikingly, DHM25 was shown to be a selective and covalent inhibitor of mTOR using biochem. and cellular analyses, modeling, and a large panel of kinase activity assays spanning the human kinome (243 kinases). Finally, in vivo, this novel drug was an efficient inhibitor of growth and metastasis of triple-neg. breast cancer cells, paving the way for its clin. application in oncol.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Koishi, Hideo published the artcile< A critical examination of Folin's method for determination of creatinine concentration in the urine>, Formula: C8H3BrO3, the main research area is .

A critical examination of Folin’s method (CA 8,2735) showed that the intensity of the color is sensitive to temperature with an increase in values of 0.5 to 1.1% per degree within 10 to 30 °.

Osaka City Medical Journal published new progress about Esters. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ariano, R. published the artcile< Determining the proportion of cement in finished concrete>, COA of Formula: C8H3BrO3, the main research area is .

The methods of Kriege (cf. C. A. 25, 4680) and Florentin (cf. C. A. 21, 3440) consist in solubilizing the SiO2 of the cement (which is present as Ca silicates) by treating with HCl and then determining it by the usual methods. In Scheibe’s method (cf. C. A. 29, 8273.5) the coarse aggregate is eliminated, the residue (sand and cement) is pulverized and the portions soluble and insoluble in HCl are determined after calcination; it is assumed arbitrarily that the sum of the loss on ignition and the insoluble matter in the cement = 3%. It is then easy to calculate the amount of cement. None of these methods gives reliable results, and the same is true of indirect methods based only on the finished concrete and on samples of the sand and gravel entering into its composition There always remains a certain degree of uncertainty if the complete composition of the cement and the loss on ignition are not known. It should be noted that in all cases where the concrete itself is analyzed, the results give the composition of the finished concrete, and not that of the original mix. For the water also, it is possible to establish only the quantity which is actually combined in the concrete.

Ricerche studi ist. sper. stradale published new progress about Cement. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, COA of Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schmidt, Jurema; Rotter, Marco; Weiser, Tim; Wittmann, Sandra; Weizel, Lilia; Kaiser, Astrid; Heering, Jan; Goebel, Tamara; Angioni, Carlo; Wurglics, Mario; Paulke, Alexander; Geisslinger, Gerd; Kahnt, Astrid; Steinhilber, Dieter; Proschak, Ewgenij; Merk, Daniel published the artcile< A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis>, Application of C9H8BrFO2, the main research area is benzylbenzamide dual modulator analog preparation nonalcoholic steatohepatitis; dual modulator analog FXR sEH benzylbenzamide analog pharmacokinetics.

Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health burden with alarming incidence, but there is no satisfying pharmacol. therapy to date. Considering the disease’s multifactorial nature, modulation of multiple targets might provide superior therapeutic efficacy. In particular, farnesoid X receptor (FXR) activation that revealed antisteatotic and antifibrotic effects in clin. trials combined with inhibition of soluble epoxide hydrolase (sEH) as anti-inflammatory strategy promises synergies. To exploit this dual concept, we developed agents exerting partial FXR agonism and sEH inhibitory activity. Merging known pharmacophores and systematic exploration of the structure-activity relationship on both targets produced dual modulators with low nanomolar potency. Extensive in vitro characterization confirmed high dual efficacy in cellular context combined with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics as well as engagement on both targets in vivo.

Journal of Medicinal Chemistry published new progress about Antifibrotic agents. 128577-47-9 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Application of C9H8BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary