Tag: M.W=200-250

Zhang, Qian-Qian; Li, Yaokai; Wang, Di; Chen, Zeng; Li, Yuhao; Li, Shuixing; Zhu, Haiming; Lu, Xinhui; Chen, Hongzheng; Li, Chang-Zhi published the artcile< Intrinsically Chemo- and Thermostable Electron Acceptors for Efficient Organic Solar Cells#>, Computed Properties of 6942-39-8, the main research area is organic solar cell acceptor dnor stille coupling.

The traditional preparation of non-fullerene acceptors (NFAs) via Knoevenagel condensation reaction (KCR) of aldehyde and active methylene leaves vulnerable and reversible exocyclic vinyl bonds in structures, which undermine the intrinsic chemo- and photostability of NFAs. In this work, we demonstrate a new access to acceptor-donor-acceptor (A-D-A) NFAs via Stille coupling between new electron deficient groups and classic donor core in over 90% yield, wherein the robust carbon-carbon bonds, replacing the exocyclic double bonds from traditional KCR, result in stable A-D-A acceptors, Q1-XF (X representing 0, 2 and 4 fluorine atoms, resp.). Among the three studied examples, Q1-4F exhibits improved optoelectronic and electron transport properties, leading to the best photovoltaic performance with optimal charge kinetics for Q1-4F based OSCs. Overall, this strategy can lead to a new way for developing stable photovoltaic materials.

Bulletin of the Chemical Society of Japan published new progress about Coupling reaction. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Computed Properties of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stephenson, G. Richard; Roe, Caroline; Sandoe, Elizabeth J. published the artcile< Electrophilic C12 Building Blocks for Alkaloids: 1,1 Iterative Organoiron-Mediated Routes to (±)-Lycoramine and (±)-Maritidine>, SDS of cas: 135999-16-5, the main research area is lycoramine formal synthesis arylcyclohexadienyl iron intermediate; maritidine formal synthesis arylcyclohexadienyl iron intermediate.

Aryllithium reagents generated from protected 6-bromoguaiacol and 2-bromo-4,5-dimethoxybenzyl alc. derivatives were used to prepare ortho-substituted (1-arylcyclohexadienyl)iron(1+) electrophiles. These were treated with Na+[Me3SiCH2CH2O2CCHCN]- to build aryl-substituted quaternary centers in new examples of 1,1 iterative {[η4] → [η5]+ → [η4] → [η5]+ → [η4]} reaction sequences, which make use of the electrophilicity of the metal complex in two key carbon-carbon bond-formation steps. MOM protection of the guaiacol was better than SEM for access to the lycoramine skeleton, and TBDPS was best for maritidine. Decomplexation, hydrolysis, and cyclization completed formal total syntheses of the Amaryllidaceae alkaloids (±)-lycoramine and (±)-maritidine, establishing the compatibility of the organoiron method with the presence of ortho substituents on the aryl group, and nucleophile addition ipso to the substituted arene.

European Journal of Organic Chemistry published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, SDS of cas: 135999-16-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nian, Si-Yun; Wang, Guo-Ping; Jiang, Zheng-Li; Xiao, Ying; Huang, Mo-Han; Zhou, Yi-Huan; Tan, Xiang-Duan published the artcile< Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists>, Recommanded Product: 4-(2-Bromoacetyl)benzoic acid, the main research area is hypercholesterolemia farnesoid X receptor antagonist SIPI7623; FXR antagonists; Guggulsterone; Molecular docking; SIPI-7623; Structure activity relationship.

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC50 = 7.8 ± 1.1 μM) showed better activity compared to SIPI-7623 (IC50 = 40.8 ± 1.7 μM) and guggulsterone (IC50 = 45.9 ± 1.1 μM). Docking of A-11 in FXR′s ligand-binding domain was also studied.

Molecular Diversity published new progress about Drug design. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Recommanded Product: 4-(2-Bromoacetyl)benzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Huai-Ri; Zhao, Qingyang; Yang, Hui; Yang, Sen; Gou, Bo-Bo; Chen, Jie; Zhou, Ling published the artcile< Chiral Phosphoric-Acid-Catalyzed Cascade Prins Cyclization>, Electric Literature of 29124-57-0, the main research area is chiral phosphoric acid catalyst cascade Prins cyclization; trans fused pyrano furo tetrahydroquinoline stereoselective preparation; stereoselective cascade Prins cyclization quinone methide aminobenzaldehyde.

Asym. Prins cyclization of in situ generated quinone methides and o-aminobenzaldehyde has been developed with chiral phosphoric acid as an efficient catalyst. This unconventional method provides a facile access to diverse functionalized trans-fused pyrano-/furo-tetrahydroquinoline derivatives in excellent yield and with excellent diastereo- and enantioselectivities (up to 99% yield and 99% ee). Mechanistic studies suggested that the three adjacent tertiary stereocenters were constructed through the sequential formation of C-O, C-C, and C-N bonds.

Organic Letters published new progress about Diastereoselective synthesis. 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Electric Literature of 29124-57-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xiao, Guiying; Xie, Chaochao; Guo, Qianling; Zi, Guofu; Hou, Guohua; Huang, Yuping published the artcile< Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives>, Synthetic Route of 401-78-5, the main research area is lactone preparation enantioselective; keto acid hydrogenation nickel catalyst; hydroxy ester preparation enantioselective; ketoester hydrogenation nickel catalyst; hydroxyamide preparation enantioselective; ketoamide hydrogenation nickel catalyst.

A highly efficient asym. hydrogenation of a series of γ-keto acid derivatives, including γ-keto acids RC(O)CH2CH2C(O)OH (R = Me, Ph, cyclopentyl, 3,4-dimethylphenyl, etc.), esters RC(O)CH2CH2C(O)OR1 (R1 = Me, Et, t-Bu), and amides RC(O)CH2CH2C(O)NR2R3 (R2 = H, Bn, iPr; R3 = H, iPr), using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral γ-hydroxy acid derivatives RCH(OH)CH2CH2C(O)OR1 and RCH(OH)CH2CH2C(O)NR2R3 with excellent enantioselectivities, up to 99.9% ee. This method provides not only an economical one-pot approach for the synthesis of chiral γ-lactones I but also access to (S)-norfluoxetine, an inhibitor of neural serotonin reuptake and an essential intermediate for pharmaceutical synthesis.

Organic Letters published new progress about Amides, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Synthetic Route of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Xiaoqiang; Jones, Gavin O.; Watson, Donald A.; Bhayana, Brijesh; Buchwald, Stephen L. published the artcile< Enantioselective Synthesis of Axially Chiral Biaryls by the Pd-Catalyzed Suzuki-Miyaura Reaction: Substrate Scope and Quantum Mechanical Investigations>, Reference of 16426-64-5, the main research area is enantioselective preparation axially chiral biaryl; palladium catalyzed Suzuki Miyaura substrate scope quantum mech crystallog.

The authors report efficient syntheses of axially chiral biaryl amides in yields ranging from 80-92%, and with enantioselectivity in the range 88-94% ee employing an asym. Suzuki-Miyaura process with Pd(OAc)2 and KenPhos as ligand. Electron-rich and electron-deficient o-halobenzamides can be efficiently coupled with 2-methyl-1-naphthylboronic acid and 2-ethoxy-1-naphthylboronic acid. The yields and selectivities of the reactions are independent of the nature of halogen substituent on the benzamide coupling partner. Studies demonstrate that axially chiral heterocyclic and biphenyl compounds can also be synthesized with this methodol. The authors also report computational studies used to determine the origin of stereoselectivity during the selectivity-determining reductive elimination step of the related coupling of tolylboronic acid with naphthylphosphonate bromide that was reported in a previous publication. The stereoselectivity arises from a combination of weak -(C)H··O interactions as well as steric interactions between the tolyl and naphthylphosphonate addends in the transition state for C-C coupling.

Journal of the American Chemical Society published new progress about Amides Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Reference of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hong, Bor-Cherng; Lin, Cheng-Wei; Liao, Wei-Kai; Lee, Gene-Hsiang published the artcile< Sequential Asymmetric Catalysis in Michael-Michael-Michael-Aldol Reactions: Merging Organocatalysis with Photoredox Catalysis in a One-Pot Enantioselective Synthesis of Highly Functionalized Decalines Bearing a Quaternary Carbon Stereocenter>, HPLC of Formula: 3893-18-3, the main research area is enantioselective synthesis decalin Michael Michael aldol organocatalyst photochem.

An expedited method has been developed for the enantioselective synthesis of highly functionalized decaline systems (e.g., I) containing seven contiguous stereogenic centers with high enantioselectivities (>99% ee). The one-pot methodol. comprises a cascade of organocatalytic double Michael-photocatalyzed Michael-aldol reactions of Et 2-bromo-6-formylhex-2-enoate, β-alkyl-α,β-unsaturated aldehydes, and α-alkyl-α,β-unsaturated aldehydes. The structure and absolute configuration of an appropriate product were confirmed by X-ray anal.

Organic Letters published new progress about Aldol addition. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, HPLC of Formula: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ohkanda, Junko; Strickland, Corey L.; Blaskovich, Michelle A.; Carrico, Dora; Lockman, Jeffrey W.; Vogt, Andreas; Bucher, Cynthia J.; Sun, Jiazhi; Qian, Yimin; Knowles, David; Pusateri, Erin E.; Sebti, Said M.; Hamilton, Andrew D. published the artcile< Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase>, SDS of cas: 16426-64-5, the main research area is structure design imidazole peptidomimetic inhibitor protein farnesyltransferase antitumor; Suzuki coupling imidazole peptidomimetic inhibitor protein farnesyltransferase antitumor.

A series of imidazole-containing peptidomimetic PFTase inhibitors and their co-crystal structures bound to PFTase and FPP are reported. The structures reveal that the peptidomimetics adopt a similar conformation to that of the extended CVIM tetrapeptide, with the imidazole group coordinating to the catalytic zinc ion. Both mono- and bis-imidazole-containing derivatives, 13 and 16, showed remarkably high enzyme inhibition activity against PFTase in vitro with IC50 values of 0.86 and 1.7 nM, resp. The peptidomimetics were also highly selective for PFTase over PGGTase-I both in vitro and in intact cells. In addition, peptidomimetics 13 and 16 were found to suppress tumor growth in nude mouse xenograft models with no gross toxicity at a daily dose of 25 mg·kg-1.

Organic & Biomolecular Chemistry published new progress about Antitumor agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, SDS of cas: 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meazza, Marta; Leth, Lars A.; Erickson, Jeremy D.; Jorgensen, Karl Anker published the artcile< Indium(III)-catalyzed Aza-Conia-Ene Reaction for the Synthesis of Indolizines>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is indolizine pyrroloquinoline preparation aza Conia ene cyclization indium catalyst; heterocycles; indium; indolizines; synergistic catalysis.

A new indium(III)-catalyzed reaction for the synthesis of a series of indolizine scaffolds has been developed. This methodol. was highly efficient, allowing a low catalyst loading of 2 mol % (down to 0.5 mol %) and rendering the products in high yields through a 5-exo-dig aza-Conia-ene reaction. Furthermore, the possibility of incorporating an electrophile into the generated pyrrolidone ring in a one-pot synergistic fashion was demonstrated. Finally, based on exptl. observations, a mechanism proposal was outlined.

Chemistry – A European Journal published new progress about Enantioselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Tianyue; Liu, Fengbo; Hu, Xianchen; Zhao, Zhiyong; Liu, Simin published the artcile< Cucurbit[n]uril-based host-guest interaction enhancing organic room-temperature phosphorescence of phthalic anhydride derivatives in aqueous solution>, Electric Literature of 82-73-5, the main research area is cucurbituril ammonium chloride inclusion reaction phosphorescence.

Purely organic room temperature phosphorescence (RTP) materials in the solid state have been widely researched, while water-soluble mols. with single structure and RTP emission in water are still rare. Here, cyan RTP in aqueous solution of water-soluble halogen-substituted phthalic anhydride (PA) derivatives was enhanced by supramol. host-guest complexation with cucurbit[n]urils (CB[n]s). This successful attempt further suggests a feasible strategy for creating visible RTP materials in aqueous solution through CB[n]-based host-guest complexation.

New Journal of Chemistry published new progress about Cucurbiturils Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Electric Literature of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary