Tag: M.W=200-250

Shestakov, V. A.; Lisitsyn, V. N. published the artcile< Mobility of bromide atoms in 4-substituted 2-bromobenzoic acids during copper(I) catalysis>, COA of Formula: C7H4BrNO4, the main research area is bromo benzoic acid substitution; benzoic acid bromo substitution; substitution bromo benzoic acid.

The effect of R in 4,2-RBrC6H3-CO2H on the mobility of Br in aqueous piperidine at 60° in the presence of CuCl varies in the order OH > NH2 > I > H > NO2. Thus, the introduction of an electron-donor substituent facilitates the formation of a Cu-Br bond and increases the tendency of an aryl halogen to substitution reactions.

Trudy Instituta – Moskovskii Khimiko-Tekhnologicheskii Institut imeni D. I. Mendeleeva published new progress about Solvolysis. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, COA of Formula: C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Han, Hongwei; Xu, Xinhong; Ma, Yingying; Luo, Yuelin; Wang, Zizhen; Yang, Minkai; Wen, Zhongling; Zhang, Yahan; Yin, Tongming; Zhao, Quan; Lin, Hongyan; Lu, Guihua; Yang, Rongwu; Wang, Xiaoming; Qi, Jinliang; Yang, Yonghua published the artcile< Discovering Podophyllotoxin Derivatives as Potential Anti-Tubulin Agents: Design, Synthesis and Biological Evaluation>, Safety of Ethyl 2-(3-bromophenyl)acetate, the main research area is podophyllotoxin preparation antitubulin antitumor mol docking human.

Here, a series of novel aryl 1,3,4-oxadiazole/1,3,4-thiadiazole acid podophyllotoxin ester derivatives were synthesized. Among these compounds, I (R = C6H5, 4-ClC6H4CH2, 3-FC6H4CH2, etc.) exhibited excellent antiproliferation activity against MCF-7 cells (IC50 = 2.46 +/- 0.12μM). Furthermore, I caused cell cycle arrest at the G2/M phase and induced cell apoptosis. Confocal microscopy showed that I inhibited microtubule polymerization by causing cancer cell growth inhibition. Mol. docking results suggested I could bind to the active binding site of tubulin. In a mouse model, compound I suppressed malignant growth without causing significant toxicity to normal tissues. These findings support the utility of I as a novel compound for the development of anticancer agent.

ChemistrySelect published new progress about Antitumor agents. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Safety of Ethyl 2-(3-bromophenyl)acetate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Pengcheng; Li, Chengcheng; Mou, Chengli; Pan, Dingwu; Wu, Shuquan; Xue, Wei; Jin, Zhichao; Chi, Yonggui Robin published the artcile< Efficient Access to 2-Pyrones via Carbene-Catalyzed Oxidative [3+3] Reactions between Enals and Nitrogen Ylides>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is pyrone preparation; enal nitrogen ylide oxidative cycloaddition carbene catalyst.

A carbene-catalyzed oxidative [3+3] cycloaddition reaction between enals and nitrogen ylides for quick access to 2-pyrones I [R = Et, Ph, 2-naphthyl, etc.; Ar = Ph, 4-BrC6H4, 2-furyl, etc.] was reported. Inexpensive and easily prepared 2′-pyridinium bromide salts were used as precursors of pyridinium ylides to react with enals in this catalytic reactions.

Asian Journal of Organic Chemistry published new progress about [3+3] Cycloaddition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Nannan; Huang, Yafei; Yu, Mingcheng; Zhao, Yunpeng; Chen, Ji-An; Zhu, Chenyu; Song, Meiqi; Guo, Huimin; Xie, Qiong; Wang, Yonghui published the artcile< Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists>, Application In Synthesis of 215949-57-8, the main research area is autoimmune diseases ROR gamma t inverse agonists Th17 cells; Autoimmune diseases; Biaryl ureas; Inverse agonists; RORγt; Th17 cells.

GSK805 (1) is a potent RORγt inverse agonist, but a drawback of 1 is its low solubility, leading to a limited absorption in high doses. We have explored detailed structure-activity relationship on the amide linker, biaryl and arylsulfonyl moieties of 1 trying to improve solubility while maintaining RORγt activity. As a result, a novel series of carboxyl-containing biaryl urea derivatives was discovered as potent RORγt inverse agonists with improved drug-like properties. Compound 3i(I) showed potent RORγt inhibitory activity and subtype selectivity with an IC50 of 63.8 nM in RORγ FRET assay and 85 nM in cell-based RORγ-GAL4 promotor reporter assay. Reasonable inhibitory activity of 3i was also achieved in mouse Th17 cell differentiation assay (76% inhibition at 0.3 μM). Moreover, 3i had greatly improved aqueous solubility at pH 7.4 compared to 1, exhibited decent mouse PK profile and demonstrated some in vivo efficacy in an imiquimod-induced psoriasis mice model.

European Journal of Medicinal Chemistry published new progress about Autoimmune disease. 215949-57-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO2, Application In Synthesis of 215949-57-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Long, Rong; Huang, Jun; Shao, Wenbin; Liu, Song; Lan, Yu; Gong, Jianxian; Yang, Zhen published the artcile< Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition>, Application In Synthesis of 16426-64-5, the main research area is lingzhiol asym total synthesis rhodium catalyzed cycloaddition.

The development of efficient reactions for the one-pot construction of bicyclic ring systems bearing two quaternary carbon centers at their bridgehead positions represents a significant challenge to synthetic chem. The development of new methods capable of overcoming this challenge is highly desirable, because this motif can be found in a wide range of natural products with significant biol. activities. Herein, we report an efficient [3+2] cycloaddition reaction between an enal and an alleno rhodium species, which was generated in situ from the corresponding enynol via a retro metal-propargylation reaction, to give [3.3.0] and [3.4.0] bicyclic systems bearing two quaternary atoms at their bridgehead positions. The developed chem. has been successfully applied to the asym. total synthesis of natural product (-)-lingzhiol (I) for the first time in 17 steps.

Nature Communications published new progress about [3+2] Cycloaddition reaction, stereoselective. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application In Synthesis of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Miyake, Yoshihiro; Nakajima, Kazunari; Nishibayashi, Yoshiaki published the artcile< Visible light-mediated oxidative decarboxylation of arylacetic acids into benzyl radicals: addition to electron-deficient alkenes by using photoredox catalysts>, COA of Formula: C10H11BrO2, the main research area is oxidative decarboxylation arylacetic acid photoredox catalyst; benzyl radical formation radical addition electron deficient alkene.

Reactions of alkenes with arylacetic acids bearing an amino group at the para-position in the benzene ring in the presence of a catalytic amount of transition metal polypyridyl complexes as photocatalysts under visible light illumination proceed smoothly to give the corresponding benzylated products via oxidative decarboxylation in good to high yields. E.g., in presence of [Ir(ppy)2(bpy)]BF4 as catalyst, visible light-mediated oxidative decarboxylation of 4-Me2NC6H4CH2CO2H in presence of (E)-PhCH:C(CN)CO2Et gave 85% 4-Me2NC6H4CH2CHPhCH(CN)CO2Et.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, COA of Formula: C10H11BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Su, Shun; Clarke, Adam; Han, Ying; Chao, Hannguang J.; Bostwick, Jeffrey; Schumacher, William; Wang, Tao; Yan, Mujing; Hsu, Mei-Yin; Simmons, Eric; Luk, Chiuwa; Xu, Carrie; Dabros, Marta; Galella, Michael; Onorato, Joelle; Gordon, David; Wexler, Ruth; Gargalovic, Peter S.; Lawrence, R. Michael published the artcile< Biphenyl acid derivatives as APJ receptor agonists>, Name: Methyl 2-bromo-4-methoxybenzoate, the main research area is heart failure cardioprotective APJ apelin receptor agonist biphenyl acid.

The APJ receptor and its endogenous peptidic ligand apelin have been implicated as important modulators of cardiovascular function, and APJ receptor agonists may be beneficial in the treatment of heart failure. In this article, we describe the discovery of a series of biphenyl acid derivatives as potent APJ receptor agonists. Following the identification of initial high-throughput screen lead 2(I), successive optimization led to the discovery of lead compound 15a(II). II demonstrated comparable in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. In vivo, II demonstrated a dose-dependent improvement in the cardiac output in male Sprague Dawley rats with no significant changes in either mean arterial blood pressure or heart rate, consistent with the hemodynamic profile of apelin-13 in an acute pressure volume loop model.

Journal of Medicinal Chemistry published new progress about Apelin receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (agonists). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Name: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ressmann, Anna K.; Schwendenwein, Daniel; Leonhartsberger, Simon; Mihovilovic, Marko D.; Bornscheuer, Uwe T.; Winkler, Margit; Rudroff, Florian published the artcile< Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes>, Product Details of C9H7BrO, the main research area is aldehyde quantification high throughput assay aminobenzamidoxime derivative.

The selective and direct reduction of carboxylic acids into the corresponding aldehydes by chem. methods is still a challenging task in synthesis. Several reductive and oxidative chem. methods are known to produce aldehydes, but most of them require expensive reagents, special reaction conditions, are 2-step procedures and often lack chemoselectivity. Nature provides an elegant tool, so called carboxylic acid reductases (CARs) for the direct reduction of carboxylic acids to aldehydes. Discovery as well as engineering of novel CAR enzymes necessitates a robust, product selective high-throughput assay (HTA). The authors report a simple and fast HTA that allows the substrate-independent and chemoselective quantification of aldehydes (irresp. of their chem. structure) and is sensitive to the nM range. The HTA was validated by NMR and GC analyses and in microbial cells by reexamination of the substrate scope of CAR from Nocardia iowensis (CARNi). The results were fully consistent with reported data.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: ANT (Analyte), RCT (Reactant), SPN (Synthetic Preparation), ANST (Analytical Study), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Getter, Tamar; Margalit, Raanan; Kahremany, Shirin; Levy, Laura; Blum, Eliav; Khazanov, Netaly; Keshet-Levy, Nimrod Y.; Tamir, Tigist Y.; Ben Major, M.; Lahav, Ron; Zilber, Sofia; Senderowitz, Hanoch; Bradfield, Paul; Imhof, Beat A.; Alpert, Evgenia; Gruzman, Arie published the artcile< Novel inhibitors of leukocyte transendothelial migration>, Safety of Methyl 4-(bromomethyl)-2-fluorobenzoate, the main research area is benzylidene trioxotetrahydropyrimidine preparation leukocyte transendothelial migration inhibitor docking human; Arthritis; Fatty liver; IBD/Crohn’s disease; Leukocyte transmigration; Multiple sclerosis; Trioxotetrahydropyrimidin derivatives.

In this study, based on previous trioxotetrahydropyrimidine based integrin inhibitors that suboptimally blocked leukocyte adhesion, twelve mols. with a modified scaffold were designed, synthesized, and tested in vitro for their capacity to block the transendothelial migration of immune cells. One of the mols. I, completely blocked leukocyte transendothelial migration, without any toxic effects on immune or endothelial cells (IC50 = 2.4 μM). In vivo, compound I exhibited significant therapeutic effects in inflammatory bowel disease (IBD)/Crohn’s disease, multiple sclerosis, fatty liver disease, and rheumatoid arthritis models. A detailed acute and chronic toxicity profile of the lead compound in vivo did not reveal any toxic effects. Such a type of mol. might therefore provide a unique starting point for designing a novel class of leukocyte transmigration blocking agents with broad therapeutic applications in inflammatory and auto-immune pathologies.

Bioorganic Chemistry published new progress about Anti-inflammatory agents. 85070-57-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Safety of Methyl 4-(bromomethyl)-2-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Khalifa, Muhammad M.; Philkhana, Satish Chandra; Golden, Jennifer E. published the artcile< Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam>, Related Products of 20776-50-5, the main research area is isatoic anhydride ketone base promoted anionic annulation; quinolinone preparation; penicinotam total synthesis.

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam I, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

Journal of Organic Chemistry published new progress about Cyclization. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary