Tag: M.W=200-250

Huang, Shuaishuai; Nie, Yixue; Yang, Jingjing; Zheng, Zhanjiang; Cao, Jian; Xu, Zheng; Xu, Liwen published the artcile< Copper-catalyzed arylated etherification of 2,2-difluoroethanol and its mechanistic study>, Electric Literature of 401-78-5, the main research area is haloarene difluoroethanol copper catalyst Ullmann type arylated etherification; difluoroethoxy arene preparation.

A mild and efficient method for the preparation of difluoroethyl aryl ethers was developed by the copper-catalyzed Ullmann-type arylated etherification reaction of aryl bromides or iodides with 2,2-difluoroethanol. This reaction proceeded smoothly in the presence of CuI and 8-hydroxyquinoline/t-BuOK and has a broad substrate scope. ESI-MS anal. supported the existence of LCu(III)Ar(OR) species during this catalytic reaction. Further d. functional theory (DFT) calculations suggested a proposed mechanism of arylated etherification reaction involving oxidative addition, followed by nucleophile substitution and reductive elimination would be rational.

Youji Huaxue published new progress about Alkyl aryl ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Electric Literature of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Melin, Lea; Abdullayev, Shuay; Fnaiche, Ahmed; Vu, Victoria; Gonzalez Suarez, Narjara; Zeng, Hong; Szewczyk, Magdalena M.; Li, Fengling; Senisterra, Guillermo; Allali-Hassani, Abdellah; Chau, Irene; Dong, Aiping; Woo, Simon; Annabi, Borhane; Halabelian, Levon; LaPlante, Steven R.; Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam; Gagnon, Alexandre published the artcile< Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid>, Synthetic Route of 6942-39-8, the main research area is anticancer agent cell migration TEAD LM98 flufenamic acid; Flufenamic acid; Hippo pathway; SAR; TEAD; palmitic acid.

The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been reported in a wide range of cancers. Inhibition of TEAD represses the expression of associated genes, demonstrating the value of this transcription factor for the development of novel anti-cancer therapies. We report herein the design, synthesis and biol. evaluation of LM98, a flufenamic acid analog. LM98 shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. Binding of LM98 to TEAD was supported by 19F-NMR studies while co-crystallization experiments confirmed that LM98 is anchored within the palmitic acid pocket of TEAD. LM98 reduces the expression of CTGF and Cyr61, inhibits MDA-MB-231 breast cancer cell migration and arrests cell cycling in the S phase during cell division.

ChemMedChem published new progress about Antitumor agents. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Synthetic Route of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wales, David J. published the artcile< Symmetry, near-symmetry and energetics. [Erratum to document cited in CA128:313179]>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is erratum symmetry energetic correlation; symmetry energetic correlation erratum; total energy symmetry correlation erratum; mean energy symmetry correlation erratum.

On page 332, there is a missing < and r appears in the wrong font in the sentence beginning : ""The {εt'} set..."". In Eq. (4) and on the top of page 333, the variance is missing the term 〈(A'ε')2〉n' - 〈A'ε'〉n2. Brackets are missing around Reference [24]. In the Fig. 1 caption, ""39809 and 81534"" should be ""39809 and 82735"". Chemical Physics Letters published new progress about Cluster structure. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kong, Xiang-Fei; Guo, Xiu-Yun; Gu, Zi-Yu; Wei, Lin-Su; Liu, Lu-Lu; Mo, Dong-Liang; Pan, Cheng-Xue; Su, Gui-Fa published the artcile< Silver(I)-catalyzed selective hydroalkoxylation of C2-alkynyl quinazolinones to synthesize quinazolinone-fused eight-membered N,O-heterocycles>, Category: bromides-buliding-blocks, the main research area is quinazoline fuse oxygen nitrogen heterocycle preparation antiiflammation.

A silver-catalyzed hydroalkoxylation of C2-alkynyl quinazolinones to prepare a series of novel quinazolinone-fused eight-membered N,O-heterocycles I [X = O, N; R1 = H, 12-Me, 12-MeO, etc; R2 = H, 2-MeO, 2-Br, etc; R3=R4 = H, Me, etc; R5 = H, n-pentyl, Ph, etc] in good-to-excellent yields through a selective 8-endo-dig cyclization. Mechanistic studies revealed that the silver catalyst might aid bidentate coordination of an imine group and alkyne to facilitate 8-endo-dig cyclization to afford eight-membered N,O-heterocycles I. Also, the proposed bimetal silver intermediates might promote hydroalkoxylation rapidly for quinazolinones bearing terminal alkynes at the C2-position. Biol. evaluations revealed that most of the designed quinazolinone-fused eight-membered N,O-heterocycles I inhibited nitric-oxide generation significantly in lipopolysaccharide-stimulated RAW264.7 cells and displayed their bioactivity as potentially good anti-inflammatory agents.

Organic Chemistry Frontiers published new progress about Alkoxylation catalysts, reductive (regioselective). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Mukesh; Chauhan, Pankaj; Valkonen, Arto; Rissanen, Kari; Enders, Dieter published the artcile< Asymmetric Synthesis of Functionalized Tricyclic Chromanes via an Organocatalytic Triple Domino Reaction>, Electric Literature of 3893-18-3, the main research area is asym synthesis functionalized tricyclic chromane organocatalysis triple domino; secondary amine catalyzed domino Michael aldol condensation aldehyde nitrochromene; alpha beta unsaturated aldehyde Michael aldol condensation nitrochromene; crystal mol structure tricyclic chromane.

A highly stereoselective triple domino reaction for the synthesis of functionalized tricyclic chromane scaffolds has been developed. A secondary amine-catalyzed domino Michael/Michael/aldol condensation reaction between aliphatic aldehydes, nitro-chromenes, and α,β-unsaturated aldehydes leads to the formation of synthetically important tricyclic chromanes bearing four contiguous stereogenic centers including a tetrasubstituted carbon in good yields (20-66%) and excellent stereoselectivities (>20:1 dr and >99% ee).

Organic Letters published new progress about Aldol condensation. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Plunkett, Shane; DeRatt, Lindsey G.; Kuduk, Scott D.; Balsells, Jaume published the artcile< Synthesis of 4-Alkylated Isocoumarins via Pd-Catalyzed α-Arylation Reaction>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is isocoumarin preparation; palladium catalyst cyclocondensation aldehyde halobenzoate.

A convergent method for the rapid preparation of substituted isocoumarins such as I is reported. The transformation takes advantage of a spontaneous intramol. cyclization that follows the Pd-catalyzed α-arylation of aldehydes such as butyraldehyde and ketones (cyclohexanone and 2,3-dihydro-4-benzopyranone) with 2-halobenzoic esters such as Me 2-bromo-5-methoxybenzoate. The reaction uses an air-stable, single-component palladium catalyst (Xantphos Pd G3) and provides access to 4-alkylated isocoumarins in one step from com. starting materials. The applicability of the method using both cyclic and linear ketones as well as transformations of the isocoumarin core is also demonstrated.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chang-An; Li, Yan-Wei; Han, Yin-Feng; Zhang, Jian-Ping; Wu, Ren-Tao; He, Guo-Fang published the artcile< The ""bottom-up"" construction of chiral porous organic polymers for heterogeneous asymmetric organocatalysis: MacMillan catalyst built-in nanoporous organic frameworks>, Name: 3-(4-Bromophenyl)acrylaldehyde, the main research area is chiral porous polymer organocatalyst enantioselectivity.

Although many porous organic polymers (POPs) embedded with chiral ligand-metal catalytic activities have been examined as heterogeneous asym. catalysts, examples of metal-free stereoselective POP catalysts are very scarce. Herein, we report a “”bottom-up”” strategy used to construct a MacMillan catalyst-embedded chiral porous organic polymer, Mac-CPOPs. The porosity of the Mac-CPOPs frameworks could be adjusted by varying the mol. length of the rigid structural monomers. Due to the high Brunauer-Emmett-Teller sp. surface area and the built-in character of the covalently linked MacMillan catalyst, the Mac-CPOP-2 polymer can be applied as a highly efficient and recoverable heterogeneous organocatalyst in the asym. Diels-Alder reaction, which gives products in good yields and with good enantioselectivity. Moreover, the Mac-CPOP-2 polymer can be reused 6 times for the asym. Diels-Alder reaction without any significant loss of catalytic activity and enantioselectivity.

Polymer Chemistry published new progress about Adsorption. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Name: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Matharu, Daljit S.; Flaherty, Daniel P.; Simpson, Denise S.; Schroeder, Chad E.; Chung, Donghoon; Yan, Dan; Noah, James W.; Jonsson, Colleen B.; White, E. Lucile; Aube, Jeffrey; Plemper, Richard K.; Severson, William E.; Golden, Jennifer E. published the artcile< Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity>, SDS of cas: 14062-30-7, the main research area is quinazolinedione inhibitor respiration syncytial virus RNA polymerase.

A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability (selectivity index, SI ∼ 24). Scaffold optimization delivered analogs with improved potency and selectivity profiles. Most notable were compounds 15 and 19 (EC50 = 300-500 nM, CC50 > 50 μM, SI > 100), which significantly reduced viral titer (>400,000-fold), and several analogs were shown to block the activity of the RNA-dependent RNA-polymerase complex of RSV.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, SDS of cas: 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Kai; Lin, Xiangfeng; Liu, Yan; Li, Can published the artcile< Palladium-Catalyzed Asymmetric Allylic C-H Functionalization for the Synthesis of Hydroquinolines through Intermolecular [4+2] Cycloadditions>, Quality Control of 51605-97-1, the main research area is hydroquinoline preparation stereoselective; ortho allyl aniline alkene allylic alkylation intermol cycloaddition palladium.

Catalytic asym. [4+2] cycloadditions via allylic C-H functionalization are of great interest and importance but remain unexplored. Herein, an intermol. [4+2] cycloaddition involving the direct Pd(0)-catalyzed allylic C-H functionalization with readily accessible olefin substrates is reported. Key to the success of this reaction is a chiral alkylphosphine ligand, which enables the asym. allylic C-H alkylation to deliver a broad range of hydroquinolines in high diastereoselectivities (up to >20:1) and enantioselectivities (up to 98% ee). Control experiments show that allylic C-H functionalization takes place possibly via the concerted proton and two-electron transfer process. This strategy opens a route for synthesizing chiral heterocycles in a straightforward way with readily accessible substrates and minimal functional-group manipulation.

ACS Catalysis published new progress about [4+2] Cycloaddition reaction. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Quality Control of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Naeim, Mahtab; Naghipour, Ali; Fakhri, Akram; Sayadi, Mohsen published the artcile< Palladium nanoparticles stabilized on the amino acids-functionalized Fe3O4 as the magnetically recoverable nanocatalysts for Heck and Suzuki reactions>, Application In Synthesis of 401-78-5, the main research area is palladium iron oxide nanocatalyst magnetization Heck Suzuki reaction.

Regarding the green chem. goals, well-organized processes for catalyst separation and reuse have drawn much attention in the past few decades. The strategy of magnetic separation offers a convenient approach for recycling catalysts by applying an appropriate magnetic field. In this paper, a palladium nanoparticle-based Catalyst that is stabilized on the glutathione and aspartic acid-functionalized superparamagnetic Fe3O4 nanoparticles has been prepared by an eco-friendly, economical and effective procedure. The catalytic performance of these novels, highly active and recoverable catalysts was investigated under low loading of the supported palladium nanoparticles for Heck and Suzuki reactions. Under optimal reaction conditions, the nanocomposites afford the corresponding products in excellent yield. The catalysts could be easily separated from the reaction system and efficiently recycled for four consecutive runs without a remarkable loss of their activity. The structural and magnetic properties of the catalysts were identified by Fourier transform IR (FT-IR), Powder X-ray diffraction (XRD), SEM (SEM), vibration sample magnetometer (VSM), inductively coupled plasma at. emission anal. (ICP-AES) and thermogravimetric anal. (TGA).

Inorganica Chimica Acta published new progress about Heck reaction. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application In Synthesis of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary