Tag: M.W=200-250

Li, Q B; Chang, L; Ye, F; Luo, Q H; Tao, Y X; Shu, H H published the artcile< Corrigendum to 'Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats' (Br J Anaesth 2018; 120: 827-35).>, Product Details of C8H3BrO3, the main research area is .

There is no abstract available for this document.

British journal of anaesthesia published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Product Details of C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Furuta, Shohei; Mori, Toshiaki; Yoshigoe, Yusuke; Sekine, Kohei; Kuninobu, Yoichiro published the artcile< Synthesis, structures and photophysical properties of hexacoordinated organosilicon compounds with 2-(2-pyridyl)phenyl groups>, SDS of cas: 401-78-5, the main research area is optimized geometry hexacoordinated pyridylaryl silicon fluoride compound DFT; crystal structure hexacoordinated pyridylaryl silicon fluoride compound; mol structure hexacoordinated pyridylaryl silicon fluoride compound; bromoarylpyridine preparation cyclization silicon chloride.

The authors synthesized novel hexacoordinated organosilicon compounds with two 2-(2-pyridyl)phenyl groups. Single-crystal x-ray structure analyses indicated that Lewis acid-base interactions exist between the Si atom and two N atoms of the pyridine rings, and that hexacoordinated organosilicon compounds have slightly distorted octahedral structures in the solid state. The hexacoordinated organosilicon compounds are stable in air, H2O, heat, acids, and bases. The fluorescent quantum yield increased dramatically and a significant red shift of the maximum fluorescence wavelength was observed with the introduction of amino groups on the 2-(2-pyridyl)phenyl aromatic rings. The fluorescence colors of a hexacoordinated organosilicon compound with two amino groups can be switched by protonation and deprotonation (neutralization) of the amino groups.

Organic & Biomolecular Chemistry published new progress about Crystal structure. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, SDS of cas: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mousseau, James J.; Vallee, Frederic; Lorion, Melanie M.; Charette, Andre B. published the artcile< Umpolung Direct Arylation Reactions: Facile Process Requiring Only Catalytic Palladium and Substoichiometric Amount of Silver Salts>, Quality Control of 17100-65-1, the main research area is palladium catalyzed umpolung direct arylation aryl halide arene; biaryl preparation umpolung direct arylation palladium catalyst; aryl iodide bromide arene reactant palladium catalyzed direct arylation.

An umpolung direct arylation process is described. The reaction requires only a catalytic amount of Pd(OAc)2 and a substoichiometric amount of silver salts, without any external base or ligand to proceed. The directed oxidative insertion of the transition metal followed by the coupling into the C-H bond of an unactivated arene has surprisingly not yet been reported, despite the clear advantages in the ease of starting material synthesis. The reaction is regioselective with regards to the arene partner, and the role of the acetate and carbonate groups has been elucidated. This methodol. adds to the very few examples of benzene coupling without the inclusion of electron-withdrawing groups to increase acidity.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Quality Control of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luo, Xiaoyan; Zhou, Zhiqiang; Li, Xin; Liang, Xinmiao; Ye, Jinxing published the artcile< Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes>, Reference of 3893-18-3, the main research area is enantioselective organocatalytic phospha Michael alpha beta unsaturated aldehyde; diaryl phosphine oxide phospha Michael alpha beta unsaturated aldehyde; diphenyl trimethylsilyloxy pyrrolidine catalyzed phospha Michael unsaturated aldehyde; crystal mol structure bromophenyl diphenylphosphoryl propanol.

The enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes with diaryl phosphine oxides is explored for the first time using (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine as a catalyst. It afforded 1,4-addition adducts in good to excellent yields with up to 99% ee.

RSC Advances published new progress about Addition reaction (1,4-addition reaction). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Kun; Tiwari, Bhoopendra; Chi, Yonggui Robin published the artcile< Access to Spirocyclic Oxindoles via N-Heterocyclic Carbene-Catalyzed Reactions of Enals and Oxindole-Derived α,β-Unsaturated Imines>, Reference of 3893-18-3, the main research area is unsaturated imine enal NHC stereoselective spirocyclization catalyst; beta lactam fused spirocyclic oxindole stereoselective preparation.

A diastereoselective access to β-lactam fused spirocyclic oxindoles, e.g., I and II, and related compounds bearing all carbon spiro centers is described. This N-heterocyclic carbene-catalyzed process employed challenging β,β-disubstituted α,β-unsaturated imines to react with enals.

Organic Letters published new progress about Diastereoselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Koike, Tatsuki; Yoshikawa, Masato; Ando, Haruhi Kamisaki; Farnaby, William; Nishi, Toshiya; Watanabe, Etsurou; Yano, Jason; Miyamoto, Maki; Kondo, Shigeru; Ishii, Tsuyoshi; Kuroita, Takanobu published the artcile< Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)>, Computed Properties of 6942-39-8, the main research area is arylpyridine derivative soticlestat preparation drug design; cholesterol 24 hydroxylase inhibitor.

Cholesterol 24-hydroxylase (CH24H, CYP46A1), a brain-specific cytochrome P 450 (CYP) family enzyme, plays a role in the homeostasis of brain cholesterol by converting cholesterol to 24S-hydroxycholesterol (24HC). Despite a wide range of potential of CH24H as a drug target, no potent and selective inhibitors have been identified. Here, authors report on the structure-based drug design (SBDD) of novel 4-arylpyridine derivatives based on the X-ray co-crystal structure of hit derivative I. Optimization of 4-arylpyridine derivatives led authors to identify (4-benzyl-4-hydroxypiperidin-1-yl)(2,4′-bipyridin-3-yl)methanone (soticlestat, also known as TAK-935), (IC50 = 7.4 nM) as a highly potent, selective, and brain-penetrant CH24H inhibitor. Following oral administration to mice, soticlestat resulted in a dose-dependent reduction of 24HC levels in the brain (1, 3, and 10 mg/kg). Soticlestat is currently under clin. investigation for the treatment of Dravet syndrome and Lennox-Gastaut syndrome as a novel drug class for epilepsies.

Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Computed Properties of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Peng; Liu, Ying; Yang, Hua; Liu, Hong-Min published the artcile< Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors>, Name: 2-Amino-4-bromobenzoic acid, the main research area is piperidinylmethyl amino quinazolinone preparation USP7 inhibitor antitumor docking SAR; Gastric cancer; Inhibitors; Quinazolin-4(3H)-one; SAR; USP7; Ubiquitination.

The design, synthesis and biol. evaluation of novel I [R1 = pyrrolyl, Ph, pyridinyl, etc.] and II [R2 = Et, furanyl, dimethylaminomethylene, etc.;R3 = H, methyl] as potent USP7 inhibitors was reported. This results indicated that the compounds II [R2 = pyrrolidinylmethylene, dimethylaminomethylene;R3 = H, methyl] exhibited the greatest potency against the USP7 catalytic domain, with IC50 values of 4.86μM and 1.537μM, resp. Ub-AMC assays further confirmed IC50 values of 5.048μM and 0.595μM for II [R2 = pyrrolidinylmethylene, dimethylaminomethylene; R3 = H, methyl] resp. MTT assays indicated that gastric cancer MGC-803 cells were more sensitive to these compounds than BGC-823 cells. Flow cytometry anal. revealed that II [R2 = pyrrolidinylmethylene; R3 = H ] restricted cancer cell growth at the G0/G1 and S phases and inhibited the proliferation and clone formation of MGC-803 cells. Further biochem. experiments indicated that II [R2 = pyrrolidinylmethylene; R3 = H ] decreased the MDM2 protein level and increased the levels of the tumor suppressors p53 and p21 in a dose-dependent manner. Docking studies predicted that solvent exposure of the side chains of II [R2 = pyrrolidinylmethylene, dimethylaminomethylene; R3 = H, methyl] would uniquely form hydrogen bonds with Met407 of USP7. Addnl., II [R2 = pyrrolidinylmethylene; R3 = H ] exhibited a remarkable anticancer effect in a zebrafish gastric cancer MGC-803 cell model. Results demonstrated that I [R1 = pyrrolyl, Ph, pyridinyl, etc.] and II [R2 = Et, furanyl, dimethylaminomethylene etc.; R3 = H, methyl] were suitable as leads for the development of novel USP7 inhibitors and especially for anti-gastric cancer drugs.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Name: 2-Amino-4-bromobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Liangbing; Xu, Mizhi; Yu, Jiyao; Gutekunst, Will R. published the artcile< Halide-Rebound Polymerization of Twisted Amides>, Reference of 17100-65-1, the main research area is halide rebound polymerization twisted amide.

The first living polymerization of twisted amides is reported, achieved using simple primary alkyl iodides as initiators. Polymerization occurs through a halide-rebound mechanism in which the nucleophilic twisted amide is quaternized and subsequently ring-opened by the iodide counterion. The covalent electrophilic polymerization generates polymers with living chain ends that are both isolable and stable to ambient conditions, enabling the synthesis of block polymers. This presents a new class of polymers for study that possess high glass transition temperatures and robust thermal stability.

Journal of the American Chemical Society published new progress about Chain extension polymerization. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Reference of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yamano, Ryota; Hara, Jun; Murayama, Koichi; Sugiyama, Haruki; Teraoka, Kota; Uekusa, Hidehiro; Kawauchi, Susumu; Shibata, Yu; Tanaka, Ken published the artcile< Rh-Mediated Enantioselective Synthesis, Crystal Structures, and Photophysical/Chiroptical Properties of Phenanthrenol-Based [9]Helicene-like Molecules>, Application of C7H7BrO2, the main research area is enantioselective synthesis phenanthrenol based nonahelicene.

The enantioselective synthesis of phenanthrenol-based [9]helicene-like mols. has been achieved via the rhodium-mediated intramol. [2+2+2] cycloadditions of 3-phenanthrenol-linked triynes. Crystal structures and photophys./chiroptical properties of these [9]helicene-like mols. were compared with the corresponding [7]helicene-like mols.

Organic Letters published new progress about [2+2+2] Cycloaddition reaction. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Application of C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Marvi, Omid; Giahi, Masoud published the artcile< Montmorillonite KSF clay as novel and recyclable heterogeneous catalyst for the microwave mediated synthesis of indan-1,3-diones>, Related Products of 82-73-5, the main research area is montmorillonite clay catalyst microwave irradiation indan dione synthesis.

Various indan-1,3-dione derivatives were synthesized from the reaction of different phthalic anhydrides with diethyl-malonate using montmorillonite KSF clay as a recyclable heterogeneous acidic catalyst and microwave irradiation in good yields and short reaction times.

Bulletin of the Korean Chemical Society published new progress about Microwave irradiation. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Related Products of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary