Tag: M.W=200-250

Tan, Ze published the artcileSelective Synthesis of Epolactaene Featuring Efficient Construction of Methyl (Z)-2-Iodo-2-butenoate and (2R,3S,4S)-2-Trimethylsilyl-2,3-epoxy-4-methyl-γ-butyrolactone, COA of Formula: C7H13BrSi, the publication is Organic Letters (2006), 8(13), 2783-2785, database is CAplus and MEDLINE.

(+)-Epolactaene (I) was synthesized in 14 steps in the longest linear sequence. The synthesis was highlighted by a highly efficient preparation of the lactone intermediate II, which only required three steps from the com. available (S)-3-butyn-2-ol. It also featured a fully stereocontrolled synthesis of the intermediate (2E,3E,5E,9E)-2-ethylidene-4,10-dimethyl-11-oxo-3,5,9-undecatrienoic acid Me ester, which was constructed through the use of Zr-catalyzed methylalumination of alkynes and a series of Pd-catalyzed organozinc cross-coupling reactions, such as homopropargylation, direct ethynylation, and alkenylation of (Z)-α-iodocrotonic acid Me ester.

Organic Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C5H5NO3S, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Deyab, M. A. published the artcileFour novel imidazolium-derived ionic liquids: Synthesis and anti-corrosion characteristics, Category: bromides-buliding-blocks, the publication is Journal of Molecular Liquids (2022), 118984, database is CAplus.

This paper described the corrosion inhibiting action of four new imidazolium-derived ionic liquids (ILs) I [X = H, Me, Cl, NO₂]. Elements anal., IR, TGA, ¹H-¹³C NMR, XRD and HSQC-NMR were used to confirm the mol. formula of ILs. The corrosion suppressive effectiveness was calculated using loss of mass and electrochem. experiments and ranged from 53 to 96%. Their adsorption on a steel substrate was precisely characterized using the Langmuir isotherm. Gibbs free energies vary from – 35.24 kJ mol^-1 to – 41.82 kJ mol^-1, indicating that ILs were adsorbing via physi-chemisorption scenario. SEM/EDX and FTIR were used to validate the process of adsorption of ionic liquids

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Jones, Seamus D. published the artcileDesign of Polymeric Zwitterionic Solid Electrolytes with Superionic Lithium Transport, Application In Synthesis of 55788-44-8, the publication is ACS Central Science (2022), 8(2), 169-175, database is CAplus and MEDLINE.

Progress toward durable and energy-dense lithium-ion batteries has been hindered by instabilities at electrolyte-electrode interfaces, leading to poor cycling stability, and by safety concerns associated with energy-dense lithium metal anodes. Solid polymeric electrolytes (SPEs) can help mitigate these issues; however, the SPE conductivity is limited by sluggish polymer segmental dynamics. We overcome this limitation via zwitterionic SPEs that self-assemble into superionically conductive domains, permitting decoupling of ion motion and polymer segmental rearrangement. Although crystalline domains are conventionally detrimental to ion conduction in SPEs, we demonstrate that semicrystalline polymer electrolytes with labile ion-ion interactions and tailored ion sizes exhibit excellent lithium conductivity (1.6 mS/cm) and selectivity (t₊ ≈ 0.6-0.8). This new design paradigm for SPEs allows for simultaneous optimization of previously orthogonal properties, including conductivity, Li selectivity, mechanics, and processability.

ACS Central Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Application In Synthesis of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tucker, Joseph W. published the artcileTin-free radical cyclization reactions initiated by visible light photoredox catalysis, HPLC of Formula: 69361-41-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(27), 4985-4987, database is CAplus and MEDLINE.

Herein, we report an advancement in the application of visible light photoredox catalysts in a classic free radical mediated reaction, cyclization onto unactivated π-systems. The reactive radical intermediate is generated by the single electron reduction of an activated C-Br bond by an electron-rich redox catalyst afforded by a visible light induced catalytic cycle.

Chemical Communications (Cambridge, United Kingdom) published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C15H12O6, HPLC of Formula: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mizushima, Sanichiro published the artcileNature of the potential hindering internal rotation, Name: 2,3-Dibromo-2,3-dimethylbutane, the publication is Nippon Kagaku Kaishi (1921-47) (1952), 621-3, database is CAplus.

The exptl. results on the infrared absorption, Raman effect, dipole moment, electron diffraction, etc., of ethylene chloride and related compounds are reviewed and the nature of the hindering potential is discussed. The mol. configuration of rotational isomers of XH₂CCH₂Y-type mols. is independent of the elec. properties of X and Y. Hence the most important factor affecting the hindering potential is something other than electrostatic force. Steric repulsion due to exchange integral between atoms not directly bound together is supposed to be the most important. The internal rotation in Cl₃SiSiCl₃ is almost free, whereas the hindering barrier in Cl₃CCCl₃ amounts to 10-15 kcal./mole. This fact suggests that the force hindering internal rotation is very sensitive to at. distance. This also favors the view that steric repulsion rather than electrostatic force plays the major role. Since Br and CH₃ have nearly the same van der Waals radii, the energy difference between trans and gauche forms of Br(CH₃)₂CC(CH₃)₂Br indicate that electrostatic contribution must not be neglected. Hydrogen-bond formation is important in ClH₂CCH₂OH, since in this mol. the trans form is less stable than the gauche form. The case of ClOCCOCl with trans configuration as the most stable position reveals importance of resonance giving to the CC bond some double-bond character. Intermol. forces in liquid and solid can affect the equilibrium of rotational isomers but not the mol. configurations determined mainly by steric effect.

Nippon Kagaku Kaishi (1921-47) published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Name: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yasuhara, Akio published the artcileTemperature-programmed retention indexes of 221 halogenated organic compounds with 1-bromoalkanes as references, Computed Properties of 594-81-0, the publication is Journal of Chromatography (1985), 35-48, database is CAplus.

Retention indexes (I‘) of 221 halogenated aliphatic and alicyclic compounds were measured on the 1-bromoalkane scale by temperature-programmed gas chromatog. using a fused-silica capillary column coated with Me silicone. An LFER was observed between the retention indexes of the solutes and their b.p. There is an LFER between b.p. and C atom number in a homologous series. Consequently, there is also an LFER between I‘ and b.p. and mol. refraction. Regularities were observed between I‘ and the mol. structure.

Journal of Chromatography published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C38H24F4O4P2, Computed Properties of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ruasse, Marie Francoise published the artcileSolvation and steric effects on electrophilic reactivity of ethylenic compounds. 1. Stereochemistry and bromination of congested adamantylidenealkanes, Category: bromides-buliding-blocks, the publication is Journal of Organic Chemistry (1990), 55(8), 2298-303, database is CAplus.

Rate constants for bromine addition to I (R, R¹ given: H, H; H, Me; H, Et; H, Me₂CH; H, Me₃C; H, neopentyl; Me, Me; Et, Et; Me, Me₂CH; Me₂CH, Me₂CH) were determined in MeOH and in AcOA. The data indicate that solvent effect is markedly smaller than that on linear alkenes, which suggests that greater steric retardation in I can be attributed to mechanistic changes: inhibition of nucleophilic solvent assistance in the ionization step and/or return resulting from a slow product-forming step.

Journal of Organic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kolundzic, Filip published the artcileA Cyclization-Rearrangement Cascade for the Synthesis of Structurally Complex Chiral Gold(I)-Aminocarbene Complexes, SDS of cas: 69361-41-7, the publication is Angewandte Chemie, International Edition (2014), 53(31), 8122-8126, database is CAplus and MEDLINE.

A facile synthesis of chiral cyclic alkyl aminocarbene-Au(I) complexes from Au-free 1,7-enyne substrates was developed. The novel cyclization-rearrangement reaction sequence is triggered by the addition of (Me₂S)AuCl to different 1,7-enynes and leads to structurally unique carbene-Au(I) complexes in high yields. These novel complexes are catalytically active and inhibit the proliferation of different human cancer cell lines.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tamaoku, Katsumi published the artcileNew water-soluble hydrogen donors for the enzymatic spectrophotometric determination of hydrogen peroxide, Product Details of C3H6BrNaO3S, the publication is Analytica Chimica Acta (1982), 121-7, database is CAplus.

Eight N-alkyl-N-sulfopropylaniline derivatives were synthesized and assessed as water-soluble H donors for the spectrophotometric determination of H₂O₂ in the presence of peroxidase. The Na salts of N-ethyl-N-sulfopropylaniline (I), N-ethyl-N-sulfopropyl-m-toluidine (II), and N-ethyl-N-sulfopropyl-m-anisidine (III) are recommended. They have excellent water solubilities, and the optimum pH range for oxidative condensation with 4-aminoantipyrine in the presence of H₂O₂ and peroxidase is 5.5-9.5. The absorbances of the resulting chromogens are 2-3-fold higher than that achieved with PhOH. The molar absorptivities of the chromogens with 4-aminoantipyrine are 41,300 (I, γ_max 561 nm), 37,400 (II, γ_max 550 nm) and 27,900 (III, γ_max 540 nm). Calibration graphs for the determination of H₂O₂ in the presence of a control serum are linear for 7-40 × 10^-6 mol H₂O₂/L.

Analytica Chimica Acta published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C13H16O2, Product Details of C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Negoro, Toshiyuki published the artcileNovel, Highly Potent Aldose Reductase Inhibitors: (R)-(-)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine- 4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone (AS-3201) and Its Congeners, COA of Formula: C7H8BrClFN, the publication is Journal of Medicinal Chemistry (1998), 41(21), 4118-4129, database is CAplus and MEDLINE.

A series of novel tetrahydropyrrolo[1,2-a]pyrazine derivatives were synthesized and evaluated as aldose reductase inhibitors on the basis of their abilities to inhibit porcine lens aldose reductase in vitro and to inhibit sorbitol accumulation in the sciatic nerve of streptozotocin-induced diabetic rats in vivo. Of these compounds, spirosuccinimide-fused tetrahydropyrrolo[1,2-a]pyrazine-1,3-dione derivatives showed significantly potent aldose reductase inhibitory activity. In the in vivo activity of these derivatives, 2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3′-pyrrolidine-1,2′,3,5′-tetrone (I) (SX-3030) showed the best oral activity. The enantiomers of I were synthesized, and the biol. activities were evaluated. It was found that aldose reductase inhibitory activity resides in the (-)-I (AS-3201), which was 10 times more potent in inhibition of the aldose reductase (IC₅₀ = 1.5 × 10^-8 M) and 500 times more potent in the in vivo activity (ED₅₀ = 0.18 mg/kg/day for 5 days) than the corresponding (+)-I (SX-3202). From these results, AS-3201 was selected as the candidate for clin. development. The absolute configuration of AS-3201 was also established to be (R)-form by single-crystal X-ray anal. In this article we report the preparation and structure-activity relationship of tetrahydropyrrolopyrazine derivatives including a novel aldose reductase inhibitor, AS-3201.

Journal of Medicinal Chemistry published new progress about 147181-08-6. 147181-08-6 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Salt,Amine,Benzene, name is (4-Bromo-2-fluorophenyl)methanamine hydrochloride, and the molecular formula is C7H8BrClFN, COA of Formula: C7H8BrClFN.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary