Tag: M.W=200-250

Nachtergaele, Sigrid published the artcileOxysterols are allosteric activators of the oncoprotein Smoothened, SDS of cas: 69361-41-7, the publication is Nature Chemical Biology (2012), 8(2), 211-220, database is CAplus and MEDLINE.

Oxysterols are a class of endogenous signaling mols. that can activate the Hedgehog pathway, which has critical roles in development, regeneration and cancer. However, it has been unclear how oxysterols influence Hedgehog signaling, including whether their effects are mediated through a protein target or indirectly through effects on membrane properties. To answer this question, we synthesized the enantiomer and an epimer of the most potent oxysterol, 20(S)-hydroxycholesterol. Using these mols., we show that the effects of oxysterols on Hedgehog signaling are exquisitely stereoselective, consistent with the hypothesis that they function through a specific protein target. We present several lines of evidence that this protein target is the seven-pass transmembrane protein Smoothened (Smo), a major drug target in oncol. Our work suggests that these enigmatic sterols, which have multiple effects on cell physiol., may act as ligands for signaling receptors and provides a generally applicable framework for probing sterol signaling mechanisms.

Nature Chemical Biology published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kim, Choung Un published the artcileA new class of acyclic phosphonate nucleotide analogs: Phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents, Product Details of C8H15BrO2, the publication is Journal of Medicinal Chemistry (1991), 34(7), 2286-94, database is CAplus and MEDLINE.

Novel phosphonate isosteres of acyclovir (ACV) and ganciclovir (DHPG) monophosphates I (R = H, CH₂OH) were found to be potent and selective antiherpesvirus agents. In the series of phosphonate analogs of ACV monophosphate, only the guanine analog I (R = H) exhibited activity against herpesviruses, similar to the structure-activity relationship observed for base modification of ACV analogs. The phosphonate isostere of ACV monophosphate I (R = H) was more effective than ACV in the HSV-1 infected mouse model. The 3′-carba analog of 9-[3-hydroxy-2-(phosphonomethoxy)propyl]purines/ pyrimidines (adenine:HPMPA; guanine:HPMPG; cytosine:HPMPC) are devoid of antiherpesvirus activity. This result confirms that the β-oxygen atom of the phosphonomethyl ether functionality in HPMP-purines/pyrimidines plays a critical role for activity against herpesviruses. The crystal structure of [(benzoyloxy)methoxy]methyladenine II was determined

Journal of Medicinal Chemistry published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Product Details of C8H15BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Razuvaev, G. A. published the artcileReactions of triethylaluminum and triphenylaluminum with benzoyl peroxide in benzene solution, Related Products of bromides-buliding-blocks, the publication is Zhurnal Obshchei Khimii (1961), 2340-3, database is CAplus.

cf. Ziegler, Ger. (East) 13539 and Ger. (East) 24757. Reaction of Et₃Al with Bz₂O₂ in C₆H₆ was exothermic and required cooling; run at 25-35°, the reaction gave Et₂AlOBz and EtOBz; at higher temperature, the reaction was very complex and no definite products could be isolated. Approx. 3% Bz₂O₂ failed to react regardless of reagent proportions and the reaction, while very vigorous at first, slowed abruptly in further progress. Ph₃Al and Bz₂O₂ under similar conditions gave Ph₂AlOBz, m. 159-60°, some PhOBz, and C₆H₆.

Zhurnal Obshchei Khimii published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Han, Hoon published the artcileDevelopment of a proton exchange membrane based on trifluoromethanesulfonylimide-grafted polybenzimidazole, Name: Sodium 3-bromopropane-1-sulfonate, the publication is Polymer Journal (Tokyo, Japan) (2021), 53(12), 1403-1411, database is CAplus.

Trifluoromethanesulfonylimide-grafted polybenzimidazole (PBI-TFSI) was synthesized for proton exchange membrane (PEM) applications. Its proton conductivity was (a) less dependent on humidity and (b) higher than that of conventional fluorine-based PEM (Nafion) and propanesulfonic acid-grafted PBI (PBI-PS) at a relative humidity of 40%. The chem. structure of PBI-TFSI was investigated using ¹H and ¹⁹F NMR and Fourier transform IR spectroscopy. The membranes exhibited good transparency, flexibility, and thermal stability up to 350 °C. Membranes with different side chain grafting ratios were prepared, and the water uptake and hydration number of the PBI-TFSI membranes were lower than those of the PBI-PS membranes, most likely because of the hydrophobicity of the side chain. The higher proton concentration provided by TFSI with stronger acidity than PS might be the reason for the higher proton conductivities of PBI-TFSI.

Polymer Journal (Tokyo, Japan) published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Name: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Morino, Yonezo published the artcileDipole moments of 2,3-dihalo-2,3-dimethylbutane, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Bulletin of the Chemical Society of Japan (1955), 165-71, database is CAplus.

cf. C.A. 45, 947i; 48, 13297h. The dipole moments of X(Me)₂CC(Me)₂X [where X = Cl(I) and Br(II)] are 1.24, -; -, 0.88; 1.30, -; -, 0.97; 1.37, 1.03; and 1.47, 1.15 for -20; -15; 0; 6; 25; and 55°, resp., in CCl₄, and 1.74, 1.24 D. at 25° in C₆H₆. These data indicate the existence of a rotational isomer or gauche form with a ΔΕ of 1.1 and 1.3 for I and 1.5 and 1.5 kcal./mole for II in CCl₄ and heptane, resp. The dipole moments of the gauche form are 2.8 and 3.2 for I and 2.6 and 2.6 D. for II in CCl₄ and heptane, resp.

Bulletin of the Chemical Society of Japan published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Matsumoto, Mutsuyoshi published the artcileReversible Light-Induced Morphological Change in Langmuir-Blodgett Films, Recommanded Product: Sodium 3-bromopropane-1-sulfonate, the publication is Journal of the American Chemical Society (1998), 120(7), 1479-1484, database is CAplus.

An amphiphilic anionic azobenzene derivative, soluble in water, formed a monolayer on an aqueous subphase containing a water-soluble polycation. The monolayers were transferred onto solid substrate by the Langmuir-Blodgett (LB) technique. XPS measurements showed that ion exchange reaction proceeded almost completely at the air-water interface and that the ratio of the monomer unit of the polycation to the azobenzene was almost unity. UV/visible absorption and IR measurements indicated that the azobenzene photoisomerized reversibly in the LB films on alternate illumination with UV and visible light. Furthermore, a reversible morphol. change induced by light was observed in the LB films with AFM. Before illumination, the surface of the single-layer LB film was very smooth with a surface undulation of less than 1 nm. On illumination with UV light, however, a number of hills, with the height of ca. 5 nm and the diameter of the base of ca. 100 nm, appeared on the film surface. These structures almost disappeared on illumination with visible light. This indicates that the widely accepted assumption that photoisomerization should not change the two-dimensional structures significantly does not hold in the present case.

Journal of the American Chemical Society published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Recommanded Product: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Khudolei, V. V. published the artcileThe study of mutagenic activity of carcinogens and other chemical agents with Salmonella typhimurium assays: testing of 126 compounds, Quality Control of 97845-58-4, the publication is Archiv fuer Geschwulstforschung (1987), 57(6), 453-62, database is CAplus and MEDLINE.

A total of 126 chem. compounds were tested in the Ames assay with S. typhimurium of 8 various strains (mainly TA98 + TA100). For metabolic activation liver S₉ from arochlor-treated rats was used. In the first group of substances tested (51 compounds with confirmed carcinogenicity for animals) 45 agents possessed mutagenicity and 6 gave false-neg. response (1,2-dimethylhydrazine, urethane, DDT, chloroform, carbon tetrachloride, 1,4-dioxane). In group 2 (27 compounds which did not possess carcinogenic activity) 22 agents were correctly identified and the other 5 gave false-pos. responses (acrolein, styrene oxide, acridine orange, 1-naphthylamine, dichloromethane). After summation of data obtained, test sensitivity for both groups together made 88.2%; specificity 81.5% and predictive value 90%. In group 3 (48 compounds, presented by chem., pharmaceutical and food industries, for which either there are insufficient data on their carcinogenicity, or they were tested for the first time), 8 appeared mutagenic (1-aminoanthraquinone, 2-aminoanthraquinone, 1-amino-4-chloroanthraquinone, 2-amino-3-oxyanthraquinone, Rhoduline blue 5B, dinitrochlorbenzene, nitrosodiphenylamine and 2,3,5-trinitronaphthalene).

Archiv fuer Geschwulstforschung published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Quality Control of 97845-58-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abdelhafiz, Fatma M. published the artcileDesigning of quaternized hyperbranched polyamidoamines dendrimers: Surface activity, pharmaceutical efficacy, and safety approach, HPLC of Formula: 143-15-7, the publication is Journal of Drug Delivery Science and Technology (2022), 102929, database is CAplus.

The low solubility of the drug considers a major challenge for pharmaceutical formulation of both oral and parenteral products. In this work various generations of cationic hyperbranched polyamidoamine (PAMAM) quaternary ammonium salt dendrimers terminated with amine end groups were synthesized. The pharmaceutical application of these quaternized cationic surfactants ended with amine end groups and those ended with ester end groups which prepared in an earlier study were investigated. These dendrimers were compared as solubilizing agents for coenzyme Q10 (poorly soluble drug) and the dendrimers that showed high solubilizing potential (G_2.5 C₈, G_2.5 C₁₂) were selected to be evaluated as a dendrimer in dissolution study for coenzyme Q10 or Ledipasvir drug. In our investigation a comparison between four dissolution media with different surfactants namely, G_2.5 C₈, G_2.5 C₁₂, CTAB and Labrasol used for the dissolution test of Q10 was carried out. The results revealed that % Q10 released after 4 h was 86.7, 70.5, 43 and 10.5% for these dissolution media, resp. These results indicated the priority of the synthesized cationic surfactants than the known com. cationic surfactant (CTAB) or than Labrasol as recommended surfactant in previous lectures. Therefore, the profiles of the ledipasvir dissolution in the three-dissolution media G_2.5 C₈, G_2.5 C₁₂ and FDA surfactant (1.5% tween 80 and 0.0075 mg/mL Butylated Hydroxytoluene (BHT)) are similar. The obtained results emphasized that the new surfactants can be used as alternative to FDA surfactant in the dissolution media of Ledipasvir. Eventually, the toxicity study was performed for two selected compounds from the prepared dendrimers, and these compounds were proved to be safe.

Journal of Drug Delivery Science and Technology published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Prakash, Chandran published the artcileSynthesis of angularly fused carbocycles via tandem radical cyclization of α-carbonyl radicals, Category: bromides-buliding-blocks, the publication is European Journal of Organic Chemistry (2008), 1535-1543, database is CAplus.

An α-carbonyl radical cyclization approach towards the synthesis of angularly fused tricyclic systems is described. On reduction with tributyltin hydride, bromo ketones yield a α-carbonyl radical that undergoes successive 5-exo-dig/trig cyclizations, resulting in two or four contiguous stereocenters.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Caputo, Romualdo published the artcileSelective debromination of substituted vic-dibromides, Computed Properties of 594-81-0, the publication is Rendiconto dell’Accademia delle Scienze Fisiche e Matematiche, Naples (1983), 50(2), 299-300, database is CAplus.

Vicinal dibromides possessing at least 1 bromine atom bonded to a tertiary carbon were debrominated by heating in DMF at 60°. Thus, heating 2β,3α-dibromo-3β-methyl-5α-cholestane in DMF 1 h gave 90% 3-methyl-5α-cholest-2-ene; heating Me₂CBrCBrMe₂ in DMF 9 h gave 80% Me₂C:CMe₂.

Rendiconto dell’Accademia delle Scienze Fisiche e Matematiche, Naples published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Computed Properties of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary