Tag: M.W=200-250

Wang, Yipu published the artcileVisualizing Aβ deposits in live young AD model mice with a simple red/near-infrared-fluorescent AIEgen, Category: bromides-buliding-blocks, the publication is Science China: Chemistry (2022), 65(2), 339-352, database is CAplus.

Precise and early detection of β-amyloid (Aβ) deposits in situ and in real time is pivotal to the diagnosis and early intervention of Alzheimer’s disease (AD). Optical imaging stands out to be a promising technique for such a task; however, it still remains a big challenge, due to the lack of high-performance imaging contrast agent. Restricted by poor blood-brain barrier (BBB) penetrability, short-wavelength excitation and emission, as well as the aggregation-caused quenching effect, the widely used gold-standard probes cannot be used for early in-vivo imaging of Aβ deposits. Herein, we integrate the Aβ deposits-favored geometry, amphiphilic and zwitterionic mol. structure, extended D-π-A electronic structure, and 3D conformation into one mol., facilely establishing a simple and economic imaging contrast agent that enjoys high specificity and affinity to Aβ deposits, good BBB penetrability, bright red/near-IR fluorescence, low interference from autofluorescence, aggregation-induced emission (AIE) feature, high signal-to-noise ratio (SNR), and high contrast. In-vitro, ex-vivo, and in-vivo experiments with different strains of mice indicate that AIE-CNPy-AD holds the universality to Aβ deposits identification. Noteworthily, AIE-CNPy-AD is even able to precisely trace the small and sparsely-distributed Aβ deposits in AD model mice as young as 4-mo-old APP/PS1 mice, the youngest having Aβ deposits. Moreover, the present probe could clearly reveal the increase and enlargement of Aβ deposits as the mice grow. Therefore, AIE-CNPy-AD might be an ideal alternative for early AD diagnosis and highly reliable monitoring of AD progression.

Science China: Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C15H12O6, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tanner, Dennis D. published the artcileReexamination of the reaction of a “graded set” of radicals with N-bromosuccinimide: a kinetic argument concerning the π, and ω states of succinimidyl, Product Details of C6H12Br2, the publication is Journal of the American Chemical Society (1985), 107(23), 6584-9, database is CAplus.

The NBS [N-bromosuccinimide] of CH₂Cl₂ with added substrates which yield stable radicals was reinvestigated. The proposal that these substrates would affect the ratio of BrCH₂CH₂CONCO (BPI)/CHCl₂Br, the solvent bromination product, was not substantiated. Bromination of Me₂CHCHMe₂, cyclohexene, and butadiene by NBS in CH₂Cl₂ plus H₂C:CCl₂ gives essentially the same BPI/CHCl₂Br ratios as in the presence of neopentane but large yields of brominated and polybrominated products. Similar reactions in the presence of up to 2.5 M C₆H₆ always yield BPI but also highly brominated benzene derivatives BPI is detected in the NBS bromination of CHCl₃ under all conditions and is the major product in the presence of H₂C:CCl₂ chloride. Photolysis of N-iodosuccinimide-I₂ in CHCl₃ gives ICH₂CH₂CONCO as the chief product. None of these observations support the hypothesis of σ and π states of the succinimidyl radical (S·), while the NBS results appear consistent with competing S·-Br· chains.

Journal of the American Chemical Society published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C12H16N2O2, Product Details of C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

D’yachenko, A. I. published the artcilePreparation of spiro[2.4]-4,6-heptadienes by the cycloalkylation of 1,3-cyclopentadiene with 1,2-dibromoalkanes under phase transfer catalysis conditions, Computed Properties of 594-81-0, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1984), 1664-6, database is CAplus.

Cycloalkylation of cyclopentadiene with RCHBrCHBrR¹ (R = R¹ = H, Me; R = H, R¹ = Me) in 50% aqueous NaOH containing PhCH₂NEt₃⁺ Cl^– in 1.1:1:4:0.005-0.02 molar ratio gave 70-85% title compounds (I; same R, R¹). No I were obtained with BrCMe₂ZBr (Z = CH₂, CHMe, CMe₂).

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Computed Properties of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abd Karim, Nurul H. published the artcileSalphen metal complexes as tunable G-quadruplex binders and optical probes, Related Products of bromides-buliding-blocks, the publication is RSC Advances (2014), 4(7), 3355-3363, database is CAplus.

A series of seven new metal complexes (metal = Ni^II, Cu^II, Pt^II and VO²⁺) with substituted salphen ligands have been prepared and their duplex and G-quadruplex DNA affinities determined The selectivity of the complexes towards a given DNA topol. is dictated by several factors including geometry, overall charge and substitution pattern of the complex. Also the two platinum(II)-salphen complexes developed as part of this series are emissive. Confocal microscopy studies were carried out with these two complexes using four different cell lines (CHO, HeLa, U2OS and HepG2). The cell permeability and localization are different for the two probes and highly dependent on the cell line used.

RSC Advances published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Larsen, John W. published the artcileThermodynamic stabilities of some cyclic halonium ions in magic acid, SDS of cas: 594-81-0, the publication is Journal of the American Chemical Society (1972), 94(5), 1614-19, database is CAplus.

The heats of formation of a series of methyl-substituted ethylene- and tetramethylene-bromonium ions and a chloronium ion from the appropriate dihaloalkane precursors were measured calorimetrically in 11.5 mole % SbF5-F SO3H at -60°. The tetramethylenebromonium ions are about as stable as the tert-Bu cation and are ∼10 kcal/mole more stable than a correspondingly substituted ethylenebromonium ion. The tetramethylenechloronium ion is ∼7.5 kcal/mole less stable than its bromo analog. The interaction of a Me group with a 3-membered ring is unusually favorable.

Journal of the American Chemical Society published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, SDS of cas: 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sommers, Kyle J. published the artcileQuaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance, Application In Synthesis of 143-15-7, the publication is ACS Infectious Diseases (2022), 8(2), 387-397, database is CAplus and MEDLINE.

Quaternary ammonium compounds (QACs) serve as mainstays in the formulation of disinfectants and antiseptics. However, an over-reliance and misuse of our limited QAC arsenal has driven the development and spread of resistance to these compounds, as well as co-resistance to common antibiotics. Extensive use of these compounds throughout the COVID-19 pandemic thus raises concern for the accelerated proliferation of antimicrobial resistance and demands for next-generation antimicrobials with divergent architectures that may evade resistance. To this end, we endeavored to expand beyond canonical ammonium scaffolds and examine quaternary phosphonium compounds (QPCs). Accordingly, a synthetic and biol. investigation into a library of novel QPCs unveiled biscationic QPCs to be effective antimicrobial scaffolds with improved broad-spectrum activities compared to com. QACs. Notably, a subset of these compounds was found to be less effective against a known QAC-resistant strain of MRSA. Bioinformatic anal. revealed the unique presence of a family of small multiresistant transporter proteins, hypothesized to enable efflux-mediated resistance to QACs and QPCs. Further investigation of this resistance mechanism through efflux-pump inhibition and membrane depolarization assays illustrated the superior ability of P6P-10,10 to perturb the cell membrane and exert the observed broad-spectrum potency compared to its com. counterparts. Collectively, this work highlights the promise of biscationic phosphonium compounds as next-generation disinfectant mols. with potent bioactivities, thereby laying the foundation for future studies into the synthesis and biol. investigation of this nascent antimicrobial class.

ACS Infectious Diseases published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Balczewski, Piotr published the artcilePhosphorus containing radicals. 1. Free radical reaction of α-haloalkylphosphonates with alkenes and alkynes: a new approach to modified phosphonates, Product Details of C5H12BrO3P, the publication is Synthesis (1995), 392-6, database is CAplus.

A new approach to the synthesis of phosphonates functionalized in the α- and γ-phosphonate positions by alkyl, ethoxy, butoxy, acetoxy, acetyl and cyanide groups and allylphosphonate is described. It is based on the radical reaction of α-halosubstituted phosphonates (EtO)₂P(O)CHR¹X (1, R¹ = H, Me, X = Cl, Br, I) with the terminally unsubstituted alkenes (1-heptene, ethoxyethene, butoxyethene, acetoxyethene, acrylonitrile, Me vinyl ketone) and alkyne (hept-1-yne). The reaction involving the tin hydride method (Bu₃SnH/AlBN) was more effective with alkenes than with alkynes (40-72% vs. 20-30%). With electron-rich alkenes, chloro- and bromomethylphosphonates 1 (X = Cl, Br) gave higher yields than iodomethylphosphonate 1 (X = I). Di-Et methylphosphonate, as a reduction product of 1, accompanied in the above reactions. The yield of di-Et methylphosphonate could be reduced by optimizing the reaction conditions.

Synthesis published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Product Details of C5H12BrO3P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Boyer, Joseph H. published the artcileNitrodibromoacetonitrile: an agent for bromination and for the formation of adducts formally derived from cyanonitrocarbene, SDS of cas: 594-81-0, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1989), 1381-5, database is CAplus.

The reactions of nitrodibromoacetonitrile (NDBA) with alkenes, aromatic compounds, amines, and sulfides have been studied. Products were formally derived from bromine or nitrocyanocarbene except for bis(2-bromocyclohexyl)nitroacetonitrile, an adduct (2:1) obtained from cyclohexene and NDBA. 2,3-Dimethylbut-2-ene was converted into 3-cyano-4,4,5,5-tetramethyl-4,5-dihydroisoxazole 2-oxide and 2,3-dibromo-2,3-dimethylbutane. meso-1,2-Dibromo-1,2-diphenylethane was obtained from trans-stilbene. In a reaction catalyzed by copper, benzene and NDBA gave benzoyl cyanide. From anthracene, phenol, and cupric acetylacetonate, 9,10-dibromoanthracene, 4-bromophenol, and cupric bromoacetylacetonate were obtained, resp. Di-Me sulfide, tetrahydrothiophene, and triethylamine afforded the corresponding sulfonium and ammonium cyanomethylide derivatives and, with the latter, co-formation of triethylammonium bromide. Rationales for the reactions are discussed.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, SDS of cas: 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Smith, Davis E. published the artcileExploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors, Related Products of bromides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2015), 54(40), 11754-11759, database is CAplus and MEDLINE.

Many biol. active mols. exist as rapidly interconverting atropisomeric mixtures Whereas one atropisomer inhibits the desired target, the other can lead to off-target effects. Herein, we study atropisomerism as a possibility to improve the selectivities of kinase inhibitors through the synthesis of conformationally stable pyrrolopyrimidines. Each atropisomer was isolated by HPLC on a chiral stationary phase and subjected to inhibitor profiling across a panel of 18 tyrosine kinases. Notably different selectivity patterns between atropisomers were observed, as well as improved selectivity compared to a rapidly interconverting parent mol. Computational docking studies then provided insights into the structure-based origins of these effects. This study is one of the first examples of the intentional preorganization of a promiscuous scaffold along an atropisomeric axis to increase target selectivity, and provides fundamental insights that may be applied to other atropisomeric target scaffolds.

Angewandte Chemie, International Edition published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C12H17NO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Perera, Tharushi A. published the artcilePhotoreduction of Pt(IV) Chloro Complexes: Substrate Chlorination by a Triplet Excited State, Formula: C6H12Br2, the publication is Inorganic Chemistry (2014), 53(14), 7608-7621, database is CAplus and MEDLINE.

The Pt(IV) complexes trans-Pt(PEt₃)₂(Cl)₃(R) (2; R = Cl, Ph, 9-phenanthryl, 2-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-perylenyl) were prepared by chlorination of the Pt(II) complexes trans-Pt(PEt₃)₂(R)(Cl) (1) with Cl₂ gas or PhICl₂. Mixed bromo-chloro complexes trans,trans-Pt(PEt₃)₂(Cl)₂(Br)(R) (R = 9-phenanthryl, 4-trifluoromethylphenyl), trans,cis-Pt(PEt₃)₂(Cl)₂(Br)(4-trifluoromethylphenyl), trans,trans-Pt(PEt₃)₂(Br)₂(Cl)(R) (R = 9-phenanthryl), and trans,cis-Pt(PEt₃)₂(Br)₂(Cl)(4-trifluoromethylphenyl) were obtained by halide exchange or by oxidative addition of Br₂ to 1 or Cl₂ to trans-Pt(PEt₃)₂(R)(Br). Except for 2 (R = Ph, 4-trifluoromethylphenyl), all of the Pt(IV) complexes are photosensitive to UV light and undergo net halogen reductive elimination to give Pt(II) products, trans-Pt(PEt₃)₂(R)(X) (X = Cl, Br). Chlorine trapping experiments with alkenes indicate a reductive-elimination mechanism that does not involve mol. chlorine and is sensitive to steric effects at the Pt center. DFT calculations suggest a radical pathway involving ³LMCT excited states. Emission from a triplet is observed in glassy 2-methyltetrahydrofuran at 77 K where photoreductive elimination is markedly slowed.

Inorganic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Formula: C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary