Tag: M.W=200-250

Inam, Maria published the artcileControlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers, Recommanded Product: Sodium 3-bromopropane-1-sulfonate, the publication is ACS Central Science (2018), 4(1), 63-70, database is CAplus and MEDLINE.

A wide range of biorelevant applications, particularly in pharmaceutical formulations and the food and cosmetic industries, require the stabilization of two water-soluble blended components which would otherwise form incompatible biphasic mixtures Such water-in-water emulsions can be achieved using Pickering stabilization, where two-dimensional (2D) nanomaterials are particularly effective due to their high surface area. However, control over the shape and size of the 2D nanomaterials is challenging, where it has not yet been possible to examine chem. identical nanostructures with the same thickness but different surface areas to probe the size-effect on emulsion stabilization ability. Hence, the rationale design and realization of the full potential of Pickering water-in-water emulsion stabilization have not yet been achieved. Herein, we report for the first time 2D poly(lactide) platelets with tunable sizes (with varying coronal chem.) and of uniform shape using a crystallization-driven self-assembly methodol. We have used this series of nanostructures to explore the effect of 2D platelet size and chem. on the stabilization of a water-in-water emulsion of a poly(ethylene glycol) (PEG)/dextran mixture We have demonstrated that cationic, zwitterionic, and neutral large platelets (ca. 3.7 × 10⁶ nm²) all attain smaller droplet sizes and more stable emulsions than their resp. smaller platelets (ca. 1.2 × 10⁵ nm²). This series of 2D platelets of controlled dimensions provides an excellent exemplar system for the investigation of the effect of just the surface area on the potential effectiveness in a particular application.

ACS Central Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Recommanded Product: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dobbs, Adrian P. published the artcileIndole radical cyclizations: a rapid route to mitosenes, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Tetrahedron Letters (1995), 36(27), 4857-60, database is CAplus.

The syntheses and radical cyclization of 2-bromoindoles carrying an unsaturated N-alkyl group is described. The radical cyclization of 1-(3-butenyl)-2-bromo-1H-indole gave 2,3-dihydro-1-methyl-1H-pyrrolo[1,2-a]indole (79% yield). The cyclization of 2-bromo-1-(4-pentenyl)-1H-indole gave 6,7,8,9-tetrahydro-9-methylpyrido[1,2-a]indole (74% yield).

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ellis, Gwynn P. published the artcileOne-step synthesis and spectral study of 1-methylbenzimidazoles including use of a lanthanide shift reagent, Name: 4-Bromo-N-methyl-2-nitroaniline, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1974), 903-9, database is CAplus.

4-Substituted 1,2-phenylenediamines and their N-1-Ac derivatives with HCHO in boiling EtOH containing HCl gave 5- and 6-substituted 1-methylbenzimidazoles. E.g., 1,2-(H2N)2C6H3R-4 (R = NO2, Cl) gave 42% 6-nitro- and 43% 5-chloro-1-methyl-benzimidazole. Other 4-substituted 1,2-phenylenediamines gave mixtures The preparation of 5- and 6-substituted 1-methylbenzimid-azoles by other routes and the differentiation of isomeric pairs by lanthanide shift NMR spectroscopy is described.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C7H7BrN2O2, Name: 4-Bromo-N-methyl-2-nitroaniline.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dumas, Stephane published the artcileHigh relaxivity magnetic resonance imaging contrast agents part 1: impact of single donor atom substitution on relaxivity of serum albumin-bound gadolinium complexes, Recommanded Product: Diethyl (bromomethyl)phosphonate, the publication is Investigative Radiology (2010), 45(10), 600-612, database is CAplus and MEDLINE.

Rationale and objectives: The donor atoms that bind to gadolinium in contrast agents influence inner-sphere water exchange and electronic relaxation, both of which determine observed relaxivity. The effect of these mol. parameters on relaxivity is greatest when the contrast agent is protein bound. We sought to determine an optimal donor atom set to yield high relaxivity compounds Methods: A total of 38 gadolinium-1,4,7,10-tetraazacyclo-dodecane-N,N’,N”,N”’-tetraacetato derivatives were prepared and relaxivity was determined in the presence and absence of human serum albumin as a function of temperature and magnetic field. Each compound had a common albumin-binding group and differed only by substitution of different donor groups at one of the macrocycle nitrogens. Oxygen-17 isotope relaxometry at 7.05 T was performed to estimate water exchange rates. Results: Changing a single donor atom resulted in changes in water exchange rates ranging across 3 orders of magnitude. Donor groups increased water exchange rate in the order: phosphonate ∼ phenolate > α-substituted acetate > acetate > hydroxamate ∼ sulfonamide > amide ∼ pyridyl ∼ imidazole. Relaxivites at 0.47 and 1.4 T, 37°C, ranged from 12.3 to 55.6 mMs and from 8.3 to 32.6 mMs resp. Optimal relaxivities were observed when the donor group was an α-substituted acetate. Electronic relaxation was slowest for the acetate derivatives as well. Conclusions: Water exchange dynamics and relaxivity can be predictably tuned by choice of donor atoms.

Investigative Radiology published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Recommanded Product: Diethyl (bromomethyl)phosphonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nechaev, Anton A. published the artcileSynthesis of fused 1,2-naphthoquinones with cytotoxic activity using a one-pot three-step reaction, Computed Properties of 89694-44-0, the publication is Organic & Biomolecular Chemistry (2021), 19(15), 3434-3440, database is CAplus and MEDLINE.

A method for the synthesis of fused 1,2-naphthoquinones, as analogs of biol. active natural terpene quinones, was described. The intermediate polycyclic naphthalenes were prepared by a one-pot palladium-catalyzed process from simple alkynes, one of which was made from an optically pure biomass-derived levoglucosenone. The prepared methoxy-substituted naphthalenes were subsequently transformed in one step to 1,2-naphthoquinones by a trivalent-iodine-mediated oxidation The naphthoquinone products were found to have cytotoxic properties.

Organic & Biomolecular Chemistry published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Computed Properties of 89694-44-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dimitrov, Ivaylo published the artcileSynthesis of polystyrene-based random copolymers with balanced number of basic or acidic functional groups, Computed Properties of 55788-44-8, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2010), 48(9), 2044-2052, database is CAplus.

Pairs of polystyrene-based random copolymers with balanced number of pendant basic or acidic groups were synthesized utilizing the template strategy. The same poly[(4-hydroxystyrene)-ran-styrene] was used as a template backbone for modification. Two different synthetic approaches for the functionalization were applied. The first one involved direct functionalization of the template backbone through alkylation of the phenolic groups with suitable reagents. The second modification approach was based on “click” chem., where the introduction of alkyne groups onto the template backbone was followed by copper-catalyzed 1,3 cycloaddition of aliphatic sulfonate- or amine-containing azides. Both synthetic approaches proved to be highly efficient as evidenced by ¹H-NMR analyses. The thermal properties were evaluated by differential scanning calorimetry and thermal gravimetric analyses and were influenced by the type of functionality and the modification method. The ether-linked functional copolymers were thermally more stable than their “clicked” analogs. © 2010 Wiley Periodicals, Inc. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2044-2052, 2010.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Computed Properties of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Karlsson, Lina E. published the artcilePolysulfone ionomers for proton-conducting fuel cell membranes: sulfoalkylated polysulfones, Synthetic Route of 55788-44-8, the publication is Journal of Membrane Science (2004), 230(1-2), 61-70, database is CAplus.

Polysulfones (PSUs) carrying short pendant alkyl side-chains with terminal sulfonic acid units were prepared and studied as proton-conducting membrane materials. The 1st step in the preparation involved quenching of lithiated PSU with SO₂ gas, resulting in sulfonated PSU. In the 2nd step, the lithium sulfonate units on the polymer were reacted with sodium 2-bromoethanesulfonate, sodium 3-bromopropanesulfonate, or 1,4-butane sultone to produce sulfoethylated, sulfopropylated, or sulfobutylated PSUs, resp. Anal. by TG showed that membranes based on the sulfoalkylated polymers were stable up to ∼300° under N₂ atmosphere. Calorimetry measurements revealed that the modified polymers absorbed large amounts of non-freezing water, corresponding to 11-14 mol H₂O/mol SO₃H under immersed conditions. The proton conductivity of a membrane based on a PSU carrying 0.9 sulfopropyl chains per repeating unit is 77 mS/cm at 70° under humidifying conditions.

Journal of Membrane Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Synthetic Route of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Harnden, M. R. published the artcileAn improved synthesis of the antiviral acyclonucleoside 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, Product Details of C8H15BrO2, the publication is Tetrahedron Letters (1985), 26(35), 4265-8, database is CAplus.

Alkylation of 2-amino-6-chloropurine with 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxane and subsequent acid hydrolysis provides an improved procedure for synthesis of the antiviral title acyclonucleoside I.

Tetrahedron Letters published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Product Details of C8H15BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Harnden, Michael R. published the artcileSynthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines, Recommanded Product: 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, the publication is Journal of Medicinal Chemistry (1987), 30(9), 1636-42, database is CAplus and MEDLINE.

Alkylation of 2-amino-6-chloropurine with 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxane provided 2-amino-6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]purine (I) in high yield. I was readily converted to the antiviral acyclonucleoside II [R = NH₂, R¹ = R² = H (III)] and to its 6-chloro, 6-thio, 6-alkoxy, 6-amino, and 6-deoxy purine analogs. III was also converted to its xanthine analog. Similarly, alkylation of 6-chloropurine provided a route to II (R = R¹ = R² = H).. Of these 9-substituted purines, III showed the highest activity against herpes simplex virus types 1 and 2 in cell cultures, and in some tests it was more active than acyclovir, with no evidence of toxicity for the cells. A series of monoesters and diesters of III were prepared, and some of these also showed antiherpes virus activity in cell cultures, the most active ester being the dihexanoate II [R = NH₂, R¹ = R² = Me(CH₂)₄CO].

Journal of Medicinal Chemistry published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Recommanded Product: 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Govindan, Karthick published the artcileMetal-Free N-H/C-H Carbonylation by Phenyl Isocyanate: Divergent Synthesis of Six-Membered N-Heterocycles, HPLC of Formula: 143-15-7, the publication is Journal of Organic Chemistry (2022), 87(13), 8719-8729, database is CAplus and MEDLINE.

A method using Ph isocyanate to synthesize carbonyl-containing N-heterocycles is reported. The metal-free novel approach for both N-H and C-H carbonylation processes was successfully refined, delivering a range of synthetically valuable derivatives of quinazoline-2,4(1H,3H)-dione, 2H-benzo[e] [1,2,4] thiadiazin-3(4H)-one 1,1-dioxide, and pyrrolo[1,2-a] quinoxalin-4(5H)-one. The protocol features broad substrates with diverse reactions suitable for excellent yields, mild conditions, and good functional group compatibility. Moreover, the applicability of the reaction was characterized by gram-scale synthesis and synthetic transformations for drug mols.

Journal of Organic Chemistry published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary