Tag: M.W=200-250

Wan, Honghe published the artcileBenzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)-Hit to Lead studies, Synthetic Route of 53484-26-7, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(17), 5063-5066, database is CAplus and MEDLINE.

Hit to Lead optimization and SAR development led to the identification of the potent and selective benzo[d]imidazole inhibitor (17b)(I) of Co-activator Associated Arginine Methyltransferase (CARM1).

Bioorganic & Medicinal Chemistry Letters published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C6H7BFNO2, Synthetic Route of 53484-26-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Arno, Maria C. published the artcileExploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties, Computed Properties of 55788-44-8, the publication is Nature Communications (2020), 11(1), 1420, database is CAplus and MEDLINE.

The ability to control nanostructure shape and dimensions presents opportunities to design materials in which their macroscopic properties are dependent upon the nature of the nanoparticle. Although particle morphol. has been recognized as a crucial parameter, the exploitation of the potential shape-dependent properties has, to date, been limited. Herein, we demonstrate that nanoparticle shape is a critical consideration in the determination of nanocomposite hydrogel properties. Using translationally relevant calcium-alginate hydrogels, we show that the use of poly(L-lactide)-based nanoparticles with platelet morphol. as an adhesive results in a significant enhancement of adhesion over nanoparticle glues comprised of spherical or cylindrical micelles. Furthermore, gel nanocomposites containing platelets showed an enhanced resistance to breaking under strain compared to their spherical and cylindrical counterparts. This study opens the doors to a change in direction in the field of gel nanocomposites, where nanoparticle shape plays an important role in tuning mech. properties.

Nature Communications published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Computed Properties of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tsuchiya, Motoki published the artcileSynthesis of Twisted Anthracenes: Induction of Twist Chirality by the Planar Chiral [2.2]Paracyclophane, COA of Formula: C12H25Br, the publication is Chemistry – An Asian Journal (2022), 17(15), e202200418, database is CAplus and MEDLINE.

Planar chiral [2.2]paracyclophane was employed as chiral scaffolds to twist an anthracene ring by tethering at its 1- and 8-positions; thus, twist chirality was induced in the anthracene moiety. The chiroptical properties of the resulting mol. I, including CD (CD) and circularly polarized luminescence (CPL), were found to be derived from the twist chirality. An analogous mol. II bearing long alkyl chains was a viscous liquid at ambient temperature, and its liquid film exhibited good CD and CPL profiles. Theor. studies were carried out to determine the origin of these properties in the ground and excited states, which reproduced well the exptl. results.

Chemistry – An Asian Journal published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C8H6ClN, COA of Formula: C12H25Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grosse, Aristid V. published the artcileThe alkylation of paraffins with olefins. The identification of the paraffins formed, Synthetic Route of 594-81-0, the publication is Journal of Organic Chemistry (1943), 438-47, database is CAplus.

The hexanes obtained by the reaction between Me₃CH and CH₂:CH₂ with BF₃ or AlCl₃ as catalyst are investigated and identified by converting them into Br and NO₂ derivatives and by the Raman spectrum. The hexane fractions consist chiefly of 90-70% Me₂CHCHMe₂ (I), 10-25% Me₂CHPr (II) and of less than 3% Me₃CEt (III). ETCHMeEt and n-hexane cannot be detected and may be present only in traces, if at all. Since I is the only hexane which gives a solid Br derivative on direct bromination, the hexane fraction is brominated in direct sunlight, giving Me₂CBr CBrMe₂ (IV). IV sublimes 165-75° without melting and m. 166-8° (decomposition) in a sealed tube. On further bromination, IV gives Me(BrCH₂)CBrCBr(CH₂Br)Me, m. 130-1°. When boiled with Zn in 95% EtOH, IV gives Me₂C:CMe₂, b₇₆₀ 72°, n²⁰_D 1.4155, which is converted by Thiele’s method (Ber. 27, 456(1894)) into Me₂C(NO)CClMe₂, m. 121°. Me₂CBrCHMe₂ (V), m. 24-5°, and Me₃CCBr₂Me, m. 191.5°, are not formed by direct bromination. The liquid bromides left after the separation of IV consist chiefly of monobromides, b₂₀₀ 75-85°, n²⁰_D 1.45, which are free from V. Nitration of the hexane fraction by boiling 20 cc. with 60 cc. 38% HNO₃ for 6 hrs. gives Me₂C(NO₂)C(NO₂)₂Et, colorless plates or needles, m. 96°, indicating the presence of II in the hexane mixture The presence of III was first observed when a fraction, b₇₆₀ 49.2-9.9°, d²⁰₄ 0.6492, n²⁰_D 1.3689, was obtained. Treatment of this fraction with 38% HNO₃ at 120° and distillation give 3-nitro-2,2-dimethylbutane, b₇₆₀ 168°. It dissolves completely in 5% EtONa in EtOH, remains in solution on addition of an equal volume of H₂O and is precipitated from this solution by CO₂ as an oil. For the results of the Raman spectrum, see C. A. 34, 3205.2. The reactions taking place between Me₃CH and CH₂:CH₂ in the presence of catalysts are briefly discussed.

Journal of Organic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Synthetic Route of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Malamas, Michael S. published the artcileNovel Spirosuccinimide Aldose Reductase Inhibitors Derived from Isoquinoline-1,3-diones: 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4(11H),3′-pyrrolidine]-1,2′,3,5′(2H)-tetrone and Congeners. 1, Computed Properties of 147181-08-6, the publication is Journal of Medicinal Chemistry (1994), 37(13), 2043-58, database is CAplus and MEDLINE.

Spiro[isoquinolinepyrrolidine]tetrones I [R¹ = H, Cl, F, Br, OMe, CF₃, Me, NO₂; R² = (un)substituted benzyl, benzothiazolylmethyl, alkyl] were prepared and evaluated in vitro for their ability to inhibit glyceraldehyde reduction, using a partially purified bovine lens aldose reductase preparation, and in vivo for their ability to inhibit galactitol accumulation in the lens and sciatic nerve of galactose-fed rats. Substitution at the N-2 position of I with diverse structural substituents (i.e., aralkyl, benzothiazolylmethyl, methyl) produced several excellent series of aldose reductase inhibitors. Optimization of these new series of spirosuccinimides through structure-activity relationship (SAR) studies, including analogy from other drug series (ponalrestat, zopolrestat), led to the design of the clin. candidate I [R¹ = 6-F, R² = 2,4-F(Br)C₆H₃, II]. II exhibited exceptional oral potency in two animal models of diabetic complications, the 14-day galactose-fed and streptozocin-induced diabetic rats, with ED₅₀ values for the sciatic nerve of 0.1 and 0.09 mg/kg/day, resp. Both enantiomeric forms of II exhibited similar inhibitory activity in both in vitro and in vivo assays possibly due to their rapid interconversion. In an ex vivo experiment, the pharmacodynamic effect of II in the plasma of rats and dogs, after a single dose, appeared to be comparable to that of tolrestat.

Journal of Medicinal Chemistry published new progress about 147181-08-6. 147181-08-6 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Salt,Amine,Benzene, name is (4-Bromo-2-fluorophenyl)methanamine hydrochloride, and the molecular formula is C7H8BrClFN, Computed Properties of 147181-08-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fox, Martin E. published the artcileN-Alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 7. Hydroxylamine-alkyne cyclizations. Formation of cyclic nitrones and application to the synthesis of the proposed structure for (±)-acacialactam, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1994), 3379-95, database is CAplus.

The cyclization of alkynylhydroxylamines to give five-, six- and seven-membered cyclic nitrones is described. A concerted intramol. ene-like pathway is proposed for the addition of the N-O-H group across the triple bond. Using 3,7-dimethyl-3,4,5,6-tetrahydro-2H-azepine 1-oxide as the starting material, the seven-membered lactam structure proposed for the natural product acacialactam was prepared and was found to be incorrect. (E)-CH₂:CHCMe(OH)CH₂CH₂CH:CMeCONH₂ is proposed as the structure for acacialactam.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yoshida, Tatsuki published the artcileN-Methylphenothiazine S-Oxide Enabled Oxidative C(sp²)-C(sp²) Coupling of Boronic Acids with Organolithiums via Phenothiaziniums, Quality Control of 849062-12-0, the publication is Organic Letters (2021), 23(24), 9664-9668, database is CAplus and MEDLINE.

The development of a transition-metal-free oxidative C(sp²)-C(sp²) coupling of readily available boronic acids RB(OH)₂ (R = Ph, 2-naphthyl, 1-hexenyl, 2-(4-bromophenyl)vinyl, etc.) and organolithiums R¹Li (R¹ = 4-bromophenyl, vinyl, 2-naphthyl, etc.) via phenothiazinium ions I was reported. Various biaryl, styrene, and diene derivatives RR¹ were obtained using this reaction system. The key to this process is N-methylphenothiazine S-oxide (PTZSO), which allows efficient conversion of boronic acids to phenothiazinium ions I. The mechanism of phenothiazinium formation using PTZSO was investigated using theor. calculations and experiments, which provided insight into the unique reactivity of PTZSO.

Organic Letters published new progress about 849062-12-0. 849062-12-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Bromo-5-methoxyphenyl)boronic acid, and the molecular formula is C4H4N2O2, Quality Control of 849062-12-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Matsuzawa, Tsubasa published the artcileTransition-Metal-Free Synthesis of N-Arylphenothiazines through an N- and S-Arylation Sequence, Computed Properties of 89694-44-0, the publication is Organic Letters (2021), 23(6), 2347-2352, database is CAplus and MEDLINE.

An efficient synthetic method of N-arylphenothiazines, e.g., I, from o-sulfanylanilines under transition-metal-free conditions is disclosed. An N- and S-arylation sequence of o-sulfanylanilines enabled the authors to synthesize a wide variety of N-arylphenothiazines. In particular, one-pot synthesis of N-arylphenothiazines was accomplished from easily available modules through preparation of o-sulfanylanilines by thioamination of aryne intermediates and following N- and S-arylation sequence.

Organic Letters published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Computed Properties of 89694-44-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Haihua published the artcileConcurrent alkylation and crosslinking of polyaniline for enhanced anticorrosive performance of waterborne alkyd coating, Application In Synthesis of 143-15-7, the publication is Progress in Organic Coatings (2022), 106865, database is CAplus.

The uniform dispersion and long-term stability of hydrophobic polyaniline (PANI) in waterborne polymer matrix always remains a challenge. Here, PANI was chem. modified by 1,12-dibromododecane to prepare functionalized PANI (PANI-12Br(II)), and simultaneously achieve N-alkylation and chem. crosslinking of PANI chains. In addition, 1-bromododecane was utilized to modify PANI to prepare PANI-12Br(I) as a control. The degree of alkylation of PANI-12Br(II) was higher than that of PANI-12Br(I), as well as the content of N⁺ species in PANI-12Br(II). Also, the interaction between the PANI-12Br(II) chains decreased. The colloidal particle size decreased from 703.9 nm to 297.3 nm, and the dispersibility and long-term colloidal stability of PANI-12Br(II) in aqueous system were significantly improved. The water adsorption of as-prepared PANI-12Br(II)/WAR nanocomposite decreased from 18.37% to 4.27%, and the contact angle increased from 63.4° to 112.5°. Compared with WAR and PANI/WAR-0.5%, the coating resistance of PANI-12Br(II)/WAR-0.5% increased by 5 and 4 orders of magnitude, and the corrosion c.d. decreased by 3 and 2 orders of magnitude. The PANI-12Br(II)/WAR-0.5% displayed better long-term anticorrosive performance than PANI-12Br(I)/WAR-0.5%. The anticorrosive mechanisms were also put forward. The PANI-12Br(II) can be applied as a promising class of corrosion inhibitors in waterborne polymer matrixes.

Progress in Organic Coatings published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C3H5BN2O2, Application In Synthesis of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chia, Lawrence H. L. published the artcileMolecular polarizability. Conformations of polar substituted ethanes, SDS of cas: 594-81-0, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1973), 766-71, database is CAplus.

The mol. distributions of the rotational isomers and the dihedral angles between polar groups of CICH2CCl:CH2 and ten bromo- and chloro-substituted ethane derivatives were estimated from dipole moments and molar Kerr constants determined for CCl4 solutions at infinite dilution at 25°. Polarizations and refractions of these solutions were also determined

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, SDS of cas: 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary