Tag: M.W=200-250

Liu, Shaohui published the artcileEffect of Decarboxylation on the Photoinitiation Behavior of Nitrocarbazole-Based Oxime Esters, Computed Properties of 143-15-7, the publication is Macromolecules (Washington, DC, United States) (2022), 55(7), 2475-2485, database is CAplus.

A series of 50 oxime esters bearing various substituents were designed and synthesized as photoinitiators (48 of them were never synthesized before and only B1 and B10 were reported). Good light absorption properties in the visible range were observed for these oxime esters. Some structures exhibited better photoinitiation abilities than diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) upon exposure to a LED@405 nm. Interestingly, PIs with Me substituent on the oxime ester group have better photoinitiation performance than the others. Substituent effects were investigated through MOs calculations, the detection of CO₂, and the investigation of the generated free radicals. The results demonstrate that the substituents on the oxime ester group exert major effects on the photoinitiation ability via the decarboxylation reaction. In addition, a chem. mechanism was proposed. 3D printed objects were successfully obtained by using the most reactive oxime ester as photoinitiator, and their thermal initiation behaviors of several oxime esters were also studied (dual thermal/photochem. initiator behavior).

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Computed Properties of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sorci, Mirco published the artcileVirucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, HPLC of Formula: 143-15-7, the publication is ACS Applied Materials & Interfaces (2022), 14(22), 25135-25146, database is CAplus and MEDLINE.

N95 respirator face masks serve as effective phys. barriers against airborne virus transmission, especially in a hospital setting. However, conventional filtration media materials, such as nonwoven polypropylene fibers, have no inherent virucidal activity, and thus, the risk of surface contamination increases with wear time. The ability of face masks to protect against infection can be likely improved by incorporating components that deactivate viruses on contact. We present a facile method for covalently attaching antiviral quaternary ammonium polymers to the fiber surfaces of nonwoven polypropylene fabrics that are commonly used as active filtration materials in N95 respirators via UV-initiated grafting of biocidal agents. Here, C₁₂-quaternized benzophenone is simultaneously polymerized and grafted onto melt-blown or spunbond polypropylene fabric using 254 nm UV light. This grafting method generated ultrathin polymer coatings which imparted a permanent cationic charge without grossly changing the fiber morphol. or air resistance across the filter. For melt-blown polypropylene, which comprises the filtration layer of N95 respirator masks, filtration efficiency was neg. impacted from 72.5 to 51.3% for uncoated and coated single-ply samples, resp. Similarly, directly applying the antiviral polymer to full N95 masks decreased the filtration efficiency from 90.4 to 79.8%. This effect was due to the exposure of melt-blown polypropylene to organic solvents used in the coating process. However, N95-level filtration efficiency could be achieved by wearing coated spunbond polypropylene over an N95 mask or by fabricating N95 masks with coated spunbond as the exterior layer. Coated materials demonstrated broad-spectrum antimicrobial activity against several lipid-enveloped viruses and Escherichia coli bacteria. For example, a 4.3-log reduction in infectious MHV-A59 virus and a 3.3-log reduction in infectious SuHV-1 virus after contact with coated filters were observed, although the level of viral deactivation varied significantly depending on the virus strain and protocol for assaying infectivity.

ACS Applied Materials & Interfaces published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C11H10O, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gleiter, Rolf published the artcileRegiochemistry of the intramolecular [2+2] photocycloaddition of enones to vinyl ethers as a function of chain length, Formula: C7H13BrSi, the publication is Chemische Berichte (1992), 125(8), 1899-911, database is CAplus.

The intramol. [2+2] cycloaddition of a cyclohexenone moiety bound to a vinyl ether fragment has been explored. The regiochem. and the quantum yield of the reaction have been investigated as a function of the chain length n and the position of the methoxy group. In those cases where the chain consists of 3 and 4 members the position of the methoxy group has no influence on the regiochem. but on the quantum yield. Only head-to-head cycloaddition is observed In the case of n = 2 both the regiochem. and the quantum yield depend strongly on the position of the methoxy group. The main reason for the different behavior of n = 2 is due to a through-bond effect between the two olefinic units mediated by a C₂H₄ bridge.

Chemische Berichte published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chenede, Alain published the artcileCationic rearrangements controlled by the presence of a silyl group, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Journal of Organometallic Chemistry (2003), 686(1-2), 84-93, database is CAplus.

1,1-Disilylcarbinols having two alkyl groups on the adjacent carbon atom react with thionyl chloride in sulfur dioxide to give the product in which one of the alkyl groups has migrated towards the two silyl groups, and one of the silyl groups has been removed from the resultant cation. The reaction is seen in ring-expansion, as in the conversion of cyclohexylbis[dimethyl(phenyl)silyl]carbinol into 1-dimethyl(phenyl)silylcycloheptene, and in open chains, as in the conversion of 1,1-bis[dimethyl(phenyl)silyl]-2-methylpropanol into (E)- and (Z)-2-dimethyl(phenyl)silylbut-2-ene. Phenyldimethylsilyllithium reacts with pinacolone to give the α-silyl carbinol, which rearranges in the same way to give 2,3-dimethylbut-2-ene, effectively achieving a pinacolone-to-pinacol rearrangement.

Journal of Organometallic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Davison, Edwin C. published the artcileN-Alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 8. The scope of tandem reactions involving hydroxylamine-alkyne cyclizations, COA of Formula: C7H13BrSi, the publication is Tetrahedron (1996), 52(35), 11601-11624, database is CAplus.

A tandem sequence of hydroxylamine-alkyne cyclization/1,3-dipolar cycloaddition, provides useful entry into tricyclic systems of type I. The scope of such reactions is explored in this paper. A novel cascade cyclization of N-hydroxypyrrolidines of type II (n = 1, 3) involving hydroxylamine-alkyne cyclization, Cope elimination and 1,3-dipolar cycloaddition is also reported.

Tetrahedron published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

El-Saeed, H. M. published the artcileSynthesis and characterization of novel ionic liquids based on imidazolium for acid corrosion inhibition of aluminum: Experimental, spectral, and computational study, Application of 1-Bromododecane, the publication is Journal of Molecular Liquids (2022), 119177, database is CAplus.

Three newly ionic liquids I [R = C₈H₁₇, C₁₀H₂₁, C₁₂H₂₅] were synthesized and their chem. structures characterized via different spectra techniques (FT-IR, elemental anal., and ¹H NMR). The corrosion inhibition of newly ionic liquids was evaluated on aluminum alloy in 1 M HCl at varied exposure temperatures (298-318 K) and varied concentrations via various exptl. and theor. methods for example mass loss, electrochem., spectral, and computational calculations The results illustrate that these types of ionic liquids inhibit corrosion of aluminum in acid solution with maximum inhibition efficiency was reached 83.2% at 298 K. The inhibition efficiency increases with the addition of zinc sulfate which had a synergistic impact which was reached to 92.7%. Also, the concentration of ionic liquids and the kind of cation have an impact on the obtained results. The existence of these inhibitors in the acidic solution improves the charge transfer resistance and lessens the double-layer capacitance. The Langmuir adsorption isotherm governs the adsorption of these inhibitors’ mols. on the aluminum alloy surface, and they behave as mixed-type inhibitors. The outputs reveal that the computational calculations match the exptl. data rather well.

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Application of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kiprianov, G. I. published the artcileSynthesis of some derivatives of β-phenylisopropylamine. I. Reaction of symmetric dihaloalkanes with β-phenylisopropylamine, COA of Formula: C6H12Br2, the publication is Ukrains’kii Khemichnii Zhurnal (1950), 16(No. 6), 620-6, database is CAplus.

Heating 5 g. (CH₂Br)₂ with 35 g. PhCH₂CHMeNH₂ (I) 5 hrs. at 130° gave 7.4 g. (CH₂NHCHMeCH₂Ph)₂, b₃ 195-200°; di-HCl salt, m. 272-4°. Heating 37.5 g. I with 17 g. (CMe₂Br)₂ 6 hrs. on a steam bath gave 5.6 g. PhCH₂CHMeNHCMe₂CMe:CH₂, b₇ 135-43°; HCl salt, m. 173-4°; the free amine with Br yields a product m. 120-1°. Heating 67.5 g. I with 12 g. 1,2-dibromocyclohexane 7 hrs. at 100° and 4 hrs. at 120° gave 7.2 g. N-(1-(or 2-)cyclohexen-1-yl)-2-phenylisopropylamine, b₃ 130-5°; HCl salt, m. 186-9°. (CH₂)₃Br₂ (10.1 g.) and 67.5 g. I kept 24 hrs. at room temperature gave 10 g. 1,3-bis(2-phenylisopropylamino)propane, b₂ 200-5°; di-HCl salt, m. 238-9°. Similarly (CH₂)₄Br₂ gave 94% 1-(2-phenylisopropyl)pyrrolidine, b₄ 117-23°; HCl salt, m. 136-8°. (CH₂)₅Br₂ gave 62% 1-(2-phenylisopropyl)piperidine, b₄ 115-17°; HCl salt, m. 215-16°. (CH₂)₆Br₂ and I kept 24 hrs. at room temperature gave 58% 1,6-bis(2-phenylisopropylamino)hexane, b₂ 224°; picrate, m. 183-4°; di-HCl salt m. 253-4°.

Ukrains’kii Khemichnii Zhurnal published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, COA of Formula: C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lerch, Swantje published the artcileThe Mizoroki-Heck Reaction in Tunable Aryl Alkyl Ionic Liquids, HPLC of Formula: 143-15-7, the publication is European Journal of Organic Chemistry (2022), 2022(6), e202200008, database is CAplus.

Authors report the use of imidazolium based tunable aryl alkyl ionic liquids (TAAILs) as solvents in the Mizoroki-Heck reaction. Different com. available palladium sources, inorganic bases, TAAILs and reaction conditions were tested for the synthesis of trans-stilbene using bromobenzene and styrene. A variety of different stilbene derivatives were synthesized with exclusive formation of the (E)-isomers and isolated yields up to 97%. Author’s were able to optimize the reaction conditions using only 0.25 mol% of Pd(OAc)₂ as the catalyst and a reaction time of 4 h. No addnl. ligands or additives are used in the reaction. The catalytic system using TAAILs achieved higher yields than com. available imidazolium and phosphonium ionic liquids, demonstrating the potential of tailored ionic liquids as a reaction medium for the Mizoroki-Heck reaction.

European Journal of Organic Chemistry published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Shotaro published the artcileRapid and efficient synthesis of a novel cholinergic muscarinic M₁ receptor positive allosteric modulator using flash chemistry, Product Details of C7H7BrFN, the publication is Organic & Biomolecular Chemistry (2019), 17(35), 8166-8174, database is CAplus and MEDLINE.

Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative as a key intermediate of a novel cholinergic muscarinic M₁ pos. allosteric modulator I bearing an isoindolin-1-one ring system as a pharmacophore was achieved using flow microreactors through selective I/Li exchange of 1-bromo-2-iodobenzene derivative with BuLi and subsequent formylation at -40° of the highly reactive 2-bromophenyllithium intermediate using DMF, which was difficult to achieve by a conventional batch process due to the conversion of the highly reactive 2-bromophenyllithium intermediate into benzyne even at -78°. Late-stage cyclization gave the isoindolin-1-one ring system, through reductive amination of 2-bromobenzaldehyde derivative followed by palladium-catalyzed carbonylation with carbon monoxide and intramol. cyclization, efficiently afforded I for its further research and development.

Organic & Biomolecular Chemistry published new progress about 1540204-53-2. 1540204-53-2 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Amine,Benzene, name is 4-Bromo-2-fluoro-3-methylaniline, and the molecular formula is C7H7BrFN, Product Details of C7H7BrFN.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Evans, Genevieve L. published the artcileAnthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha-D-ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design, Synthetic Route of 66197-72-6, the publication is Biochimica et Biophysica Acta, Proteins and Proteomics (2018), 1866(2), 264-274, database is CAplus and MEDLINE.

Phosphoribosyltransferases (PRTs) bind 5′-phospho-α-D-ribosyl-1′-pyrophosphate (PRPP) and transfer its phosphoribosyl group (PRib) to specific nucleophiles. Anthranilate PRT (AnPRT) is a promiscuous PRT that can phosphoribosylate both anthranilate and alternative substrates, and is the only example of a type III PRT. Comparison of the PRPP binding mode in type I, II and III PRTs indicates that AnPRT does not bind PRPP, or nearby metals, in the same conformation as other PRTs. A structure with a stereoisomer of PRPP bound to AnPRT from Mycobacterium tuberculosis (Mtb) suggests a catalytic or post-catalytic state that links PRib movement to metal movement. Crystal structures of Mtb-AnPRT in complex with PRPP and with varying occupancies of the two metal binding sites, complemented by activity assay data, indicate that this type III PRT binds a single metal-coordinated species of PRPP, while an adjacent second metal site can be occupied due to a sep. binding event. A series of compounds were synthesized that included a phosphonate group to probe PRPP binding site. Compounds containing a “bianthranilate”-like moiety are inhibitors with IC₅₀ values of 10-60 μM, and K_i values of 1.3-15 μM. Structures of Mtb-AnPRT in complex with these compounds indicate that their phosphonate moieties are unable to mimic the binding modes of the PRib or pyrophosphate moieties of PRPP. The AnPRT structures presented herein indicated that PRPP binds a surface cleft and becomes enclosed due to re-positioning of two mobile loops.

Biochimica et Biophysica Acta, Proteins and Proteomics published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Synthetic Route of 66197-72-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary