Tag: M.W=200-250

King, James Frederick published the artcileReductive elimination of 1,2-dibromides with sodium borohydrides, Quality Control of 594-81-0, the publication is Canadian Journal of Chemistry (1968), 46(5), 805-8, database is CAplus.

Sodium trimethoxyborohydride or a 1:3 mixture of NaBH4 and sodium tetramethylborate reacts with a number of vicinal dibromides to form the corresponding olefin. Variable (sometimes good) yields were obtained when the Br atoms were on secondary or tertiary carbons, but little or no olefin was detected when one Br was primary.

Canadian Journal of Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Quality Control of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Koide, Tsutomu published the artcilePhase transition of the solid phase of 2,2-dibromo-3,3-dimethylbutane and 2,3-dibromo-2,3-dimethylbutane, Formula: C6H12Br2, the publication is Nippon Kagaku Kaishi (1973), 214-19, database is CAplus.

The phase transition temperature of Br2MeC-CMe3 (I) was -59° by DTA. High values of the dielec. constant were observed in the high temperature solid Phase, although in the low tem. phase it was low. The ir spectra showed no remarkable change at temperatures both above and below the phase transition. An x-ray study showed that the crystal structure at room temperature was a body centered cubic lattice with A 7.71 Å and Z = 2. From comparisons between symmetries of the mol. and the crystal, it was concluded that the mol. axis should run parallel to each of the 4 body-diagonals of the unit cell with equal statistical weight and that the C-C axis at the same time acquired at least a statistical symmetry of 3. Reinvestigation of the mol. from BrMe2C-CMe2Br (II) was done by the spectroscopic method. Only the transformed mol. existed in the solid phase II (-89 ∼ 90°) and in CCl4 solution Mechanism of the phase transtions for these 2 crystals was studied from an entropy anal., for I, the statistical orientation of the mol. mentioned above and the intramol rotation should occur at the transition point. At the lower transition point (-89°) of II, the mol. should have the orientational freedom which satisfied a statistical symmetry 4 about the Br… Br mol. axis.

Nippon Kagaku Kaishi published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Formula: C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kan, S. B. Jennifer published the artcileA cascade palladium-mediated cross-coupling/electrocyclization approach to the construction of fused bi- and tricyclic rings, Related Products of bromides-buliding-blocks, the publication is Organic Letters (2008), 10(11), 2323-2326, database is CAplus and MEDLINE.

A versatile palladium-catalyzed cyclization/cross-coupling/electrocyclization strategy for the synthesis of fused bi- and tricyclic ring systems is described. Excellent yields of the polycyclic products are obtained with a range of tethering ring sizes and functionality, including an unprecedented 5,6,4,5-fused tetracycle. The reaction mechanism features two unusual palladium-mediated isomerizations prior to electrocyclization.

Organic Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bauer, Daniel published the artcileFunctionalisable acyclic cucurbiturils, Computed Properties of 55788-44-8, the publication is Organic Chemistry Frontiers (2019), 6(10), 1555-1560, database is CAplus.

Synthetic strategies were described to prepare acyclic cucurbituril derivatives with two different types of appended functional groups, one that mediates water solubility and another one that allows further functionalization. The synthesis started with the coupling of a 1,4-disubstituted naphthalene derivative containing one 2-chloroethoxy and one 3-sulfonatopropoxy group to a suitable tetrameric glycoluril-derived precursor. This reaction afforded two regioisomers, differing in the relative orientation of the peripheral substituents, which could be separated in a straightforward fashion and structurally characterized. Both isomers were then converted into the corresponding diazides and diamines that served to append further residues by, resp., copper(I)-catalyzed azide-alkyne cycloaddition or amide formation. Binding studies showed that the functionalized dianionic acyclic cucurbiturils thus obtained possess a notable cation affinity in water, albeit a lower one than an analog with four peripheral neg. charged substituents. This work constitutes the basis for the development of water-soluble acyclic cucurbiturils whose applications could potentially go beyond the use as receptors.

Organic Chemistry Frontiers published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Computed Properties of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chapman, Robert D. published the artcileSelective syntheses of mono- and bis(2-fluoro-2,2-dinitroethoxy)alkanes. Scope of the utility of triflate intermediates, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Journal of Organic Chemistry (1988), 53(16), 3771-5, database is CAplus.

Displacement of the bromide in BrCH₂CHMeOCH₂CF(NO₂)₂ (I) cannot be effected by AgO₃SCF₃ because of the electroneg. vicinal alkoxide’s deactivating inductive effect on the primary bromine; however substituents in the secondary position are more labile with respect to nucleophile displacement. The scope of the utility of nucleophilic substitutions using homologous α,ψ-dibromoalkanes, Br(CH₂)_nCHMeBr (n = 1,2,3) and a vicinal dibromoalkane, MeCHBrCHBrMe, is reported. This approach produced a variety of new fluorodinitroethyl ethers, including the novel (O₂N)₂CFCH₂OCH₂CHMeOCH₂CF(NO₂)₂, which possesses two electroneg. alkoxy substituents in a vicinal arrangement, from the fortuitous intermediate (O₂N)₂CFCH₂OCH₂CHBrMe (II) by way of anchimeric assistance in the reaction of BrCH₂CHBrMe, also yielding I, the regioisomer of II. Typically, α,ψ- and α,ω-dibromoalkanes are distinctly stepwise in their 2 possible S_N1Ag⁺ displacements of bromide by AgO₃SCF₃, a characteristic which allows selective incorporation of relatively nonnucleophilic alkoxy substituents via displacements of triflate intermediates.

Journal of Organic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Yulin published the artcileDiscovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes, SDS of cas: 55788-44-8, the publication is Journal of Medicinal Chemistry (2013), 56(12), 5094-5114, database is CAplus and MEDLINE.

The apical sodium-dependent bile acid transporter (ASBT) transports bile salts from the lumen of the gastrointestinal (GI) tract to the liver via the portal vein. Multiple pharmaceutical companies have exploited the physiol. link between ASBT and hepatic cholesterol metabolism, which led to the clin. investigation of ASBT inhibitors as lipid-lowering agents. While modest lipid effects were demonstrated, the potential utility of ASBT inhibitors for treatment of type 2 diabetes has been relatively unexplored. We initiated a lead optimization effort that focused on the identification of a potent, nonabsorbable ASBT inhibitor starting from the first-generation inhibitor 264W94 (1). Extensive SAR studies culminated in the discovery of GSK2330672 (56) as a highly potent, nonabsorbable ASBT inhibitor which lowers glucose in an animal model of type 2 diabetes and shows excellent developability properties for evaluating the potential therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes.

Journal of Medicinal Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C9H7NO2, SDS of cas: 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lv, Xin-Yang published the artcileDihydroquinazolinones as adaptative C(sp³) handles in arylations and alkylations via dual catalytic C-C bond-functionalization, SDS of cas: 143-15-7, the publication is Nature Communications (2022), 13(1), 2394, database is CAplus and MEDLINE.

C-C bond forming cross-couplings are convenient technologies for the construction of functional mols. Consequently, there is continual interest in approaches that can render traditionally inert functionality as cross-coupling partners, included in this are ketones which are widely-available commodity chems. and easy to install synthetic handles. Herein, a dual catalytic strategy that utilizes dihydroquinazolinones derived from ketone congeners as adaptative one-electron handles for forging C(sp³) architectures via α C-C cleavage with aryl and alkyl bromides is reported. This approach is achieved by combining the flexibility and modularity of nickel catalysis with the propensity of photoredox events for generating open-shell reaction intermediates. This method is distinguished by its wide scope and broad application profile–including chem. diversification of advanced intermediates–, providing a catalytic technique complementary to existing C(sp³) cross-coupling reactions that operates within the C-C bond-functionalization arena.

Nature Communications published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, SDS of cas: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hodges, Alastair J. published the artcileIntramolecular nitrone dipolar cycloadditions: control of regioselectivity and synthesis of naturally-occurring spirocyclic alkaloids, HPLC of Formula: 69361-41-7, the publication is Organic & Biomolecular Chemistry (2012), 10(45), 8963-8974, database is CAplus and MEDLINE.

The intramol. nitrone dipolar cycloaddition of in situ-generated nitrones such as compound I has been used for the synthesis of cyclic isoxazolidines II and III. The regioselectivity of the intramol. cycloaddition depends on the nature of the terminal substituent on the dipolarophile. The influence of the substituent on the regioselectivity of the cycloaddition has been examined using several model systems and two methods of nitrone formation. These studies demonstrated that the cyano-substituent plays a special role in favoring the formation of the 6,6,5-ring fused adduct II under thermodynamically controlled conditions. The utility of the cyclo-adduct IV (BOM = CH₂OCH₂Ph; see Scheme 12) as a precursor for the naturally occurring histrionicotoxins is illustrated by the synthesis of three “unsym.” (i.e. with each side chain bearing different functional groups) members of the histrionicotoxin family HTX-259A, HTX-285C and HTX-285E [V; R = CH:CH₂, CH₂CH₂CH:CH₂, and CH:CHCH:CH-(Z), resp.].

Organic & Biomolecular Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, HPLC of Formula: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Pujala, Brahmam published the artcileDiscovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ, COA of Formula: C7H8BBrO3, the publication is ACS Medicinal Chemistry Letters (2016), 7(12), 1161-1166, database is CAplus and MEDLINE.

The aberrant activation of B-cells has been implicated in several types of cancers and hematol. disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clin. benefit in certain types of lymphoma. Simultaneous inhibition of these pathways could result in more robust responses or overcome resistance as observed in single agent use. The authors report a series of novel compounds that have low nanomolar potency against both BTK and PI3Kδ as well as acceptable PK properties that could be useful in the development of treatments against B-cell related diseases.

ACS Medicinal Chemistry Letters published new progress about 1256345-59-1. 1256345-59-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-Bromo-3-methoxyphenyl)boronic acid, and the molecular formula is C7H8BBrO3, COA of Formula: C7H8BBrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Uner, Osman published the artcileMicellization and thermodynamics study of n-alkyl-4-methylpyridinium bromides in water and mixed water-ethanol media, HPLC of Formula: 143-15-7, the publication is Journal of Molecular Liquids (2022), 118765, database is CAplus.

The micellization behaviors of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide were studied in water and mixed water-ethanol media by using conductivity measurements over the temperature range of 293.15-318.15 K. The critical micelle concentrations (CMC) of all n-alkyl-4-Me pyridinium bromides studied increased with increasing temperature, but they decreased with increasing hydrocarbon chain length. Their CMC values of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide in water at the temperature range of 293.15-318.15 K were determined as in the range of 43.62-46.42, 10.45-11.57, and 2.78-3.20 mM, resp. Moreover, the lowest CMC values of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide were found with 15, 5, and 5 vol% ethanol additions, resp. The calculated neg. ΔG_m⁰ and ΔH_m⁰ values proved that their micellizations in water and mixed water-ethanol media were spontaneous and exothermic. Also, ΔG_m⁰ values became the more neg. with the longer the hydrocarbon chain length. Furthermore, their micellization processes in water were determined to be entropy controlled, however enthalpic contributions in the mixed water-ethanol systems started to predominate with increasing ethanol concentrations and/or temperature

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C21H37BO, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary