M.W=200-250 Archives - Page 46 of 208 - Bromides-buliding-blocks

Lutteke, Ginger’s team published research in European Journal of Organic Chemistry in | CAS: 69361-41-7

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Lutteke, Ginger published the artcileFormation of bicyclic pyrroles and furans through an enone allene photocycloaddition and fragmentation sequence, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is European Journal of Organic Chemistry (2008), 925-933, database is CAplus.

The [2 + 2] photocycloaddition of dimedone-substituted allenes was studied. Irradiation of a solution of these substrates in acetonitrile at 300 nm resulted in the clean conversion of the starting materials into a mixture of photoproducts. The major product in all cases was a bicyclic pyrrole or furan fused to an eight membered ring (43-70% yield). The formation of these products is thought to be a result of a heteroatom-induced fragmentation of the straight adduct. This is supported by irradiation of 3-(penta-3,4-dienyl)cyclohex-2-en-1-one which allowed the isolation of tricyclic adduct after catalytic hydrogenation in 27 %. The minor crossed photoproducts were isolated in 10-20% yield. The observed major/minor ratio of 4:1 was not affected by the variation of substituents on the cyclohexene ring. Introduction of a substituent on the allene had a more significant effect on the ratio which changed to 2:1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Martins, Nayara Silva’s team published research in New Journal of Chemistry in 42 | CAS: 594-81-0

New Journal of Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Formula: C6H12Br2.

Martins, Nayara Silva published the artcileDibromination of alkenes with LiBr and H₂O₂ under mild conditions, Formula: C6H12Br2, the publication is New Journal of Chemistry (2018), 42(1), 161-167, database is CAplus.

Electron-rich and electron-poor alkenes, and alkenes bearing protecting groups can be efficiently and stereoselectively converted to trans-dibromides using LiBr/H₂O₂ and AcOH as a proton source in 1,4-dioxane. For most substrates addition of 0.1 mol% of PhTeTePh enhances the reaction rate and the yield of the products. Exptl. data suggest that the brominating agent prepared in situ is mol. bromine and that LiBr assists the activation of H₂O₂ allowing bromination to occur using AcOH as a mild proton source in uncatalyzed experiments Scale-up is feasible: 10.0 mmol of 1-octene was quant. converted to 1,2-dibromooctene in one hour of reaction at room temperature

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Palais, Laetitia’s team published research in Chemistry – A European Journal in 15 | CAS: 69361-41-7

Chemistry – A European Journal published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Related Products of bromides-buliding-blocks.

Palais, Laetitia published the artcileCopper-Catalyzed Asymmetric Conjugate Addition with Chiral SimplePhos Ligands, Related Products of bromides-buliding-blocks, the publication is Chemistry – A European Journal (2009), 15(40), 10473-10485, S10473/1-S10473/113, database is CAplus and MEDLINE.

SimplePhos ligands, e.g., I [R = Ph, 3-(F₃C)C₆H₄, 3,5-Me₂C₆H₃], represent a novel class of monodentate chiral ligands based on a chiral amine moiety and flexible diaryl groups on the phosphorous atom. They were easily prepared by two different pathways and could be highly functionalized. Their application as ligands in the copper-catalyzed asym. conjugate addition of di-Et zinc and trialkylaluminum reagents to cyclic enones, acyclic enones and nitroalkenes was reported, and resulted in giving high enantioselectivity with up to 98.6% ee. In particular, the reaction of trialkylaluminum reagents with a wide range of 3-substituted enones allowed the formation of stereogenic quaternary carbon centers.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Al-Hamouz, Othman Charles S.’s team published research in Journal of Polymer Science, Part A: Polymer Chemistry in 50 | CAS: 66197-72-6

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, COA of Formula: C5H12BrO3P.

Al-Hamouz, Othman Charles S. published the artcilepH-responsive polyphosphonates using butler’s cyclopolymerization, COA of Formula: C5H12BrO3P, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2012), 50(17), 3580-3591, database is CAplus.

The cationic monomer, N,N-diallyl-(diethylphosphonato)methylammonium chloride, and zwitterionic monomer, Et 3-(N,N-diallylammonio)methanephosphonate, were cyclopolymd. in aqueous solutions using ammonium persulfate or t-butylhydroperoxide as initiators to afford a cationic polyelectrolyte (CPE) and a polyzwitterion ester (PZE), resp. The CPE and PZE on acidic hydrolysis of the ester functionalities afforded the same polyzwitterionic acid (PZA): poly[3-(N,N-diallylammonio)methanephosphonic acid]. The solution properties of the CPE, pH-responsive PZE, and PZA were studied in detail by potentiometric and viscometric techniques. Basicity constants of the phosphonate (P=O(OEt)O^–) and amine groups in the PZE and in the conjugate base of the PZE, resp., were found to be “apparent” and as such follow the modified Henderson-Hasselbalch equation. In contrast to many polycarbobetaines and sulfobetaines, PZE was found to be soluble in salt-free water as well as salt (including Ca²⁺, Li⁺)-added solutions, and demonstrated “antipolyelectrolyte” solution behavior. The PZA, on the other hand, was found to be insoluble in salt-free water, and on treatment with NaOH gave dianionic polyelectrolyte (DAPE) containing trivalent nitrogen and [P=O(O)₂^2-] groups. For the first time, several new phase diagrams of polyethylene glycol-DAPE aqueous two-phase systems (ATPSs) have been constructed in the presence of varying proportions of HCl. The ATPSs may find application in affinity partitioning of metal ions because DAPE is expected to be an effective chelator. © 2012 Wiley Periodicals, Inc., J Polym Sci Part A: Polym Chem, 2012.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Constantine, P. R.’s team published research in Journal of the Chemical Society [Section] C: Organic in 1966 | CAS: 10172-35-7

Journal of the Chemical Society [Section] C: Organic published new progress in CAplus about 10172-35-7, 10172-35-7 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxy-6-nitroaniline, and the molecular formula is C7H7BrN2O3, Quality Control of 10172-35-7.

Constantine, P. R. published the artcileBiphenylenes. XIV. Synthesis of 1- and 2-phenyl-, 2,7-dimethyl-, and 2,3,6,7-tetramethylbiphenylene, Quality Control of 10172-35-7, the main research area is .

cf. CA 63, 13171f. 1- and 2-Phenylbiphenylene were prepared from 1- and 2-lithiobiphenylene, resp., by treatment with cyclohexanone followed by dehydration and dehydrogenation. 2-Phenylbiphenylene was also prepared by pyrolysis of 4- and 5-phenylbiphenylene-2,2′-iodonium iodide with Cu2O. One new synthesis of 2,7-dimethyl- and two new syntheses of 2,3,6,7-tetramethylbiphenylene were described. 17 references.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Harrison, Charles R.’s team published research in Journal of the Chemical Society [Section] C: Organic in 1966 | CAS: 10172-35-7

Harrison, Charles R. published the artcileBiphenylenes. XV. 3,7-Dimethyl- and 3,7-dimethoxy-1,5-dinitrobiphenylene, Category: bromides-buliding-blocks, the main research area is .

cf. preceding abstracts The compound produced by treatment of 3,4-dibromo-5-nitrotoluene with Cu bronze was shown to be 3,7-dimethyl-1,5-dinitrobiphenylene. The analogous 3,7-dimethoxybiphenylene was prepared similarly from 3,4-dibromo-5-nitroanisole. The dipole moment of the dimethyl-dinitrobiphenylene was ∼2.4 D. This unexpected result is discussed.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Dehui’s team published research in European Journal of Medicinal Chemistry in 2022-12-05 | CAS: 74317-85-4

European Journal of Medicinal Chemistry published new progress about Analgesics. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Category: bromides-buliding-blocks.

Zhang, Dehui published the artcileIsoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects, Category: bromides-buliding-blocks, the main research area is isoquinolone preparation analgesic LPA5 antagonism SAR; Analgesic; Antagonist; Brain penetrant; LPA5; Structure-activity relationship.

A series of isoquinolone derivatives were designed and synthesized and their potency in LPA5 calcium mobilization and cAMP assays were evaluated. The results showed that substituted Ph groups or bicyclic aromatic rings such as benzothiophenes or benzofurans are tolerated at the 2-position, 4-substituted piperidines are favored at the 4-position, and methoxy groups at the 6- and 7-positions are essential for activity. Compounds I and II showed comparable in vitro potency, excellent selectivity against LPA1-LPA4 and >50 other GPCRs, moderate metabolic stability, and high aqueous solubility and brain permeability. Both I and II significantly attenuated nociceptive hypersensitivity at lower doses than III and had longer-lasting effects in an inflammatory pain model, and II also dose-dependently reduced mech. allodynia in the chronic constriction injury model and opioid-induced hyperalgesia at doses that had no effect on the locomotion in rats. These results suggest that these isoquinolone derivatives as LPA5 antagonists are of promise as potential analgesics.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wertjes, William C.’s team published research in Organic Letters in 2013-12-06 | CAS: 74317-85-4

Organic Letters published new progress about Amidation. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Quality Control of 74317-85-4.

Wertjes, William C. published the artcileNickel or phenanthroline mediated intramolecular arylation of sp3 C-H bonds using aryl halides, Quality Control of 74317-85-4, the main research area is isoindolinone preparation; haloarylcarboxamide preparation intramol arylation nickel phenanthroline catalyst.

The development of the intramol. arylation of sp3 C-H bonds adjacent to nitrogen using aryl halides is described. Arylation was accomplished using either Ni(COD)2 or 1,10-phenanthroline in substoichiometric amounts, and the reaction conditions were applied to a variety of electronically differentiated benzamide substrates. Preliminary studies suggest a mechanism involving aryl and alkyl radical intermediates.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Faury, Thomas’s team published research in CrystEngComm in 2013 | CAS: 74386-13-3

CrystEngComm published new progress about Annealing. 74386-13-3 belongs to class bromides-buliding-blocks, name is 4-Bromo-3-nitrophenylboronic acid, and the molecular formula is C6H5BBrNO4, Application In Synthesis of 74386-13-3.

Faury, Thomas published the artcileSide functionalization of diboronic acid precursors for covalent organic frameworks, Application In Synthesis of 74386-13-3, the main research area is side functionalized benzenediboronate preparation precursor covalent organic framework.

Substituted 1,4-benzenediboronic acids (BDBA) were synthesized and their thermal properties studied. Two diboronic acids were studied as building-blocks for covalent organic framework (COF) formation, 2,5-dimethoxy-1,4-benzenediboronic acid and 2-nitro-1,4-benzeneboronic acid. Substitution of the BDBA core caused a dramatic decrease of the polymerization temperature giving a less organized structure.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Chao’s team published research in Molecular Catalysis in 2021-08-31 | CAS: 74317-85-4

Molecular Catalysis published new progress about Arylation. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Recommanded Product: 2-Bromo-4-methoxybenzoic acid.

Liu, Chao published the artcileRapid construction of C4-substituted phenanthridinones through palladium-catalyzed domino N-arylation/aryl-aryl coupling process, Recommanded Product: 2-Bromo-4-methoxybenzoic acid, the main research area is phenanthridinone preparation chemoselective regioselective; bromobenzamide cascade arylation coupling palladium catalyst.

An excellent chemo- and regioselective palladium-catalyzed cascade intermol. N-arylation/aryl-aryl coupling process had been developed. Employing Pd(TFA)2, PCy3•HBF4, K2CO3 and 1,4-dioxane in an oil bath at 100°C for 12 h, diverse C4-substituted phenanthridinones I [R = H, Me, OMe; R1 = Me, Ph, 2-thienyl, etc.; R2 = H, Me, OMe, F] were synthesized from o-bromobenzamides in 42-92% yield. Broad substrate scope and excellent functional group tolerance were observed The synthetic utility of this method was illustrated by the further derivatization to prepare multiple-substituted phenanthridinones II [R3 = Et, Bn, 1-adamantyl] in 30-75% yield.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary