Tag: M.W=200-250

Zhang, Yun published the artcileChiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct, Related Products of bromides-buliding-blocks, the main research area is chiral phosphoric acid catalyzed asym Ugi dynamic kinetic resolution; enantioselective synthesis aryloxoisoindolinecarboxamide; formylbenzoic acid aniline isonitrile asym Ugi reaction; asymmetric synthesis; kinetic resolution; multicomponent reaction; organocatalysis; reaction mechanisms.

Reaction of isonitriles with 3-(arylamino)isobenzofuran-1(3H)-ones in the presence of a catalytic amount of an octahydro (R)-binol-derived chiral phosphoric acid afforded 3-oxo-2-arylisoindoline-1-carboxamides in high yields with good to high enantioselectivities [e.g., I + tert-BuNC → II (93% yield, 87% ee)]. An enantioselective Ugi four-center three-component reaction of 2-formylbenzoic acids, anilines, and isonitriles was subsequently developed for the synthesis of the same heterocycle. Mechanistic studies indicate that the enantioselectivity results from the dynamic kinetic resolution of the primary Ugi adduct, rather than from the C-C bond-forming process. The resulting heterocycle products are of significant medicinal importance.

Angewandte Chemie, International Edition published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tsarev, A. A. published the artcileTitanium and zirconium complexes with η5:η1-4-(alkyl/arylamino)(dimethyl)silylindene ligands as catalysts for ethene polymerization, Safety of 7-Bromo-2-methyl-1H-indene, the main research area is titanium zirconium complex catalyst polyethylene polymerization.

First members of a novel family of constrained geometry complexes of titanium and zirconium containing a short bridge between the amide and inden-4-yl fragments were obtained. When activated with methylaluminoxane, these complexes can be used as highly active catalysts for ethene polymerization producing high-mol.-weight polymers.

Russian Chemical Bulletin published new progress about Aluminoxanes, Me Role: CAT (Catalyst Use), USES (Uses). 880652-93-7 belongs to class bromides-buliding-blocks, name is 7-Bromo-2-methyl-1H-indene, and the molecular formula is C10H9Br, Safety of 7-Bromo-2-methyl-1H-indene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chu, John C. K. published the artcileZn-Catalyzed Enantio- and Diastereoselective Formal [4 + 2] Cycloaddition Involving Two Electron-Deficient Partners: Asymmetric Synthesis of Piperidines from 1-Azadienes and Nitro-Alkenes, Formula: C8H7BrO3, the main research area is zinc catalyst stereoselective formal cycloaddition azadiene nitroalkene kinetics; stereoselective preparation piperidine.

We report a catalytic asym. synthesis of piperidines, e.g. I, through [4 + 2] cycloaddition of 1-azadienes and nitro-alkenes. The reaction uses earth abundant Zn as catalyst and is highly diastereo- and regioselective. A novel BOPA ligand (F-BOPA) confers high reactivity and enantioselectivity in the process. The presence of ortho substitution on the arenes adjacent to the bis(oxazolines) was found to be particularly impactful, due to limiting the undesired coordination of 1-azadiene to the Lewis acid and thus allowing the reaction to be carried out at lower temperature A series of secondary kinetic isotope effect studies using a range of ligands implicates a stepwise mechanism for the transformation, involving an initial Michael-type addition of the imine to the nitro-alkene followed by a cyclization event. The stepwise mechanism obviates the electronic requirement inherent to a concerted mechanism, explaining the successful cycloaddition between two electron-deficient partners.

Journal of the American Chemical Society published new progress about [4+2] Cycloaddition reaction (formal stereoselective). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Formula: C8H7BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Meifang published the artcileOxypalladation Initiating the Oxidative Heck Reaction with Alkenyl Alcohols: Synthesis of Isocoumarin-Alkanones, Quality Control of 651341-68-3, the main research area is isocoumarin alkanone preparation palladium catalyst oxidative Heck alkenyl alc.

Highly regioselective nucleopalladation for the oxidative coupling of internal alkynes with alkenyl alcs. by using green and low-costing oxygen as the sole oxidant was studied. This one-pot cascade cyclization proceeds through Pd-catalyzed intramol. C-O bond cyclization, insertion of nonbiased alkenyl alcs., -H elimination, and reinsertion of a HPdX species, which is finally transferred to the target ketones. This method has the advantages of mild conditions, good functional group tolerance, and can be performed with unactivated alkenes to afford isocoumarin derivatives

European Journal of Organic Chemistry published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 651341-68-3 belongs to class bromides-buliding-blocks, name is Ethyl 2-bromo-4-fluorobenzoate, and the molecular formula is C9H8BrFO2, Quality Control of 651341-68-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wei, Hao published the artcileNovel atropisomeric bisphosphine ligands with a bridge across the 5,5′-position of the biphenyl for asymmetric catalysis, Synthetic Route of 74317-85-4, the main research area is biphenyl diphosphine atropisomeric preparation chiral ligand asym hydrogenation; cinnamic acid acetamido asym hydrogenation; phenylalanine substituted asym synthesis.

A new type of atropisomeric bisphosphine ligand I [X = (CH2)8, (CH2)10] with a bridge across the 5,5′-position of the biphenyl has been developed. The axial chirality of this type of ligands can be retained by macrocyclic ring strain produced from 5,5′-linkage of the biphenyl even without 6,6′-substituents on the biphenyls. Ligand (R)-I [X = (CH2)8] showed good catalytic activity and enantioselectivity for Rh(I)-catalyzed asym. hydrogenation of (Z)-α-acetamidocinnamic acids RCH:C(COOH)NHAc.

Tetrahedron: Asymmetry published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Synthetic Route of 74317-85-4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Zenan published the artcileHydroxyl Assisted Rhodium Catalyst Supported on Goethite Nanoflower for Chemoselective Catalytic Transfer Hydrogenation of Fully Converted Nitrostyrenes, SDS of cas: 123158-68-9, the main research area is hydroxyl assisted rhodium supported goethite nanoflower catalyst preparation; aniline chemoselective green preparation; nitrostyrene hydrazine hydrate transfer hydrogenation rhodium catalyst; nitroarene hydrazine hydrate transfer hydrogenation rhodium catalyst.

A flower-like Rh/α-FeOOH catalyst was used for the chemoselective hydrogenation of nitrostyrenes/nitroarenes to anilines. This catalyst did not showed desirable selectivity for the anilines, but also exhibits the inertness to various other reducible groups over wide reaction duration. The catalytic selectivity for the reduction of the nitro group towards vinyl group was investigated by the control experiments and FT-IR anal. The abundant hydroxyl groups in the α-FeOOH might contribute to the improvement of catalytic activity and selectivity. Furthermore, the catalyst exhibited excellent stability and kept its catalytic performance even after 6 cycles.

Advanced Synthesis & Catalysis published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation). 123158-68-9 belongs to class bromides-buliding-blocks, name is 3-Bromo-5-ethylaniline, and the molecular formula is C8H10BrN, SDS of cas: 123158-68-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pirrung, Michael C. published the artcile19F-Encoded Combinatorial Libraries: Discovery of Selective Metal Binding and Catalytic Peptoids, Recommanded Product: 3-Bromo-2-fluoro-5-methylbenzoic acid, the main research area is aryl fluoride preparation labeling solid support combinatorial chem; fluorine 19 encoded combinatorial peptoid library solid phase synthesis; metal binding screening combinatorial peptoid library; acylation autocatalyst screening combinatorial peptoid library; amine cyclic anhydride coupling solid phase combinatorial library.

A 19F NMR method for encoding of combinatorial libraries has been developed. Aryl fluorides whose chem. shifts are modified by aromatic substituents were prepared and attached to resin support beads that were used in the split-pool synthesis of peptoids. The detection of the 19F NMR signal of tags derived from a single “”big bead”” was demonstrated. The library diversity arises from amines and the cyclic anhydrides used in their acylation. The resulting 90-compound library was examined for metal ion binding, whereupon novel ligands for iron and copper were discovered. The metal-binding constants of some of these peptoids were in the low micromolar range. The library was also examined for catalysis of self-acylation.

Journal of Combinatorial Chemistry published new progress about Amines Role: CMB (Combinatorial Study), RCT (Reactant), RACT (Reactant or Reagent). 72518-16-2 belongs to class bromides-buliding-blocks, name is 3-Bromo-2-fluoro-5-methylbenzoic acid, and the molecular formula is C8H6BrFO2, Recommanded Product: 3-Bromo-2-fluoro-5-methylbenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tanimoto, Kouichi published the artcileA convenient one-pot access to phenanthridinones via Suzuki-Miyaura cross-coupling reaction, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate, the main research area is phenanthridinone preparation Suzuki Miyaura coupling aminophenylboronic acid halobenzoate.

A convenient one-step access to biol. important phenanthridinones has been realized based upon Suzuki-Miyaura cross-coupling reaction. Reactions of 2-aminophenylboronic acid with 2-halobenzoate took place smoothly to afford substituted phenanthridinones in excellent yields in the presence of palladium(II) acetate and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos) as pre-catalysts. A natural product phenaglydon was synthesized in one-pot manner from readily available starting materials in 95% yield.

Tetrahedron Letters published new progress about Aromatic carboxylic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent). 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carlson, Lars A. published the artcilePotential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo, SDS of cas: 41668-13-7, the main research area is fatty acid mobilization fluoronicotinate blood; fluoropyridylacetate fatty acid mobilization blood; methylpyrazole fatty acid mobilization blood.

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization.

Acta Pharmaceutica Suecica published new progress about Fatty acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, SDS of cas: 41668-13-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Chao published the artcilePalladium-Catalyzed Arylative Dearomatization and Subsequent Aromatization/Dearomatization/Aza-Michael Addition: Access to Zephycarinatine and Zephygranditine Skeletons, Recommanded Product: 2-Bromo-4-methoxybenzoic acid, the main research area is zephycarinatine scaffold synthesis; zephygranditine scaffold synthesis; palladium catalyzed arylative dearomatization Ugi adduct chemoselective stereoselective.

We have developed a novel palladium-catalyzed arylative dearomatization and subsequent aromatization/dearomatization/aza-Michael addition process of Ugi adducts, enabling the rapid construction of diverse zephycarinatine and zephygranditine scaffolds containing two adjacent quaternary carbon stereocenters with excellent chemoselectivity and stereoselectivity in a rapid, step-economical, and highly efficient manner. This approach shows broad substrate scope and excellent functional-group tolerance with diverse electron-rich and electron-deficient aromatic substrates. The synthetic utility of this method is further demonstrated by versatile transformations of the products.

Organic Letters published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (plicamine). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Recommanded Product: 2-Bromo-4-methoxybenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary