Tag: M.W=200-250

Chen, Xiaohan published the artcileRedox deracemization of α-substituted 1,3-dihydroisobenzofurans, Computed Properties of 74317-85-4, the main research area is alpha substituted dihydroisobenzofuran preparation enantioselective; dihydroisobenzofuran alpha substituted one pot redox resolution.

Chiral α-substituted 1,3-dihydroisobenzofurans are key scaffolds in a number of bioactive natural products and synthetic pharmaceuticals. However, catalytic asym. approaches have been rarely developed. Here, a redox deracemization technol. is adopted to address the catalytic asym. synthesis. A broad range of α-aryl substituted 1,3-dihydroisobenzofurans are effectively deracemized in high efficiency with excellent ee. α-alkynyl substituted ethers were also compatible with the deracemization technol.

Chinese Chemical Letters published new progress about Benzenecarboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Computed Properties of 74317-85-4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yan, Qiaozhi published the artcileRh-Catalyzed Asymmetric Hydrogenation of α,β- and β,β-Disubstituted Unsaturated Boronate Esters, Product Details of C8H6BrFO2, the main research area is phenethyl boronate chiral preparation styrylboronate asym hydrogenation rhodium catalyst; chiral amine alc preparation asym hydrogenation styrylboronate oxidation amination; asymmetric catalysis; asymmetric hydrogenation; chiral boronate; enantioselectivity; unsaturated boronates.

Chiral phenethyl boronates ArCHRCH2Bpin and ArCH2CHRBpin were prepared by asym. hydrogenation of α- and β-substituted β-styrylboronates. A highly enantioselective hydrogenation of α,β-unsaturated boronate esters catalyzed by Rh-(S)-DTBM-Segphos complex has been developed. Both (Z)-α,β- and β,β-disubstituted substrates can be successfully hydrogenated to afford chiral boronates with excellent enantioselectivities, up to 98% ee. Furthermore, the obtained chiral boronate esters, as important versatile synthetic intermediates are successfully transformed to the corresponding chiral alcs., amines and other important derivatives with maintained enantioselectivities.

Chemistry – A European Journal published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Product Details of C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dinesh, Chimmanamada U. published the artcileCatalytic halogenation of selected organic compounds mimicking vanadate-dependent marine metalloenzymes, Recommanded Product: 2-Bromobenzene-1,3,5-triol, the main research area is halogenation mimic vanadate marine metalloenzyme; benzene halogenation mimic vanadate marine metalloenzyme; benzentriol halogenation mimic vanadate marine metalloenzyme; iodination mimic vanadate marine metalloenzyme; chlorination mimic vanadate marine metalloenzyme; fluorination mimic vanadate marine metalloenzyme; bromination mimic vanadate marine metalloenzyme.

The ammonium metavanadate, mimicking vanadate-dependent metalloenzymes, efficiently catalyzes the halogenation of a variety of organic substrates in dilute conditions in moderate to good yields using dilute hydrogen peroxide (30%) as an oxidizing agent exhibiting remarkable ortho selectivity with electron-rich aromatic compounds Bromination of 1,3,5-benzenetriol (ammonium vanadate/hydrogen peroxide) gave 2-bromo-1,3,5-benzenetriol in 75% yield.

Journal of the Chemical Society, Chemical Communications published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 84743-77-1 belongs to class bromides-buliding-blocks, name is 2-Bromobenzene-1,3,5-triol, and the molecular formula is C6H5BrO3, Recommanded Product: 2-Bromobenzene-1,3,5-triol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wei, Dong published the artcileSynthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes, SDS of cas: 74317-85-4, the main research area is naphthalene preparation; alkyne bromo vinylbenzene palladium migration annulation.

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes such as I [ R1 = Me, 2-thienyl, Ph, etc.; R2 = 7-Me, 7-OMe, 7-F, etc.; R3 = R4 = Me, 2-thienyl, Ph, etc.]. A controllable aryl to vinylic 1,4-palladium migration process was the key for success of this transformation. A wide variety of substituted naphthalene compounds were prepared in good to excellent yields.

Chinese Journal of Chemistry published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, SDS of cas: 74317-85-4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Garcia-Gonzalez, Ma. Carmen published the artcileUgi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles, Related Products of bromides-buliding-blocks, the main research area is benzopyrrolizidinone benzoindolizidinone pyrazinoisoquinoline pyrazionoisoquinolindione preparation.

Various readily available, Ugi-derived dehydroalanines were used as pivotal templates to easily and efficiently assemble diverse pharmacol. important polyheterocyclic systems through a cascade palladium-catalyzed C-C bond formation processes (tandem reaction). Allyl, homoallyl and propargyl amine led to the formation of benzopyrrolizidinone derivatives, benzoindolizidinone derivatives and pyrazinoisoquinoline derivatives, resp., while benzylamines and o-bromobenzylamine were used as precursors of tetracyclic-fused systems and pyrazionoisoquinolindione derivatives Under optimized conditions the synthesis of the target compounds was achieved using dichlorobis(triphenylphosphine)palladium as a catalyst. Starting materials included 2-propen-1-amine (allyl amine), 2-iodobenzoic acid derivatives 2-bromobenzoic acid derivatives, 2-(benzoyloxy)acetaldehyde, isocyanides (isonitriles), 3-buten-1-amine (homoallyl amine). Dehydro amino acid amides (dehydroalanine derivatives) intermediates included N-[1-[[(1,1-dimethylethyl)amino]carbonyl]ethenyl]-2-iodo-N-(phenylmethyl)benzamide, thiophene derivatives, furan derivatives, pyrrole derivatives, indole derivatives The title compounds thus formed included (methylene)(oxo)pyrrolo[2,1-a]isoindolecarboxamides, (methylene)(oxo)pyrido[2,1-a]isoindolecarboxamides, isoindolo[2,1-b]isoquinolinecarboxamides, pyrazino[1,2-b]isoquinolinedione derivatives.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Izmer, Vyatcheslav V. published the artcilePalladium-Catalyzed Pathways to Aryl-Substituted Indenes: Efficient Synthesis of Ligands and the Respective ansa-Zirconocenes, SDS of cas: 880652-93-7, the main research area is Pd catalyzed coupling reaction bromoindene aryl halide; crystal structure bisindenylsilyl bridging chiral ansazirconocene methoxyindenylboronic acid; mol structure bisindenylsilyl bridging chiral ansazirconocene methoxyindenylboronic acid; indenylboronic acid Suzuki coupling aryl halide.

Substituted 4-/7-halo-1H-indenes and 5-methyl-3-bromo-4-/6H-cyclopenta[b]thiophenes are convenient starting materials for Suzuki-Miyaura, Negishi, and Murahashi protocols to give the corresponding aryl-substituted indenes and cyclopenta[b]thiophenes of importance for further synthesis of ansa-metallocenes. Alternatively, (2-methyl-1H-inden-4-yl)boronic acid and (1-methoxy-2-methyl-2,3-dihydro-1H-inden-4-yl)boronic acid as well as the resp. organozinc and -Mg reagents can be used for synthesizing aryl-substituted indenes via the Pd-catalyzed reactions with aryl halides. These synthetic methods have a very broad scope to afford libraries of aryl-substituted indenes. Finally, synthesis and structure characterization of several representative chiral ansa-zirconocenes, potentially useful as components of highly active and stereoselective olefin polymerization catalysts, were performed.

Organometallics published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 880652-93-7 belongs to class bromides-buliding-blocks, name is 7-Bromo-2-methyl-1H-indene, and the molecular formula is C10H9Br, SDS of cas: 880652-93-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Walker, James A. published the artcileNi-Catalyzed alkene carboacylation via amide C-N bond activation, Name: 2-Bromo-4-methoxybenzoic acid, the main research area is allylbenzamide carboacylation nickel; indanone preparation; nickel carboacylation catalyst.

A Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters is reported. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.

Journal of the American Chemical Society published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (esters). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Name: 2-Bromo-4-methoxybenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pump, Eva published the artcileImpact of Electronic Modification of the Chelating Benzylidene Ligand in cis-Dichloro-Configured Second-Generation Olefin Metathesis Catalysts on Their Activity, Product Details of C8H7BrO3, the main research area is benzylidene ruthenium imidazolidene carbene chelating complex preparation catalyst polymerization; impact electronic modification chelating benzylidene ruthenium dichloro metathesis catalyst; configured olefin metathesis catalyst benzylidene ruthenium imidazolidene carbene complex; cis trans isomerization benzylidene ruthenium imidazolidene carbene dichloro complex; crystal mol structure benzylidene ruthenium imidazolidene carbene chelating complex.

A series of electronically modified second-generation cis-dichloro ruthenium ester chelating benzylidene complexes was prepared, characterized, and benchmarked in a typical ring-opening metathesis polymerization (ROMP) experiment The electronic tuning of the parent chelating benzylidene ligand (2-Et ester benzylidene) was achieved by substitution at the 4- and 5-positions with electron-withdrawing nitro or electron-donating methoxy groups. The effect of the electronic tuning on the cis-trans isomerization process was studied exptl. and theor. D. functional theory calculations clearly revealed the influence of electronic modification on the relative stability between the cis and trans isomers, which is decisive for the activity of the studied compounds as initiators in ROMP.

Organometallics published new progress about Cis-trans isomerization. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Product Details of C8H7BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Ren-Xiao published the artcileA Pd-catalyzed domino Larock annulation/dearomative Heck reaction, Safety of 2-Bromo-4-methoxybenzoic acid, the main research area is benzoyl iodoaniline alkyne palladium tandem Larock heteroannulation dearomative Heck; phenyldihydroisoindoloindolone preparation.

A palladium-catalyzed domino Larock annulation/dearomative Heck reaction was developed, which delivered a range of tetracyclic indoline derivatives in moderate to excellent yields through a Larock annulation of N-bromobenzoyl o-iodoanilines with alkynes and a subsequent intramol. dearomative Heck reaction. This protocol provided a straightforward route to structurally diverse indolines from readily available starting materials by forming two new rings and three chem. bonds in a single step.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Safety of 2-Bromo-4-methoxybenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rajca, Andrzej published the artcileSynthesis of Sterically Hindered 1,3-Connected Polyarylmethanes, Name: Methyl 5-bromo-2,4-dimethylbenzoate, the main research area is sterically hindered polyarylmethane; polyether aryl sterically hindered; ether poly sterically hindered; propeller mol sterically hindered.

Sterically hindered 1,3-connected polyarylmethanes, e.g. I, were prepared by repetitive additions of aryllithiums to carbonyl compounds Synthetic routes with various degree of convergence were used. Variable temperature NMR spectroscopy, in conjunction with other techniques, was used to characterize the products.

Journal of Organic Chemistry published new progress about Steric hindrance. 152849-72-4 belongs to class bromides-buliding-blocks, name is Methyl 5-bromo-2,4-dimethylbenzoate, and the molecular formula is C10H11BrO2, Name: Methyl 5-bromo-2,4-dimethylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary